ATE221120T1 - Morphinone reduktase zur herstellung von hydromorphone und hydrocodone - Google Patents

Morphinone reduktase zur herstellung von hydromorphone und hydrocodone

Info

Publication number
ATE221120T1
ATE221120T1 AT93913236T AT93913236T ATE221120T1 AT E221120 T1 ATE221120 T1 AT E221120T1 AT 93913236 T AT93913236 T AT 93913236T AT 93913236 T AT93913236 T AT 93913236T AT E221120 T1 ATE221120 T1 AT E221120T1
Authority
AT
Austria
Prior art keywords
pct
morphinone
enzyme
hydrocodones
hydromorphones
Prior art date
Application number
AT93913236T
Other languages
English (en)
Inventor
Anne Maria Lower Road Hailes
Christopher Edward French
Neil Charles Bruce
Original Assignee
Macfarlan Smith Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macfarlan Smith Ltd filed Critical Macfarlan Smith Ltd
Application granted granted Critical
Publication of ATE221120T1 publication Critical patent/ATE221120T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/001Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y103/00Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/0104212-Oxophytodienoate reductase (1.3.1.42), i.e. morphinone-reductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT93913236T 1992-06-25 1993-05-28 Morphinone reduktase zur herstellung von hydromorphone und hydrocodone ATE221120T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929213524A GB9213524D0 (en) 1992-06-25 1992-06-25 Biocatalysis in the synthesis of analgesic and antitussive compounds
PCT/GB1993/001129 WO1994000565A1 (en) 1992-06-25 1993-05-28 Morphinone reductase for the preparation of hydromorphone and hydrocodone

Publications (1)

Publication Number Publication Date
ATE221120T1 true ATE221120T1 (de) 2002-08-15

Family

ID=10717731

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93913236T ATE221120T1 (de) 1992-06-25 1993-05-28 Morphinone reduktase zur herstellung von hydromorphone und hydrocodone

Country Status (14)

Country Link
US (1) US5571685A (de)
EP (1) EP0649465B1 (de)
JP (1) JP3638022B2 (de)
AT (1) ATE221120T1 (de)
AU (1) AU660103B2 (de)
CA (1) CA2137548C (de)
DE (1) DE69332146T2 (de)
DK (1) DK0649465T3 (de)
ES (1) ES2179053T3 (de)
GB (1) GB9213524D0 (de)
HU (1) HU213750B (de)
PT (1) PT649465E (de)
SK (1) SK282363B6 (de)
WO (1) WO1994000565A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6533752B1 (en) 2000-01-05 2003-03-18 Thomas C Waram Variable shape guide apparatus
CA2477739A1 (en) * 2002-02-28 2003-09-12 Mallinckrodt Inc. Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
US7321038B2 (en) * 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) * 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7323565B2 (en) * 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US6946556B1 (en) 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
US7348430B2 (en) * 2005-01-21 2008-03-25 Acura Pharmaceuticals, Inc. Production of opioid analgesics
WO2010118271A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of saturated ketone morphinan compounds by catalytic isomerization
WO2010118274A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of 6-keto, 3-alkoxy morphinans
WO2010118275A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of saturated ketone morphinan compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8910958D0 (en) * 1989-05-12 1989-06-28 Bruce Neil C Assay

Also Published As

Publication number Publication date
HU9403723D0 (en) 1995-02-28
ES2179053T3 (es) 2003-01-16
DK0649465T3 (da) 2002-11-11
CA2137548C (en) 2005-10-25
JPH07508167A (ja) 1995-09-14
PT649465E (pt) 2002-12-31
GB9213524D0 (en) 1992-08-12
WO1994000565A1 (en) 1994-01-06
DE69332146T2 (de) 2002-11-07
EP0649465A1 (de) 1995-04-26
US5571685A (en) 1996-11-05
EP0649465B1 (de) 2002-07-24
HU213750B (en) 1997-09-29
DE69332146D1 (de) 2002-08-29
AU660103B2 (en) 1995-06-08
HUT69982A (en) 1995-09-28
AU4337093A (en) 1994-01-24
SK159194A3 (en) 1995-07-11
SK282363B6 (sk) 2002-01-07
CA2137548A1 (en) 1994-01-06
JP3638022B2 (ja) 2005-04-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee