DK0614911T3 - Forbindelser med sulfonamid- og amidingruppe, fremgangsmåde til fremstilling deraf samt farmaceutiske sammensætninger indeh - Google Patents

Forbindelser med sulfonamid- og amidingruppe, fremgangsmåde til fremstilling deraf samt farmaceutiske sammensætninger indeh

Info

Publication number: DK0614911T3
Authority: DK; Denmark
Prior art keywords: alkyl; compounds; alkylamino; alkylene; linked
Prior art date: 1993-02-15

Application number

DK94400331T

Other languages

English (en)

Inventor

Bernard Christophe

Loic Foulon

Alain Pellet

Claudine Serradeil-Le-Gal

Gerard Valette

Original Assignee

Sanofi Synthelabo

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-15

Filing date

1994-02-15

Publication date

1999-11-08

1994-02-15 Application filed by Sanofi Synthelabo, Sanofi Sa filed Critical Sanofi Synthelabo

1999-11-08 Application granted granted Critical

1999-11-08 Publication of DK0614911T3 publication Critical patent/DK0614911T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000003368 amide group Chemical group 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000003282 alkyl amino group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 2
-1 piperidino, morpholino, piperazinyl Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000005956 isoquinolyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
210000001428 peripheral nervous system Anatomy 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

DK94400331T 1993-02-15 1994-02-15 Forbindelser med sulfonamid- og amidingruppe, fremgangsmåde til fremstilling deraf samt farmaceutiske sammensætninger indeh DK0614911T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9301686A FR2701480B1 (fr)	1993-02-15	1993-02-15	Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Publications (1)

Publication Number	Publication Date
DK0614911T3 true DK0614911T3 (da)	1999-11-08

Family

ID=9444071

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94400331T DK0614911T3 (da)	1993-02-15	1994-02-15	Forbindelser med sulfonamid- og amidingruppe, fremgangsmåde til fremstilling deraf samt farmaceutiske sammensætninger indeh

Country Status (23)

Country	Link
US (2)	US5506258A (da)
EP (1)	EP0614911B1 (da)
JP (1)	JP2994546B2 (da)
KR (1)	KR940019682A (da)
CN (1)	CN1104634A (da)
AT (1)	ATE179430T1 (da)
AU (1)	AU673398B2 (da)
CA (1)	CA2115631A1 (da)
DE (1)	DE69418083T2 (da)
DK (1)	DK0614911T3 (da)
ES (1)	ES2132351T3 (da)
FI (1)	FI940680A7 (da)
FR (1)	FR2701480B1 (da)
GR (1)	GR3030243T3 (da)
HU (1)	HUT66960A (da)
IL (1)	IL108649A (da)
MX (1)	MX9401191A (da)
NO (1)	NO304313B1 (da)
NZ (1)	NZ250878A (da)
PH (1)	PH30887A (da)
RU (1)	RU2126382C1 (da)
TW (1)	TW372233B (da)
ZA (1)	ZA941029B (da)

Families Citing this family (50)

