DK0635014T3 - Indolderivater som 5-HT1-lignende agonister - Google Patents

Indolderivater som 5-HT1-lignende agonister

Info

Publication number: DK0635014T3
Authority: DK; Denmark
Prior art keywords: pct; date oct; sec; optionally substituted; agonists
Prior art date: 1992-04-10

Application number

DK93906620.5T

Other languages

English (en)

Inventor

John Eugene Macor

Martin James Wythes

Original Assignee

Pfizer Ltd

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-10

Filing date

1993-03-25

Publication date

1996-02-12

1993-03-25 Application filed by Pfizer Ltd, Pfizer Res & Dev filed Critical Pfizer Ltd

1996-02-12 Application granted granted Critical

1996-02-12 Publication of DK0635014T3 publication Critical patent/DK0635014T3/da

Links

239000000556 agonist Substances 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
125000002947 alkylene group Chemical group 0.000 abstract 2
206010009094 Chronic paroxysmal hemicrania Diseases 0.000 abstract 1
208000006561 Cluster Headache Diseases 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000018912 cluster headache syndrome Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
208000007777 paroxysmal Hemicrania Diseases 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1
102220315634 rs1196125127 Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK93906620.5T 1992-04-10 1993-03-25 Indolderivater som 5-HT1-lignende agonister DK0635014T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929207930A GB9207930D0 (en)	1992-04-10	1992-04-10	Indoles

Publications (1)

Publication Number	Publication Date
DK0635014T3 true DK0635014T3 (da)	1996-02-12

Family

ID=10713831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93906620.5T DK0635014T3 (da)	1992-04-10	1993-03-25	Indolderivater som 5-HT1-lignende agonister

Country Status (16)

Country	Link
US (1)	US5639779A (da)
EP (1)	EP0635014B1 (da)
JP (1)	JP2784265B2 (da)
CN (1)	CN1082039A (da)
AT (1)	ATE133169T1 (da)
AU (1)	AU3752593A (da)
CA (1)	CA2131000C (da)
DE (1)	DE69301357T2 (da)
DK (1)	DK0635014T3 (da)
ES (1)	ES2082639T3 (da)
FI (1)	FI111255B (da)
GB (1)	GB9207930D0 (da)
GR (1)	GR3019132T3 (da)
IL (1)	IL105311A0 (da)
WO (1)	WO1993021177A1 (da)
ZA (1)	ZA932534B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5559246A (en) *	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5578612A (en) *	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
US5545644A (en) *	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
US5607951A (en) *	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
US5559129A (en) *	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
KR100191973B1 (ko) *	1993-08-31	1999-06-15	디. 제이. 우드, 스피겔 알렌 제이	5-아릴인돌 유도체
GB9417310D0 (en) *	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
GB9420503D0 (en) *	1994-10-11	1994-11-23	Pfizer Ltd	Therapeutic agents
GB9420529D0 (en)	1994-10-12	1994-11-30	Pfizer Ltd	Indoles
US5994352A (en) *	1998-11-13	1999-11-30	Pfizer Inc.	5-arylindole derivatives
GB9923314D0 (en) *	1999-10-01	1999-12-08	Pfizer Ltd	Acylation process
EP1132389A1 (en) *	2000-03-06	2001-09-12	Vernalis Research Limited	New aza-indolyl derivatives for the treatment of obesity
US8754239B2 (en)	2010-01-19	2014-06-17	Sms Pharmaceuticals Limited	Process for preparing eletriptan hydrobromide having α-form
WO2025104491A1 (en)	2023-11-14	2025-05-22	Mindset Pharma Inc.	Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
SE454777B (sv) *	1980-08-12	1988-05-30	Glaxo Group Ltd	5-substituerade 3-aminoalkyl-1h-indoler, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
ZA815541B (en) *	1980-08-12	1983-03-30	Glaxo Group Ltd	Heterocyclic compounds
GB8600397D0 (en) *	1986-01-08	1986-02-12	Glaxo Group Ltd	Chemical compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
IL96891A0 (en) *	1990-01-17	1992-03-29	Merck Sharp & Dohme	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
PT97888B (pt) *	1990-06-07	1998-12-31	Zeneca Ltd	Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
PL170330B1 (pl) *	1990-10-15	1996-11-29	Pfizer	Sposób wytwarzania nowych pochodnych indolu PL PL PL PL PL PL
US5208248A (en) *	1991-01-11	1993-05-04	Merck Sharpe & Dohme, Ltd.	Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5409941A (en) *	1992-02-03	1995-04-25	Pfizer Inc.	5-heteroyl indole derivatives

