DK0639176T3 - Benzendimethanolderivat, der er egnet til mikronisering - Google Patents

Benzendimethanolderivat, der er egnet til mikronisering

Info

Publication number: DK0639176T3
Authority: DK; Denmark
Prior art keywords: salt; micronization; benzene dimethanol; derivative suitable; hydroxy
Prior art date: 1990-11-29

Application number

DK92900167.5T

Other languages

English (en)

Inventor

Steven Frederick Beach

David William Stuart Latham

Tony Gordon Roberts

Colin Brian Sidgwick

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-29

Filing date

1991-11-28

Publication date

1996-12-23

1991-11-28 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1996-12-23 Application granted granted Critical

1996-12-23 Publication of DK0639176T3 publication Critical patent/DK0639176T3/da

Links

GCBSCAKBRSMFCP-UHFFFAOYSA-N benzene;methanol Chemical class OC.OC.C1=CC=CC=C1 GCBSCAKBRSMFCP-UHFFFAOYSA-N 0.000 title 1
UPHOPMSGKZNELG-UHFFFAOYSA-N 2-hydroxynaphthalene-1-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 UPHOPMSGKZNELG-UHFFFAOYSA-N 0.000 abstract 1
SWPCURCTHNTSKL-UHFFFAOYSA-N C1=CC=CC2=C(O)C(C(=O)O)=CC=C21.C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21.C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 SWPCURCTHNTSKL-UHFFFAOYSA-N 0.000 abstract 1
239000002152 aqueous-organic solution Substances 0.000 abstract 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000013081 microcrystal Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000010791 quenching Methods 0.000 abstract 1
230000000171 quenching effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
- C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyesters Or Polycarbonates (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fats And Perfumes (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)

DK92900167.5T 1990-11-29 1991-11-28 Benzendimethanolderivat, der er egnet til mikronisering DK0639176T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909026005A GB9026005D0 (en)	1990-11-29	1990-11-29	Drug material suitable for micronisation

Publications (1)

Publication Number	Publication Date
DK0639176T3 true DK0639176T3 (da)	1996-12-23

Family

ID=10686212

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92900167.5T DK0639176T3 (da)	1990-11-29	1991-11-28	Benzendimethanolderivat, der er egnet til mikronisering

Country Status (27)

Country	Link
US (1)	US5380922A (da)
EP (2)	EP0639176B1 (da)
JP (1)	JP3375626B2 (da)
KR (1)	KR100192196B1 (da)
AT (1)	ATE144244T1 (da)
AU (1)	AU644505B2 (da)
BG (1)	BG61340B1 (da)
CA (1)	CA2099586C (da)
CY (1)	CY2009A (da)
CZ (1)	CZ282996B6 (da)
DE (1)	DE69122780T2 (da)
DK (1)	DK0639176T3 (da)
ES (1)	ES2093812T3 (da)
FI (2)	FI118155B (da)
GB (1)	GB9026005D0 (da)
GR (1)	GR3022088T3 (da)
HK (1)	HK78997A (da)
HU (1)	HU218205B (da)
IE (1)	IE914146A1 (da)
OA (2)	OA09861A (da)
PL (2)	PL167976B1 (da)
RU (2)	RU2116293C1 (da)
SG (1)	SG49741A1 (da)
SK (1)	SK281095B6 (da)
TW (1)	TW309425B (da)
WO (1)	WO1992009557A1 (da)
ZA (1)	ZA919401B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9026005D0 (en) *	1990-11-29	1991-01-16	Glaxo Group Ltd	Drug material suitable for micronisation
WO1993016031A1 (en) *	1992-02-11	1993-08-19	Glaxo Group Limited	Benzenedimethanol derivative suitable for micronisation
US6254882B1 (en)	1997-09-16	2001-07-03	Sepracor Inc.	Methods and compositions for treating pulmonary disorders using optically pure (S)—salmeterol
DK1169019T3 (da)	1999-04-14	2003-06-02	Glaxo Group Ltd	Farmaceutisk aerosolformulering
CA2423585A1 (en)	2000-09-26	2002-04-04	Temple University Of The Commonwealth System Of Higher Education	Analgesic and glucosamine compositions
EP2127641A1 (en)	2008-05-26	2009-12-02	Inke, S.A.	Micronisable form of salmeterol xinafoate
KR101100614B1 (ko)	2010-09-20	2011-12-29	한국수력원자력 주식회사	농축폐액 건조물의 펠렛화 장치 및 방법과 이를 이용한 유리조성개발 방법
WO2016142582A1 (en)	2015-03-11	2016-09-15	Fermion Oy	Process for the preparation of crystalline salmeterol and its xinafoate salt

