SK282363B6 - Enzým morfínovej reduktázy, spôsob produkcie enzýmu, metóda detekcie morfinónu alebo kodeinónu alebo ich prekurzorov vo vzorke, metóda produkcie hydromorfónu alebo hydrokodónu a hostiteľ transformovaný génom - Google Patents

Enzým morfínovej reduktázy, spôsob produkcie enzýmu, metóda detekcie morfinónu alebo kodeinónu alebo ich prekurzorov vo vzorke, metóda produkcie hydromorfónu alebo hydrokodónu a hostiteľ transformovaný génom Download PDF

Info

Publication number: SK282363B6
Authority: SK; Slovakia
Prior art keywords: enzyme; morphinone; codeinone; morphine; hydromorphone
Prior art date: 1992-06-25

Application number

SK1591-94A

Other languages

English (en)

Slovak (sk)

Other versions

SK159194A3 (en

Inventor

Anne Maria Hailes

Christopher Edward French

Neil Charles Bruce

Original Assignee

Macfarlan Smith Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-25

Filing date

1993-05-28

Publication date

2002-01-07

1993-05-28 Application filed by Macfarlan Smith Limited filed Critical Macfarlan Smith Limited

1995-07-11 Publication of SK159194A3 publication Critical patent/SK159194A3/sk

2002-01-07 Publication of SK282363B6 publication Critical patent/SK282363B6/sk

Links

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YMIZSYUAZJSOFL-SRVKXCTJSA-N Phe-Ser-Asn Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O YMIZSYUAZJSOFL-SRVKXCTJSA-N 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
241000607598 Vibrio Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
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239000003463 adsorbent Substances 0.000 description 1
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230000000202 analgesic effect Effects 0.000 description 1
230000000954 anitussive effect Effects 0.000 description 1
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125000003118 aryl group Chemical group 0.000 description 1
229940090047 auto-injector Drugs 0.000 description 1
239000013060 biological fluid Substances 0.000 description 1
239000002981 blocking agent Substances 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
238000010531 catalytic reduction reaction Methods 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
150000001793 charged compounds Chemical class 0.000 description 1
239000002962 chemical mutagen Substances 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000001268 conjugating effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
229910000365 copper sulfate Inorganic materials 0.000 description 1
229960004544 cortisone Drugs 0.000 description 1
239000000287 crude extract Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
150000001923 cyclic compounds Chemical class 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
229960000920 dihydrocodeine Drugs 0.000 description 1
RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 description 1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000001952 enzyme assay Methods 0.000 description 1
150000002211 flavins Chemical class 0.000 description 1
238000013467 fragmentation Methods 0.000 description 1
238000006062 fragmentation reaction Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
238000001641 gel filtration chromatography Methods 0.000 description 1
108010066198 glycyl-leucyl-phenylalanine Proteins 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229960002764 hydrocodone bitartrate Drugs 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000006698 induction Effects 0.000 description 1
239000002440 industrial waste Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000007689 inspection Methods 0.000 description 1
230000010354 integration Effects 0.000 description 1
OROGSEYTTFOCAN-KEMUOJQUSA-N isocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-KEMUOJQUSA-N 0.000 description 1
238000001155 isoelectric focusing Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
238000011068 loading method Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
229940049920 malate Drugs 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
239000003550 marker Substances 0.000 description 1
238000001819 mass spectrum Methods 0.000 description 1
150000002736 metal compounds Chemical class 0.000 description 1
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239000007003 mineral medium Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000002808 molecular sieve Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
229930013053 morphinan alkaloid Natural products 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
229960005118 oxymorphone Drugs 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229960003387 progesterone Drugs 0.000 description 1
239000000186 progesterone Substances 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000005215 recombination Methods 0.000 description 1
238000006479 redox reaction Methods 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
235000019192 riboflavin Nutrition 0.000 description 1
229960002477 riboflavin Drugs 0.000 description 1
239000002151 riboflavin Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000012085 test solution Substances 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000012795 verification Methods 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01042—12-Oxophytodienoate reductase (1.3.1.42), i.e. morphinone-reductase

