DK0669936T3 - Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer - Google Patents

Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer

Info

Publication number: DK0669936T3
Authority: DK; Denmark
Prior art keywords: mercaptoacetylamide; pct; enkephalinase; bicyclic lactam; hydrogen
Prior art date: 1992-10-30

Application number

DK94914243T

Other languages

Danish (da)

English (en)

Inventor

Gary A Flynn

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-30

Filing date

1993-09-23

Publication date

2001-02-05

1993-09-23 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2001-02-05 Application granted granted Critical

2001-02-05 Publication of DK0669936T3 publication Critical patent/DK0669936T3/da

Links

-1 bicyclic lactam Chemical class 0.000 title abstract 3
102000003729 Neprilysin Human genes 0.000 title abstract 2
108090000028 Neprilysin Proteins 0.000 title abstract 2
239000005541 ACE inhibitor Substances 0.000 title 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title 1
239000002792 enkephalinase inhibitor Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
125000005869 (methoxyethoxy)methanyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])* 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK94914243T 1992-10-30 1993-09-23 Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer DK0669936T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US96877092A	1992-10-30	1992-10-30
PCT/US1993/009001 WO1994010193A1 (fr)	1992-10-30	1993-09-23	Nouveaux derives de lactame bicyclique de mercaptoacetylamide utiles, comme inhibiteurs de l'encephalinase et de l'eca

Publications (1)

Publication Number	Publication Date
DK0669936T3 true DK0669936T3 (da)	2001-02-05

Family

ID=25514751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94914243T DK0669936T3 (da)	1992-10-30	1993-09-23	Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer

Country Status (21)

Country	Link
US (1)	US5635502A (fr)
EP (1)	EP0669936B1 (fr)
JP (1)	JP3420766B2 (fr)
KR (1)	KR100311166B1 (fr)
AT (1)	ATE197714T1 (fr)
AU (1)	AU673857B2 (fr)
CA (1)	CA2146238C (fr)
DE (1)	DE69329701T2 (fr)
DK (1)	DK0669936T3 (fr)
ES (1)	ES2155852T3 (fr)
FI (1)	FI110263B (fr)
GR (1)	GR3035416T3 (fr)
HU (1)	HUT71243A (fr)
IL (1)	IL107413A (fr)
MX (1)	MX9306758A (fr)
NO (1)	NO951646L (fr)
NZ (1)	NZ256589A (fr)
PT (1)	PT669936E (fr)
TW (1)	TW327172B (fr)
WO (1)	WO1994010193A1 (fr)
ZA (1)	ZA937912B (fr)

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US5508272A (en) *	1993-06-15	1996-04-16	Bristol-Myers Squibb Company	Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
PT750631E (pt) *	1994-02-14	2000-07-31	Merrell Pharma Inc	Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
CA2183313C (fr) *	1994-02-14	2001-01-02	Gary A. Flynn	Nouveaux derives de bisulfure d'indane-2-mercaptoacetylamide utiles en tant qu'inhibiteurs de l'encephalinase
JP3561753B2 (ja) *	1994-02-14	2004-09-02	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
JP3444666B2 (ja)	1994-08-24	2003-09-08	エーザイ株式会社	（２ｓ，３ｓ）−３− メチル−２− チオペンタン酸誘導体の製造方法
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US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US6245764B1 (en)	1995-03-24	2001-06-12	Molecumetics Ltd.	β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
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US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
WO1999065500A1 (fr)	1998-06-17	1999-12-23	Bristol-Myers Squibb Company	Prevention de l'infarctus cerebral par administration d'une combinaison d'un anti-agregant plaquettaire bloquant les recepteurs d'adp et d'un medicament antihypertenseur
JP2002540106A (ja) *	1999-03-22	2002-11-26	ザ・ボード・オブ・ガバナーズ・フォー・ハイヤー・エデュケイション、ステイト・オブ・ロード・アイランド・アンド・プロビデンス・プランテーションズ	オキサゾールおよびチアゾールコンビナトリアル・ライブラリー
US7015212B1 (en)	1999-05-12	2006-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Thiazepine inhibitors of HIV-1 integrase
AU2003219809A1 (en)	2002-02-14	2003-09-04	Myriad Genetics, Inc.	Beta-sheet mimetics and composition and methods relating thereto
FR2984716B1 (fr)	2011-12-22	2013-12-27	Essilor Int	Dispositif et procede de determination d'au moins un parametre de refraction oculaire objective d'un sujet en fonction d'une pluralite de directions de regard
CA2896577C (fr)	2012-11-30	2024-01-23	Sanford-Burnham Medical Research Institute	Antagonistes des proteines inhibitrices de l'apoptose (iaps)
EP3151920B1 (fr)	2014-06-04	2025-08-06	Sanford-Burnham Medical Research Institute	Utilisation d'un inhibiteur des antagonistes de la protéine d'apoptose (iap) dans une thérapie contre le vih
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CA3106239A1 (fr)	2018-07-27	2020-01-30	Biotheryx, Inc.	Composes bifonctionnels agissant par agonisme sur des cdk
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1993
- 1993-09-23 PT PT94914243T patent/PT669936E/pt unknown
- 1993-09-23 KR KR1019950701668A patent/KR100311166B1/ko not_active Expired - Fee Related
- 1993-09-23 AU AU51362/93A patent/AU673857B2/en not_active Expired
- 1993-09-23 CA CA002146238A patent/CA2146238C/fr not_active Expired - Lifetime
- 1993-09-23 AT AT94914243T patent/ATE197714T1/de active
- 1993-09-23 DK DK94914243T patent/DK0669936T3/da active
- 1993-09-23 WO PCT/US1993/009001 patent/WO1994010193A1/fr not_active Ceased
- 1993-09-23 ES ES94914243T patent/ES2155852T3/es not_active Expired - Lifetime
- 1993-09-23 DE DE69329701T patent/DE69329701T2/de not_active Expired - Lifetime
- 1993-09-23 US US08/406,979 patent/US5635502A/en not_active Expired - Lifetime
- 1993-09-23 HU HU9501239A patent/HUT71243A/hu unknown
- 1993-09-23 EP EP94914243A patent/EP0669936B1/fr not_active Expired - Lifetime
- 1993-09-23 NZ NZ256589A patent/NZ256589A/en not_active IP Right Cessation
- 1993-09-23 JP JP51105294A patent/JP3420766B2/ja not_active Expired - Fee Related
- 1993-10-25 ZA ZA937912A patent/ZA937912B/xx unknown
- 1993-10-26 TW TW082108885A patent/TW327172B/zh not_active IP Right Cessation
- 1993-10-27 IL IL10741393A patent/IL107413A/en not_active IP Right Cessation
- 1993-10-29 MX MX9306758A patent/MX9306758A/es unknown
1995
- 1995-04-27 FI FI952014A patent/FI110263B/fi not_active IP Right Cessation
- 1995-04-28 NO NO951646A patent/NO951646L/no not_active Application Discontinuation
2001
- 2001-02-14 GR GR20010400246T patent/GR3035416T3/el unknown

