DK0670898T3 - Interleukin-3 (IL-3)-mutantpolypeptider - Google Patents

Interleukin-3 (IL-3)-mutantpolypeptider

Info

Publication number
DK0670898T3
DK0670898T3 DK94902293T DK94902293T DK0670898T3 DK 0670898 T3 DK0670898 T3 DK 0670898T3 DK 94902293 T DK94902293 T DK 94902293T DK 94902293 T DK94902293 T DK 94902293T DK 0670898 T3 DK0670898 T3 DK 0670898T3
Authority
DK
Denmark
Prior art keywords
hil
muteins
amino acid
relates
present
Prior art date
Application number
DK94902293T
Other languages
Danish (da)
English (en)
Inventor
S Christopher Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
Kumman Paik
Joseph O Polazzi
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0670898T3 publication Critical patent/DK0670898T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94902293T 1992-11-24 1993-11-22 Interleukin-3 (IL-3)-mutantpolypeptider DK0670898T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98104492A 1992-11-24 1992-11-24
PCT/US1993/011198 WO1994012639A2 (en) 1992-11-24 1993-11-22 Interleukin-3 (il-3) mutant polypeptides

Publications (1)

Publication Number Publication Date
DK0670898T3 true DK0670898T3 (da) 2004-02-09

Family

ID=25528061

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94901584T DK0672145T3 (da) 1992-11-24 1993-11-22 Interleukin-3-(IL-3)-polypeptider med flere mutationer
DK94902293T DK0670898T3 (da) 1992-11-24 1993-11-22 Interleukin-3 (IL-3)-mutantpolypeptider

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK94901584T DK0672145T3 (da) 1992-11-24 1993-11-22 Interleukin-3-(IL-3)-polypeptider med flere mutationer

Country Status (12)

Country Link
US (11) US5604116A (pt)
EP (4) EP1361273A3 (pt)
JP (3) JPH08503706A (pt)
KR (1) KR100332139B1 (pt)
AT (2) ATE251669T1 (pt)
AU (3) AU690088B2 (pt)
CA (2) CA2150116A1 (pt)
DE (2) DE69333243T2 (pt)
DK (2) DK0672145T3 (pt)
ES (2) ES2211875T3 (pt)
PT (2) PT670898E (pt)
WO (2) WO1994012639A2 (pt)

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US6361976B1 (en) * 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US6413509B1 (en) * 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
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US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
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Also Published As

Publication number Publication date
JPH08503489A (ja) 1996-04-16
ES2211875T3 (es) 2004-07-16
US20040018618A1 (en) 2004-01-29
WO1994012639A2 (en) 1994-06-09
JPH08503706A (ja) 1996-04-23
AU690088B2 (en) 1998-04-23
EP1283264A3 (en) 2004-03-10
EP1283264A2 (en) 2003-02-12
US5677149A (en) 1997-10-14
WO1994012638A3 (en) 1994-09-01
CA2150116A1 (en) 1994-06-09
AU5670994A (en) 1994-06-22
US5817486A (en) 1998-10-06
DK0672145T3 (da) 2003-08-11
EP0670898A1 (en) 1995-09-13
ATE251669T1 (de) 2003-10-15
AU6078398A (en) 1998-06-18
PT670898E (pt) 2004-02-27
JP2003259886A (ja) 2003-09-16
US6479261B1 (en) 2002-11-12
AU5612594A (en) 1994-06-22
EP0672145B1 (en) 2003-04-23
US6440407B1 (en) 2002-08-27
US5604116A (en) 1997-02-18
WO1994012638A2 (en) 1994-06-09
US6051217A (en) 2000-04-18
US20030103936A1 (en) 2003-06-05
US6458931B1 (en) 2002-10-01
KR100332139B1 (ko) 2002-11-30
ATE238421T1 (de) 2003-05-15
KR950704490A (ko) 1995-11-20
EP0670898B1 (en) 2003-10-08
DE69332908D1 (de) 2003-05-28
ES2198416T3 (es) 2004-02-01
DE69333243D1 (de) 2003-11-13
DE69332908T2 (de) 2003-12-24
EP1361273A2 (en) 2003-11-12
EP0672145A1 (en) 1995-09-20
PT672145E (pt) 2003-08-29
US20030220472A1 (en) 2003-11-27
US20050244372A1 (en) 2005-11-03
WO1994012639A3 (en) 1994-07-21
EP1361273A3 (en) 2004-02-11
CA2150117A1 (en) 1994-06-09
DE69333243T2 (de) 2004-08-19

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