DK0664116T3 - Fremgangsmåde til fremstilling af liposomer eller proliposomer - Google Patents

Fremgangsmåde til fremstilling af liposomer eller proliposomer

Info

Publication number: DK0664116T3
Authority: DK; Denmark
Prior art keywords: homogenisation; liposomes; prodn; vitamins; agitator
Prior art date: 1994-01-20

Application number

DK95100156T

Other languages

English (en)

Inventor

Sabina Ganter

Karl Manfred Voelker

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-20

Filing date

1995-01-07

Publication date

1999-06-07

1995-01-07 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-06-07 Application granted granted Critical

1999-06-07 Publication of DK0664116T3 publication Critical patent/DK0664116T3/da

Links

239000002502 liposome Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
239000000796 flavoring agent Substances 0.000 abstract 3
238000000265 homogenisation Methods 0.000 abstract 3
235000019634 flavors Nutrition 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 2
-1 vitamins A Natural products 0.000 abstract 2
LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 abstract 1
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
235000019499 Citrus oil Nutrition 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
244000061176 Nicotiana tabacum Species 0.000 abstract 1
235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
244000299461 Theobroma cacao Species 0.000 abstract 1
235000009470 Theobroma cacao Nutrition 0.000 abstract 1
244000290333 Vanilla fragrans Species 0.000 abstract 1
235000009499 Vanilla fragrans Nutrition 0.000 abstract 1
235000012036 Vanilla tahitensis Nutrition 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
229960003942 amphotericin b Drugs 0.000 abstract 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
229960004316 cisplatin Drugs 0.000 abstract 1
239000010500 citrus oil Substances 0.000 abstract 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
229960003529 diazepam Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229960003913 econazole Drugs 0.000 abstract 1
239000003205 fragrance Substances 0.000 abstract 1
239000011521 glass Substances 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
239000001525 mentha piperita l. herb oil Substances 0.000 abstract 1
238000003801 milling Methods 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
235000019477 peppermint oil Nutrition 0.000 abstract 1
238000005549 size reduction Methods 0.000 abstract 1
239000011782 vitamin Substances 0.000 abstract 1
235000013343 vitamin Nutrition 0.000 abstract 1
229940088594 vitamin Drugs 0.000 abstract 1
229930003231 vitamin Natural products 0.000 abstract 1
235000019155 vitamin A Nutrition 0.000 abstract 1
239000011719 vitamin A Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
Crushing And Grinding (AREA)

DK95100156T 1994-01-20 1995-01-07 Fremgangsmåde til fremstilling af liposomer eller proliposomer DK0664116T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH17494		1994-01-20

Publications (1)

Publication Number	Publication Date
DK0664116T3 true DK0664116T3 (da)	1999-06-07

Family

ID=4180953

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95100156T DK0664116T3 (da)	1994-01-20	1995-01-07	Fremgangsmåde til fremstilling af liposomer eller proliposomer

Country Status (8)

