DK0655458T3 - Ny fremgangsmåde til fremstilling af finasterid - Google Patents

Ny fremgangsmåde til fremstilling af finasterid

Info

Publication number: DK0655458T3
Authority: DK; Denmark
Prior art keywords: finasteride; magnesium halide; new process; disclosed; preparation
Prior art date: 1992-11-19

Application number

DK95200270T

Other languages

Danish (da)

English (en)

Inventor

Ulf H Dolling

James A Mccauley

Richard J Varsolona

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-19

Filing date

1993-11-12

Publication date

1999-09-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26681536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0655458(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-11-12 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1999-09-27 Application granted granted Critical

1999-09-27 Publication of DK0655458T3 publication Critical patent/DK0655458T3/da

Links

DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 title abstract 4
229960004039 finasteride Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
-1 magnesium halide salt Chemical class 0.000 abstract 2
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000004792 aryl magnesium halides Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N5/00—Details of television systems
- H04N5/74—Projection arrangements for image reproduction, e.g. using eidophor
- H04N5/7416—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal
- H04N5/7458—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal the modulator being an array of deformable mirrors, e.g. digital micromirror device [DMD]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Multimedia (AREA)
Signal Processing (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Dental Preparations (AREA)
Seasonings (AREA)
Confectionery (AREA)

DK95200270T 1992-11-19 1993-11-12 Ny fremgangsmåde til fremstilling af finasterid DK0655458T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97853592A	1992-11-19	1992-11-19
US08/010,734 US5468860A (en)	1992-11-19	1993-01-29	New finasteride processes

Publications (1)

Publication Number	Publication Date
DK0655458T3 true DK0655458T3 (da)	1999-09-27

Family

ID=26681536

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK93203163T DK0599376T4 (da)	1992-11-19	1993-11-12	Fremgangsmåde til fremstilling af finasterid
DK95200270T DK0655458T3 (da)	1992-11-19	1993-11-12	Ny fremgangsmåde til fremstilling af finasterid

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK93203163T DK0599376T4 (da)	1992-11-19	1993-11-12	Fremgangsmåde til fremstilling af finasterid

Country Status (32)

Country	Link
US (3)	US5468860A (fr)
EP (3)	EP0823436A3 (fr)
JP (2)	JPH07110875B2 (fr)
CN (1)	CN1058018C (fr)
AT (2)	ATE164850T1 (fr)
AU (1)	AU658774B2 (fr)
BG (2)	BG62362B1 (fr)
CA (1)	CA2103107C (fr)
CY (1)	CY2135B1 (fr)
CZ (3)	CZ301160B6 (fr)
DE (4)	DE599376T1 (fr)
DK (2)	DK0599376T4 (fr)
DZ (1)	DZ1733A1 (fr)
ES (2)	ES2052476T5 (fr)
FI (4)	FI107450B (fr)
GR (4)	GR940300045T1 (fr)
HR (2)	HRP931410B1 (fr)
HU (2)	HU216195B (fr)
IL (1)	IL107574A (fr)
IS (2)	IS1692B (fr)
LV (2)	LV12212B (fr)
MX (1)	MX9307222A (fr)
MY (2)	MY110410A (fr)
NO (3)	NO305912B1 (fr)
PH (1)	PH31120A (fr)
RO (2)	RO115165B1 (fr)
RU (1)	RU2120445C1 (fr)
SI (1)	SI9300603B (fr)
SK (2)	SK286488B6 (fr)
TW (1)	TW257766B (fr)
UA (1)	UA41341C2 (fr)
WO (1)	WO1994011387A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones
IT1270660B (it) *	1994-10-13	1997-05-07	Poli Ind Chimica Spa	Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
US5670643A (en) *	1995-03-16	1997-09-23	Glaxo Wellcome Inc.	Method for preparing finasteride
US5585383A (en) *	1995-05-03	1996-12-17	Merck & Co., Inc.	Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
EP0859761A4 (fr) *	1995-09-15	2000-01-26	Merck & Co Inc	4-azasteroides utilises pour le traitement d'etats hyperandrogeniques
GB2338234B (en) *	1998-06-10	2000-05-03	Torcan Chemical Ltd	Preparation of finasteride
ES2153789B1 (es) *	1999-07-05	2001-10-16	Raga Consultores S L	Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
EP1228084A1 (fr) *	1999-11-01	2002-08-07	TORCAN CHEMICAL Ltd	Production de formes polymorphes i et ii de finasteride par complexation avec des sels de metaux de groupe i ou ii
KR20030029947A (ko) *	2000-09-07	2003-04-16	닥터 레디스 레보러터리즈 리미티드	17-β-(엔-티-부틸카르바모일)-4-아자-5-α-안드로스트-1-엔-3-온의 신규의다형태 및 그 제조방법
JP2004508380A (ja) *	2000-09-07	2004-03-18	ドクター・レディーズ・ラボラトリーズ・リミテッド	１７−β−（Ｎ−ｔｅｒ−ブチルカルバモイル）−４−アザ−５−α−アンドロスト−１−エン−３−オンの新規の多形体及びその調製方法
SK2732003A3 (en) *	2000-09-07	2004-01-08	Reddys Lab Ltd Dr	Novel polymorphic form of 17-beta-(N-ter.butyl carbamoyl)-4-aza- 5-alpha-androst-1-en-3-one and a process for preparing it
KR100415858B1 (ko) *	2001-09-22	2004-01-24	한미약품 주식회사	17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법
CN100428897C (zh) *	2002-08-16	2008-10-29	浙江寿峰堂生物工程有限公司	抗疲劳改善亚健康的保健食品及其制备方法
ES2206065B1 (es) *	2002-10-31	2005-08-16	Ragactives, S.L.	Procedimiento para la obtencion de la forma polimorfica i de finasterida.
WO2004083230A1 (fr) *	2003-03-19	2004-09-30	Hetero Drugs Limited	Nouvelles formes cristallines de finasteride
US7550593B2 (en) *	2003-07-03	2009-06-23	Cipla Limited	Process for the preparation of finasteride Form I
US20050136015A1 (en) *	2003-12-17	2005-06-23	McKie Derrick B.	Topical use of halosalicylic acid derivatives
US20070167477A1 (en) *	2006-01-13	2007-07-19	Mandava Venkata Naga Brahmeswa	Processes to prepare finasteride polymorphs
US7531658B2 (en) *	2006-01-20	2009-05-12	Apotex Pharmachem Inc.	Process for the preparation of 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones
US7687650B2 (en)	2006-02-03	2010-03-30	Jr Chem, Llc	Chemical compositions and methods of making them
WO2007089267A1 (fr)	2006-02-03	2007-08-09	Jr Chem, Llc	Traitement anti-vieillissement utilisant des préparations de cuivre et de zinc
US7897800B2 (en)	2006-02-03	2011-03-01	Jr Chem, Llc	Chemical compositions and methods of making them
US7867522B2 (en)	2006-09-28	2011-01-11	Jr Chem, Llc	Method of wound/burn healing using copper-zinc compositions
US20090076058A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched finasteride
US8273791B2 (en)	2008-01-04	2012-09-25	Jr Chem, Llc	Compositions, kits and regimens for the treatment of skin, especially décolletage
US9004752B2 (en) *	2008-05-05	2015-04-14	Abbvie, Inc.	Method for evaluating the solubility of a crystalline substance in a polymer
CA2750636C (fr)	2009-01-23	2017-07-25	Jr Chem, Llc	Traitements pour l'acne rosacee et trousses medicales pour les mettre en pratique
US8952057B2 (en)	2011-01-11	2015-02-10	Jr Chem, Llc	Compositions for anorectal use and methods for treating anorectal disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL74365A (en) *	1984-02-27	1990-07-26	Merck & Co Inc	17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
US4760071A (en) *	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
DE3888378T2 (de) *	1987-04-03	1994-09-29	Merck & Co Inc	Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
NZ225100A (en)	1987-06-29	1991-09-25	Merck & Co Inc	Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) *	1988-04-18	1992-01-28	Merck & Co., Inc.	Dehydrogenation process
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids
DE69112917T2 (de) *	1990-06-15	1996-05-15	Merck & Co Inc	Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
EP0462662A3 (en) *	1990-06-20	1992-08-19	Merck & Co. Inc.	17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5091534A (en)	1990-08-27	1992-02-25	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5120847A (en) †	1990-08-27	1992-06-09	Merck & Co., Inc.	Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5061801A (en) *	1990-09-24	1991-10-29	Merck & Co., Inc.	Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
CA2050824A1 (fr) *	1990-09-24	1992-03-25	John M. Williams	Methode de preparation de 3-oxo-4-azaandrost-1-en-17.beta.-ones
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes

1993
- 1993-01-29 US US08/010,734 patent/US5468860A/en not_active Expired - Fee Related
- 1993-11-05 RU RU95112521A patent/RU2120445C1/ru active
- 1993-11-05 IS IS4286A patent/IS1692B/is unknown
- 1993-11-05 UA UA95058438A patent/UA41341C2/uk unknown
- 1993-11-05 WO PCT/US1993/010659 patent/WO1994011387A2/fr not_active Ceased
- 1993-11-05 RO RO99-00785A patent/RO115165B1/ro unknown
- 1993-11-05 SK SK1897-2000A patent/SK286488B6/sk not_active IP Right Cessation
- 1993-11-05 US US08/411,685 patent/US5652365A/en not_active Expired - Lifetime
- 1993-11-05 SK SK659-95A patent/SK281765B6/sk unknown
- 1993-11-05 CZ CZ20003685A patent/CZ301160B6/cs not_active IP Right Cessation
- 1993-11-05 CZ CZ19951268A patent/CZ287842B6/cs not_active IP Right Cessation
- 1993-11-05 RO RO95-00940A patent/RO115164B1/ro unknown
- 1993-11-05 CZ CZ20003686A patent/CZ301191B6/cs not_active IP Right Cessation
- 1993-11-11 TW TW082109464A patent/TW257766B/zh not_active IP Right Cessation
- 1993-11-11 MY MYPI93002365A patent/MY110410A/en unknown
- 1993-11-11 MY MYPI96001019A patent/MY110411A/en unknown
- 1993-11-11 IL IL10757493A patent/IL107574A/xx not_active IP Right Cessation
- 1993-11-12 DK DK93203163T patent/DK0599376T4/da active
- 1993-11-12 AT AT93203163T patent/ATE164850T1/de active
- 1993-11-12 DE DE0599376T patent/DE599376T1/de active Pending
- 1993-11-12 ES ES93203163T patent/ES2052476T5/es not_active Expired - Lifetime
- 1993-11-12 DE DE69323754T patent/DE69323754T2/de not_active Expired - Fee Related
- 1993-11-12 DK DK95200270T patent/DK0655458T3/da active
- 1993-11-12 DE DE69317856T patent/DE69317856T2/de not_active Expired - Lifetime
- 1993-11-12 EP EP97201712A patent/EP0823436A3/fr not_active Withdrawn
- 1993-11-12 ES ES95200270T patent/ES2072848T3/es not_active Expired - Lifetime
- 1993-11-12 DE DE0655458T patent/DE655458T1/de active Pending
- 1993-11-12 EP EP95200270A patent/EP0655458B1/fr not_active Expired - Lifetime
- 1993-11-12 AT AT95200270T patent/ATE177112T1/de not_active IP Right Cessation
- 1993-11-12 EP EP93203163A patent/EP0599376B2/fr not_active Expired - Lifetime
- 1993-11-15 CA CA2103107A patent/CA2103107C/fr not_active Expired - Lifetime
- 1993-11-16 IS IS4094A patent/IS1671B/is unknown
- 1993-11-17 DZ DZ930120A patent/DZ1733A1/fr active
- 1993-11-18 MX MX9307222A patent/MX9307222A/es not_active IP Right Cessation
- 1993-11-18 HR HR931410A patent/HRP931410B1/xx not_active IP Right Cessation
- 1993-11-18 AU AU50787/93A patent/AU658774B2/en not_active Expired
- 1993-11-18 JP JP5289536A patent/JPH07110875B2/ja not_active Expired - Fee Related
- 1993-11-18 HU HU9303275A patent/HU216195B/hu unknown
- 1993-11-19 CN CN93114530A patent/CN1058018C/zh not_active Expired - Lifetime
- 1993-11-19 SI SI9300603A patent/SI9300603B/sl unknown
- 1993-11-19 PH PH47298A patent/PH31120A/en unknown
1994
- 1994-07-29 GR GR940300045T patent/GR940300045T1/el unknown
- 1994-11-07 HU HU94P/P00041P patent/HU210535A9/hu unknown
1995
- 1995-05-16 BG BG99637A patent/BG62362B1/bg unknown
- 1995-05-18 FI FI952422A patent/FI107450B/fi not_active IP Right Cessation
- 1995-05-19 NO NO951986A patent/NO305912B1/no not_active IP Right Cessation
- 1995-07-31 GR GR950300043T patent/GR950300043T1/el unknown
1996
- 1996-09-30 JP JP8259373A patent/JP2742409B2/ja not_active Expired - Lifetime
1997
- 1997-03-26 US US08/824,426 patent/US5886184A/en not_active Expired - Lifetime
1998
- 1998-04-09 GR GR980400749T patent/GR3026577T3/el unknown
- 1998-10-26 LV LVP-98-236A patent/LV12212B/en unknown
1999
- 1999-02-01 NO NO19990468A patent/NO307888B3/no not_active IP Right Cessation
- 1999-02-11 BG BG103170A patent/BG64464B1/bg unknown
- 1999-03-04 GR GR990400546T patent/GR3029554T3/el unknown
- 1999-05-28 NO NO992580A patent/NO307609B1/no not_active IP Right Cessation
- 1999-09-07 CY CY9900028A patent/CY2135B1/xx unknown
2000
- 2000-02-23 LV LVP-00-26A patent/LV12460B/en unknown
- 2000-05-12 HR HR20000295A patent/HRP20000295B1/xx not_active IP Right Cessation
2001
- 2001-02-15 FI FI20010290A patent/FI114215B/fi not_active IP Right Cessation
- 2001-02-15 FI FI20010289A patent/FI114800B/fi not_active IP Right Cessation
2004
- 2004-04-21 FI FI20040559A patent/FI116941B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI114215B (fi)	2004-09-15
HRP20000295B1 (en)	2002-08-31
HRP931410A2 (en)	1996-06-30
ES2052476T3 (es)	1998-06-16
NO951986D0 (no)	1995-05-19
DE69317856T2 (de)	1998-11-05
BG64464B1 (bg)	2005-03-31
HU210535A9 (en)	1995-04-28
EP0599376A3 (en)	1994-09-28
JP2742409B2 (ja)	1998-04-22
RO115165B1 (ro)	1999-11-30
EP0655458B1 (fr)	1999-03-03
CN1090583A (zh)	1994-08-10
FI20040559A7 (fi)	2004-04-21
IS1671B (is)	1997-12-19
CZ301160B6 (cs)	2009-11-18
FI20010289L (fi)	2001-02-15
IS4094A (is)	1994-05-20
MY110411A (en)	1998-05-30
ES2052476T1 (es)	1994-07-16
BG99637A (bg)	1996-04-30
HRP20000295A2 (en)	2000-08-31
HRP931410B1 (en)	2000-06-30
DE599376T1 (de)	1994-12-08