1992
- 1992-04-10 GB GB929207930A patent/GB9207930D0/en active Pending
1993
- 1993-03-25 ES ES93906620T patent/ES2082639T3/es not_active Expired - Lifetime
- 1993-03-25 AU AU37525/93A patent/AU3752593A/en not_active Abandoned
- 1993-03-25 JP JP5517929A patent/JP2784265B2/ja not_active Expired - Fee Related
- 1993-03-25 CA CA002131000A patent/CA2131000C/en not_active Expired - Fee Related
- 1993-03-25 EP EP93906620A patent/EP0635014B1/en not_active Expired - Lifetime
- 1993-03-25 DK DK93906620.5T patent/DK0635014T3/da active
- 1993-03-25 US US08/313,106 patent/US5639779A/en not_active Expired - Fee Related
- 1993-03-25 DE DE69301357T patent/DE69301357T2/de not_active Expired - Fee Related
- 1993-03-25 WO PCT/EP1993/000738 patent/WO1993021177A1/en not_active Ceased
- 1993-03-25 AT AT93906620T patent/ATE133169T1/de not_active IP Right Cessation
- 1993-04-05 IL IL105311A patent/IL105311A0/xx unknown
- 1993-04-08 ZA ZA932534A patent/ZA932534B/xx unknown
- 1993-04-10 CN CN93105712A patent/CN1082039A/zh active Pending
1994
- 1994-10-07 FI FI944727A patent/FI111255B/fi not_active IP Right Cessation
1996
- 1996-02-28 GR GR960400556T patent/GR3019132T3/el unknown

Also Published As

Publication number	Publication date
WO1993021177A1 (en)	1993-10-28
EP0635014B1 (en)	1996-01-17
IL105311A0 (en)	1993-08-18
CA2131000A1 (en)	1993-10-28
GB9207930D0 (en)	1992-05-27
ATE133169T1 (de)	1996-02-15
AU3752593A (en)	1993-11-18
CA2131000C (en)	1998-09-22
CN1082039A (zh)	1994-02-16
EP0635014A1 (en)	1995-01-25
ES2082639T3 (es)	1996-03-16
JP2784265B2 (ja)	1998-08-06
FI111255B (fi)	2003-06-30
FI944727L (fi)	1994-10-07
FI944727A0 (fi)	1994-10-07
DE69301357T2 (de)	1996-06-13
ZA932534B (en)	1994-10-08
US5639779A (en)	1997-06-17
JPH07505402A (ja)	1995-06-15
DE69301357D1 (de)	1996-02-29
GR3019132T3 (en)	1996-05-31

Publication	Publication Date	Title
DK0635014T3 (da)	1996-02-12	Indolderivater som 5-HT1-lignende agonister
NO960365D0 (no)	1996-01-29	Perhydroisoindolderivater som substans-P-antagonister
CA2157397A1 (en)	1994-10-27	Indole derivatives as 5-ht1-like agonists for use in migraine
DE3882614D1 (de)	1993-09-02	Indol-derivate.
DK391289A (da)	1990-02-11	Indolderivater
NO943261L (no)	1994-09-02	Indolderivater som 5-HT, agonister
ATE177096T1 (de)	1999-03-15	4-substituierte 1,2,4-triazolderivate
FI943931A0 (fi)	1994-08-26	Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina
DK0785933T3 (da)	1998-05-11	Indolderivater som 5HT1-lignende agonister
DE69004989D1 (de)	1994-01-20	Indolderivate.
DK0514267T3 (da)	1996-11-11	Hidtil ukendte amidderivater af 1-aminooctahydropyrido(2,1-c)(1,4)oxazin, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem