ATE133169T1 - Indol derivate als ''5-ht1-like'' agonisten - Google Patents

Indol derivate als ''5-ht1-like'' agonisten

Info

Publication number: ATE133169T1
Authority: AT; Austria
Prior art keywords: pct; date oct; sec; optionally substituted; agonists
Prior art date: 1992-04-10

Application number

AT93906620T

Other languages

English (en)

Inventor

John Eugene Macor

Martin James Wythes

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-10

Filing date

1993-03-25

Publication date

1996-02-15

1993-03-25 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

1996-02-15 Application granted granted Critical

1996-02-15 Publication of ATE133169T1 publication Critical patent/ATE133169T1/de

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
239000000556 agonist Substances 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
125000002947 alkylene group Chemical group 0.000 abstract 2
206010009094 Chronic paroxysmal hemicrania Diseases 0.000 abstract 1
208000006561 Cluster Headache Diseases 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000018912 cluster headache syndrome Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
208000007777 paroxysmal Hemicrania Diseases 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1
102220315634 rs1196125127 Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000019553 vascular disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT93906620T 1992-04-10 1993-03-25 Indol derivate als ''5-ht1-like'' agonisten ATE133169T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929207930A GB9207930D0 (en)	1992-04-10	1992-04-10	Indoles

Publications (1)

Publication Number	Publication Date
ATE133169T1 true ATE133169T1 (de)	1996-02-15

Family

ID=10713831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93906620T ATE133169T1 (de)	1992-04-10	1993-03-25	Indol derivate als ''5-ht1-like'' agonisten

Country Status (16)

Country	Link
US (1)	US5639779A (de)
EP (1)	EP0635014B1 (de)
JP (1)	JP2784265B2 (de)
CN (1)	CN1082039A (de)
AT (1)	ATE133169T1 (de)
AU (1)	AU3752593A (de)
CA (1)	CA2131000C (de)
DE (1)	DE69301357T2 (de)
DK (1)	DK0635014T3 (de)
ES (1)	ES2082639T3 (de)
FI (1)	FI111255B (de)
GB (1)	GB9207930D0 (de)
GR (1)	GR3019132T3 (de)
IL (1)	IL105311A0 (de)
WO (1)	WO1993021177A1 (de)
ZA (1)	ZA932534B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5545644A (en) *	1990-10-15	1996-08-13	Pfizer Inc.	Indole derivatives
US5559129A (en) *	1990-10-15	1996-09-24	Pfizer Inc	Indole derivatives
US5559246A (en) *	1990-10-15	1996-09-24	Pfizer Inc.	Indole derivatives
US5607951A (en) *	1990-10-15	1997-03-04	Pfizer Inc	Indole derivatives
US5578612A (en) *	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
AU686654B2 (en) *	1993-08-31	1998-02-12	Pfizer Inc.	5-arylindole derivatives
GB9417310D0 (en)	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
GB9420503D0 (en) *	1994-10-11	1994-11-23	Pfizer Ltd	Therapeutic agents
GB9420529D0 (en)	1994-10-12	1994-11-30	Pfizer Ltd	Indoles
US5994352A (en) *	1998-11-13	1999-11-30	Pfizer Inc.	5-arylindole derivatives
GB9923314D0 (en) *	1999-10-01	1999-12-08	Pfizer Ltd	Acylation process
EP1132389A1 (de)	2000-03-06	2001-09-12	Vernalis Research Limited	Neue Azaindolyl-Derivate für die Behandlung von Fettleibigheit
WO2011089614A1 (en)	2010-01-19	2011-07-28	Sms Pharmaceuticals Limited	PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM
WO2025104491A1 (en)	2023-11-14	2025-05-22	Mindset Pharma Inc.	Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
ZA815541B (en) *	1980-08-12	1983-03-30	Glaxo Group Ltd	Heterocyclic compounds
DK157995C (da) *	1980-08-12	1990-08-06	Glaxo Group Ltd	Analogifremgangsmaade til fremstilling af indolderivater
GB8600397D0 (en) *	1986-01-08	1986-02-12	Glaxo Group Ltd	Chemical compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
IL96891A0 (en) *	1990-01-17	1992-03-29	Merck Sharp & Dohme	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CZ288351B6 (en) *	1990-06-07	2001-05-16	Astrazeneca Ab	Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
HU225055B1 (en) *	1990-10-15	2006-05-29	Pfizer	Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
US5208248A (en) *	1991-01-11	1993-05-04	Merck Sharpe & Dohme, Ltd.	Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5409941A (en) *	1992-02-03	1995-04-25	Pfizer Inc.	5-heteroyl indole derivatives