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1591-94A 1992-06-25 1993-05-28 Enzým morfínovej reduktázy, spôsob produkcie enzýmu, metóda detekcie morfinónu alebo kodeinónu alebo ich prekurzorov vo vzorke, metóda produkcie hydromorfónu alebo hydrokodónu a hostiteľ transformovaný génom SK282363B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213524A GB9213524D0 (en)	1992-06-25	1992-06-25	Biocatalysis in the synthesis of analgesic and antitussive compounds
PCT/GB1993/001129 WO1994000565A1 (en)	1992-06-25	1993-05-28	Morphinone reductase for the preparation of hydromorphone and hydrocodone

Publications (2)

Publication Number	Publication Date
SK159194A3 SK159194A3 (en)	1995-07-11
SK282363B6 true SK282363B6 (sk)	2002-01-07

Family

ID=10717731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1591-94A SK282363B6 (sk)	1992-06-25	1993-05-28	Enzým morfínovej reduktázy, spôsob produkcie enzýmu, metóda detekcie morfinónu alebo kodeinónu alebo ich prekurzorov vo vzorke, metóda produkcie hydromorfónu alebo hydrokodónu a hostiteľ transformovaný génom

Country Status (14)

Country	Link
US (1)	US5571685A (de)
EP (1)	EP0649465B1 (de)
JP (1)	JP3638022B2 (de)
AT (1)	ATE221120T1 (de)
AU (1)	AU660103B2 (de)
CA (1)	CA2137548C (de)
DE (1)	DE69332146T2 (de)
DK (1)	DK0649465T3 (de)
ES (1)	ES2179053T3 (de)
GB (1)	GB9213524D0 (de)
HU (1)	HU213750B (de)
PT (1)	PT649465E (de)
SK (1)	SK282363B6 (de)
WO (1)	WO1994000565A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6533752B1 (en)	2000-01-05	2003-03-18	Thomas C Waram	Variable shape guide apparatus
ATE407136T1 (de) *	2002-02-28	2008-09-15	Mallinckrodt Inc	Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographie
US7321038B2 (en) *	2002-11-11	2008-01-22	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) *	2002-11-11	2008-07-15	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7323565B2 (en) *	2002-11-11	2008-01-29	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone and hydromorphone
US6946556B1 (en)	2004-05-21	2005-09-20	Acura Pharmaceuticals, Inc.	Preparation of opioid analgesics by a one-pot process
US7348430B2 (en) *	2005-01-21	2008-03-25	Acura Pharmaceuticals, Inc.	Production of opioid analgesics
WO2010118271A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of saturated ketone morphinan compounds by catalytic isomerization
US9040705B2 (en) *	2009-04-09	2015-05-26	Mallinckrodt Llc	Preparation of saturated ketone morphinan compounds
US20100261906A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of 6-Keto, 3-Alkoxy Morphinans

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8910958D0 (en) *	1989-05-12	1989-06-28	Bruce Neil C	Assay

