PH30887A - Compounds bearing sulphamoyl and amidino radicals,their and pharmaceutical compositions containing them. - Google Patents

Compounds bearing sulphamoyl and amidino radicals,their and pharmaceutical compositions containing them.

Info

Publication number: PH30887A
Authority: PH; Philippines
Prior art keywords: alkyl; alkylamino; alkylene; linked; optionally substituted
Prior art date: 1993-02-15

Application number

PH47736A

Other languages

English (en)

Inventor

Christophe Bernard

Pellet Alain

Serradell-Legal Claudine

Valette Gerard

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-15

Filing date

1994-02-09

Publication date

1997-12-23

1994-02-09 Application filed by Sanofi Elf filed Critical Sanofi Elf

1997-12-23 Publication of PH30887A publication Critical patent/PH30887A/en

Links

150000001875 compounds Chemical group 0.000 title abstract 3
-1 sulphamoyl Chemical group 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000003282 alkyl amino group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000005956 isoquinolyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
210000001428 peripheral nervous system Anatomy 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

PH47736A 1993-02-15 1994-02-09 Compounds bearing sulphamoyl and amidino radicals,their and pharmaceutical compositions containing them. PH30887A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9301686A FR2701480B1 (fr)	1993-02-15	1993-02-15	Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Publications (1)

Publication Number	Publication Date
PH30887A true PH30887A (en)	1997-12-23

Family

ID=9444071

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH47736A PH30887A (en)	1993-02-15	1994-02-09	Compounds bearing sulphamoyl and amidino radicals,their and pharmaceutical compositions containing them.

Country Status (23)

Country	Link
US (2)	US5506258A (da)
EP (1)	EP0614911B1 (da)
JP (1)	JP2994546B2 (da)
KR (1)	KR940019682A (da)
CN (1)	CN1104634A (da)
AT (1)	ATE179430T1 (da)
AU (1)	AU673398B2 (da)
CA (1)	CA2115631A1 (da)
DE (1)	DE69418083T2 (da)
DK (1)	DK0614911T3 (da)
ES (1)	ES2132351T3 (da)
FI (1)	FI940680A7 (da)
FR (1)	FR2701480B1 (da)
GR (1)	GR3030243T3 (da)
HU (1)	HUT66960A (da)
IL (1)	IL108649A (da)
MX (1)	MX9401191A (da)
NO (1)	NO304313B1 (da)
NZ (1)	NZ250878A (da)
PH (1)	PH30887A (da)
RU (1)	RU2126382C1 (da)
TW (1)	TW372233B (da)
ZA (1)	ZA941029B (da)

Families Citing this family (50)

