DK0592440T3 - Technetium-99m-komplekser til anvendelse som radiofarmaceutiske midler - Google Patents
Technetium-99m-komplekser til anvendelse som radiofarmaceutiske midlerInfo
- Publication number
- DK0592440T3 DK0592440T3 DK91920326T DK91920326T DK0592440T3 DK 0592440 T3 DK0592440 T3 DK 0592440T3 DK 91920326 T DK91920326 T DK 91920326T DK 91920326 T DK91920326 T DK 91920326T DK 0592440 T3 DK0592440 T3 DK 0592440T3
- Authority
- DK
- Denmark
- Prior art keywords
- complexes
- technetium
- radiopharmaceuticals
- compositions
- preparing
- Prior art date
Links
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical class [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 229940121896 radiopharmaceutical Drugs 0.000 title abstract 2
- 239000012217 radiopharmaceutical Substances 0.000 title abstract 2
- 230000002799 radiopharmaceutical effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- 230000003907 kidney function Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
- C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/92—Ketonic chelates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/605,207 US5116598A (en) | 1990-10-29 | 1990-10-29 | N4 technetium-99 m complexes for use as radiopharmaceuticals |
| PCT/US1991/007908 WO1992007860A2 (en) | 1990-10-29 | 1991-10-25 | TECHNETIUM-99m COMPLEXES FOR USE AS RADIOPHARMACEUTICALS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0592440T3 true DK0592440T3 (da) | 2000-03-27 |
Family
ID=24422678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91920326T DK0592440T3 (da) | 1990-10-29 | 1991-10-25 | Technetium-99m-komplekser til anvendelse som radiofarmaceutiske midler |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US5116598A (da) |
| EP (1) | EP0592440B1 (da) |
| JP (1) | JPH06502640A (da) |
| AT (1) | ATE187731T1 (da) |
| AU (1) | AU658847B2 (da) |
| CA (1) | CA2093931A1 (da) |
| DE (1) | DE69131850T2 (da) |
| DK (1) | DK0592440T3 (da) |
| WO (1) | WO1992007860A2 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116598A (en) * | 1990-10-29 | 1992-05-26 | Mallinckrodt Medical, Inc. | N4 technetium-99 m complexes for use as radiopharmaceuticals |
| US5808091A (en) | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| EP0663900B1 (en) * | 1992-10-08 | 1999-09-22 | Nycomed Amersham PLC | Metal-oxime chelates for use as radiopharmaceutical agents |
| US5688485A (en) * | 1992-12-31 | 1997-11-18 | The Dupont Merck Pharmaceutical Company | Radiolabelled complexes of ester-substituted diaminethiols |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| CA2168652A1 (en) * | 1993-08-04 | 1995-02-16 | Colin Mill Archer | Radiometal complexes that localise in hypoxic tissue |
| ES2114735T3 (es) * | 1994-01-12 | 1998-06-01 | Bracco Int Bv | Ligandos y complejos metalicos de los mismos. |
| US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
| US5968477A (en) * | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
| CA2190727C (en) * | 1994-05-19 | 2006-07-18 | Sudhakar Kasina | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging |
| WO1996007629A1 (en) * | 1994-09-08 | 1996-03-14 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| US5986074A (en) * | 1996-05-06 | 1999-11-16 | Emory University | Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof |
| JP2001504801A (ja) * | 1996-06-10 | 2001-04-10 | ジー．ディー．サール アンド カンパニー | 血栓サイトに局在化可能な放射性医薬組成物 |
| US6005083A (en) | 1997-03-28 | 1999-12-21 | Neorx Corporation | Bridged aromatic substituted amine ligands with donor atoms |
| GB0513812D0 (en) | 2005-07-05 | 2005-08-10 | Isis Innovation | Compounds for imaging and therapy |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3883595A (en) * | 1970-05-28 | 1975-05-13 | Us Agriculture | Process for the preparation of beta dicarbonyl |
| US3968128A (en) * | 1970-07-01 | 1976-07-06 | Exxon Research And Engineering Company | Magnesium-group VIII transition metal carbonyl and substituted carbonyl complexes |
