DK0613459T3 - N-Tritylasparaginsyrederivater til fremstilling af phosphonat NMDA antagonister - Google Patents

N-Tritylasparaginsyrederivater til fremstilling af phosphonat NMDA antagonister

Info

Publication number
DK0613459T3
DK0613459T3 DK92921774.3T DK92921774T DK0613459T3 DK 0613459 T3 DK0613459 T3 DK 0613459T3 DK 92921774 T DK92921774 T DK 92921774T DK 0613459 T3 DK0613459 T3 DK 0613459T3
Authority
DK
Denmark
Prior art keywords
preparation
tritylaspartic
acid derivatives
nmda antagonists
phosphonate
Prior art date
Application number
DK92921774.3T
Other languages
English (en)
Inventor
Jeffrey P Whitten
Duane E Rudisill
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0613459T3 publication Critical patent/DK0613459T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92921774.3T 1991-11-15 1992-10-13 N-Tritylasparaginsyrederivater til fremstilling af phosphonat NMDA antagonister DK0613459T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79283491A 1991-11-15 1991-11-15

Publications (1)

Publication Number Publication Date
DK0613459T3 true DK0613459T3 (da) 1996-04-01

Family

ID=25158215

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921774.3T DK0613459T3 (da) 1991-11-15 1992-10-13 N-Tritylasparaginsyrederivater til fremstilling af phosphonat NMDA antagonister

Country Status (16)

Country Link
EP (1) EP0613459B1 (da)
JP (1) JP3168563B2 (da)
KR (1) KR100241480B1 (da)
AT (1) ATE134989T1 (da)
AU (1) AU667845B2 (da)
CA (1) CA2121835A1 (da)
DE (1) DE69208888T2 (da)
DK (1) DK0613459T3 (da)
ES (1) ES2087555T3 (da)
FI (1) FI942248A0 (da)
GR (1) GR3019587T3 (da)
HU (1) HU214055B (da)
IL (1) IL103710A (da)
MX (1) MX9206448A (da)
NO (1) NO305314B1 (da)
WO (1) WO1993010075A1 (da)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU632362B2 (en) * 1989-09-19 1992-12-24 Merrell Dow Pharmaceuticals Inc. Nmda antagonists

Also Published As

Publication number Publication date
NO305314B1 (no) 1999-05-10
DE69208888D1 (de) 1996-04-11
CA2121835A1 (en) 1993-05-27
FI942248A7 (fi) 1994-05-13
FI942248L (fi) 1994-05-13
HU9401469D0 (en) 1994-08-29
IL103710A0 (en) 1993-04-04
FI942248A0 (fi) 1994-05-13
GR3019587T3 (en) 1996-07-31
ES2087555T3 (es) 1996-07-16
AU667845B2 (en) 1996-04-18
EP0613459A1 (en) 1994-09-07
MX9206448A (es) 1993-05-01
HUT70551A (en) 1995-10-30
DE69208888T2 (de) 1996-08-01
KR100241480B1 (ko) 2000-03-02
JPH07501523A (ja) 1995-02-16
WO1993010075A1 (en) 1993-05-27
EP0613459B1 (en) 1996-03-06
NO941820L (no) 1994-05-13
HU214055B (en) 1997-12-29
IL103710A (en) 1998-02-08
AU2864292A (en) 1993-06-15
NO941820D0 (no) 1994-05-13
JP3168563B2 (ja) 2001-05-21
ATE134989T1 (de) 1996-03-15

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