DK0649465T3 - En ny morfinonreduktase samt anvendelsen heraf - Google Patents
En ny morfinonreduktase samt anvendelsen herafInfo
- Publication number
- DK0649465T3 DK0649465T3 DK93913236T DK93913236T DK0649465T3 DK 0649465 T3 DK0649465 T3 DK 0649465T3 DK 93913236 T DK93913236 T DK 93913236T DK 93913236 T DK93913236 T DK 93913236T DK 0649465 T3 DK0649465 T3 DK 0649465T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- morphinone
- enzyme
- new
- sec
- Prior art date
Links
- 108010053700 morphinone reductase Proteins 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 2
- XYYVYLMBEZUESM-CMKMFDCUSA-N codeinone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=CC(=O)[C@@H]1OC1=C2C3=CC=C1OC XYYVYLMBEZUESM-CMKMFDCUSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 abstract 1
- 229960000240 hydrocodone Drugs 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 abstract 1
- 229960001410 hydromorphone Drugs 0.000 abstract 1
- PFBSOANQDDTNGJ-YNHQPCIGSA-N morphinone Chemical compound O([C@H]1C(C=C[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O PFBSOANQDDTNGJ-YNHQPCIGSA-N 0.000 abstract 1
- LJVKMVSYTWPNGA-UUWFMWQGSA-N neopinone Chemical compound O=C([C@@H]1O2)CC=C3[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C LJVKMVSYTWPNGA-UUWFMWQGSA-N 0.000 abstract 1
- LJVKMVSYTWPNGA-UHFFFAOYSA-N neopinone Natural products O1C2C(=O)CC=C3C4CC5=CC=C(OC)C1=C5C23CCN4C LJVKMVSYTWPNGA-UHFFFAOYSA-N 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01042—12-Oxophytodienoate reductase (1.3.1.42), i.e. morphinone-reductase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929213524A GB9213524D0 (en) | 1992-06-25 | 1992-06-25 | Biocatalysis in the synthesis of analgesic and antitussive compounds |
| PCT/GB1993/001129 WO1994000565A1 (en) | 1992-06-25 | 1993-05-28 | Morphinone reductase for the preparation of hydromorphone and hydrocodone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0649465T3 true DK0649465T3 (da) | 2002-11-11 |
Family
ID=10717731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93913236T DK0649465T3 (da) | 1992-06-25 | 1993-05-28 | En ny morfinonreduktase samt anvendelsen heraf |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5571685A (de) |
| EP (1) | EP0649465B1 (de) |
| JP (1) | JP3638022B2 (de) |
| AT (1) | ATE221120T1 (de) |
| AU (1) | AU660103B2 (de) |
| CA (1) | CA2137548C (de) |
| DE (1) | DE69332146T2 (de) |
| DK (1) | DK0649465T3 (de) |
| ES (1) | ES2179053T3 (de) |
| GB (1) | GB9213524D0 (de) |
| HU (1) | HU213750B (de) |
| PT (1) | PT649465E (de) |
| SK (1) | SK282363B6 (de) |
| WO (1) | WO1994000565A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6533752B1 (en) | 2000-01-05 | 2003-03-18 | Thomas C Waram | Variable shape guide apparatus |
| JP2005522460A (ja) | 2002-02-28 | 2005-07-28 | マリンクロッド・インコーポレイテッド | 逆相分取用クロマトグラフィーを用いる少なくとも１種の麻薬性アルカロイドの分離および精製のための方法およびシステム |
| US7399858B2 (en) * | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| US7323565B2 (en) * | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US6946556B1 (en) | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
| US7348430B2 (en) * | 2005-01-21 | 2008-03-25 | Acura Pharmaceuticals, Inc. | Production of opioid analgesics |
| ES2571232T3 (es) * | 2009-04-09 | 2016-05-24 | Mallinckrodt Llc | Preparación de compuestos de morfinano de cetona saturada mediante isomerización catalítica |
| WO2010118275A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of saturated ketone morphinan compounds |
| WO2010118274A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of 6-keto, 3-alkoxy morphinans |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910958D0 (en) * | 1989-05-12 | 1989-06-28 | Bruce Neil C | Assay |
-
1992
- 1992-06-25 GB GB929213524A patent/GB9213524D0/en active Pending
-
1993
- 1993-05-28 PT PT93913236T patent/PT649465E/pt unknown
- 1993-05-28 CA CA002137548A patent/CA2137548C/en not_active Expired - Fee Related
- 1993-05-28 AT AT93913236T patent/ATE221120T1/de not_active IP Right Cessation
- 1993-05-28 WO PCT/GB1993/001129 patent/WO1994000565A1/en not_active Ceased
- 1993-05-28 AU AU43370/93A patent/AU660103B2/en not_active Ceased
- 1993-05-28 JP JP50212994A patent/JP3638022B2/ja not_active Expired - Fee Related
- 1993-05-28 SK SK1591-94A patent/SK282363B6/sk not_active IP Right Cessation
- 1993-05-28 ES ES93913236T patent/ES2179053T3/es not_active Expired - Lifetime
- 1993-05-28 US US08/343,606 patent/US5571685A/en not_active Expired - Lifetime
- 1993-05-28 DK DK93913236T patent/DK0649465T3/da active
- 1993-05-28 EP EP93913236A patent/EP0649465B1/de not_active Expired - Lifetime
- 1993-05-28 HU HU9403723A patent/HU213750B/hu not_active IP Right Cessation
- 1993-05-28 DE DE69332146T patent/DE69332146T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HU9403723D0 (en) | 1995-02-28 |
| AU4337093A (en) | 1994-01-24 |
| HU213750B (en) | 1997-09-29 |
| CA2137548A1 (en) | 1994-01-06 |
| US5571685A (en) | 1996-11-05 |
| GB9213524D0 (en) | 1992-08-12 |
| ATE221120T1 (de) | 2002-08-15 |
| AU660103B2 (en) | 1995-06-08 |
| EP0649465B1 (de) | 2002-07-24 |
| CA2137548C (en) | 2005-10-25 |
| WO1994000565A1 (en) | 1994-01-06 |
| SK159194A3 (en) | 1995-07-11 |
| EP0649465A1 (de) | 1995-04-26 |
| JP3638022B2 (ja) | 2005-04-13 |
| DE69332146D1 (de) | 2002-08-29 |
| SK282363B6 (sk) | 2002-01-07 |
| PT649465E (pt) | 2002-12-31 |
| ES2179053T3 (es) | 2003-01-16 |
| HUT69982A (en) | 1995-09-28 |
| JPH07508167A (ja) | 1995-09-14 |
| DE69332146T2 (de) | 2002-11-07 |
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