DK0619304T3 - 22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf - Google Patents

22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0619304T3
DK0619304T3 DK93900419.8T DK93900419T DK0619304T3 DK 0619304 T3 DK0619304 T3 DK 0619304T3 DK 93900419 T DK93900419 T DK 93900419T DK 0619304 T3 DK0619304 T3 DK 0619304T3
Authority
DK
Denmark
Prior art keywords
oxacholecalciferol
derivatives
preparation
same
hyperparathyroidism
Prior art date
Application number
DK93900419.8T
Other languages
English (en)
Inventor
Masahiro Kato
Tetsuhiro Mikami
Kiyoshige Ochi
Hiroyoshi Watanabe
Noboru Kubodera
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK0619304T3 publication Critical patent/DK0619304T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DK93900419.8T 1991-12-18 1992-12-18 22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf DK0619304T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP36105191 1991-12-18

Publications (1)

Publication Number Publication Date
DK0619304T3 true DK0619304T3 (da) 1998-02-16

Family

ID=18471985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93900419.8T DK0619304T3 (da) 1991-12-18 1992-12-18 22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf

Country Status (12)

Country Link
US (1) US5436401A (da)
EP (1) EP0619304B1 (da)
JP (1) JP3493037B2 (da)
KR (1) KR100247214B1 (da)
AT (1) ATE157966T1 (da)
DE (1) DE69222183T2 (da)
DK (1) DK0619304T3 (da)
ES (1) ES2107650T3 (da)
GR (1) GR3025468T3 (da)
SG (1) SG78265A1 (da)
TW (1) TW222621B (da)
WO (1) WO1993012083A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3563310D1 (en) * 1985-07-30 1988-07-21 Salzgitter Ind Method and device for the preparation of suspensions with constant indications from basic materials with variable properties
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
DK0764443T3 (da) * 1994-04-19 2002-10-07 Chugai Pharmaceutical Co Ltd Midler tl behandling af med tumorer forbundet kakeksi
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
EP1426352A2 (en) * 1996-09-03 2004-06-09 The Trustees of Columbia University in the City of New York Intermediates for the sythesis of vitamin D and steroid derivatives
GB9804861D0 (en) * 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
WO2000001477A1 (en) * 1998-07-03 2000-01-13 Chugai Seiyaku Kabushiki Kaisha Ultraviolet irradiation apparatus for photochemical reaction and method for preparing vitamin d derivative using the same
WO2001016099A1 (fr) * 1999-08-27 2001-03-08 Chugai Seiyaku Kabushiki Kaisha DÉRIVÉS DE VITAMINE D AYANT DES SUBSTITUANTS À LA POSITION 2$g(a)
AU2001248777A1 (en) 2000-04-19 2001-10-30 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives
CA2411409C (en) * 2000-06-15 2011-05-17 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives
KR100611544B1 (ko) * 2000-08-30 2006-08-10 쥬가이 세이야쿠 가부시키가이샤 오씨티 제제
WO2012122451A2 (en) 2011-03-09 2012-09-13 Teva Pharmaceutical Industries Ltd. Polymorphs of maxacalcitol and process for the preparation of maxacalcitol
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN103508999B (zh) 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途
CN107286067A (zh) * 2016-04-05 2017-10-24 湖南华腾制药有限公司 一种马沙骨化醇的制备方法
US12351551B2 (en) 2019-11-27 2025-07-08 Yonsung Fine Chemical Co., Ltd. Method for producing maxacalcitol, and intermediate therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140560A (ja) * 1984-12-12 1986-06-27 Chugai Pharmaceut Co Ltd ２０−オキサ−２１−ノルビタミンｄ３誘導体
JPS61267550A (ja) * 1984-12-28 1986-11-27 Chugai Pharmaceut Co Ltd ９，１０−セコ−５，７，１０（１９）−プレグナトリエン誘導体
JP3050564B2 (ja) * 1989-12-15 2000-06-12 中外製薬株式会社 新規な２２―オキサビタミンｄ誘導体

Also Published As

Publication number Publication date
DE69222183T2 (de) 1998-01-22
JPH0672994A (ja) 1994-03-15
WO1993012083A1 (fr) 1993-06-24
US5436401A (en) 1995-07-25
SG78265A1 (en) 2001-02-20
DE69222183D1 (de) 1997-10-16
ATE157966T1 (de) 1997-09-15
EP0619304A1 (en) 1994-10-12
HK1002729A1 (en) 1998-09-11
EP0619304A4 (en) 1995-03-29
KR940703807A (ko) 1994-12-12
EP0619304B1 (en) 1997-09-10
KR100247214B1 (ko) 2000-03-15
GR3025468T3 (en) 1998-02-27
TW222621B (da) 1994-04-21
JP3493037B2 (ja) 2004-02-03
ES2107650T3 (es) 1997-12-01

Similar Documents

Publication Publication Date Title
ATE157966T1 (de) 22-oxacholecalziferol-derivate und ihre herstellung
ES2186672T3 (es) Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.
ZA200110520B (en) Pyrazole derivatives and process for producing the same, and pesticides containing the same as the active ingredient.
SE8804609D0 (sv) Adenosine derivatives
MY104627A (en) A 1-pyridylimidazole derivative and its production and use.
NZ240676A (en) Heterocyclic compounds substituted by a (piperidin-4-yl)-1-oxoalkyl group and pharmaceutical compositions thereof
MX9606331A (es) Nuevos compuestos, procesos para la preparacion de los mismos y agentes antitumor.
AU747521C (en) Cycloalkene derivatives, process for producing the same, and use
DK0625147T3 (da) Fremgangsmåde til fremstilling af taxanderivater
HUT59378A (en) Process for producing urea derivatives and pharmaceutical compositions comprising such compounds
NO308659B1 (no) Nye 4,6-diarylpyrimidin-derivater, salter derav, anvendelse derav og farmasøytisk preparat
HU9302090D0 (en) New aryl-glycide-amide derivatives and method for producing them
NO913087D0 (no) Ny tricyklisk forbindelse eller salter derav, fremgangsmaate for fremstilling derav og antimikrobielt middel inneholdende slike.
HUT49349A (en) Process for producing substituted 6-phenyldihydro-3-/2h/-pyridazinone derivatives and pharmaceutical compositions comprising such compounds
ATE251157T1 (de) Bicyclische aminderivate
DK0394889T3 (da) Heterocycliske dioner som pesticider og plantevækstregulatorer
ES2086442T3 (es) Derivados de fluoroetilcamptotecina.
DK0424899T3 (da) Hidtil ukendte anthracyclinglycosidderivater og fremgangsmåde til fremstilling deraf
ES526922A0 (es) Un procedimiento para producir derivados de antraciclina
ES2144013T3 (es) Derivado de la vitamina d y procedimiento para su produccion.
GB9121943D0 (en) Organic compounds,processes for their production and their use
DK480389D0 (da) Antitumorstof, fremgangsmaade til dets fremstilling og anticancermiddel indeholdende stoffet
JPS55111492A (en) Thiazole derivative and its manufacture
HU906407D0 (en) Process for producing new inozine- and guanozine derivatives and pharmaceutical compositions containing them as active components
FI860364A0 (fi) Nya 6-aminometyl-furo-(3,4-c) -pyridinderivat, deras framstaellning och dessa innehaollande terapeutiska blandningar.