ATE221120T1 - Morphinone reduktase zur herstellung von hydromorphone und hydrocodone - Google Patents
Morphinone reduktase zur herstellung von hydromorphone und hydrocodoneInfo
- Publication number
- ATE221120T1 ATE221120T1 AT93913236T AT93913236T ATE221120T1 AT E221120 T1 ATE221120 T1 AT E221120T1 AT 93913236 T AT93913236 T AT 93913236T AT 93913236 T AT93913236 T AT 93913236T AT E221120 T1 ATE221120 T1 AT E221120T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- morphinone
- enzyme
- hydrocodones
- hydromorphones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01042—12-Oxophytodienoate reductase (1.3.1.42), i.e. morphinone-reductase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929213524A GB9213524D0 (en) | 1992-06-25 | 1992-06-25 | Biocatalysis in the synthesis of analgesic and antitussive compounds |
| PCT/GB1993/001129 WO1994000565A1 (en) | 1992-06-25 | 1993-05-28 | Morphinone reductase for the preparation of hydromorphone and hydrocodone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE221120T1 true ATE221120T1 (de) | 2002-08-15 |
Family
ID=10717731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93913236T ATE221120T1 (de) | 1992-06-25 | 1993-05-28 | Morphinone reduktase zur herstellung von hydromorphone und hydrocodone |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5571685A (de) |
| EP (1) | EP0649465B1 (de) |
| JP (1) | JP3638022B2 (de) |
| AT (1) | ATE221120T1 (de) |
| AU (1) | AU660103B2 (de) |
| CA (1) | CA2137548C (de) |
| DE (1) | DE69332146T2 (de) |
| DK (1) | DK0649465T3 (de) |
| ES (1) | ES2179053T3 (de) |
| GB (1) | GB9213524D0 (de) |
| HU (1) | HU213750B (de) |
| PT (1) | PT649465E (de) |
| SK (1) | SK282363B6 (de) |
| WO (1) | WO1994000565A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6533752B1 (en) | 2000-01-05 | 2003-03-18 | Thomas C Waram | Variable shape guide apparatus |
| CA2477739A1 (en) * | 2002-02-28 | 2003-09-12 | Mallinckrodt Inc. | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
| US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7399858B2 (en) * | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| US7323565B2 (en) * | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US6946556B1 (en) | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
| US7348430B2 (en) * | 2005-01-21 | 2008-03-25 | Acura Pharmaceuticals, Inc. | Production of opioid analgesics |
| WO2010118271A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of saturated ketone morphinan compounds by catalytic isomerization |
| WO2010118274A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of 6-keto, 3-alkoxy morphinans |
| WO2010118275A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of saturated ketone morphinan compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910958D0 (en) * | 1989-05-12 | 1989-06-28 | Bruce Neil C | Assay |
-
1992
- 1992-06-25 GB GB929213524A patent/GB9213524D0/en active Pending
-
1993
- 1993-05-28 SK SK1591-94A patent/SK282363B6/sk not_active IP Right Cessation
- 1993-05-28 AT AT93913236T patent/ATE221120T1/de not_active IP Right Cessation
- 1993-05-28 WO PCT/GB1993/001129 patent/WO1994000565A1/en not_active Ceased
- 1993-05-28 JP JP50212994A patent/JP3638022B2/ja not_active Expired - Fee Related
- 1993-05-28 CA CA002137548A patent/CA2137548C/en not_active Expired - Fee Related
- 1993-05-28 ES ES93913236T patent/ES2179053T3/es not_active Expired - Lifetime
- 1993-05-28 PT PT93913236T patent/PT649465E/pt unknown
- 1993-05-28 US US08/343,606 patent/US5571685A/en not_active Expired - Lifetime
- 1993-05-28 HU HU9403723A patent/HU213750B/hu not_active IP Right Cessation
- 1993-05-28 DE DE69332146T patent/DE69332146T2/de not_active Expired - Fee Related
- 1993-05-28 AU AU43370/93A patent/AU660103B2/en not_active Ceased
- 1993-05-28 DK DK93913236T patent/DK0649465T3/da active
- 1993-05-28 EP EP93913236A patent/EP0649465B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HU9403723D0 (en) | 1995-02-28 |
| ES2179053T3 (es) | 2003-01-16 |
| DK0649465T3 (da) | 2002-11-11 |
| CA2137548C (en) | 2005-10-25 |
| JPH07508167A (ja) | 1995-09-14 |
| PT649465E (pt) | 2002-12-31 |
| GB9213524D0 (en) | 1992-08-12 |
| WO1994000565A1 (en) | 1994-01-06 |
| DE69332146T2 (de) | 2002-11-07 |
| EP0649465A1 (de) | 1995-04-26 |
| US5571685A (en) | 1996-11-05 |
| EP0649465B1 (de) | 2002-07-24 |
| HU213750B (en) | 1997-09-29 |
| DE69332146D1 (de) | 2002-08-29 |
| AU660103B2 (en) | 1995-06-08 |
| HUT69982A (en) | 1995-09-28 |
| AU4337093A (en) | 1994-01-24 |
| SK159194A3 (en) | 1995-07-11 |
| SK282363B6 (sk) | 2002-01-07 |
| CA2137548A1 (en) | 1994-01-06 |
| JP3638022B2 (ja) | 2005-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |