DK0669342T3 - Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner - Google Patents

Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner

Info

Publication number
DK0669342T3
DK0669342T3 DK95102504T DK95102504T DK0669342T3 DK 0669342 T3 DK0669342 T3 DK 0669342T3 DK 95102504 T DK95102504 T DK 95102504T DK 95102504 T DK95102504 T DK 95102504T DK 0669342 T3 DK0669342 T3 DK 0669342T3
Authority
DK
Denmark
Prior art keywords
isolating
vitamin
dependent proteins
proteins
dependent
Prior art date
Application number
DK95102504T
Other languages
Danish (da)
English (en)
Inventor
Friedrich Prof Dorner
Artur Dr Mitterer
Bernhard Dr Fischer
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Application granted granted Critical
Publication of DK0669342T3 publication Critical patent/DK0669342T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95102504T 1994-02-28 1995-02-22 Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner DK0669342T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4406515A DE4406515C1 (de) 1994-02-28 1994-02-28 Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine

Publications (1)

Publication Number Publication Date
DK0669342T3 true DK0669342T3 (da) 2001-11-12

Family

ID=6511421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95102504T DK0669342T3 (da) 1994-02-28 1995-02-22 Fremgangsmåde til isolering og rensning af vitamin K-afhængige proteiner

Country Status (13)

Country Link
US (1) US5633350A (fr)
EP (1) EP0669342B1 (fr)
JP (1) JPH07258286A (fr)
AT (1) ATE205218T1 (fr)
CA (1) CA2143510C (fr)
CZ (1) CZ290471B6 (fr)
DE (1) DE4406515C1 (fr)
DK (1) DK0669342T3 (fr)
ES (1) ES2161790T3 (fr)
FI (1) FI116526B (fr)
HU (1) HU219828B (fr)
NO (1) NO322372B1 (fr)
SK (1) SK22695A3 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3137699A (en) * 1998-04-15 1999-11-01 Novo Nordisk A/S Novel process for the separation of proteins using a Ca ++ containing eluant
CN1250567C (zh) * 2000-07-21 2006-04-12 财团法人化学及血清疗法研究所 钙离子结合蛋白的提纯方法
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
ES2395544T3 (es) * 2004-12-23 2013-02-13 Novo Nordisk Health Care Ag Reducción del contenido de contaminantes proteínicos en composiciones que comprenden una proteína dependiente de la vitamina K de interés
ES2349112T3 (es) * 2005-01-14 2010-12-28 Bayer Healthcare Llc Método de purificación de factor vii.
WO2006114448A2 (fr) * 2005-04-28 2006-11-02 Novo Nordisk Health Care Ag Contenant ferme renfermant un polypeptide de facteur vii active, processus de preparation dudit contenant, kit associe, et procede d'utilisation dudit kit
US7375084B2 (en) 2006-03-07 2008-05-20 Baxter International Inc. Highly phosphorylated and sulfated recombinant factor IX
WO2008104372A1 (fr) * 2007-02-28 2008-09-04 Baxter International Inc. Méthode de purification du facteur ix de coagulation du sang de recombinaison enrichi en molécules sulfatées et/ou phosphorylées
EP2526115B1 (fr) * 2010-01-18 2018-08-01 Novo Nordisk Health Care AG Purification des facteurs de coagulation sanguine
MX336728B (es) 2010-04-29 2016-01-27 Baxter Int Metodo de purificacion para proteinas de union de cation divalente en resina de intercambio anionico.
AU2012213432B2 (en) 2011-02-01 2016-10-13 Novo Nordisk A/S Purification of insulin
AU2012322948B2 (en) * 2011-10-14 2014-11-06 Takeda Pharmaceutical Company Limited Protein purification by anion exchange chromatography
JP6117219B2 (ja) * 2011-10-14 2017-04-19 バクスアルタ ゲーエムベーハー 陰イオン交換クロマトグラフィによるタンパク質の精製方法
WO2014140289A1 (fr) * 2013-03-15 2014-09-18 Baxter International Inc. Procédé de purification pour protéines dépendantes de la vitamine k par chromatographie d'échange d'anions
JP7606185B2 (ja) * 2020-09-03 2024-12-25 日機装株式会社 フェノールレッド吸着剤およびフェノールレッドの除去方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101752A1 (de) * 1981-01-21 1982-08-26 Behringwerke Ag, 3550 Marburg "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
DE3877529T2 (de) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
AT395596B (de) * 1991-06-20 1993-01-25 Immuno Ag Verfahren zur herstellung von aktiviertem protein c

Also Published As

Publication number Publication date
HU9500594D0 (en) 1995-04-28
HUT72844A (en) 1996-05-28
US5633350A (en) 1997-05-27
SK22695A3 (en) 1995-09-13
FI116526B (fi) 2005-12-15
FI950888A0 (fi) 1995-02-27
ES2161790T3 (es) 2001-12-16
ATE205218T1 (de) 2001-09-15
EP0669342A3 (fr) 1997-04-16
DE4406515C1 (de) 1995-10-19
FI950888L (fi) 1995-08-29
NO322372B1 (no) 2006-09-25
EP0669342A2 (fr) 1995-08-30
CZ53995A3 (en) 1995-09-13
HU219828B (hu) 2001-08-28
CA2143510A1 (fr) 1995-08-29
CZ290471B6 (cs) 2002-07-17
NO950733L (no) 1995-08-29
EP0669342B1 (fr) 2001-09-05
CA2143510C (fr) 1999-12-21
NO950733D0 (no) 1995-02-27
JPH07258286A (ja) 1995-10-09

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