1992
- 1992-04-10 GB GB929207930A patent/GB9207930D0/en active Pending
1993
- 1993-03-25 CA CA002131000A patent/CA2131000C/en not_active Expired - Fee Related
- 1993-03-25 WO PCT/EP1993/000738 patent/WO1993021177A1/en not_active Ceased
- 1993-03-25 US US08/313,106 patent/US5639779A/en not_active Expired - Fee Related
- 1993-03-25 DE DE69301357T patent/DE69301357T2/de not_active Expired - Fee Related
- 1993-03-25 JP JP5517929A patent/JP2784265B2/ja not_active Expired - Fee Related
- 1993-03-25 ES ES93906620T patent/ES2082639T3/es not_active Expired - Lifetime
- 1993-03-25 AT AT93906620T patent/ATE133169T1/de not_active IP Right Cessation
- 1993-03-25 EP EP93906620A patent/EP0635014B1/de not_active Expired - Lifetime
- 1993-03-25 DK DK93906620.5T patent/DK0635014T3/da active
- 1993-03-25 AU AU37525/93A patent/AU3752593A/en not_active Abandoned
- 1993-04-05 IL IL105311A patent/IL105311A0/xx unknown
- 1993-04-08 ZA ZA932534A patent/ZA932534B/xx unknown
- 1993-04-10 CN CN93105712A patent/CN1082039A/zh active Pending
1994
- 1994-10-07 FI FI944727A patent/FI111255B/fi not_active IP Right Cessation
1996
- 1996-02-28 GR GR960400556T patent/GR3019132T3/el unknown

Also Published As

Publication number	Publication date
DK0635014T3 (da)	1996-02-12
CA2131000C (en)	1998-09-22
GB9207930D0 (en)	1992-05-27
WO1993021177A1 (en)	1993-10-28
AU3752593A (en)	1993-11-18
DE69301357T2 (de)	1996-06-13
EP0635014B1 (de)	1996-01-17
US5639779A (en)	1997-06-17
JPH07505402A (ja)	1995-06-15
ZA932534B (en)	1994-10-08
CA2131000A1 (en)	1993-10-28
CN1082039A (zh)	1994-02-16
GR3019132T3 (en)	1996-05-31
IL105311A0 (en)	1993-08-18
JP2784265B2 (ja)	1998-08-06
DE69301357D1 (de)	1996-02-29
EP0635014A1 (de)	1995-01-25
FI111255B (fi)	2003-06-30
FI944727L (fi)	1994-10-07
FI944727A0 (fi)	1994-10-07
ES2082639T3 (es)	1996-03-16

Legal Events

Date	Code	Title
1996-08-15	UEP	Publication of translation of european patent specification
2006-02-15	EEIH	Change in the person of patent owner
2006-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69301357D1 (de)	1996-02-29	Indol derivate als "5-ht1-like" agonisten
ATE171445T1 (de)	1998-10-15	Perhydroisoindolderivate als substanz p antagonisten
FI954944A0 (fi)	1995-10-17	Indolijohdannaisia 5-HT1-kaltaisina agonisteina käytettäväksi migreenin hoitoon
BR9206810A (pt)	1995-10-31	Derivados de indol
DE3882614D1 (de)	1993-09-02	Indol-derivate.
NO924310L (no)	1992-11-09	Nevrobeskyttende indolon- og beslektede derivater
DK391289A (da)	1990-02-11	Indolderivater
GB9210400D0 (en)	1992-07-01	Therapeutic agents
ATE275545T1 (de)	2004-09-15	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
NO943261L (no)	1994-09-02	Indolderivater som 5-HT, agonister
ATE177096T1 (de)	1999-03-15	4-substituierte 1,2,4-triazolderivate
DK0635015T3 (da)	1997-03-17	Acylaminoindolderivater som 5-Htl agonister
FI943931A0 (fi)	1994-08-26	Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina
DE69501791D1 (de)	1998-04-16	Indol-derivate als 5-ht1-like agonisten
ES2070087A1 (es)	1995-05-16	Derivados de indol