DK0647649T3 - Ny krystal af heterocyklisk bis(phosphonsyre)monohydratderivat - Google Patents

Ny krystal af heterocyklisk bis(phosphonsyre)monohydratderivat

Info

Publication number
DK0647649T3
DK0647649T3 DK93913541T DK93913541T DK0647649T3 DK 0647649 T3 DK0647649 T3 DK 0647649T3 DK 93913541 T DK93913541 T DK 93913541T DK 93913541 T DK93913541 T DK 93913541T DK 0647649 T3 DK0647649 T3 DK 0647649T3
Authority
DK
Denmark
Prior art keywords
monohydrate
phosphonic acid
derivative
bis
new crystal
Prior art date
Application number
DK93913541T
Other languages
English (en)
Inventor
Yasuo Isomura
Makoto Takeuchi
Mamoru Hamada
Yoshisaburo Kaneko
Noriya Yamamoto
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of DK0647649T3 publication Critical patent/DK0647649T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK93913541T 1992-06-23 1993-06-18 Ny krystal af heterocyklisk bis(phosphonsyre)monohydratderivat DK0647649T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20587292 1992-06-23
PCT/JP1993/000821 WO1994000462A1 (fr) 1992-06-23 1993-06-18 Nouveau cristal de monohydrate de derive de bis(acide phosphonique) heterocyclique

Publications (1)

Publication Number Publication Date
DK0647649T3 true DK0647649T3 (da) 1999-07-26

Family

ID=16514129

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93913541T DK0647649T3 (da) 1992-06-23 1993-06-18 Ny krystal af heterocyklisk bis(phosphonsyre)monohydratderivat

Country Status (11)

Country Link
US (1) US5480875A (da)
EP (1) EP0647649B1 (da)
JP (1) JP2721434B2 (da)
KR (1) KR950702200A (da)
AT (1) ATE173267T1 (da)
AU (1) AU4356693A (da)
CA (1) CA2137665A1 (da)
DE (1) DE69322087T2 (da)
DK (1) DK0647649T3 (da)
ES (1) ES2124787T3 (da)
WO (1) WO1994000462A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
ZA986614B (en) 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
WO2000038694A1 (en) 1998-12-25 2000-07-06 Yamanouchi Pharmaceutical Co., Ltd. Medicinal compositions for treating osseous lesion in multiple myeloma
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
MXPA05007016A (es) 2003-01-14 2005-09-12 Gilead Sciences Inc Composiciones y metodos para terapia antiviral de combinacion.
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
CN101781333B (zh) * 2010-02-10 2013-06-05 浙江车头制药股份有限公司 一种阿德福韦酯晶型及其制备方法
CN102114025A (zh) * 2011-03-30 2011-07-06 北京美迪康信医药科技有限公司 一种治疗骨质疏松症的药物组合物
CN102850401B (zh) * 2011-07-01 2015-03-11 天津药物研究院 一种米诺膦酸二水合物晶型及其制备方法和用途
CN103183709B (zh) * 2011-12-30 2015-11-18 天津药物研究院 一种米诺膦酸新晶型及其制备方法和用途
JP2017512183A (ja) 2014-02-13 2017-05-18 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
WO2016024287A1 (en) * 2014-08-14 2016-02-18 Ind-Swift Laboratories Limited An improved process for preparing pure minodronic acid and intermediates thereof
JP6538501B2 (ja) * 2014-09-26 2019-07-03 プロコス ソシエタ ペル アチオニＰｒｏｃｏｓ Ｓ．Ｐ．Ａ． 結晶型ｅのミノドロン酸水和物の工業的生産方法
CN104610361A (zh) * 2015-03-02 2015-05-13 北京万全德众医药生物技术有限公司 一种米诺膦酸e晶型的制备方法
JP6492321B2 (ja) * 2015-03-23 2019-04-03 株式会社大阪合成有機化学研究所 ［１−ヒドロキシ−２−（イミダゾ［１，２−ａ］ピリジン−３−イル）エチリデン］ビスホスホン酸一水和物の製造方法
WO2016198117A1 (en) 2015-06-12 2016-12-15 Polycrystalline S.R.L. New crystal forms of minodronic acid
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение
CN112972400A (zh) * 2021-03-09 2021-06-18 华侨大学 可快速崩解的米诺膦酸颗粒及制备方法
CN113214321B (zh) * 2021-03-22 2022-06-21 南京海纳医药科技股份有限公司 一种米诺膦酸e晶型的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
JPH0699457B2 (ja) 1988-08-12 1994-12-07 山之内製薬株式会社 ヘテロ環ビスフォスフォン酸誘導体およびその医薬

Also Published As

Publication number Publication date
EP0647649B1 (en) 1998-11-11
DE69322087D1 (de) 1998-12-17
KR950702200A (ko) 1995-06-19
ATE173267T1 (de) 1998-11-15
EP0647649A4 (en) 1995-02-09
JP2721434B2 (ja) 1998-03-04
CA2137665A1 (en) 1994-01-06
DE69322087T2 (de) 1999-04-08
AU4356693A (en) 1994-01-24
ES2124787T3 (es) 1999-02-16
US5480875A (en) 1996-01-02
WO1994000462A1 (fr) 1994-01-06
EP0647649A1 (en) 1995-04-12

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