ATE122041T1 - Pyrimidinnucleosidderivat. - Google Patents

Pyrimidinnucleosidderivat.

Info

Publication number: ATE122041T1
Authority: AT; Austria
Prior art keywords: pyrimidine nucleoside; nucleoside derivative; hydroxy; hydrogen; represent
Prior art date: 1990-06-15

Application number

AT91911192T

Other languages

English (en)

Inventor

Akira Matsuda

Takuma Sasaki

Tohru Ueda

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-15

Filing date

1991-06-13

Publication date

1995-05-15

1991-06-13 Application filed by Sankyo Co filed Critical Sankyo Co

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE122041T1 publication Critical patent/ATE122041T1/de

Links

150000003833 nucleoside derivatives Chemical class 0.000 title abstract 2
239000002718 pyrimidine nucleoside Substances 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT91911192T 1990-06-15 1991-06-13 Pyrimidinnucleosidderivat. ATE122041T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP15668890		1990-06-15

Publications (1)

Publication Number	Publication Date
ATE122041T1 true ATE122041T1 (de)	1995-05-15

Family

ID=15633157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91911192T ATE122041T1 (de)	1990-06-15	1991-06-13	Pyrimidinnucleosidderivat.

Country Status (13)

Country	Link
US (2)	US5616567A (de)
EP (1)	EP0535231B1 (de)
JP (1)	JP2559917B2 (de)
KR (1)	KR970011306B1 (de)
AT (1)	ATE122041T1 (de)
CA (1)	CA2085345C (de)
DE (1)	DE69109482T2 (de)
DK (1)	DK0535231T3 (de)
ES (1)	ES2074719T3 (de)
HK (1)	HK1005871A1 (de)
HU (1)	HU218924B (de)
RU (1)	RU2116306C1 (de)
WO (1)	WO1991019713A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI105556B (fi) *	1991-09-30	2000-09-15	Sankyo Co	Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
JP3265548B2 (ja)	1992-05-12	2002-03-11	メレルファーマス−ティカルズインコーポレイテッド	リボヌクレオチド還元酵素阻害剤の製法
EP1736478B1 (de) *	2000-05-26	2015-07-22	IDENIX Pharmaceuticals, Inc.	Verfahren und Zusammensetzungen zur Behandlung von Flaviviren und Pestiviren
JP3748536B2 (ja) *	2001-02-09	2006-02-22	三共株式会社	ピリミジンヌクレオシド誘導体の結晶
TW200637870A (en)	2005-01-31	2006-11-01	Taiho Pharmaceutical Co Ltd	Novel pyrimidine nucleoside compound and salt thereof
DE602006016103D1 (de) *	2005-05-11	2010-09-23	Nippon Kayaku Kk	Polymer-derivat von cytidin metabolit antagonist
GB0523041D0 (en) *	2005-11-11	2005-12-21	Cyclacel Ltd	Combination
GB0526419D0 (en) *	2005-12-23	2006-02-08	Cyclacel Ltd	Formulation
EP2045256A4 (de) *	2006-07-21	2009-09-02	Taiho Pharmaceutical Co Ltd	2'-cyanopyrimidinnukleosidverbindung
KR101057239B1 (ko) *	2006-10-10	2011-08-16	에프. 호프만-라 로슈 아게	뉴클레오사이드 리보푸라노실 피리미딘의 제조
GB0625283D0 (en)	2006-12-19	2007-01-24	Cyclacel Ltd	Combination
WO2009042767A1 (en) *	2007-09-26	2009-04-02	Mount Sinai School Of Medicine	Azacytidine analogues and uses thereof
US8124593B2 (en)	2007-11-05	2012-02-28	Cyclacel Limited	Methods of treatment using sapacitabine
US7863255B2 (en) *	2008-04-29	2011-01-04	Taiho Pharmaceutical Co., Ltd.	Methods of administering antitumor agent comprising deoxycytidine derivative
GB0808357D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
GB0808359D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
AU2009259136B2 (en)	2008-06-09	2014-09-25	Cyclacel Limited	Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine
FI2431376T4 (fi) *	2009-05-15	2024-03-13	Delta Fly Pharma Inc	1-(2'-syano-2'-deoksi-beeta-D-arabinofuranosyyli)sytosiinimonohydrokloridin uusi vakaa kide
PL2696878T3 (pl)	2011-04-14	2020-01-31	Cyclacel Limited	Schemat dawkowania dla sapacytabiny i decytabiny w kombinacji do leczenia ostrej białaczki szpikowej
SG10201913554YA (en)	2011-12-22	2020-03-30	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
JP6286421B2 (ja)	2012-05-15	2018-02-28	サイクラセルリミテッド	サパシタビン及びセリシクリブの投与レジメン
WO2019081951A1 (en)	2017-10-27	2019-05-02	Cyclacel Limited	DOSAGE REGIME
EP4183397A4 (de)	2020-07-17	2024-03-27	Delta-Fly Pharma, Inc.	Neue therapie und neues therapeutikum für blutkrebs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2007094A6 (es) *	1987-07-29	1989-06-01	Consejo Superior Investigacion	Procedimiento para la preparacion de 3 -c- ciano-2,3 -didesoxinucleosido.