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US5516653A (en) *	1993-12-28	1996-05-14	Synaptic Pharmaceutical Corporation	DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) *	1994-02-03	1996-08-13	Synaptic Pharmaceutical Corporation	DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5989920A (en)	1994-12-02	1999-11-23	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5602024A (en) *	1994-12-02	1997-02-11	Synaptic Pharmaceutical Corporation	DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5668151A (en) *	1995-06-07	1997-09-16	Bristol-Myers Squibb Company	Dihydropyridine NPY antagonists: piperidine derivatives
PT861236E (pt) *	1995-11-13	2002-07-31	Hoechst Ag	Acidos alfa-iminohidoxamicos e carboxilicos n-substituidos ciclicos e heterociclicos
AU7692896A (en) *	1995-12-01	1997-06-27	Novartis Ag	Quinazolin-2,4-diazirines as NPY receptor antagonist
WO1997019682A1 (en)	1995-12-01	1997-06-05	Synaptic Pharmaceutical Corporation	Aryl sulfonamide and sulfamide derivatives and uses thereof
WO1997020823A2 (en) *	1995-12-01	1997-06-12	Novartis Ag	2-amino quinazoline derivatives as npy receptor antagonists
US6433185B1 (en) *	1996-01-11	2002-08-13	Sanofi-Synthelabo	N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them
FR2743562B1 (fr)	1996-01-11	1998-04-03	Sanofi Sa	Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant
CA2249222C (en) *	1996-03-21	2005-11-08	Banyu Pharmaceutical Co., Ltd.	Aminopyridine derivatives
ES2176776T3 (es)	1996-08-23	2002-12-01	Agouron Pharma	Ligandos del neuropeptido-y.
FR2754709B1 (fr)	1996-10-23	1999-03-05	Sanofi Sa	Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
AU6144098A (en) *	1997-02-14	1998-09-08	Bayer Corporation	Amide derivatives as selective neuropeptide y receptor antagonists
US6245817B1 (en)	1997-02-14	2001-06-12	Bayer Corporation	NPY5 receptor antagonists and methods for using same
US6048900A (en)	1998-02-13	2000-04-11	Bayer Corporation	Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
DE19719817A1 (de) *	1997-05-13	1998-11-19	Hoechst Ag	Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
US6713265B1 (en)	1997-06-04	2004-03-30	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
US5889016A (en) *	1997-06-26	1999-03-30	Bristol-Myers Squibb Company	Dihydropyrimidone derivatives as NPY antagonists
PE20000127A1 (es) *	1997-12-22	2000-03-14	Novartis Ag	Derivado de bencenosulfonamida
ID26128A (id) *	1998-04-29	2000-11-23	Ortho Mcneil Pharm Inc	Senyawa-senyawa aminotetralin tersubstitusi-n sebagai ligan-ligan untuk reseptor neupeptida y y5 yang bermanfaat dalam pengobatan obesitas dan gangguan-gangguan lain
GB2344050A (en) *	1998-11-26	2000-05-31	Ferring Bv	Agents useful in the treatment of reproductive disorders.
WO2001037826A1 (en) *	1999-11-26	2001-05-31	Shionogi & Co., Ltd.	Npyy5 antagonists
FR2819254B1 (fr) *	2001-01-08	2003-04-18	Fournier Lab Sa	Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
FR2822827B1 (fr) *	2001-03-28	2003-05-16	Sanofi Synthelabo	Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
WO2002083863A2 (en) *	2001-04-17	2002-10-24	Sepracor, Inc.	Thiazole and other heterocyclic ligands and use thereof
GB0130219D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Compounds for the treatment of sexual dysfunction
FR2840897B1 (fr)	2002-06-14	2004-09-10	Fournier Lab Sa	Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
DE602004021358D1 (de) *	2003-03-25	2009-07-16	Fournier Lab Sa	Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen
JP4806628B2 (ja)	2003-05-05	2011-11-02	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤
DE10344936A1 (de) *	2003-09-27	2005-04-21	Aventis Pharma Gmbh	Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen
WO2005049027A2 (en)	2003-11-03	2005-06-02	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
KR101099206B1 (ko)	2004-02-05	2011-12-27	프로비오드룩 아게	신규한 글루타미닐 시클라제 저해제
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
JP5523107B2 (ja)	2006-11-30	2014-06-18	プロビオドルグエージー	グルタミニルシクラーゼの新規阻害剤
EP2481408A3 (en)	2007-03-01	2013-01-09	Probiodrug AG	New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
EP2155711A1 (en) *	2007-06-05	2010-02-24	Sanofi-Aventis	Substituted benzoylamino-indan-2-carboxylic acids and related compounds
JPWO2009110510A1 (ja)	2008-03-06	2011-07-14	Ｍｓｄ株式会社	アルキルアミノピリジン誘導体
FR2949674A1 (fr) *	2009-09-10	2011-03-11	Oreal	Utilisation d'un antagoniste du neuropeptide y pour augmenter le volume et/ou la coloration naturelle des levres
MX2012002993A (es)	2009-09-11	2012-04-19	Probiodrug Ag	Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej
WO2019079243A1 (en) *	2017-10-17	2019-04-25	Albert Einstein College Of Medicine, Inc.	MITOFUSIN ACTIVATORS AND USES THEREOF
EP3740482A1 (en)	2018-01-17	2020-11-25	Migal Galilee Research Institute Ltd.	New methionine metabolic pathway inhibitors
BR112020014561A2 (pt) *	2018-01-17	2020-12-08	Migal - Galilee Research Institute Ltd.	Nibidores inovadores da via metabólica da metionina

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CA1131621A (en) *	1977-01-19	1982-09-14	Shosuke Okamoto	N.sup.2-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
PT84170B (pt) *	1986-01-24	1989-03-30	Sanofi Sa	Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
PT84171B (pt) *	1986-01-24	1989-03-30	Sanofi Sa	Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem
DE3939797A1 (de) *	1989-12-01	1991-06-06	Basf Ag	Neue vom neuropeptid y abgeleitete peptide
WO1992016549A1 (de) *	1991-03-18	1992-10-01	Pentapharm Ag	Para-substituierte phenylalanin-derivate
JP3283114B2 (ja) *	1992-09-07	2002-05-20	クミアイ化学工業株式会社	縮合ヘテロ環誘導体及び農園芸用殺菌剤

1993
- 1993-02-15 FR FR9301686A patent/FR2701480B1/fr not_active Expired - Fee Related
1994
- 1994-02-09 PH PH47736A patent/PH30887A/en unknown
- 1994-02-14 CA CA002115631A patent/CA2115631A1/en not_active Abandoned
- 1994-02-14 HU HU9400414A patent/HUT66960A/hu unknown
- 1994-02-14 FI FI940680A patent/FI940680A7/fi unknown
- 1994-02-14 NO NO940503A patent/NO304313B1/no unknown
- 1994-02-14 US US08/195,281 patent/US5506258A/en not_active Expired - Fee Related
- 1994-02-14 RU RU94004977A patent/RU2126382C1/ru active
- 1994-02-15 NZ NZ250878A patent/NZ250878A/en unknown
- 1994-02-15 CN CN94102694A patent/CN1104634A/zh active Pending
- 1994-02-15 KR KR1019940002676A patent/KR940019682A/ko not_active Ceased
- 1994-02-15 AU AU55165/94A patent/AU673398B2/en not_active Ceased
- 1994-02-15 EP EP94400331A patent/EP0614911B1/fr not_active Expired - Lifetime
- 1994-02-15 IL IL10864994A patent/IL108649A/en not_active IP Right Cessation
- 1994-02-15 DE DE69418083T patent/DE69418083T2/de not_active Expired - Fee Related
- 1994-02-15 MX MX9401191A patent/MX9401191A/es not_active IP Right Cessation
- 1994-02-15 ZA ZA941029A patent/ZA941029B/xx unknown
- 1994-02-15 ES ES94400331T patent/ES2132351T3/es not_active Expired - Lifetime
- 1994-02-15 JP JP6018511A patent/JP2994546B2/ja not_active Expired - Lifetime
- 1994-02-15 TW TW083101254A patent/TW372233B/zh active
- 1994-02-15 DK DK94400331T patent/DK0614911T3/da active
- 1994-02-15 AT AT94400331T patent/ATE179430T1/de not_active IP Right Cessation
1996
- 1996-01-04 US US08/582,887 patent/US5674890A/en not_active Expired - Fee Related
1999
- 1999-05-19 GR GR990401334T patent/GR3030243T3/el unknown

Also Published As

Publication number	Publication date
FI940680A0 (fi)	1994-02-14
PH30887A (en)	1997-12-23
AU673398B2 (en)	1996-11-07
NO304313B1 (no)	1998-11-30
MX9401191A (es)	1994-08-31
RU2126382C1 (ru)	1999-02-20
IL108649A (en)	1998-09-24
KR940019682A (ko)	1994-09-14
GR3030243T3 (en)	1999-08-31
NZ250878A (en)	1996-02-27
DE69418083T2 (de)	1999-11-25
HUT66960A (en)	1995-01-30
ATE179430T1 (de)	1999-05-15
EP0614911A1 (fr)	1994-09-14
ZA941029B (en)	1995-08-15
ES2132351T3 (es)	1999-08-16
CN1104634A (zh)	1995-07-05
IL108649A0 (en)	1994-05-30
JPH06293794A (ja)	1994-10-21
NO940503D0 (no)	1994-02-14
HU9400414D0 (en)	1994-05-30
FI940680A7 (fi)	1994-08-16
FR2701480B1 (fr)	1995-05-24
NO940503L (da)	1994-08-16
US5674890A (en)	1997-10-07
CA2115631A1 (en)	1994-08-16
TW372233B (en)	1999-10-21
FR2701480A1 (fr)	1994-08-19
EP0614911B1 (fr)	1999-04-28
US5506258A (en)	1996-04-09
JP2994546B2 (ja)	1999-12-27
DE69418083D1 (de)	1999-06-02
AU5516594A (en)	1994-08-18

Publication	Publication Date	Title
GR3030243T3 (en)	1999-08-31	Compounds having a sulfonamide and an amidinegroup, process for preparation and pharmaceutical compositions comprising them.
ES2190264T3 (es)	2003-07-16	N-(2-aril-propionil)sulfonamidas y preparaciones farmaceuticas que las contienen.
NO306901B1 (no)	2000-01-10	Piperazinderivater, anvendelser derav, samt farmasöytiske preparater omfattende slike derivater
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