| DD118526A5 (da) * | 1974-04-30 | 1976-03-12 | ||
| EP0024464B1 (en) * | 1979-08-29 | 1982-05-12 | Nihon Medi-Physics Co., Ltd. | 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use |
| US4324676A (en) * | 1980-01-21 | 1982-04-13 | The Dow Chemical Company | Compositions containing β-diketo chelating compounds |
| US4418208A (en) * | 1980-12-29 | 1983-11-29 | E. R. Squibb & Sons, Inc. | N-Substituted iminodiacetic acids |
| DE3171920D1 (en) * | 1981-09-16 | 1985-09-26 | Nihon Mediphysics Co Ltd | Radioactive diagnostic agent and its preparation |
| AU561568B2 (en) * | 1983-04-19 | 1987-05-14 | Nihon Medi-Physics Co., Ltd. | P-glyoxyloylphenylalkanoic acid bis thiosemicarbazone derivatives |
| US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
| US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
| GB8426845D0 (en) * | 1984-10-24 | 1984-11-28 | Amersham Int Plc | Complexes of technetium-99m |
| DE3687467T2 (de) * | 1985-03-11 | 1993-04-29 | Amersham Int Plc | Komplexe von technetium-99m mit propylen-amin-oximen. |
| US4795626A (en) * | 1985-05-10 | 1989-01-03 | University Of Cincinnati | 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo |
| ATE52516T1 (de) * | 1986-05-28 | 1990-05-15 | Mallinckrodt Inc | Technetiumchelate fuer die bestimmung der nierenfunktion. |
| GB8615916D0 (en) * | 1986-06-30 | 1986-08-06 | Amersham Int Plc | Bone-seeking complexes of technetium-99m |
| US4714605A (en) * | 1986-10-14 | 1987-12-22 | E. R. Squibb & Sons, Inc. | Technetium-99m labeled dioxime complexes |
| KR960001742B1 (en) * | 1986-12-30 | 1996-02-05 | Nihon Medi Physics K K | High molecular compound comprising unit of asialoglycoprotein |
| US4952393A (en) * | 1987-04-02 | 1990-08-28 | The General Hospital Corporation | Organ infarct imaging with technetium labelled glucarate |
| AU2068588A (en) * | 1987-08-12 | 1989-02-16 | Immunomedics Inc. | Preparation of radiolabeled conjugates |
| JPH01186899A (ja) * | 1988-01-18 | 1989-07-26 | Nippon Mejifuijitsukusu Kk | 膜透過性を有するＴｃ−９９ｍ単核錯体 |
| US4925650A (en) * | 1988-11-16 | 1990-05-15 | Mallinckrodt, Inc. | Technetium -99m complex for examining the renal function |
| US5116598A (en) * | 1990-10-29 | 1992-05-26 | Mallinckrodt Medical, Inc. | N4 technetium-99 m complexes for use as radiopharmaceuticals |
| US5104638A (en) * | 1990-10-29 | 1992-04-14 | Mallinckrodt Medical, Inc. | Method of making a radiopharmaceutical complex from a kit |
-
1990
- 1990-10-29 US US07/605,207 patent/US5116598A/en not_active Expired - Lifetime
-
1991
- 1991-10-25 WO PCT/US1991/007908 patent/WO1992007860A2/en not_active Ceased
- 1991-10-25 DE DE69131850T patent/DE69131850T2/de not_active Expired - Fee Related
- 1991-10-25 AU AU89458/91A patent/AU658847B2/en not_active Expired - Fee Related
- 1991-10-25 CA CA002093931A patent/CA2093931A1/en not_active Abandoned
- 1991-10-25 DK DK91920326T patent/DK0592440T3/da active
- 1991-10-25 AT AT91920326T patent/ATE187731T1/de not_active IP Right Cessation
- 1991-10-25 EP EP91920326A patent/EP0592440B1/en not_active Expired - Lifetime
- 1991-10-25 JP JP4500816A patent/JPH06502640A/ja active Pending
-
1992
- 1992-03-23 US US07/855,279 patent/US5330738A/en not_active Expired - Lifetime
- 1992-03-23 US US07/855,256 patent/US5419905A/en not_active Expired - Lifetime
-
1995
- 1995-05-26 US US08/451,637 patent/US5840273A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU8945891A (en) | 1992-05-26 |
| WO1992007860A2 (en) | 1992-05-14 |
| AU658847B2 (en) | 1995-05-04 |
| EP0592440A1 (en) | 1994-04-20 |
| CA2093931A1 (en) | 1992-04-30 |
| DE69131850T2 (de) | 2000-05-18 |
| DE69131850D1 (de) | 2000-01-20 |
| JPH06502640A (ja) | 1994-03-24 |
| EP0592440B1 (en) | 1999-12-15 |
| WO1992007860A3 (en) | 1992-09-03 |
| ATE187731T1 (de) | 2000-01-15 |
| US5330738A (en) | 1994-07-19 |
| US5840273A (en) | 1998-11-24 |
| US5116598A (en) | 1992-05-26 |
| US5419905A (en) | 1995-05-30 |
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