1992
- 1992-06-25 GB GB929213524A patent/GB9213524D0/en active Pending
1993
- 1993-05-28 SK SK1591-94A patent/SK282363B6/sk not_active IP Right Cessation
- 1993-05-28 HU HU9403723A patent/HU213750B/hu not_active IP Right Cessation
- 1993-05-28 AT AT93913236T patent/ATE221120T1/de not_active IP Right Cessation
- 1993-05-28 DE DE69332146T patent/DE69332146T2/de not_active Expired - Fee Related
- 1993-05-28 EP EP93913236A patent/EP0649465B1/de not_active Expired - Lifetime
- 1993-05-28 DK DK93913236T patent/DK0649465T3/da active
- 1993-05-28 US US08/343,606 patent/US5571685A/en not_active Expired - Lifetime
- 1993-05-28 WO PCT/GB1993/001129 patent/WO1994000565A1/en not_active Ceased
- 1993-05-28 PT PT93913236T patent/PT649465E/pt unknown
- 1993-05-28 ES ES93913236T patent/ES2179053T3/es not_active Expired - Lifetime
- 1993-05-28 AU AU43370/93A patent/AU660103B2/en not_active Ceased
- 1993-05-28 JP JP50212994A patent/JP3638022B2/ja not_active Expired - Fee Related
- 1993-05-28 CA CA002137548A patent/CA2137548C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT649465E (pt)	2002-12-31
SK159194A3 (en)	1995-07-11
AU4337093A (en)	1994-01-24
JP3638022B2 (ja)	2005-04-13
CA2137548A1 (en)	1994-01-06
HU9403723D0 (en)	1995-02-28
ATE221120T1 (de)	2002-08-15
DK0649465T3 (da)	2002-11-11
WO1994000565A1 (en)	1994-01-06
AU660103B2 (en)	1995-06-08
ES2179053T3 (es)	2003-01-16
DE69332146T2 (de)	2002-11-07
JPH07508167A (ja)	1995-09-14
EP0649465A1 (de)	1995-04-26
EP0649465B1 (de)	2002-07-24
HUT69982A (en)	1995-09-28
DE69332146D1 (de)	2002-08-29
US5571685A (en)	1996-11-05
GB9213524D0 (en)	1992-08-12
CA2137548C (en)	2005-10-25
HU213750B (en)	1997-09-29

Legal Events

Date	Code	Title	Description
2010-02-08	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20090528

Publication	Publication Date	Title
US5387515A (en)	1995-02-07	Process for providing a 6-ketone from morphine or an ether derivative thereof using morphine dehydrogenase
Matsuoka et al.	1989	Purification and characterization of cytochrome P‐450sca from Streptomyces carbophilus: ML‐236B (compactin) induces a cytochrome P‐450sca in Streptomyces carbophilus that hydroxylates ML‐236B to pravastatin sodium (CS‐514), a tissue‐selective inhibitor of 3‐hydroxy‐3‐methylglutaryl‐coenzyme‐A reductase
Lenz et al.	1995	Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants
Houck et al.	1991	Biosynthesis of pyrroloquinoline quinone. 2. Biosynthetic assembly from glutamate and tyrosine
JPH07500005A (ja)	1995-01-05	コカイン検出用微生物エステラーゼ
Urakami et al.	1992	Production of pyrroloquinoline quinone by using methanol-utilizing bacteria
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Lin et al.	2019	Identification of a novel lactose oxidase in Myrmecridium flexuosum NUK‐21
Wilson et al.	1966	Optical rotatory dispersion of l-aspartate β-decarboxylase and its derivatives
Maloney et al.	2004	Mitochondrial malate dehydrogenase from the thermophilic, filamentous fungus Talaromyces emersonii: Purification of the native enzyme, cloning and overexpression of the corresponding gene
CN101165172A (zh)	2008-04-23	一种重组甲基营养杆菌及其应用
Iino et al.	2003	The effect of sodium acetate on the activity of L-and D-lactate dehydrogenases in Lactobacillus sakei NRIC 1071T and other lactic acid bacteria
JP2006271257A (ja)	2006-10-12	熱安定性に優れたポリオール脱水素酵素およびその製造方法
Elalami et al.	1999	Characterization of a secreted cholesterol oxidase from Rhodococcus sp. GKI (CIP 105335)
JPH09224660A (ja)	1997-09-02	アルデヒド脱水素酵素
JP3468626B2 (ja)	2003-11-17	β−グルコシダーゼおよびその製造方法
Sereikaité et al.	1993	Ascorbate oxidase: Specificity and analytical application
JP2647689B2 (ja)	1997-08-27	新規アセチルポリアミンアミドヒドロラーゼ
Yamada et al.	2001	Microbial oxidases of acidic d-amino acids
Azari	1984	A study of cytochrome P-448, a component of the monooxygenase system from Saccharomyces cerevisiae: Purification and characterization
Shinagawa et al.	2002	Purification and characterization of membrane-bound malate dehydrogenase from Acetobacter sp. SKU 14