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZW6584A1 (en) *	1983-04-18	1985-04-17	Glaxo Group Ltd	Phenethanolamine derivatives
GB9026005D0 (en) *	1990-11-29	1991-01-16	Glaxo Group Ltd	Drug material suitable for micronisation

1990
- 1990-11-29 GB GB909026005A patent/GB9026005D0/en active Pending
1991
- 1991-11-28 EP EP92900167A patent/EP0639176B1/en not_active Expired - Lifetime
- 1991-11-28 IE IE414691A patent/IE914146A1/en not_active IP Right Cessation
- 1991-11-28 ZA ZA919401A patent/ZA919401B/xx unknown
- 1991-11-28 SK SK545-93A patent/SK281095B6/sk not_active IP Right Cessation
- 1991-11-28 ES ES92900167T patent/ES2093812T3/es not_active Expired - Lifetime
- 1991-11-28 RU RU93040704A patent/RU2116293C1/ru active
- 1991-11-28 RU RU97121416/04A patent/RU2197475C2/ru active
- 1991-11-28 PL PL91299352A patent/PL167976B1/pl unknown
- 1991-11-28 CZ CS931019A patent/CZ282996B6/cs not_active IP Right Cessation
- 1991-11-28 AT AT92900167T patent/ATE144244T1/de not_active IP Right Cessation
- 1991-11-28 SG SG1996004594A patent/SG49741A1/en unknown
- 1991-11-28 DK DK92900167.5T patent/DK0639176T3/da active
- 1991-11-28 WO PCT/GB1991/002108 patent/WO1992009557A1/en not_active Ceased
- 1991-11-28 CA CA002099586A patent/CA2099586C/en not_active Expired - Lifetime
- 1991-11-28 AU AU90402/91A patent/AU644505B2/en not_active Ceased
- 1991-11-28 HU HU9301568A patent/HU218205B/hu unknown
- 1991-11-28 DE DE69122780T patent/DE69122780T2/de not_active Expired - Lifetime
- 1991-11-28 JP JP50047092A patent/JP3375626B2/ja not_active Expired - Lifetime
- 1991-11-28 PL PL91308211A patent/PL169722B1/pl unknown
1992
- 1992-05-21 EP EP92304635A patent/EP0571669B1/en not_active Expired - Lifetime
- 1992-05-29 TW TW081104199A patent/TW309425B/zh active
1993
- 1993-05-14 OA OA60370A patent/OA09861A/en unknown
- 1993-05-14 US US08/050,298 patent/US5380922A/en not_active Expired - Lifetime
- 1993-05-25 BG BG97767A patent/BG61340B1/bg unknown
- 1993-05-27 KR KR1019930701589A patent/KR100192196B1/ko not_active Expired - Lifetime
- 1993-05-27 FI FI932422A patent/FI118155B/fi not_active IP Right Cessation
- 1993-09-24 OA OA60416A patent/OA10024A/en unknown
1996
- 1996-12-18 GR GR960403534T patent/GR3022088T3/el unknown
1997
- 1997-06-12 HK HK78997A patent/HK78997A/en not_active IP Right Cessation
1998
- 1998-02-20 CY CY200998A patent/CY2009A/xx unknown
- 1998-09-28 FI FI982081A patent/FI118203B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0571669A1 (en)	1993-12-01
FI118155B (fi)	2007-07-31
CZ101993A3 (en)	1994-01-19
SG49741A1 (en)	1998-06-15
SK281095B6 (sk)	2000-11-07
EP0571669B1 (en)	1996-03-06
IE914146A1 (en)	1992-06-03
CA2099586C (en)	2002-06-25
WO1992009557A1 (en)	1992-06-11
EP0639176B1 (en)	1996-10-16
SK54593A3 (en)	1993-10-06
ES2093812T3 (es)	1997-01-01
BG97767A (bg)	1994-12-02
AU644505B2 (en)	1993-12-09
FI982081L (fi)	1998-09-28
GR3022088T3 (en)	1997-03-31
FI932422L (fi)	1993-05-27
DE69122780T2 (de)	1997-02-20
ZA919401B (en)	1992-07-29
RU2116293C1 (ru)	1998-07-27
HU9301568D0 (en)	1993-09-28
BG61340B1 (en)	1997-06-30
FI932422A0 (fi)	1993-05-27
HU218205B (hu)	2000-06-28
PL167976B1 (pl)	1995-12-30
PL169722B1 (pl)	1996-08-30
JP3375626B2 (ja)	2003-02-10
CY2009A (en)	1998-02-20
HUT64219A (en)	1993-12-28
KR100192196B1 (en)	1999-06-15
RU2197475C2 (ru)	2003-01-27
TW309425B (da)	1997-07-01
OA10024A (en)	1996-10-14
OA09861A (en)	1994-08-15
CZ282996B6 (cs)	1997-12-17
GB9026005D0 (en)	1991-01-16
AU9040291A (en)	1992-06-25
CA2099586A1 (en)	1992-05-30
DE69122780D1 (de)	1996-11-21
FI982081A0 (fi)	1998-09-28
JPH06503082A (ja)	1994-04-07
FI118203B (fi)	2007-08-31
HK78997A (en)	1997-06-20
EP0639176A1 (en)	1995-02-22
US5380922A (en)	1995-01-10
ATE144244T1 (de)	1996-11-15

