DK0648838T3 - Vævsinhibitor af metalloproteinase type tre (TIMP-3) - Google Patents

Vævsinhibitor af metalloproteinase type tre (TIMP-3)

Info

Publication number
DK0648838T3
DK0648838T3 DK94115578T DK94115578T DK0648838T3 DK 0648838 T3 DK0648838 T3 DK 0648838T3 DK 94115578 T DK94115578 T DK 94115578T DK 94115578 T DK94115578 T DK 94115578T DK 0648838 T3 DK0648838 T3 DK 0648838T3
Authority
DK
Denmark
Prior art keywords
timp
metalloproteinase
tissue inhibitor
polynucleotides encoding
metalloproteinase type
Prior art date
Application number
DK94115578T
Other languages
Danish (da)
English (en)
Inventor
Scott M Silbiger
Raymond A Koski
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22462365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0648838(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0648838T3 publication Critical patent/DK0648838T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK94115578T 1993-10-06 1994-10-04 Vævsinhibitor af metalloproteinase type tre (TIMP-3) DK0648838T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/134,231 US6562596B1 (en) 1993-10-06 1993-10-06 Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Publications (1)

Publication Number Publication Date
DK0648838T3 true DK0648838T3 (da) 2003-08-25

Family

ID=22462365

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94115578T DK0648838T3 (da) 1993-10-06 1994-10-04 Vævsinhibitor af metalloproteinase type tre (TIMP-3)
DK03005363T DK1319669T3 (da) 1993-10-06 1994-10-04 Kemisk modificeret vævsinhibitor af type-3-metalloproteinase- (TIMP-3) sammensætning samt fremgangsmåder

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03005363T DK1319669T3 (da) 1993-10-06 1994-10-04 Kemisk modificeret vævsinhibitor af type-3-metalloproteinase- (TIMP-3) sammensætning samt fremgangsmåder

Country Status (12)

