DK0633245T3 - D-vitamin-forbindelser og fremgangsmåde til fremstilling af disse forbindelser - Google Patents

D-vitamin-forbindelser og fremgangsmåde til fremstilling af disse forbindelser

Info

Publication number: DK0633245T3
Authority: DK; Denmark
Prior art keywords: compounds; group; preparing; hydroxy; branched
Prior art date: 1993-06-04

Application number

DK94201403.6T

Other languages

English (en)

Inventor

Jose P Sestelo

Antonio Mourino

Jose L Mascarenas

Sebastianus J Halkes

Jan Zorgdrager

Gerhardus D H Dijkstra

Jan-Paul Van De Velde

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-04

Filing date

1994-05-18

Publication date

1996-12-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22098649&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0633245(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-05-18 Application filed by Duphar Int Res filed Critical Duphar Int Res

1996-12-23 Application granted granted Critical

1996-12-23 Publication of DK0633245T3 publication Critical patent/DK0633245T3/da

Links

229930003316 Vitamin D Natural products 0.000 title abstract 2
-1 Vitamin D compounds Chemical class 0.000 title abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
235000019166 vitamin D Nutrition 0.000 title abstract 2
239000011710 vitamin D Substances 0.000 title abstract 2
229940046008 vitamin d Drugs 0.000 title abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
239000004215 Carbon black (E152) Substances 0.000 abstract 1
239000004593 Epoxy Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
239000002537 cosmetic Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
150000002430 hydrocarbons Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
238000001050 pharmacotherapy Methods 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/457—Saturated compounds containing a keto group being part of a ring containing halogen
- C07C49/467—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic
- C07C49/473—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system
- C07C49/477—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system having two rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
- C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
- C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)

DK94201403.6T 1993-06-04 1994-05-18 D-vitamin-forbindelser og fremgangsmåde til fremstilling af disse forbindelser DK0633245T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/070,998 US5449668A (en)	1993-06-04	1993-06-04	Vitamin D compounds and method of preparing these compounds

Publications (1)

Publication Number	Publication Date
DK0633245T3 true DK0633245T3 (da)	1996-12-23

Family

ID=22098649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94201403.6T DK0633245T3 (da)	1993-06-04	1994-05-18	D-vitamin-forbindelser og fremgangsmåde til fremstilling af disse forbindelser

Country Status (15)

