DK0540099T3 - Vandopløselige camptothecinderivater - Google Patents

Vandopløselige camptothecinderivater

Info

Publication number: DK0540099T3
Authority: DK; Denmark
Prior art keywords: water; camptothecin derivatives; soluble camptothecin; soluble; derivatives
Prior art date: 1991-10-29

Application number

DK92203263.6T

Other languages

Danish (da)

English (en)

Inventor

Jeffrey M Besterman

Michael Joseph Luzzio

Michael G Evans

Peter Leslie Myers

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-29

Filing date

1992-10-23

Publication date

1996-06-17

1992-10-23 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

1996-06-17 Application granted granted Critical

1996-06-17 Publication of DK0540099T3 publication Critical patent/DK0540099T3/da

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

DK92203263.6T 1991-10-29 1992-10-23 Vandopløselige camptothecinderivater DK0540099T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78427591A	1991-10-29	1991-10-29
US82672992A	1992-01-28	1992-01-28

Publications (1)

Publication Number	Publication Date
DK0540099T3 true DK0540099T3 (da)	1996-06-17

Family

ID=27120258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92203263.6T DK0540099T3 (da)	1991-10-29	1992-10-23	Vandopløselige camptothecinderivater

Country Status (25)

Country	Link
EP (1)	EP0540099B1 (fr)
JP (2)	JP3020760B2 (fr)
KR (1)	KR100246154B1 (fr)
CN (1)	CN1072683A (fr)
AP (1)	AP306A (fr)
AT (1)	ATE136898T1 (fr)
AU (1)	AU657007B2 (fr)
CA (1)	CA2081580A1 (fr)
CZ (1)	CZ284023B6 (fr)
DE (1)	DE69209969T2 (fr)
DK (1)	DK0540099T3 (fr)
ES (1)	ES2086643T3 (fr)
FI (3)	FI982185L (fr)
GR (1)	GR3020120T3 (fr)
HU (2)	HU217970B (fr)
IL (1)	IL103571A (fr)
IS (1)	IS1708B (fr)
MX (1)	MX9206211A (fr)
MY (1)	MY108261A (fr)
NO (1)	NO302073B1 (fr)
NZ (1)	NZ244914A (fr)
OA (1)	OA09767A (fr)
RU (1)	RU2119921C1 (fr)
SK (1)	SK279298B6 (fr)
TW (1)	TW221994B (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364858A (en) *	1987-03-31	1994-11-15	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5552154A (en) *	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6005537A (en)	1992-08-21	1999-12-21	Hitachi, Ltd.	Liquid-crystal display control apparatus
AP9300587A0 (en) *	1992-11-12	1995-05-05	Glaxo Inc	Water soluble camptothecin derivatives.
DE69409633T2 (de) *	1993-01-15	1998-08-06	The Stehlin Foundation For Cancer Research, Houston, Tex.	Transdermal behandlung von krebs mit wasserunlöslichem s-camtothecin mit geschlossenem lactoring
US5369127A (en) *	1993-04-21	1994-11-29	Allergan, Inc.	1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
IS4152A (is) *	1993-04-29	1994-10-30	Glaxo Inc.	Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
WO1994025465A1 (fr) *	1993-05-03	1994-11-10	Smithkline Beecham Corporation	METHYLENEDIOXY [3',4':6,7]INDOLIZINO[1,2,b]QUINOLINONES A SUBSTITUTIONS
US5447936A (en) *	1993-12-22	1995-09-05	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5491237A (en)	1994-05-03	1996-02-13	Glaxo Wellcome Inc.	Intermediates in pharmaceutical camptothecin preparation
IT1269862B (it) *	1994-05-30	1997-04-15	Indena Spa	Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5646159A (en) *	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds
KR960029336A (ko)	1995-01-09	1996-08-17	김충환	캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5496952A (en) *	1995-02-07	1996-03-05	North Carolina State University	Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5670500A (en) *	1995-05-31	1997-09-23	Smithkline Beecham Corporation	Water soluble camptothecin analogs
EP0837850B1 (fr) *	1995-06-27	2004-09-01	Takeda Chemical Industries, Ltd.	Derives de 4-acylamino(halogeno)alkyl-quinoline, leur preparation et leur utilisation comme agonistes de la melatonine
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
AU7732996A (en) *	1995-11-22	1997-06-11	Research Triangle Institute	Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
CA2192725C (fr)	1995-12-28	2004-04-20	Kenji Tsujihara	Derives de la camptothecine
PT918774E (pt) *	1996-06-27	2002-05-31	Ligand Pharm Inc	Compostos moduladores do receptor para androgenio e metodos
SG103322A1 (en) *	1996-10-30	2004-04-29	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en)	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
US6207673B1 (en)	1997-03-12	2001-03-27	The University Of North Carolina At Chapel Hill	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US6046209A (en) *	1997-05-27	2000-04-04	Smithkline Beecham Corporation	Water soluble camptothecin analogs
CZ20021550A3 (cs) *	1999-11-09	2003-02-12	Societe De Conseils De Recherches Et D'application	Produkt zahrnující inhibitor transdukce signálů heterotrimerického G proteinu kombinovaný s jiným protirakovinným činidlem pro terapeutické použití v léčbě rakoviny
US6288072B1 (en) *	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition
CA2401191C (fr)	2000-02-28	2006-05-02	Aventis Pharma S.A.	Composition comprenant la camptothecine et un derive de pyrimidine et destinee a etre utilisee dans le traitement du cancer
US6548488B2 (en)	2000-03-17	2003-04-15	Aventis Pharma S.A.	Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6545010B2 (en)	2000-03-17	2003-04-08	Aventis Pharma S.A.	Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6486320B2 (en)	2000-09-15	2002-11-26	Aventis Pharma S.A.	Preparation of camptothecin and of its derivatives
AU1602902A (en)	2000-10-27	2002-05-06	Aventis Pharma Sa	A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
TW200306314A (en) *	2002-04-16	2003-11-16	Tanabe Seiyaku Co	Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
ITRM20040240A1 (it) *	2004-05-13	2004-08-13	Ist Naz Stud Cura Dei Tumori	Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
US20090104254A1 (en)	2004-12-22	2009-04-23	Rutgers, The State University Of New Jersey	Controlled Release Hydrogels
WO2012050591A1 (fr)	2010-10-15	2012-04-19	Rutgers, The State University Of New Jersey	Formulation d'hydrogel pour une administration dermique et oculaire
AU2007232206B2 (en)	2006-03-30	2013-04-04	Drais Pharmaceuticals, Inc.	Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
CN101407524B (zh) *	2007-10-09	2012-07-18	江苏先声药物研究有限公司	噁嗪骈喜树碱衍生物及其制备方法和用途
CN100592871C (zh) *	2008-03-14	2010-03-03	浙江林学院	一种杀虫剂组合物及其加工方法
ES2373172B1 (es) *	2010-07-16	2012-12-10	Consejo Superior De Investigaciones Científicas (Csic)	Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales.
WO2012096832A2 (fr) *	2011-01-12	2012-07-19	Crystal Biopharmaceutical Llc	Dérivés de camptothécine inhibiteurs de hdac
BR112020020466A2 (pt) *	2018-04-06	2021-01-12	Seattle Genetics, Inc.	Conjugados de peptídeo de camptotecina
TWI851577B (zh)	2018-06-07	2024-08-11	美商思進公司	喜樹鹼結合物
CN110590796B (zh) *	2018-06-12	2022-07-15	青岛海洋生物医药研究院股份有限公司	喜树碱衍生物及其制备方法和应用
SG11202110922QA (en) *	2019-04-26	2021-10-28	Immunogen Inc	Camptothecin derivatives
JP2024532768A (ja) *	2021-08-19	2024-09-10	ハイナンシムセレザイミンファーマシューティカルカンパニーリミテッド	カンプトテシン誘導体、その薬物組成物およびその応用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells

1992
- 1992-10-23 EP EP92203263A patent/EP0540099B1/fr not_active Expired - Lifetime
- 1992-10-23 DK DK92203263.6T patent/DK0540099T3/da active
- 1992-10-23 AT AT92203263T patent/ATE136898T1/de not_active IP Right Cessation
- 1992-10-23 DE DE69209969T patent/DE69209969T2/de not_active Expired - Fee Related
- 1992-10-23 ES ES92203263T patent/ES2086643T3/es not_active Expired - Lifetime
- 1992-10-27 TW TW081108539A patent/TW221994B/zh active
- 1992-10-27 SK SK3237-92A patent/SK279298B6/sk unknown
- 1992-10-27 CZ CS923237A patent/CZ284023B6/cs not_active IP Right Cessation
- 1992-10-28 CA CA002081580A patent/CA2081580A1/fr not_active Abandoned
- 1992-10-28 MY MYPI92001954A patent/MY108261A/en unknown
- 1992-10-28 AU AU27385/92A patent/AU657007B2/en not_active Ceased
- 1992-10-28 JP JP4312862A patent/JP3020760B2/ja not_active Expired - Fee Related
- 1992-10-28 IS IS3936A patent/IS1708B/is unknown
- 1992-10-28 AP APAP/P/1992/000439A patent/AP306A/en active
- 1992-10-28 NZ NZ244914A patent/NZ244914A/xx not_active IP Right Cessation
- 1992-10-28 MX MX9206211A patent/MX9206211A/es unknown
- 1992-10-28 OA OA60295A patent/OA09767A/en unknown
- 1992-10-28 CN CN92113782A patent/CN1072683A/zh not_active Withdrawn
- 1992-10-28 KR KR1019920019884A patent/KR100246154B1/ko not_active Expired - Fee Related
- 1992-10-28 FI FI982185A patent/FI982185L/fi unknown
- 1992-10-28 NO NO924158A patent/NO302073B1/no unknown
- 1992-10-28 RU RU92004336A patent/RU2119921C1/ru not_active IP Right Cessation
- 1992-10-28 FI FI924878A patent/FI104373B/fi active
- 1992-10-28 HU HU9203384A patent/HU217970B/hu not_active IP Right Cessation
- 1992-10-28 IL IL103571A patent/IL103571A/en not_active IP Right Cessation
1995
- 1995-06-14 HU HU95P/P00203P patent/HU211349A9/hu unknown
1996
- 1996-05-31 GR GR960401497T patent/GR3020120T3/el unknown
1999
- 1999-11-02 JP JP31294099A patent/JP3229298B2/ja not_active Expired - Fee Related
2002
- 2002-06-07 FI FI20021090A patent/FI20021090L/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
FI924878A7 (fi)	1993-04-30
SK323792A3 (en)	1998-09-09
EP0540099B1 (fr)	1996-04-17
KR100246154B1 (ko)	2000-04-01
DE69209969D1 (de)	1996-05-23
HU217970B (hu)	2000-05-28
MY108261A (en)	1996-09-30
FI982185A7 (fi)	1998-10-08
FI924878A0 (fi)	1992-10-28
CA2081580A1 (fr)	1993-04-30
OA09767A (en)	1993-11-30
HUT65719A (en)	1994-07-28
AU657007B2 (en)	1995-02-23
JPH05222048A (ja)	1993-08-31
NO302073B1 (no)	1998-01-19
JP2000109475A (ja)	2000-04-18
DE69209969T2 (de)	1996-09-12
FI982185A0 (fi)	1998-10-08
NO924158D0 (no)	1992-10-28
HU9203384D0 (en)	1993-01-28
IS3936A (is)	1993-04-30
IL103571A (en)	1998-01-04
TW221994B (fr)	1994-04-01
AU2738592A (en)	1993-05-06
EP0540099A1 (fr)	1993-05-05
AP9200439A0 (en)	1992-10-31
NO924158L (no)	1993-04-30
ATE136898T1 (de)	1996-05-15
AP306A (en)	1994-01-28
HU211349A9 (en)	1995-11-28
ES2086643T3 (es)	1996-07-01
SK279298B6 (sk)	1998-09-09
FI104373B (fi)	2000-01-14
FI20021090A7 (fi)	2002-06-07
JP3229298B2 (ja)	2001-11-19
NZ244914A (en)	1995-01-27
IL103571A0 (en)	1993-03-15
FI982185L (fi)	1998-10-08
CN1072683A (zh)	1993-06-02
MX9206211A (es)	1993-05-01
RU2119921C1 (ru)	1998-10-10
IS1708B (is)	1998-12-16
JP3020760B2 (ja)	2000-03-15
GR3020120T3 (en)	1996-08-31
FI20021090L (fi)	2002-06-07
CZ284023B6 (cs)	1998-07-15
CZ323792A3 (en)	1993-10-13

Publication	Publication Date	Title
DK0540099T3 (da)	1996-06-17	Vandopløselige camptothecinderivater
DE69208877D1 (de)	1996-04-11	Chinuclidinderivate
FI924160A7 (fi)	1993-03-19	Benzanilidderivat
FI935726A7 (fi)	1993-12-20	Atsanorbornaanijohdannaisia
FI924159L (fi)	1993-03-19	Benzanilidderivat
NO922182L (no)	1992-12-04	Krystallinske oksatiolan-derivater
FI942766A7 (fi)	1994-06-10	20-metyylisubstituoituja D-vitamiinijohdannaisia
DE69119329D1 (de)	1996-06-13	Actinonin-Derivate
FI952746A7 (fi)	1995-06-05	Polymeeriin sitoutuneen kamptotesiinijohdannaiset
FI921262L (fi)	1992-09-26	4-aryltiazol- eller 4-arylimidazolderivat
FI925763A0 (fi)	1992-12-18	Fungicida 2-imidazolin-5-on- och 2-imidazolin-5-tionderivat
FI923726L (fi)	1993-02-24	Sulfaterade glykosaminoglykanoidderivat
ATE144765T1 (de)	1996-11-15	Hiv-hemmende benzenacetamidderivate
ATE171449T1 (de)	1998-10-15	Oxadolderivate
FI935243L (fi)	1994-01-11	Pyridonkarboxylsyraderivat
FI920394A7 (fi)	1992-08-02	3-kinuklidiinijohdannaiset
DE69119323D1 (de)	1996-06-13	Fluoräthylcamptothecinderivate
FI934710L (fi)	1993-10-25	4-aryl-3-(heteroarylureido)kinolinderivat
MX9206710A (es)	1993-05-01	Derivados de piridinol
FI924145L (fi)	1993-03-18	3-cykloalkylprop-2-enamidderivat
FI935293A7 (fi)	1993-11-29	Propensyraderivat
FI933346A7 (fi)	1993-07-26	Aminoalkylpyrrolidinyltiokarbapenemderivat
FI942070L (fi)	1994-05-05	Nitroksialkyyliamidijohdannaiset
DE69211197D1 (de)	1996-07-11	1-Hydroxyvitamin D-Derivate
KR930702353A (ko)	1993-09-08	2- 카르바페넴 유도체