DK0646116T3 - Fremgangsmåde og mellemprodukter til fremstilling af bis-aza-bicycliske anxiolytiske midler - Google Patents

Fremgangsmåde og mellemprodukter til fremstilling af bis-aza-bicycliske anxiolytiske midler

Info

Publication number
DK0646116T3
DK0646116T3 DK93905015T DK93905015T DK0646116T3 DK 0646116 T3 DK0646116 T3 DK 0646116T3 DK 93905015 T DK93905015 T DK 93905015T DK 93905015 T DK93905015 T DK 93905015T DK 0646116 T3 DK0646116 T3 DK 0646116T3
Authority
DK
Denmark
Prior art keywords
image
pct
intermediates
anxiolytic agents
aza
Prior art date
Application number
DK93905015T
Other languages
English (en)
Inventor
Frank J Urban
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0646116T3 publication Critical patent/DK0646116T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
DK93905015T 1992-06-16 1993-02-16 Fremgangsmåde og mellemprodukter til fremstilling af bis-aza-bicycliske anxiolytiske midler DK0646116T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89956092A 1992-06-16 1992-06-16
PCT/US1993/001208 WO1993025552A1 (en) 1992-06-16 1993-02-16 Process and intermediates for bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number Publication Date
DK0646116T3 true DK0646116T3 (da) 1999-12-27

Family

ID=25411215

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93905015T DK0646116T3 (da) 1992-06-16 1993-02-16 Fremgangsmåde og mellemprodukter til fremstilling af bis-aza-bicycliske anxiolytiske midler

Country Status (11)

Country Link
US (1) US5719286A (da)
EP (1) EP0646116B1 (da)
JP (2) JP2753146B2 (da)
AT (1) ATE185565T1 (da)
CA (1) CA2138018C (da)
DE (1) DE69326767T2 (da)
DK (1) DK0646116T3 (da)
ES (1) ES2137986T3 (da)
FI (2) FI982486A7 (da)
GR (1) GR3032285T3 (da)
WO (1) WO1993025552A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5731307A (en) * 1994-09-30 1998-03-24 Pfizer, Inc. Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
PL180899B1 (pl) * 1994-09-30 2001-04-30 Pfizer Nowe pochodne 2,7-podstawionej oktahydro-1H-pirydo[1,2-a]pirazyny i środek farmaceutyczny je zawierający
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
AP2005003390A0 (en) * 2003-03-12 2005-09-30 Pfizer Prod Inc Pyridyloxymethyl and benzisoxazole azabicyclic derivatives.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
CA2099563C (en) * 1991-01-31 1998-09-29 Charles W. Murtiashaw Preparation of (7s, trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl) octahydro-2h-pyrido[1,2-a]pyrazine
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines

Also Published As

Publication number Publication date
FI982486A0 (fi) 1998-11-17
FI102898B (fi) 1999-03-15
DE69326767T2 (de) 2000-03-02
CA2138018C (en) 1998-01-27
EP0646116A1 (en) 1995-04-05
DE69326767D1 (de) 1999-11-18
JP2753146B2 (ja) 1998-05-18
CA2138018A1 (en) 1993-12-23
EP0646116B1 (en) 1999-10-13
JP2744224B2 (ja) 1998-04-28
ES2137986T3 (es) 2000-01-01
FI932744A0 (fi) 1993-06-15
WO1993025552A1 (en) 1993-12-23
ATE185565T1 (de) 1999-10-15
US5719286A (en) 1998-02-17
FI982486A7 (fi) 1998-11-17
JPH09176166A (ja) 1997-07-08
FI932744L (fi) 1993-12-17
JPH07504678A (ja) 1995-05-25
FI102898B1 (fi) 1999-03-15
GR3032285T3 (en) 2000-04-27

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