Country	Link
US (3)	US5449668A (da)
EP (1)	EP0633245B1 (da)
KR (1)	KR100301876B1 (da)
CN (1)	CN1050829C (da)
AT (1)	ATE142198T1 (da)
AU (1)	AU679221B2 (da)
DE (1)	DE69400469T2 (da)
DK (1)	DK0633245T3 (da)
ES (1)	ES2094023T3 (da)
GR (1)	GR3021581T3 (da)
HU (1)	HU219593B (da)
IL (1)	IL109848A (da)
NZ (1)	NZ260647A (da)
PL (1)	PL179104B1 (da)
ZA (1)	ZA943830B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1333616C (en) *	1989-03-09	1994-12-20	Hector F. Deluca	19-nor-vitamin d compounds
US5260290A (en) *	1990-02-14	1993-11-09	Wisconsin Alumni Research Foundation	Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5486509A (en) *	1991-06-28	1996-01-23	University Of Miami	Method of preventing and treating chemotherapy-induced alopecia
EP0521550B1 (en) *	1991-07-05	1996-09-18	Duphar International Research B.V	Vitamin D compound, method of preparing this compound and intermediate therefor
US6291444B1 (en) *	1993-06-16	2001-09-18	Wisconsin Alumni Research Foundation	Treatment of t-cell immunodeficiencies with vitamin D compounds
GB9314400D0 (en) *	1993-07-12	1993-08-25	Leo Pharm Prod Ltd	Produktionsaktieselskab) chemical compounds
US5552392A (en) *	1993-11-03	1996-09-03	Wisconsin Alumni Research Foundation	Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5502050A (en) *	1993-11-29	1996-03-26	Cornell Research Foundation, Inc.	Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
KR970707089A (ko) *	1994-11-21	1997-12-01	리차드 에이취. 리이저	18, 19-디노르-비타민 D 화합물(18,19-Dinor-Vitamin D Compounds)
US5661140A (en) *	1994-11-21	1997-08-26	Wisconsin Alumni Research Foundation	18-nor-vitamin D compounds
US20040043971A1 (en) *	1995-04-03	2004-03-04	Bone Care International, Inc.	Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US20020183288A1 (en) *	1995-04-03	2002-12-05	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
CA2175881A1 (en) *	1995-05-09	1996-11-10	Andrzej Kutner	Vitamin d compounds and methods of preparing these compounds
DE69626539T2 (de) *	1995-11-20	2004-04-08	Kita, Kiyoshi, Shibuyaku	topische Verwendung von Vitamin D zur Behandlung von Augenerkrankungen
US5939408A (en)	1996-05-23	1999-08-17	Hoffman-La Roche Inc.	Vitamin D3 analogs
GB9622590D0 (en) *	1996-10-30	1997-01-08	Leo Pharm Prod Ltd	Chemical compounds
US6187331B1 (en)	1997-06-10	2001-02-13	New Vision Co., Ltd.	Composition for prophylaxis and/or treatment of dry syndrome comprising vitamin D
US6359152B2 (en)	1997-07-21	2002-03-19	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US5939406A (en) *	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
EP0927721A1 (de) *	1997-12-17	1999-07-07	Schering Aktiengesellschaft	Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
EP1042335A1 (de)	1997-12-17	2000-10-11	Schering Aktiengesellschaft	Vitamin d-derivate mit phosphoratomen in den seitenketten
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
EP1096950B1 (en) *	1998-07-10	2003-09-10	Duke University	Therapies using hemoproteins
WO2000053578A1 (en) *	1999-03-11	2000-09-14	Kuraray Co., Ltd.	Vitamin d derivatives and process for the preparation thereof
US6912420B2 (en) *	2001-04-10	2005-06-28	Cardiac Pacemakers, Inc.	Cardiac rhythm management system for hypotension
US7191000B2 (en) *	2001-07-31	2007-03-13	Cardiac Pacemakers, Inc.	Cardiac rhythm management system for edema
WO2003026445A1 (en) *	2001-09-27	2003-04-03	The Coca-Cola Company	Vitamin fortification of foodstuffs
US8034831B2 (en) *	2002-11-06	2011-10-11	Celgene Corporation	Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) *	2002-11-06	2009-07-21	Celgene Corporation	Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20060171983A1 (en) *	2003-07-30	2006-08-03	Jin Tian	Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
WO2005027930A1 (en) *	2003-09-19	2005-03-31	Pfizer Products Inc.	2-alkylene-19-nor-vitamin d derivatives for the treatment of osteosarcoma
WO2005087719A1 (en) *	2004-03-18	2005-09-22	Leo Pharma A/S	Stereoselective synthesis of vitamin d analogues
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US7387610B2 (en) *	2004-08-19	2008-06-17	Cardiac Pacemakers, Inc.	Thoracic impedance detection with blood resistivity compensation
WO2006094064A2 (en) *	2005-02-28	2006-09-08	Avocet Polymer Technologies, Inc.	Method of reducing scars with vitamin d
US7603170B2 (en) *	2005-04-26	2009-10-13	Cardiac Pacemakers, Inc.	Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance
US7907997B2 (en)	2005-05-11	2011-03-15	Cardiac Pacemakers, Inc.	Enhancements to the detection of pulmonary edema when using transthoracic impedance
US7340296B2 (en)	2005-05-18	2008-03-04	Cardiac Pacemakers, Inc.	Detection of pleural effusion using transthoracic impedance
WO2010088304A1 (en)	2009-01-27	2010-08-05	Cytotech Labs, Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
KR101880032B1 (ko)	2009-08-14	2018-07-20	베르그 엘엘씨	탈모증 치료용 비타민 ｄ3 및 이의 유사체들
ES2396524B2 (es) *	2012-12-11	2013-08-01	Universidade De Santiago De Compostela	Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de vitamina D
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN105481256B (zh) *	2015-12-30	2018-02-16	三川德青科技有限公司	一种铅锌浮选尾矿微晶玻璃及其制备方法
EP3802507A1 (en) *	2018-05-30	2021-04-14	Translate Bio, Inc.	Vitamin cationic lipids