Also Published As

Publication number	Publication date
JP3420766B2 (ja)	2003-06-30
US5635502A (en)	1997-06-03
ZA937912B (en)	1994-06-01
ATE197714T1 (de)	2000-12-15
DE69329701D1 (de)	2000-12-28
WO1994010193A1 (fr)	1994-05-11
PT669936E (pt)	2001-04-30
NO951646L (no)	1995-06-23
CA2146238A1 (fr)	1994-05-11
GR3035416T3 (en)	2001-05-31
TW327172B (en)	1998-02-21
KR950704349A (ko)	1995-11-20
IL107413A (en)	1999-08-17
MX9306758A (es)	1994-07-29
NZ256589A (en)	1996-05-28
JPH08502746A (ja)	1996-03-26
EP0669936A1 (fr)	1995-09-06
DE69329701T2 (de)	2001-05-10
HU9501239D0 (en)	1995-06-28
EP0669936B1 (fr)	2000-11-22
KR100311166B1 (ko)	2002-02-28
ES2155852T3 (es)	2001-06-01
CA2146238C (fr)	2001-03-13
HUT71243A (en)	1995-11-28
AU673857B2 (en)	1996-11-28
NO951646D0 (no)	1995-04-28
FI952014A0 (fi)	1995-04-27
IL107413A0 (en)	1994-01-25
FI952014L (fi)	1995-04-27
FI110263B (fi)	2002-12-31
AU5136293A (en)	1994-05-24

Publication	Publication Date	Title
NO951646D0 (no)	1995-04-28	Nye merkaptoacetylamid-bisykliske laktamderivater som er anvendbare som inhibitorer av enkefalinase og ACE
TW430664B (en)	2001-04-21	Substituted carboxamidothiazoles, their preparation and pharmaceutical compositions containing them
DE69309670D1 (de)	1997-05-15	Heterocyclische carbonsäure-derivate, die an rar rezeptoren binden können
DE69327541D1 (en)	2000-02-10	4-arylmethyloxymethyl piperidine als tachykinin antagonisten
DK0759919T3 (da)	1999-07-26	Azolidindioner som antihyperglykæmiske midler
EP0845985A4 (fr)	1998-11-04	Composes non steroidiens inhibiteurs de la sulfatase et leur procede d'utilisation
DK0659174T3 (da)	1999-09-20	Derivater af valproinsyre og 2-valproensyreamider samt deres anvendelse som antikonvulsive midler
EP0322738A3 (fr)	1991-05-08	Dérivés de la benzylidène pour l'inhibition des processus de prolifération dans les cellules des mammifères
IE45576L (en)	1978-03-27	Analgesic tetrapeptides and pentapeptides
NO944926L (no)	1995-06-22	Fremgangsmåter for å inhibere myeloperoksidaseaktivitet
FI943931A0 (fi)	1994-08-26	Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina
UA43338C2 (uk)	2001-12-17	Похідні бензолу
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