Country Link
US (5) US6562596B1 (fr)
EP (3) EP0648838B1 (fr)
AT (2) ATE239079T1 (fr)
AU (1) AU7928194A (fr)
DE (2) DE69432581T2 (fr)
DK (2) DK0648838T3 (fr)
ES (2) ES2194852T3 (fr)
IL (4) IL162152A (fr)
PT (2) PT648838E (fr)
SI (2) SI1319669T1 (fr)
WO (1) WO1995009918A1 (fr)
ZA (1) ZA947781B (fr)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
DE19524720A1 (de) * 1995-07-12 1997-01-16 Hoechst Ag Zellspezifische Gentherapie mit Hilfe eines neuen Promotors für den "Tissue Inhibitor of Metalloproteinasn-3"
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AU3759100A (en) * 1999-03-24 2000-10-09 B.F. Goodrich Company, The Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
GB9921418D0 (en) * 1999-09-11 1999-11-10 Univ Sheffield Cell transfection
AU2094101A (en) * 1999-12-13 2001-06-18 Duanqing Pei Leukolysin/mmp25/mt6-mmp
KR100774796B1 (ko) * 2000-01-19 2007-11-07 가부시키가이샤 디나벡크 겐큐쇼 파라믹소바이러스 벡터의 혈관으로의 유전자 도입용도
US6562955B2 (en) * 2000-03-17 2003-05-13 Tosoh Corporation Oligonucleotides for detection of Vibrio parahaemolyticus and detection method for Vibrio parahaemolyticus using the same oligonucleotides
GB0015761D0 (en) * 2000-06-27 2000-08-16 Univ Bristol Polypeptide
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
DE10102784A1 (de) * 2001-01-22 2002-08-01 Henkel Kgaa Kosmetische oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
ES2359136T3 (es) * 2002-03-08 2011-05-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de inhibidores de la transactivación de egfr en cáncer humano.
AUPS282002A0 (en) * 2002-06-06 2002-06-27 Gropep Limited Metalloproteinase inhibitors
ATE432347T1 (de) * 2002-06-24 2009-06-15 Exiqon As Methoden und systeme zur detektion und isolation von nucleinsäuresequenzen
US7060795B2 (en) * 2002-12-19 2006-06-13 Kimberly-Clark Worldwide, Inc. Wound care compositions
US7183256B2 (en) 2003-03-21 2007-02-27 Cleveland Clinic Foundation TIMP3 as VEGF inhibitor
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
EP2287326A1 (fr) 2003-08-08 2011-02-23 Arriva Pharmaceuticals, Inc. Procédés de production de protéines dans la levure
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
EP1737499A4 (fr) 2004-03-09 2009-07-22 Arriva Pharmaceuticals Inc Traitement de la bronchopneumopathie chronique obstructive par inhalation a faible dose d'inhibiteur de protease
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
JP4993752B2 (ja) * 2005-03-01 2012-08-08 ストラタテック コーポレーション 外因性ポリペプチドを発現するヒト皮膚同等物
US20090318342A1 (en) * 2005-07-29 2009-12-24 Imperial Innovations Limited Compounds
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
MX2012001283A (es) * 2009-07-31 2012-06-12 Amgen Inc Polipeptidos que se enlazan al inhibidor de tejidos de metaloproteinasa tipo tres (timp-3) composiciones y metodos.
WO2012048291A2 (fr) * 2010-10-08 2012-04-12 Proteapex Therapeutics Llc Compositions et procédés pour l'inhibition d'interactions de substrat de mmp:mmp
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
EP2646468B1 (fr) 2010-12-01 2018-07-25 AlderBio Holdings LLC Compositions anti-ngf et leur utilisation
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9434944B2 (en) 2011-08-31 2016-09-06 University Of Zurich Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis
US10265388B2 (en) 2012-02-21 2019-04-23 Cytonics Corporation Systems, compositions, and methods for transplantation
EP2970407B1 (fr) * 2013-03-14 2023-11-15 Amgen Inc. Variants d'inhibiteur tissulaire de la métalloprotéinase type iii (timp-3), compositions et procédés
EP3617234A1 (fr) * 2013-08-07 2020-03-04 Astute Medical, Inc. Analyses pour gène timp2 doté d'une performance améliorée dans des échantillons biologiques
AU2014312249A1 (en) 2013-08-28 2016-03-24 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
CN105764523A (zh) * 2013-09-18 2016-07-13 詹姆斯库克大学 抗炎蛋白及使用方法
JP2016532456A (ja) * 2013-09-18 2016-10-20 ジェームス・クック・ユニバーシティー 改変型抗炎症性タンパク質及び使用方法
SG11201602876WA (en) 2013-10-24 2016-05-30 Amgen Inc Injector and method of assembly
CA3168888A1 (fr) 2013-10-24 2015-04-30 Amgen Inc. Systeme de distribution de medicaments equipe d'un dispositif de commande sensible a la temperature
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
AU2015256082C1 (en) 2014-05-07 2020-09-10 Amgen Inc. Autoinjector with shock reducing elements
CN111840696B (zh) 2014-06-03 2022-12-20 安姆根有限公司 可控制药物递送系统和使用方法
WO2016025850A1 (fr) 2014-08-15 2016-02-18 Amgen Inc. Dispositif d'administration de médicament péricardique et méthode d'utilisation
MX382490B (es) * 2014-08-27 2025-03-13 Amgen Inc Variantes de inhibidor de tejido de metaloproteinasa tipo tres (timp-3), composiciones y metodos
EP3206739B1 (fr) 2014-10-14 2021-12-01 Amgen Inc. Dispositif d'injection de médicament comportant des témoins visuels et sonores
EP3848072A1 (fr) 2014-12-19 2021-07-14 Amgen Inc. Dispositif d'administration de médicament comportant un capteur de proximité
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
JP6484345B2 (ja) 2015-02-17 2019-03-20 アムジエン・インコーポレーテツド 固定及び/または戻りが真空によって支援された薬物送達装置
WO2016138434A1 (fr) 2015-02-27 2016-09-01 Amgen Inc. Dispositif d'administration de médicament ayant un mécanisme de protection d'aiguille présentant un seuil réglable de résistance au mouvement de l'élément de protection d'aiguille
US10343884B2 (en) 2015-07-10 2019-07-09 E. & J. Gallo Winery System and method for dispensing a beverage
WO2017039786A1 (fr) 2015-09-02 2017-03-09 Amgen Inc. Adaptateur d'ensemble de seringue pour une seringue
JP7082568B2 (ja) 2015-12-09 2022-06-08 アムジエン・インコーポレーテツド 信号伝達キャップ付き自動注射器
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
DK3429663T3 (da) 2016-03-15 2020-09-28 Amgen Inc Reduktion af sandsynligheden for glasbrud i anordninger til indgivelse af lægemidler
WO2017189089A1 (fr) 2016-04-29 2017-11-02 Amgen Inc. Dispositif d'administration de médicament avec étiquette de messagerie
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