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3666587D1 (en) *	1985-08-02	1989-11-30	Leo Pharm Prod Ltd	Novel vitamin d analogues
AU614372B2 (en) *	1988-04-21	1991-08-29	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)	Novel vitamin d analogues
US5401732A (en) *	1989-02-23	1995-03-28	Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab	Vitamin D analogues
US5378695A (en) *	1989-02-23	1995-01-03	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)	Vitamin D analogues
GB8904154D0 (en) *	1989-02-23	1989-04-05	Leo Pharm Prod Ltd	Chemical compounds
US5321018A (en) *	1989-03-09	1994-06-14	Wisconsin Alumni Research Foundation	Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
NZ232734A (en) *	1989-03-09	1991-11-26	Wisconsin Alumni Res Found	19-nor vitamin d derivatives and pharmaceutical compositions
US5246925A (en) *	1989-03-09	1993-09-21	Wisconsin Alumni Research Foundation	19-nor-vitamin D compounds for use in treating hyperparathyroidism
US5401731A (en) *	1989-06-29	1995-03-28	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab)	Vitamin D analogues
GB8915770D0 (en) *	1989-07-10	1989-08-31	Leo Pharm Prod Ltd	Chemical compounds
GB9007236D0 (en) *	1990-03-30	1990-05-30	Leo Pharm Prod Ltd	Chemical compounds
DE4011682A1 (de) *	1990-04-06	1991-10-10	Schering Ag	24-oxa-derivate in der vitamin d-reihe
GB9017890D0 (en) *	1990-08-15	1990-09-26	Leo Pharm Prod Ltd	Chemical compounds i
US5459136A (en) *	1990-08-24	1995-10-17	Wisconsin Alumni Research Foundation	Methods using vitamin D compounds for improvement of skin conditions
US5486509A (en) *	1991-06-28	1996-01-23	University Of Miami	Method of preventing and treating chemotherapy-induced alopecia
EP0521550B1 (en) *	1991-07-05	1996-09-18	Duphar International Research B.V	Vitamin D compound, method of preparing this compound and intermediate therefor
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU666563B2 (en) *	1992-08-07	1996-02-15	Wisconsin Alumni Research Foundation	Preparation of 19-nor-vitamin D compounds

1993
- 1993-06-04 US US08/070,998 patent/US5449668A/en not_active Expired - Lifetime
1994
- 1994-05-18 AT AT94201403T patent/ATE142198T1/de not_active IP Right Cessation
- 1994-05-18 EP EP94201403A patent/EP0633245B1/en not_active Expired - Lifetime
- 1994-05-18 ES ES94201403T patent/ES2094023T3/es not_active Expired - Lifetime
- 1994-05-18 DK DK94201403.6T patent/DK0633245T3/da active
- 1994-05-18 DE DE69400469T patent/DE69400469T2/de not_active Expired - Fee Related
- 1994-05-30 PL PL94303652A patent/PL179104B1/pl not_active IP Right Cessation
- 1994-06-01 HU HU9401637A patent/HU219593B/hu not_active IP Right Cessation
- 1994-06-01 ZA ZA943830A patent/ZA943830B/xx unknown
- 1994-06-01 KR KR1019940012472A patent/KR100301876B1/ko not_active Expired - Fee Related
- 1994-06-01 NZ NZ260647A patent/NZ260647A/en unknown
- 1994-06-01 CN CN94106201A patent/CN1050829C/zh not_active Expired - Fee Related
- 1994-06-01 IL IL10984894A patent/IL109848A/xx not_active IP Right Cessation
- 1994-06-02 AU AU63472/94A patent/AU679221B2/en not_active Ceased
1996
- 1996-11-07 GR GR960402955T patent/GR3021581T3/el unknown
1997
- 1997-05-27 US US08/863,947 patent/US6075015A/en not_active Expired - Fee Related
- 1997-09-15 US US08/931,073 patent/USRE36854E/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR100301876B1 (ko)	2001-11-22
HU219593B (hu)	2001-05-28
GR3021581T3 (en)	1997-02-28
EP0633245B1 (en)	1996-09-04
CN1050829C (zh)	2000-03-29
USRE36854E (en)	2000-09-05
HU9401637D0 (en)	1994-08-29
CN1099385A (zh)	1995-03-01
IL109848A (en)	1999-06-20
ES2094023T3 (es)	1997-01-01
DE69400469T2 (de)	1997-03-27
PL303652A1 (en)	1994-12-12
AU679221B2 (en)	1997-06-26
IL109848A0 (en)	1994-10-07
NZ260647A (en)	1995-11-27
AU6347294A (en)	1994-12-08
KR950000662A (ko)	1995-01-03
ZA943830B (en)	1995-05-04
US6075015A (en)	2000-06-13
US5449668A (en)	1995-09-12
PL179104B1 (pl)	2000-07-31
ATE142198T1 (de)	1996-09-15
EP0633245A1 (en)	1995-01-11
HUT67928A (en)	1995-05-29
DE69400469D1 (de)	1996-10-10

Publication	Publication Date	Title
DK0633245T3 (da)	1996-12-23	D-vitamin-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
ATE315567T1 (de)	2006-02-15	A-1-adenosin rezeptor antagoniste
DK1106179T3 (da)	2008-08-18	Anvendelse af östrogenantagonister og östrogenagonister til hæmning af patologiske tilstande
MX9101280A (es)	1992-05-04	Compuestos inhibidores de la trombina y composicion farmaceutica que los contiene
ES2097653T3 (es)	1997-04-01	Nuevos derivados de desoxigalactonojirimicina.
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
DK0717034T3 (da)	1999-10-18	Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
DK0742203T5 (da)	2000-09-04	Vitamin D-forbindelser og fremgangsmåde til fremstilling deraf
MX9301045A (es)	1993-09-01	Procedimiento para preparar antagonistas receptores de fibrinogeno.
ES2051692T3 (es)	1994-07-01	Procedimiento para preparar 1,2,4-triazol-3-carboxamidas herbicidas.
DK0664287T3 (da)	1999-04-19	Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse
DK0505778T3 (da)	1995-12-11	Derivater af imidazol-2-oner samt fremgangsmåde til fremstilling deraf
CO4960660A1 (es)	2000-09-25	Derivados de 5-aroil-pirrol-2-ilmetilareno, composiciones farmaceuticas que las contienen y metodos para la preparacion de estos compuestos
ATE277898T1 (de)	2004-10-15	Verfahren zu herstellung von taxol
DK1049686T3 (da)	2006-01-16	Nyttige mellemprodukter og fremgangsmåder ved semisyntese af paclitaxel og analoger deraf
FR2756565B1 (fr)	1998-12-31	Nouveaux derives d'histidine et leur utilisation en cosmetique ou en pharmacie
CA2097997A1 (en)	1994-12-09	Vitamin d compounds and method of preparing these compounds
ES8207543A1 (es)	1982-10-01	Un procedimiento para la preparacion de nuevos derivados heterotriciclicos jaula.
NO934791L (no)	1994-06-27	Cefalosporinsalter og fremgangsmåte for fremstilling derav
EA199800931A1 (ru)	1999-04-29	Способ получения ингибиторов фосфодиэстеразы iv
IL102702A (en)	1997-04-15	OPTICALLY ACTIVE g-HALO- 2-AMINOALKANECARBOXYLIC ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE PREPARATION OF OPTICALLY ACTIVE PHOSPHORUS-CONTAINING a-AMINO ACIDS
DK0705266T3 (da)	1997-09-01	Fremgangsmåde til fremstilling af et imidazolderivat.
ES476073A1 (es)	1979-05-16	Procedimiento para la obtencion de derivados tio-alquil-ni- trogenados de imidazol.
AR241406A1 (es)	1992-07-31	Metodo para la preparacion de derivados amino alcanolicos aromaticos policiclicos.
FR2672593B1 (fr)	1994-05-20	Nouveaux composes utiles pour la resolution de la dl-n-acetyle ou la dl-n-haloacetyl-hydroxyphenylglycine.