DK0537148T3 - Oprensning af humant interleukin-4 udskilt fra en Escherichia coli mutant - Google Patents

Oprensning af humant interleukin-4 udskilt fra en Escherichia coli mutant

Info

Publication number: DK0537148T3
Authority: DK; Denmark
Prior art keywords: secreted; sodium chloride; coli mutant; purification; escherichia coli
Prior art date: 1990-05-31

Application number

DK91903451.2T

Other languages

English (en)

Inventor

David Naveh

John Chu-Tay Tang

T L Nagabhushan

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-31

Filing date

1991-01-04

Publication date

1996-05-06

1991-01-04 Application filed by Schering Corp filed Critical Schering Corp

1996-05-06 Application granted granted Critical

1996-05-06 Publication of DK0537148T3 publication Critical patent/DK0537148T3/da

Links

101001002709 Homo sapiens Interleukin-4 Proteins 0.000 title abstract 3
102000055229 human IL4 Human genes 0.000 title abstract 3
241000588724 Escherichia coli Species 0.000 title abstract 2
238000000746 purification Methods 0.000 title 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
239000011780 sodium chloride Substances 0.000 abstract 3
239000000872 buffer Substances 0.000 abstract 2
239000000243 solution Substances 0.000 abstract 2
229920000936 Agarose Polymers 0.000 abstract 1
238000005277 cation exchange chromatography Methods 0.000 abstract 1
239000007979 citrate buffer Substances 0.000 abstract 1
238000011026 diafiltration Methods 0.000 abstract 1
230000007717 exclusion Effects 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
238000005227 gel permeation chromatography Methods 0.000 abstract 1
239000008363 phosphate buffer Substances 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK91903451.2T 1990-05-31 1991-01-04 Oprensning af humant interleukin-4 udskilt fra en Escherichia coli mutant DK0537148T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/531,270 US5077388A (en)	1990-05-31	1990-05-31	Purification of human interleukin-4 from a secreted escherichia coli mutant

Publications (1)

Publication Number	Publication Date
DK0537148T3 true DK0537148T3 (da)	1996-05-06

Family

ID=24116964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91903451.2T DK0537148T3 (da)	1990-05-31	1991-01-04	Oprensning af humant interleukin-4 udskilt fra en Escherichia coli mutant

Country Status (16)

Country	Link
US (1)	US5077388A (da)
EP (1)	EP0537148B1 (da)
JP (1)	JP2573767B2 (da)
AT (1)	ATE136552T1 (da)
AU (1)	AU659993B2 (da)
CA (1)	CA2084186C (da)
DE (1)	DE69118696T2 (da)
DK (1)	DK0537148T3 (da)
ES (1)	ES2085986T3 (da)
GR (1)	GR3019705T3 (da)
IE (1)	IE73668B1 (da)
IL (1)	IL96880A0 (da)
MY (1)	MY130013A (da)
NZ (1)	NZ236699A (da)
WO (1)	WO1991018919A1 (da)
ZA (1)	ZA9193B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100191223B1 (ko) *	1989-07-28	1999-06-15	둘락 노먼 씨.	인터루킨-4의 정제방법 및 이를 함유하는 약제학적 조성물
US5840851A (en) *	1993-07-23	1998-11-24	Plomer; J. Jeffrey	Purification of hemoglobin
KR0141651B1 (ko) *	1994-09-07	1998-06-15	강재헌	금속이온 친화성 크로마토그라피를 이용한 히루딘의 정제방법
AU8671798A (en) *	1997-07-30	1999-02-22	Betagene, Inc.	Methods and compositions relating to no-mediated cytotoxicity
US6171856B1 (en)	1997-07-30	2001-01-09	Board Of Regents, The University Of Texas System	Methods and compositions relating to no-mediated cytotoxicity
WO2002072615A1 (en) *	2001-03-09	2002-09-19	Chugai Seiyaku Kabushiki Kaisha	Method of purifying protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL80678A (en) *	1985-11-19	1999-05-09	Schering Biotech Corp	Human interleukin-4
EP0449949A1 (en) *	1988-12-21	1991-10-09	Schering Corporation	Use of interleukin-4 for lowering blood-cholesterol levels
KR100191223B1 (ko) *	1989-07-28	1999-06-15	둘락 노먼 씨.	인터루킨-4의 정제방법 및 이를 함유하는 약제학적 조성물

1990
- 1990-05-31 US US07/531,270 patent/US5077388A/en not_active Expired - Fee Related
1991
- 1991-01-04 EP EP91903451A patent/EP0537148B1/en not_active Expired - Lifetime
- 1991-01-04 AU AU72220/91A patent/AU659993B2/en not_active Ceased
- 1991-01-04 IE IE2791A patent/IE73668B1/en not_active IP Right Cessation
- 1991-01-04 MY MYPI91000007A patent/MY130013A/en unknown
- 1991-01-04 AT AT91903451T patent/ATE136552T1/de not_active IP Right Cessation
- 1991-01-04 WO PCT/US1991/000006 patent/WO1991018919A1/en not_active Ceased
- 1991-01-04 DK DK91903451.2T patent/DK0537148T3/da active
- 1991-01-04 CA CA002084186A patent/CA2084186C/en not_active Expired - Fee Related
- 1991-01-04 IL IL96880A patent/IL96880A0/xx unknown
- 1991-01-04 NZ NZ236699A patent/NZ236699A/en unknown
- 1991-01-04 ES ES91903451T patent/ES2085986T3/es not_active Expired - Lifetime
- 1991-01-04 ZA ZA9193A patent/ZA9193B/xx unknown
- 1991-01-04 DE DE69118696T patent/DE69118696T2/de not_active Expired - Fee Related
- 1991-01-04 JP JP3503528A patent/JP2573767B2/ja not_active Expired - Lifetime
1996
- 1996-04-22 GR GR960401088T patent/GR3019705T3/el unknown

Also Published As

Publication number	Publication date
CA2084186A1 (en)	1991-12-01
AU659993B2 (en)	1995-06-08
JP2573767B2 (ja)	1997-01-22
MY130013A (en)	2007-05-31
EP0537148B1 (en)	1996-04-10
JPH05505934A (ja)	1993-09-02
ES2085986T3 (es)	1996-06-16
NZ236699A (en)	1992-08-26
DE69118696D1 (de)	1996-05-15
IL96880A0 (en)	1992-03-29
IE73668B1 (en)	1997-07-02
US5077388A (en)	1991-12-31
DE69118696T2 (de)	1996-08-29
IE910027A1 (en)	1991-12-04
CA2084186C (en)	1999-12-14
WO1991018919A1 (en)	1991-12-12
ATE136552T1 (de)	1996-04-15
EP0537148A1 (en)	1993-04-21
GR3019705T3 (en)	1996-07-31
AU7222091A (en)	1991-12-31
ZA9193B (en)	1991-09-25

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