DK0635497T3 - Benzospiroalkenderivater, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger, der indeholder disse - Google Patents

Benzospiroalkenderivater, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger, der indeholder disse

Info

Publication number: DK0635497T3
Authority: DK; Denmark
Prior art keywords: branched; linear; group; unsubstituted; substituted
Prior art date: 1993-07-20

Application number

DK94401549T

Other languages

English (en)

Inventor

Alex Cordi

Jean-Michel Lacoste

Michel Laubie

Tony Verbeuren

Jean-Jacques Descombes

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-20

Filing date

1994-07-06

Publication date

1999-03-08

1994-07-06 Application filed by Adir filed Critical Adir

1999-03-08 Application granted granted Critical

1999-03-08 Publication of DK0635497T3 publication Critical patent/DK0635497T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK94401549T 1993-07-20 1994-07-06 Benzospiroalkenderivater, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger, der indeholder disse DK0635497T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9308861A FR2709306B1 (fr)	1993-07-20	1993-07-20	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
DK0635497T3 true DK0635497T3 (da)	1999-03-08

Family

ID=9449388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94401549T DK0635497T3 (da)	1993-07-20	1994-07-06	Benzospiroalkenderivater, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger, der indeholder disse

Country Status (13)

Country	Link
US (1)	US5436261A (da)
EP (1)	EP0635497B1 (da)
JP (1)	JP3105138B2 (da)
AT (1)	ATE166345T1 (da)
AU (1)	AU674080B2 (da)
CA (1)	CA2128359C (da)
CY (1)	CY2158B1 (da)
DE (1)	DE69410359T2 (da)
DK (1)	DK0635497T3 (da)
ES (1)	ES2119106T3 (da)
FR (1)	FR2709306B1 (da)
NZ (1)	NZ264050A (da)
ZA (1)	ZA945337B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2707981B1 (fr) *	1993-07-20	1995-09-01	Adir	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6156783A (en) *	1996-04-30	2000-12-05	Smithkline Beecham P.L.C.	Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2787450B1 (fr) *	1998-12-18	2001-01-26	Adir	Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7288559B2 (en) *	2003-03-14	2007-10-30	Merck + Co, Inc.	Carboxamide spirohydantoin CGRP receptor antagonists
US7115767B2 (en) *	2003-07-18	2006-10-03	Abbott Laboratories	Tetraline derivatives as ghrelin receptor modulators
CA2629406A1 (en)	2005-11-18	2007-05-31	Merck & Co., Inc.	Spirohydantoin aryl cgrp receptor antagonists
EP1954268B1 (en) *	2005-11-18	2012-09-26	Merck Sharp & Dohme Corp.	Spirolactam bicyclic cgrp receptor antagonists
EP1951042B1 (en) *	2005-11-18	2012-10-10	Merck Sharp & Dohme Corp.	Spirolactam tricyclic cgrp receptor antagonists
US7968540B2 (en)	2005-11-18	2011-06-28	Merck Sharp & Dohme Corp.	Spirohydantoin tricyclic CGRP receptor antagonists
AU2006316645A1 (en)	2005-11-18	2007-05-31	Merck Sharp & Dohme Corp.	Bicyclic spirohydantoin CGRP receptor antagonists
EP1954135B1 (en) *	2005-11-18	2012-10-10	Merck Sharp & Dohme Corp.	Spirolactam aryl cgrp receptor antagonists
EP2356106A1 (en)	2008-10-07	2011-08-17	Schering Corporation	Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
WO2011041181A1 (en) *	2009-10-01	2011-04-07	Schering Corporation	Reversed biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2716648A (en) *		1955-08-30		Hydantoin derivatives
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids

1993
- 1993-07-20 FR FR9308861A patent/FR2709306B1/fr not_active Expired - Fee Related
1994
- 1994-07-06 EP EP94401549A patent/EP0635497B1/fr not_active Expired - Lifetime
- 1994-07-06 DK DK94401549T patent/DK0635497T3/da active
- 1994-07-06 AT AT94401549T patent/ATE166345T1/de not_active IP Right Cessation
- 1994-07-06 DE DE69410359T patent/DE69410359T2/de not_active Expired - Fee Related
- 1994-07-06 ES ES94401549T patent/ES2119106T3/es not_active Expired - Lifetime
- 1994-07-18 AU AU67550/94A patent/AU674080B2/en not_active Ceased
- 1994-07-19 US US08/276,918 patent/US5436261A/en not_active Expired - Fee Related
- 1994-07-19 CA CA002128359A patent/CA2128359C/fr not_active Expired - Fee Related
- 1994-07-20 JP JP06198901A patent/JP3105138B2/ja not_active Expired - Fee Related
- 1994-07-20 ZA ZA945337A patent/ZA945337B/xx unknown
- 1994-07-20 NZ NZ264050A patent/NZ264050A/en unknown
1999
- 1999-11-19 CY CY9900039A patent/CY2158B1/xx unknown

Also Published As

Publication number	Publication date
JP3105138B2 (ja)	2000-10-30
HK1009648A1 (en)	1999-06-04
FR2709306B1 (fr)	1995-10-20
ZA945337B (en)	1995-03-01
CA2128359C (fr)	2002-03-19
ES2119106T3 (es)	1998-10-01
EP0635497B1 (fr)	1998-05-20
EP0635497A3 (fr)	1995-02-22
ATE166345T1 (de)	1998-06-15
EP0635497A2 (fr)	1995-01-25
FR2709306A1 (fr)	1995-03-03
NZ264050A (en)	1995-07-26
AU6755094A (en)	1995-02-02
JPH07304753A (ja)	1995-11-21
CA2128359A1 (fr)	1995-01-21
US5436261A (en)	1995-07-25
CY2158B1 (en)	2002-08-23
AU674080B2 (en)	1996-12-05
DE69410359T2 (de)	1999-01-07
DE69410359D1 (de)	1998-06-25

Publication	Publication Date	Title
AU663200B2 (en)	1995-09-28	New 3-(hydroxybenzylidenyl)-indolin-2-ones, processes for their preparation and pharmaceutical compositions containing them
AU7710591A (en)	1991-11-21	New aminopiperidine, aminopyrrolidine and aminoperhydroazepine compounds, processes for their preparation thereof and pharmaceutical compositions containing them
ES2119106T3 (es)	1998-10-01	Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
GR3019197T3 (en)	1996-06-30	Derivatives of hexahydroazepines, procedure for their preparation and pharmaceutical compositions containing same
DK0635495T3 (da)	1999-06-14	Benzospiroalkenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem
AU7414691A (en)	1991-10-10	New 3-aminochroman derivatives, process for preparing these and pharmaceutical compositions containing them
DK0635496T3 (da)	1999-02-15	Benzospiroalkenderivater, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende sådanne
AU624724B2 (en)	1992-06-18	Pyrrolo(2,1-b)thiazole derivatives
AU659738B2 (en)	1995-05-25	New pyrrolothienopyrazine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them
KR920017661A (ko)	1992-10-21	진행성 당뇨병의 진전 억제용 제약 조성물
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use