ES2072848T1 (es)	1995-08-01
JPH09235294A (ja)	1997-09-09
UA41341C2 (uk)	2001-09-17
CA2103107A1 (fr)	1994-05-20
DE69323754T2 (de)	1999-10-07
US5468860A (en)	1995-11-21
SI9300603B (sl)	2004-06-30
EP0655458A3 (fr)	1996-07-10
HUT66973A (en)	1995-01-30
DE655458T1 (de)	1995-11-30
SK286488B6 (sk)	2008-11-06
LV12212A (lv)	1999-01-20
US5652365A (en)	1997-07-29
DE69323754D1 (de)	1999-04-08
DE69317856D1 (de)	1998-05-14
HK1008338A1 (en)	1999-05-07
NO305912B1 (no)	1999-08-16
CZ301191B6 (cs)	2009-12-02
MX9307222A (es)	1994-07-29
NO307888B1 (no)	2000-06-13
FI952422L (fi)	1995-05-18
PH31120A (en)	1998-02-23
BG103170A (en)	1999-09-30
RU95112521A (ru)	1997-02-10
ES2072848T3 (es)	1999-05-01
FI107450B (fi)	2001-08-15
WO1994011387A2 (fr)	1994-05-26
LV12212B (en)	1999-03-20
MY110410A (en)	1998-05-30
CZ287842B6 (en)	2001-02-14
CN1058018C (zh)	2000-11-01
AU5078793A (en)	1994-06-16
EP0655458A2 (fr)	1995-05-31
NO992580L (no)	1995-05-19
LV12460A (lv)	2000-04-20
NO990468D0 (no)	1999-02-01
HU9303275D0 (en)	1994-03-28
EP0823436A3 (fr)	1998-11-25
GR3029554T3 (en)	1999-06-30
JPH06199889A (ja)	1994-07-19
AU658774B2 (en)	1995-04-27
CA2103107C (fr)	2010-09-28
WO1994011387A3 (fr)	1994-09-29
GR940300045T1 (en)	1994-07-29
IS1692B (is)	1998-04-20
FI20010290L (fi)	2001-02-15
EP0599376B2 (fr)	2008-04-16
FI114800B (fi)	2004-12-31
FI116941B (fi)	2006-04-13
EP0823436A2 (fr)	1998-02-11
SK65995A3 (en)	1995-10-11
BG62362B1 (bg)	1999-09-30
NO307888B3 (no)	2000-06-13
ES2052476T5 (es)	2008-11-01
IL107574A0 (en)	1994-02-27
IL107574A (en)	2000-07-16
EP0599376A2 (fr)	1994-06-01
JPH07110875B2 (ja)	1995-11-29
EP0599376B1 (fr)	1998-04-08
SI9300603A (en)	1994-06-30
TW257766B (fr)	1995-09-21
IS4286A (is)	1994-05-20
RO115164B1 (ro)	1999-11-30
CZ126895A3 (en)	1995-12-13
RU2120445C1 (ru)	1998-10-20
NO307609B1 (no)	2000-05-02
FI952422A0 (fi)	1995-05-18
US5886184A (en)	1999-03-23
SK281765B6 (sk)	2001-07-10
LV12460B (en)	2000-09-20
GR3026577T3 (en)	1998-07-31
HU216195B (hu)	1999-05-28
DK0599376T4 (da)	2008-07-28
ATE164850T1 (de)	1998-04-15
ATE177112T1 (de)	1999-03-15
NO992580D0 (no)	1999-05-28
NO951986L (no)	1995-05-19
GR950300043T1 (en)	1995-07-31
DZ1733A1 (fr)	2002-02-17
NO990468L (no)	1995-05-19
CY2135B1 (en)	2002-05-21

Publication	Publication Date	Title
DK0655458T3 (da)	1999-09-27	Ny fremgangsmåde til fremstilling af finasterid
RU95103420A (ru)	1997-05-10	Способ получения безводной фосфористой кислоты
JPS55104906A (en)	1980-08-11	Production of carbonyl selenide