DK0635495T3 - Benzospiroalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem - Google Patents

Benzospiroalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem

Info

Publication number: DK0635495T3
Authority: DK; Denmark
Prior art keywords: branched; linear; group; unsubstituted; substituted
Prior art date: 1993-07-20

Application number

DK94401547T

Other languages

English (en)

Inventor

Alex Cordi

Jean-Michel Lacoste

Michel Laubie

Tony Verbeuren

Jean-Jacques Descombes

Mark Millan

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-20

Filing date

1994-07-06

Publication date

1999-06-14

1994-07-06 Application filed by Adir filed Critical Adir

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK0635495T3 publication Critical patent/DK0635495T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK94401547T 1993-07-20 1994-07-06 Benzospiroalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem DK0635495T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9308859A FR2707981B1 (fr)	1993-07-20	1993-07-20	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
DK0635495T3 true DK0635495T3 (da)	1999-06-14

Family

ID=9449385

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94401547T DK0635495T3 (da)	1993-07-20	1994-07-06	Benzospiroalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem

Country Status (12)

Country	Link
US (2)	US5486532A (da)
EP (1)	EP0635495B1 (da)
JP (1)	JP3103271B2 (da)
AT (1)	ATE171166T1 (da)
AU (1)	AU673438B2 (da)
CA (1)	CA2128119C (da)
DE (1)	DE69413333T2 (da)
DK (1)	DK0635495T3 (da)
ES (1)	ES2124379T3 (da)
FR (1)	FR2707981B1 (da)
NZ (1)	NZ264037A (da)
ZA (1)	ZA945336B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04174725A (ja) *	1990-10-30	1992-06-22	Kanebo Ltd	紡績装置におけるドラフト装置
FR2787450B1 (fr) *	1998-12-18	2001-01-26	Adir	Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2323734A1 (en) *	2008-08-04	2011-05-25	Schering Corporation	Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
AR073630A1 (es) *	2008-10-07	2010-11-17	Schering Corp	Analogos de espiroaminooxazolina como moduladores de los receptores adrenergicos alfa2c
US8324213B2 (en)	2008-10-07	2012-12-04	Merck Sharp & Dohme Corp.	Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators
EP2482661A4 (en) *	2009-10-01	2013-03-06	Merck Sharp & Dohme	REVERSED BIARYL SPIROAMINOOXAZOLINE ANALOGS AS ALPHA-2C ADRENERGE RECEPTOR MODULATORS
CN110393714B (zh) *	2019-08-02	2022-09-02	上海市肿瘤研究所	一种抗肿瘤药物、合成方法及应用
CN116120232B (zh) *	2023-02-24	2024-09-03	上海市肿瘤研究所	一种dna-螺烯纳米药物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3429892A (en) *	1967-03-14	1969-02-25	Smithkline Corp	Spiro(naphthalene-2,2'-oxazolidine) compounds
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4226875A (en) *	1979-04-02	1980-10-07	Pfizer Inc.	Novel spiro-oxazolidinediones
ZA832679B (en) *	1982-05-07	1983-12-28	Ici Plc	Indoline derivatives
FR2709306B1 (fr) *	1993-07-20	1995-10-20	Adir	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2707982B1 (fr) *	1993-07-20	1995-09-01	Adir	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

1993
- 1993-07-20 FR FR9308859A patent/FR2707981B1/fr not_active Expired - Fee Related
1994
- 1994-07-06 DE DE69413333T patent/DE69413333T2/de not_active Expired - Fee Related
- 1994-07-06 DK DK94401547T patent/DK0635495T3/da active
- 1994-07-06 ES ES94401547T patent/ES2124379T3/es not_active Expired - Lifetime
- 1994-07-06 EP EP94401547A patent/EP0635495B1/fr not_active Expired - Lifetime
- 1994-07-06 AT AT94401547T patent/ATE171166T1/de not_active IP Right Cessation
- 1994-07-15 CA CA002128119A patent/CA2128119C/fr not_active Expired - Fee Related
- 1994-07-18 AU AU67548/94A patent/AU673438B2/en not_active Ceased
- 1994-07-19 US US08/276,910 patent/US5486532A/en not_active Expired - Fee Related
- 1994-07-19 NZ NZ264037A patent/NZ264037A/en unknown
- 1994-07-20 JP JP06168029A patent/JP3103271B2/ja not_active Expired - Fee Related
- 1994-07-20 ZA ZA945336A patent/ZA945336B/xx unknown
1995
- 1995-04-11 US US08/420,064 patent/US5648374A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0635495A2 (fr)	1995-01-25
EP0635495B1 (fr)	1998-09-16
JPH07165728A (ja)	1995-06-27
AU6754894A (en)	1995-02-02
ATE171166T1 (de)	1998-10-15
US5486532A (en)	1996-01-23
FR2707981B1 (fr)	1995-09-01
CA2128119C (fr)	2002-02-26
NZ264037A (en)	1995-04-27
DE69413333D1 (de)	1998-10-22
ES2124379T3 (es)	1999-02-01
FR2707981A1 (fr)	1995-01-27
JP3103271B2 (ja)	2000-10-30
US5648374A (en)	1997-07-15
ZA945336B (en)	1995-02-28
EP0635495A3 (fr)	1995-02-22
CA2128119A1 (fr)	1995-01-21
DE69413333T2 (de)	1999-05-12
AU673438B2 (en)	1996-11-07

Publication	Publication Date	Title
ES2109672T3 (es)	1998-01-16	1,4-tiazepinas condensadas hipolipidemicas.
DK0457686T3 (da)	1994-12-12	Hidtil ukendte aminopiperidin-, aminopyrrolidin- og aminoperhydroazepinderivater, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem
AU663200B2 (en)	1995-09-28	New 3-(hydroxybenzylidenyl)-indolin-2-ones, processes for their preparation and pharmaceutical compositions containing them
DK0635497T3 (da)	1999-03-08	Benzospiroalkenderivater, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger, der indeholder disse
DK0635495T3 (da)	1999-06-14	Benzospiroalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem
ES8304076A1 (es)	1983-03-16	"procedimiento de preparacion de compuestos del tipo arilbencensulfonamida".
DK0452204T3 (da)	1994-10-24	Hidtil ukendte 3-aminochromanderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
DK0635496T3 (da)	1999-02-15	Benzospiroalkenderivater, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende sådanne
MY109729A (en)	1997-05-31	Benzofuranylimidazole derivatives, a process for the preparation and therapeutical compositions containing the same
FI954213A0 (fi)	1995-09-08	Kasvainten vastaisia koostumuksia ja hoitomenetelmiä
FI903511A0 (fi)	1990-07-11	Pyrrolo (2,1-b) tiazolderivat.
DK0412015T3 (da)	1994-11-28	Hidtil ukendte N-(23-vincristinoyl)- og N-(5-noranhydro-23-vinblastinoyl)-1-aminomethylphosphon- syrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
AU659738B2 (en)	1995-05-25	New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them
DK0518753T3 (da)	1995-05-15	Hidtil ukendte 1,5-diyn-3-cykloalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
PL304334A1 (en)	1995-01-23	Pharmaceutical composition of gastric protective action, including antiulceric one and method of treating diseases of gastrointestinal tract
ZA939576B (en)	1994-08-11	P-(bis(2-chloroethyl) amino)phenylalanine compounds process for preparing them and pharmaceutical compositions containing them