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US5516653A (en) *	1993-12-28	1996-05-14	Synaptic Pharmaceutical Corporation	DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en)	1994-02-03	1996-08-13	Synaptic Pharmaceutical Corporation	DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5602024A (en)	1994-12-02	1997-02-11	Synaptic Pharmaceutical Corporation	DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en) *	1994-12-02	1999-11-23	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5668151A (en) *	1995-06-07	1997-09-16	Bristol-Myers Squibb Company	Dihydropyridine NPY antagonists: piperidine derivatives
US6207672B1 (en) *	1995-11-13	2001-03-27	Aventis Pharma Deutschland Gmbh	Cyclic and heterocyclic N-substituted α-iminohydroxamic and carboxyclic acids
AU7692996A (en) *	1995-12-01	1997-06-27	Ciba-Geigy Ag	Receptor antagonists
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AU1328197A (en)	1995-12-01	1997-06-19	Synaptic Pharmaceutical Corporation	Aryl sulfonamide and sulfamide derivatives and uses thereof
US6433185B1 (en) *	1996-01-11	2002-08-13	Sanofi-Synthelabo	N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them
FR2743562B1 (fr) *	1996-01-11	1998-04-03	Sanofi Sa	Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant
US6011039A (en) *	1996-03-21	2000-01-04	Banyu Pharmaceutical Co., Ltd.	Aminopyridine derivatives
AU4159297A (en)	1996-08-23	1998-03-06	Agouron Acquisition Corp.	Neuropeptide-y ligands
FR2754709B1 (fr)	1996-10-23	1999-03-05	Sanofi Sa	Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
US6048900A (en) *	1998-02-13	2000-04-11	Bayer Corporation	Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
US6245817B1 (en)	1997-02-14	2001-06-12	Bayer Corporation	NPY5 receptor antagonists and methods for using same
WO1998035957A1 (en) *	1997-02-14	1998-08-20	Bayer Corporation	Amide derivatives as selective neuropeptide y receptor antagonists
DE19719817A1 (de) *	1997-05-13	1998-11-19	Hoechst Ag	Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
US6713265B1 (en)	1997-06-04	2004-03-30	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
US5889016A (en) *	1997-06-26	1999-03-30	Bristol-Myers Squibb Company	Dihydropyrimidone derivatives as NPY antagonists
PE20000127A1 (es) *	1997-12-22	2000-03-14	Novartis Ag	Derivado de bencenosulfonamida
BR9910583A (pt) *	1998-04-29	2001-01-09	Ortho Mcneil Pharm Inc	Aminotetralinas n-substituìdas como ligantes para o receptor de neuropeptìdeo y y5 úteis no tratamento de obesidade e outros distúrbios
GB2344050A (en) *	1998-11-26	2000-05-31	Ferring Bv	Agents useful in the treatment of reproductive disorders.
SI1249233T1 (sl) *	1999-11-26	2009-02-28	Shionogi & Co	Antagonisti NPYY5
FR2819254B1 (fr) *	2001-01-08	2003-04-18	Fournier Lab Sa	Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
FR2822827B1 (fr) *	2001-03-28	2003-05-16	Sanofi Synthelabo	Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
AU2002314744A1 (en) *	2001-04-17	2002-10-28	Sepracor, Inc.	Thiazole and other heterocyclic ligands and use thereof
GB0130219D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Compounds for the treatment of sexual dysfunction
FR2840897B1 (fr)	2002-06-14	2004-09-10	Fournier Lab Sa	Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
BRPI0408689B8 (pt) *	2003-03-25	2021-05-25	Laboratoires Fournier S A	derivados de benzenosulfonamida, método para preparação e utilização disso para o tratamento da dor
WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
DE10344936A1 (de) *	2003-09-27	2005-04-21	Aventis Pharma Gmbh	Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen
AU2004290499C1 (en)	2003-11-03	2011-02-24	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
AU2008259804B2 (en) *	2007-06-05	2013-04-18	Sanofi-Aventis	Substituted benzoylamino-indan-2-carboxylic acids and related compounds
EP2264026A4 (en)	2008-03-06	2012-03-28	Msd Kk	ALKYLAMINOPYRIDINDERIVATE
FR2949674A1 (fr) *	2009-09-10	2011-03-11	Oreal	Utilisation d'un antagoniste du neuropeptide y pour augmenter le volume et/ou la coloration naturelle des levres
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa
WO2019079243A1 (en) *	2017-10-17	2019-04-25	Albert Einstein College Of Medicine, Inc.	MITOFUSIN ACTIVATORS AND USES THEREOF
EP4324329A3 (en) *	2018-01-17	2024-04-17	Migal Galilee Research Institute Ltd.	New methionine metabolic pathway inhibitors
EP3740482A1 (en)	2018-01-17	2020-11-25	Migal Galilee Research Institute Ltd.	New methionine metabolic pathway inhibitors

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CA1131621A (en) *	1977-01-19	1982-09-14	Shosuke Okamoto	N.sup.2-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
PT84170B (pt) *	1986-01-24	1989-03-30	Sanofi Sa	Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
PT84171B (pt) *	1986-01-24	1989-03-30	Sanofi Sa	Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem
DE3939797A1 (de) *	1989-12-01	1991-06-06	Basf Ag	Neue vom neuropeptid y abgeleitete peptide
AU1354292A (en) *	1991-03-18	1992-10-21	Pentapharm Ag	Parasubstituted phenylalanine derivates
JP3283114B2 (ja) *	1992-09-07	2002-05-20	クミアイ化学工業株式会社	縮合ヘテロ環誘導体及び農園芸用殺菌剤

1993
- 1993-02-15 FR FR9301686A patent/FR2701480B1/fr not_active Expired - Fee Related
1994
- 1994-02-09 PH PH47736A patent/PH30887A/en unknown
- 1994-02-14 FI FI940680A patent/FI940680A7/fi unknown
- 1994-02-14 NO NO940503A patent/NO304313B1/no unknown
- 1994-02-14 CA CA002115631A patent/CA2115631A1/en not_active Abandoned
- 1994-02-14 RU RU94004977A patent/RU2126382C1/ru active
- 1994-02-14 HU HU9400414A patent/HUT66960A/hu unknown
- 1994-02-14 US US08/195,281 patent/US5506258A/en not_active Expired - Fee Related
- 1994-02-15 ES ES94400331T patent/ES2132351T3/es not_active Expired - Lifetime
- 1994-02-15 NZ NZ250878A patent/NZ250878A/en unknown
- 1994-02-15 DE DE69418083T patent/DE69418083T2/de not_active Expired - Fee Related
- 1994-02-15 EP EP94400331A patent/EP0614911B1/fr not_active Expired - Lifetime
- 1994-02-15 TW TW083101254A patent/TW372233B/zh active
- 1994-02-15 JP JP6018511A patent/JP2994546B2/ja not_active Expired - Lifetime
- 1994-02-15 ZA ZA941029A patent/ZA941029B/xx unknown
- 1994-02-15 AT AT94400331T patent/ATE179430T1/de not_active IP Right Cessation
- 1994-02-15 DK DK94400331T patent/DK0614911T3/da active
- 1994-02-15 IL IL10864994A patent/IL108649A/en not_active IP Right Cessation
- 1994-02-15 MX MX9401191A patent/MX9401191A/es not_active IP Right Cessation
- 1994-02-15 CN CN94102694A patent/CN1104634A/zh active Pending
- 1994-02-15 AU AU55165/94A patent/AU673398B2/en not_active Ceased
- 1994-02-15 KR KR1019940002676A patent/KR940019682A/ko not_active Ceased
1996
- 1996-01-04 US US08/582,887 patent/US5674890A/en not_active Expired - Fee Related
1999
- 1999-05-19 GR GR990401334T patent/GR3030243T3/el unknown

Also Published As

Publication number	Publication date
FI940680A7 (fi)	1994-08-16
ZA941029B (en)	1995-08-15
AU5516594A (en)	1994-08-18
AU673398B2 (en)	1996-11-07
JPH06293794A (ja)	1994-10-21
KR940019682A (ko)	1994-09-14
CN1104634A (zh)	1995-07-05
NO940503D0 (no)	1994-02-14
FR2701480B1 (fr)	1995-05-24
JP2994546B2 (ja)	1999-12-27
IL108649A0 (en)	1994-05-30
HUT66960A (en)	1995-01-30
TW372233B (en)	1999-10-21
GR3030243T3 (en)	1999-08-31
US5674890A (en)	1997-10-07
CA2115631A1 (en)	1994-08-16
IL108649A (en)	1998-09-24
FR2701480A1 (fr)	1994-08-19
DE69418083D1 (de)	1999-06-02
US5506258A (en)	1996-04-09
ATE179430T1 (de)	1999-05-15
DK0614911T3 (da)	1999-11-08
RU2126382C1 (ru)	1999-02-20
NO304313B1 (no)	1998-11-30
NO940503L (da)	1994-08-16
ES2132351T3 (es)	1999-08-16
HU9400414D0 (en)	1994-05-30
EP0614911B1 (fr)	1999-04-28
EP0614911A1 (fr)	1994-09-14
FI940680A0 (fi)	1994-02-14
MX9401191A (es)	1994-08-31
DE69418083T2 (de)	1999-11-25
NZ250878A (en)	1996-02-27

Publication	Publication Date	Title
PH30887A (en)	1997-12-23	Compounds bearing sulphamoyl and amidino radicals,their and pharmaceutical compositions containing them.
EE03139B1 (et)	1998-12-15	Piperasiiniderivaadid, nende kasutamine ja farmatseutiline kompositsioon
KR970704444A (ko)	1997-09-06	트리아진 유도체 및 의약(triazine derivative and medicine)
RU94026909A (ru)	1996-01-10	Производные пиперазинкарбоновой кислоты, способ их получения, фармацевтическая композиция
GR1002281B (el)	1996-05-02	Παραγωγα 3(2η)-πυριδαζινονης και μεθοδος για την παρασκευη τους.
ATE121621T1 (de)	1995-05-15	Verwendung von tetrahydrothienopyridinderivate als angiogenese-inhibitoren.
ATE172454T1 (de)	1998-11-15	Pyridazinon derivate mit pharmazeutischer wirkung
YU7302A (sh)	2004-09-03	Heterociklična jedinjenja za inhibiranje angiogeneze
DE69112201D1 (de)	1995-09-21	4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.
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