Country	Link
US (1)	US5635206A (da)
EP (1)	EP0664116B1 (da)
JP (1)	JP3681776B2 (da)
CN (1)	CN1092044C (da)
AT (1)	ATE170398T1 (da)
DE (1)	DE59503394D1 (da)
DK (1)	DK0664116T3 (da)
ES (1)	ES2122348T3 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR002009A1 (es) *	1994-12-22	1998-01-07	Astra Ab	Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
US5927852A (en) *	1997-12-01	1999-07-27	Minnesota Mining And Manfacturing Company	Process for production of heat sensitive dispersions or emulsions
GB9902527D0 (en) *	1999-02-04	1999-03-24	Phares Pharm Res Nv	Compositions
EP1138310A1 (de) *	2000-03-28	2001-10-04	Primacare S.A.	Pro-liposomen
EP1138313A1 (de) *	2000-03-28	2001-10-04	Primacare S.A.	Pro-liposomen
EP1138311A1 (de) *	2000-03-28	2001-10-04	Primacare S.A.	Pro-liposomen
US6761901B1 (en) *	2000-05-02	2004-07-13	Enzrel Inc.	Liposome drug delivery
US6689760B1 (en)	2000-07-10	2004-02-10	Enzrel Inc.	Anti-mycobacterial compositions
US6455073B1 (en)	2000-07-10	2002-09-24	Enzrel, Inc.	Covalent microparticle-drug conjugates for biological targeting
JP4969761B2 (ja) *	2000-08-31	2012-07-04	オバン・エナジー・リミテッド	所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法
US6759058B1 (en) *	2001-04-25	2004-07-06	Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences	Enteric-coated proliposomal formulations for poorly water soluble drugs
US8658202B2 (en) *	2001-04-25	2014-02-25	Western University Of Health Sciences	Coated drug delivery formulations
JP3990880B2 (ja) *	2001-07-10	2007-10-17	キヤノン株式会社	ポリヒドロキシアルカノエート被覆リポソームの製造方法
JP2005523249A (ja) *	2002-01-09	2005-08-04	エンズレルインコーポレイテッド	多環式芳香族抗酸化剤または抗炎症化合物のリポソーム薬物配達
DE10331439B3 (de)	2003-07-10	2005-02-03	Micromod Partikeltechnologie Gmbh	Magnetische Nanopartikel mit verbesserten Magneteigenschaften
US20050169978A1 (en) *	2004-01-29	2005-08-04	Shu-Wen Fu	Wet-micro grinding
EP2402075A1 (de)	2010-06-28	2012-01-04	Bühler AG	Verfahren und Vorrichtung zur Herstellung von Vesikeln
EP2846773A4 (en)	2012-05-10	2015-12-30	Painreform Ltd	DEPOT FORMULATIONS OF A LOCAL ANESTHETICS AND METHOD FOR THE MANUFACTURE THEREOF
CN120616104A (zh) *	2014-10-20	2025-09-12	国际香料和香精公司	香料纳米乳液和制备其的方法
CN106389334A (zh) *	2016-11-09	2017-02-15	刘彦博	一种脂质体及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141674A (en) *	1984-03-08	1992-08-25	Phares Pharmaceutical Research N.V.	Methods of preparing pro-liposome dispersions and aerosols
GB8613811D0 (en) *	1986-06-06	1986-07-09	Phares Pharm Res Nv	Composition & method
SE8403905D0 (sv) *	1984-07-30	1984-07-30	Draco Ab	Liposomes and steroid esters
DE3838981A1 (de) *	1988-11-18	1990-05-23	Eirich Walter	Ruehrwerkskugelmuehle
US5145684A (en) *	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
US5310734A (en) *	1991-07-05	1994-05-10	Rhone-Poulenc Rorer	Phospholipid composition
EP0521398B1 (de) *	1991-07-05	1998-10-28	Rhone-Poulenc Rorer	Phospholipidische Zusammensetzung
WO1994028876A1 (en) *	1993-06-07	1994-12-22	Advanced Therapies, Inc.	Liposome powders

1994
- 1994-12-06 US US08/350,306 patent/US5635206A/en not_active Expired - Lifetime
1995
- 1995-01-07 AT AT95100156T patent/ATE170398T1/de not_active IP Right Cessation
- 1995-01-07 ES ES95100156T patent/ES2122348T3/es not_active Expired - Lifetime
- 1995-01-07 DK DK95100156T patent/DK0664116T3/da active
- 1995-01-07 DE DE59503394T patent/DE59503394D1/de not_active Expired - Lifetime
- 1995-01-07 EP EP95100156A patent/EP0664116B1/de not_active Expired - Lifetime
- 1995-01-18 JP JP00536295A patent/JP3681776B2/ja not_active Expired - Lifetime
- 1995-01-18 CN CN95101331A patent/CN1092044C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH07241487A (ja)	1995-09-19
DE59503394D1 (de)	1998-10-08
ATE170398T1 (de)	1998-09-15
ES2122348T3 (es)	1998-12-16
EP0664116B1 (de)	1998-09-02
CN1092044C (zh)	2002-10-09
JP3681776B2 (ja)	2005-08-10
US5635206A (en)	1997-06-03
CN1112830A (zh)	1995-12-06
EP0664116A1 (de)	1995-07-26

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