1991
- 1991-06-11 JP JP3138859A patent/JP2559917B2/ja not_active Expired - Lifetime
- 1991-06-13 CA CA002085345A patent/CA2085345C/en not_active Expired - Lifetime
- 1991-06-13 HU HU9203967A patent/HU218924B/hu unknown
- 1991-06-13 AT AT91911192T patent/ATE122041T1/de not_active IP Right Cessation
- 1991-06-13 KR KR1019920703246A patent/KR970011306B1/ko not_active Expired - Lifetime
- 1991-06-13 EP EP91911192A patent/EP0535231B1/de not_active Expired - Lifetime
- 1991-06-13 ES ES91911192T patent/ES2074719T3/es not_active Expired - Lifetime
- 1991-06-13 DE DE69109482T patent/DE69109482T2/de not_active Expired - Lifetime
- 1991-06-13 WO PCT/JP1991/000797 patent/WO1991019713A1/ja not_active Ceased
- 1991-06-13 DK DK91911192.2T patent/DK0535231T3/da active
- 1991-06-13 RU RU92016591/04A patent/RU2116306C1/ru active
1994
- 1994-09-07 US US08/301,720 patent/US5616567A/en not_active Expired - Lifetime
1995
- 1995-06-01 US US08/457,510 patent/US5654420A/en not_active Expired - Lifetime
1998
- 1998-06-05 HK HK98104955A patent/HK1005871A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2116306C1 (ru)	1998-07-27
ES2074719T3 (es)	1995-09-16
EP0535231A1 (de)	1993-04-07
HU218924B (hu)	2000-12-28
HUT62582A (en)	1993-05-28
EP0535231A4 (en)	1993-06-30
EP0535231B1 (de)	1995-05-03
KR970011306B1 (ko)	1997-07-09
KR930700485A (ko)	1993-03-15
HK1005871A1 (en)	1999-01-29
DE69109482T2 (de)	1996-02-15
CA2085345C (en)	2001-08-07
DE69109482D1 (en)	1995-06-08
US5616567A (en)	1997-04-01
JP2559917B2 (ja)	1996-12-04
JPH04235182A (ja)	1992-08-24
HU9203967D0 (en)	1993-03-29
CA2085345A1 (en)	1991-12-16
US5654420A (en)	1997-08-05
WO1991019713A1 (fr)	1991-12-26
DK0535231T3 (da)	1995-08-21

Legal Events

Date	Code	Title
1995-12-15	UEP	Publication of translation of european patent specification
2005-03-15	EEIH	Change in the person of patent owner
2006-04-15	EEIH	Change in the person of patent owner
2011-09-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE122041T1 (de)	1995-05-15	Pyrimidinnucleosidderivat.
ATE416186T1 (de)	2008-12-15	Phenylethylenamin-derivate
DE3851179D1 (de)	1994-09-29	Oxetanocin.
FI952101A0 (fi)	1995-05-03	Merkaptanfoerening
DK0784055T3 (da)	2003-06-02	Pyrimidinylpyrazolderivater
ATE86866T1 (de)	1993-04-15	Antikrebs-zusammensetzung.
FI940011A0 (fi)	1994-01-03	Mono- ja bis-alkyyliaminoantrasykliinit
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
DK0424899T3 (da)	1997-03-24	Hidtil ukendte anthracyclinglycosidderivater og fremgangsmåde til fremstilling deraf
NO904187D0 (no)	1990-09-26	Benzanilider.
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
BG60066B2 (bg)	1993-09-30	Метод за получаване на 4-/3-/4-оксотиазолидин//бутиниламин
DE69303847D1 (de)	1996-09-05	Indolderivate
ATE176242T1 (de)	1999-02-15	Uck14-verbindungen
GB0217638D0 (en)	2002-09-11	Total synthesis of myriaporones