AU2017263558B2 (en) 2016-05-13 2022-12-22 Amgen Inc. Vial sleeve assembly
WO2017200989A1 (fr) 2016-05-16 2017-11-23 Amgen Inc. Chiffrement de données dans des dispositifs médicaux à capacité de calcul limitée
US11541176B2 (en) 2016-06-03 2023-01-03 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
EP3478342B1 (fr) 2016-07-01 2025-03-12 Amgen Inc. Dispositif d'administration de médicament présentant un risque réduit au minimum de fracture de composant lors d'événements d'impact
WO2018034784A1 (fr) 2016-08-17 2018-02-22 Amgen Inc. Dispositif d'administration de médicament avec détection de positionnement.
US20200261643A1 (en) 2016-10-25 2020-08-20 Amgen Inc. On-body injector
AU2018210301A1 (en) 2017-01-17 2019-08-01 Amgen Inc. Injection devices and related methods of use and assembly
CA3052204A1 (fr) 2017-02-17 2018-08-23 Amgen Inc. Mecanisme d'insertion pour dispositif d'administration de medicament
WO2018151890A1 (fr) 2017-02-17 2018-08-23 Amgen Inc. Dispositif d'administration de médicament à trajet d'écoulement de fluide stérile et procédé d'assemblage associé
EP3592403B1 (fr) 2017-03-06 2025-08-20 Amgen Inc. Dispositif d'administration de médicaments doté d'une fonction de prévention d'activation
US11571511B2 (en) 2017-03-07 2023-02-07 Amgen Inc. Insertion mechanism and method of inserting a needle of a drug delivery device
AU2018230486B2 (en) 2017-03-09 2023-05-11 Amgen Inc. Insertion mechanism for drug delivery device
ES3023742T3 (en) 2017-03-28 2025-06-03 Amgen Inc Plunger rod and syringe assembly system
US11718682B2 (en) 2017-04-05 2023-08-08 Astute Medical, Inc. Assays for TIMP2 having improved performance in biological samples
US11590294B2 (en) 2017-06-08 2023-02-28 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
JP7200134B2 (ja) 2017-06-08 2023-01-06 アムジエン・インコーポレーテツド トルク駆動式薬物送達デバイス
JP7195276B2 (ja) 2017-06-22 2022-12-23 アムジエン・インコーポレーテツド デバイス起動による衝突/衝撃の低減
WO2018237225A1 (fr) 2017-06-23 2018-12-27 Amgen Inc. Dispositif électronique d'administration de médicament comprenant un bouchon activé par un ensemble commutateur
IL270784B2 (en) 2017-07-14 2023-11-01 Amgen Inc Needle insertion-extraction system with a double torsion spring system
JP7649105B2 (ja) 2017-07-21 2025-03-19 アムジエン・インコーポレーテツド 薬物容器のためのガス透過性シーリング部材及び組立方法
MA49676A (fr) 2017-07-25 2020-06-03 Amgen Inc Dispositif d'administration de médicament doté d'un système d'accès à un récipient et procédé d'assemblage associé
US11617837B2 (en) 2017-07-25 2023-04-04 Amgen Inc. Drug delivery device with gear module and related method of assembly
MA49838A (fr) 2017-08-09 2020-06-17 Amgen Inc Systèm de administration de médicaments avec pression hydraulique-pneumatique de chambre
EP3668567B1 (fr) 2017-08-18 2026-02-18 Amgen Inc. Injecteur portable avec patch adhésif stérile
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
WO2019070472A1 (fr) 2017-10-04 2019-04-11 Amgen Inc. Adaptateur d'écoulement destiné à un dispositif d'administration de médicament
ES2971450T3 (es) 2017-10-06 2024-06-05 Amgen Inc Dispositivo de administración de fármacos con conjunto de enclavamiento y procedimiento de montaje correspondiente
US11464903B2 (en) 2017-10-09 2022-10-11 Amgen Inc. Drug delivery device with drive assembly and related method of assembly
IL273582B2 (en) 2017-11-03 2024-12-01 Amgen Inc Systems and approaches for sterilizing a drug delivery device
EP3706830B1 (fr) 2017-11-06 2024-08-07 Amgen Inc. Dispositif d'administration de médicament avec détection de positionnement et de débit
EP3707075A1 (fr) 2017-11-06 2020-09-16 Amgen Inc. Ensembles de remplissage-finition et procédés associés
MA50557A (fr) 2017-11-10 2020-09-16 Amgen Inc Pistons pour dispositifs d'administration de médicament
JP7370969B2 (ja) 2017-11-16 2023-10-30 アムジエン・インコーポレーテツド 薬物送達デバイスの扉ラッチ機構
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
CA3103681A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs d'administration pour l'administration de medicaments
WO2020023336A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs hybrides d'administration de médicament dotés d'une partie de préhension
US12303677B2 (en) 2018-07-24 2025-05-20 Amgen Inc. Hybrid drug delivery devices with optional grip portion and related method of preparation
MA53375A (fr) 2018-07-24 2021-06-02 Amgen Inc Dispositifs d'administration pour l'administration de médicaments
CA3103105A1 (fr) 2018-07-31 2020-02-06 Amgen Inc. Ensemble de trajet de fluide pour dispositif d'administration de medicament
US20210346601A1 (en) 2018-09-24 2021-11-11 Amgen Inc. Interventional dosing systems and methods
CA3110371A1 (fr) 2018-09-28 2020-04-02 Amgen Inc. Ensemble d'activation d'echappement de fil de muscle pour un dispositif d'administration de medicament
EP3860685A1 (fr) 2018-10-02 2021-08-11 Amgen Inc. Systèmes d'injection pour administration de médicament avec transmission de force interne
US12151089B2 (en) 2018-10-05 2024-11-26 Amgen Inc. Drug delivery device having dose indicator
TW202541859A (zh) 2018-10-15 2025-11-01 美商安進公司 具有阻尼機構之藥物遞送裝置及自動注射器
WO2020081480A1 (fr) 2018-10-15 2020-04-23 Amgen Inc. Procédé d'assemblage de plate-forme pour dispositif d'administration de médicament
MA54048A (fr) 2018-11-01 2022-02-09 Amgen Inc Dispositifs d'administration de médicament avec rétraction partielle de l'organe d'administration de médicament
EP3873563A1 (fr) 2018-11-01 2021-09-08 Amgen Inc. Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
AU2020263289B2 (en) 2019-04-24 2025-05-22 Amgen Inc. Syringe sterilization verification assemblies and methods
WO2021041067A2 (fr) 2019-08-23 2021-03-04 Amgen Inc. Dispositif d'administration de médicament doté de composants configurables de mise en prise de protection d'aiguille et méthodes associées
JP2024523779A (ja) 2021-05-21 2024-07-02 アムジェン インコーポレイテッド 薬物容器用の充填レシピを最適化する方法
WO2026030152A1 (fr) 2024-07-29 2026-02-05 Amgen Inc. Système et procédé d'évaluation de la transférabilité d'une recette de remplissage

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2726981C2 (de) * 1977-06-15 1984-11-22 Fried. Krupp Gmbh, 4300 Essen Vorrichtung zur Zeitmessung zwischen Impulsen
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
EP0189784B1 (fr) 1985-01-18 1989-11-08 G.D. Searle & Co. Inhibiteur naturel humain de collagénases
AU634533B2 (en) * 1989-03-21 1993-02-25 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Matrix metalloproteinase inhibitor peptides
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
JP2657113B2 (ja) 1989-10-16 1997-09-24 アムジエン・インコーポレーテツド 幹細胞因子
DK0512071T3 (da) * 1990-01-25 1996-11-25 Childrens Hospital Fremgangsmåde og sammensætninger til inhibering af angiogenese
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Also Published As

Publication number Publication date
DE69435162D1 (de) 2008-12-11
ES2194852T3 (es) 2003-12-01
IL111171A (en) 2006-07-05
EP0648838B1 (fr) 2003-05-02
EP1319669B1 (fr) 2008-10-29
US6683155B1 (en) 2004-01-27
IL191890A0 (en) 2009-05-04
SI0648838T1 (en) 2003-08-31
IL111171A0 (en) 1994-12-29
EP2011875A1 (fr) 2009-01-07
US20100010201A1 (en) 2010-01-14
HK1055977A1 (en) 2004-01-30
EP1319669A2 (fr) 2003-06-18
US7842788B2 (en) 2010-11-30
ZA947781B (en) 1995-05-17
PT1319669E (pt) 2009-01-07
DK1319669T3 (da) 2009-02-09
ATE412749T1 (de) 2008-11-15
WO1995009918A1 (fr) 1995-04-13
EP1319669A3 (fr) 2003-10-01
HK1009287A1 (en) 1999-05-28
IL162152A0 (en) 2005-11-20
ES2315438T3 (es) 2009-04-01
SI1319669T1 (sl) 2009-02-28
DE69432581D1 (de) 2003-06-05
US20060286085A1 (en) 2006-12-21
US7071317B2 (en) 2006-07-04
PT648838E (pt) 2003-08-29
AU7928194A (en) 1995-05-01
ATE239079T1 (de) 2003-05-15
US7435719B2 (en) 2008-10-14
DE69432581T2 (de) 2004-04-08
IL162152A (en) 2008-11-03
US20030143693A1 (en) 2003-07-31
US6562596B1 (en) 2003-05-13
EP0648838A1 (fr) 1995-04-19

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