Publication	Publication Date	Title
DK0639176T3 (da)	1996-12-23	Benzendimethanolderivat, der er egnet til mikronisering
GB9309324D0 (en)	1993-06-16	Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
ES2077729T3 (es)	1995-12-01	Procedimiento y dispositivo para la obtencion de particulas esfericas a partir de fase liquida.
FI894718A0 (fi)	1989-10-05	Pigmentationssupplement foer djurfoderkompositioner.
ES2061179T3 (es)	1994-12-01	Preparaciones granuladas y metodo para producirlas.
MX9206952A (es)	1993-06-01	Polvo de dispercion redispersable a partir de un copolimerizado de acetato de vinilo de n-vinilpirrolidona su preparcion y su empleo
EP0420376A3 (en)	1991-10-02	4g-alfa-d-glucopyranosyl rutin, and its preparation and uses
FR2656526B1 (fr)	1994-10-28	Dispositif a liberation controlee et procede de preparation.
RU93040704A (ru)	1996-06-20	1-гидрокси-2-нафталинкарбоксилатная соль 4-гидрокси-альфа-[[[6-(4-фенилбутокси)гексил]амино]метил]-1,3-бензолдиметанола в форме сферических сращений микрокристаллов, способ ее измельчения, способ ее получения, применение гидроксинафтоата для получения измельченной гидроксинафтоатной соли
JPS6413004A (en)	1989-01-17	Sustained release ferrous sulfate
GR3020622T3 (en)	1996-10-31	Method to produce pellets containing an ephedrine derivative
MY108410A (en)	1996-09-30	Drug material suitable for micronisation.
GR3005944T3 (da)	1993-06-07
Verkhovskii et al.	1990	Structure and Properties of Steels After Quenching in Magnetic Liquid
Nakae	1988	The Role of Solidification in Developing Materials
Gorynya et al.	1989	Development of phase transition in the condenser photo-emf of CdP sub (2).
Marinskii et al.	1988	Examination of the Effect of Working Parameters on the Temperature and Energy Parameters of Electroslag Crucible Melting
YU56692A (sh)	1994-11-15	Novi, za mikronizaciju pogodan oblik 1-hidrok-si-2-naftalin-karboksilatne soli 4-hidroksi-alfa1-///6-(4-fenilbutoksi)-hebsil/amino/metil/-1,3 benzoldimetanola i postupak za njegovo dobijanje
Ashkinadze et al.	1978	The Metastable State of the Condensed Phase of Excitons in Germanium as Affected by Pulsed Illumination and High-Frequency Heating
NO862907L (no)	1987-01-20	Fremgangsmaate for fremstilling av et farmasoeytisk preparat med forsinket virkestoff - frigjoering.
JPS5528926A (en)	1980-02-29	Preparation of 5-fluoro-uridine
Atterbury	1979	Heat Treatment of Tools and Dies in the Seventies and Eighties
Jurci et al.	1998	Microstructural Development and Phase Transformations in Fe-4 C-12 Cr-13 V RS Powder during Annealing
Kenis et al.	1988	Optimum Control of Cooling Kinetics of the Solid Cylinder in a Sprayer
Lan et al.	1997	Magnetic-field effect on MCT crystal composition distribution