ES2053517T3 - Compuesto de elevado peso molecular que comprende una unidad de un compuesto dirigido hacia el aceotir asialoglicoproteinico y una unidad de un compuesto que forma un quelato ligado quimicamente a este y su utilizacion. - Google Patents

Compuesto de elevado peso molecular que comprende una unidad de un compuesto dirigido hacia el aceotir asialoglicoproteinico y una unidad de un compuesto que forma un quelato ligado quimicamente a este y su utilizacion.

Info

Publication number
ES2053517T3
ES2053517T3 ES87119349T ES87119349T ES2053517T3 ES 2053517 T3 ES2053517 T3 ES 2053517T3 ES 87119349 T ES87119349 T ES 87119349T ES 87119349 T ES87119349 T ES 87119349T ES 2053517 T3 ES2053517 T3 ES 2053517T3
Authority
ES
Spain
Prior art keywords
compound
unit
molecular weight
high molecular
asialoglycoproteinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87119349T
Other languages
English (en)
Inventor
Komei Washino
Miki Kurami
Nobuo Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61312435A external-priority patent/JPH0623114B2/ja
Priority claimed from JP61312434A external-priority patent/JPH0615478B2/ja
Priority claimed from JP61312436A external-priority patent/JPH0759524B2/ja
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Application granted granted Critical
Publication of ES2053517T3 publication Critical patent/ES2053517T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN COMPUESTO DE ALTO PESO MOLECULAR UTIL COMO PORTADOR NO RADIOACTIVO, QUE CONTIENE AL MENOS UNA UNIDAD DE (1) UN COMPUESTO DIRECTOR DE UN ACEPTOR DE ASIALOGLICOPROTEINA Y AL MENOS UNA UNIDAD DE (2) UN COMPUESTO QUELANTE UNIDOS QUIMICAMENTE A EL, Y QUE PUEDE SER MARCADO CON UN ELEMENTO METALICO RADIOACTIVO PARA DAR UN PRODUCTO MARCADO CON UN ELEMENTO METALICO RADIOACTIVO UTIL COMO AGENTE DE DIAGNOSTICO RADIOACTIVO O AGENTE TERAPEUTICO PARA EL HIGADO.
ES87119349T 1986-12-30 1987-12-30 Compuesto de elevado peso molecular que comprende una unidad de un compuesto dirigido hacia el aceotir asialoglicoproteinico y una unidad de un compuesto que forma un quelato ligado quimicamente a este y su utilizacion. Expired - Lifetime ES2053517T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61312435A JPH0623114B2 (ja) 1986-12-30 1986-12-30 放射性医薬品とその調製用高分子化合物
JP61312434A JPH0615478B2 (ja) 1986-12-30 1986-12-30 放射性医薬品とその調製用高分子化合物
JP61312436A JPH0759524B2 (ja) 1986-12-30 1986-12-30 放射性医薬品とその調製用高分子化合物

Publications (1)

Publication Number Publication Date
ES2053517T3 true ES2053517T3 (es) 1994-08-01

Family

ID=27339247

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87119349T Expired - Lifetime ES2053517T3 (es) 1986-12-30 1987-12-30 Compuesto de elevado peso molecular que comprende una unidad de un compuesto dirigido hacia el aceotir asialoglicoproteinico y una unidad de un compuesto que forma un quelato ligado quimicamente a este y su utilizacion.

Country Status (8)

Country Link
US (3) US5032678A (es)
EP (1) EP0273452B1 (es)
KR (1) KR960001742B1 (es)
AU (1) AU601536B2 (es)
CA (1) CA1340556C (es)
DE (1) DE3789432T2 (es)
DK (1) DK172391B1 (es)
ES (1) ES2053517T3 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5352432A (en) * 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5342607A (en) * 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
JPH04501218A (ja) 1988-08-04 1992-03-05 アドヴァンスド　マグネティックス　インコーポレーティッド 受容体媒介エンドサイト―シス型ｍｒｉ造影剤
JPH04501560A (ja) * 1988-08-24 1992-03-19 ザ ユニバーシティ オブ コネチカット 磁気共鳴断層撮影の能力向上に役立つ担体システム並びに方法
US5262175A (en) * 1989-05-10 1993-11-16 Solanki Kishor K Stabilization of radiopharmaceutical compositions
US5277892A (en) * 1990-08-08 1994-01-11 Rhomed Incorporated In vivo lymphocyte tagging
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
US5133956A (en) * 1991-05-30 1992-07-28 The Dow Chemical Company Radiolabeled metal-binding protein for the treatment of arthritis
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
US5959077A (en) * 1993-05-26 1999-09-28 Laboratori Balducci S.P.A. Hepatotropic conjugates of antiviral drugs carriers thereof and pharmaceutical compositions containing them
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
JP3794517B2 (ja) * 1997-05-08 2006-07-05 日本メジフィジックス株式会社 腫瘍診断剤
IL164079A0 (en) * 2002-03-15 2005-12-18 Us Dept Veterans Affairs Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
KR20050062605A (ko) * 2002-10-10 2005-06-23 디파트먼트 오브 베테랑스 어페어스 오피스 오브 더 제네럴 카운셀 (024) 종양 특이적 에피토프에 대해 지정된 표지된 활성화임파구를 이용한 종양의 검출, 위치결정 및 병기결정
EP1846042A2 (en) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
TWI417110B (zh) * 2007-11-30 2013-12-01 Iner Aec Executive Yuan 檢測肝殘餘功能之醣質醫學影像分子造影劑
EP2067489B1 (en) 2007-12-04 2014-07-23 Institute of Nuclear Energy Research Atomic Energy Council Glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010251A (en) * 1974-12-16 1977-03-01 Green Allan M Scanning agent composition and use in imaging liver and for biliary function
DE3060377D1 (en) * 1979-08-29 1982-07-01 Nihon Mediphysics Co Ltd 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
US4401647A (en) * 1980-03-03 1983-08-30 The Regents Of The University Of Ca Radiolabeled neoglycopeptides
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
CA1266344A (en) * 1986-02-14 1990-02-27 Miki Kurami High molecular compounds having amino groups, and their utilization
US4859449A (en) * 1987-09-14 1989-08-22 Center For Molecular Medicine And Immunology Modified antibodies for enhanced hepatocyte clearance

Also Published As

Publication number Publication date
DE3789432T2 (de) 1994-10-06
DE3789432D1 (de) 1994-04-28
DK172391B1 (da) 1998-05-18
KR960001742B1 (en) 1996-02-05
US5118798A (en) 1992-06-02
DK693987A (da) 1988-07-01
AU8314387A (en) 1988-06-30
CA1340556C (en) 1999-05-25
EP0273452A2 (en) 1988-07-06
US5032678A (en) 1991-07-16
AU601536B2 (en) 1990-09-13
DK693987D0 (da) 1987-12-30
KR880007567A (ko) 1988-08-27
EP0273452A3 (en) 1989-12-13
EP0273452B1 (en) 1994-03-23
US5089604A (en) 1992-02-18

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