DK0676398T3 - Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse - Google Patents

Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse

Info

Publication number: DK0676398T3
Authority: DK; Denmark
Prior art keywords: group; formula; heterocyclic compounds; carboxylic acyl; atom
Prior art date: 1994-04-11

Application number

DK95302409T

Other languages

English (en)

Inventor

Takashi

Koichi

Takao

Hiroaki

Toshihiko

Hiroyoshi

Minoru

Kunio

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-11

Filing date

1995-04-11

Publication date

2001-12-10

1995-04-11 Application filed by Sankyo Co filed Critical Sankyo Co

2001-12-10 Application granted granted Critical

2001-12-10 Publication of DK0676398T3 publication Critical patent/DK0676398T3/da

Links

230000003178 anti-diabetic effect Effects 0.000 title abstract 2
150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
125000003118 aryl group Chemical group 0.000 abstract 3
125000001589 carboacyl group Chemical group 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Heat Sensitive Colour Forming Recording (AREA)

DK95302409T 1994-04-11 1995-04-11 Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse DK0676398T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP7208394		1994-04-11

Publications (1)

Publication Number	Publication Date
DK0676398T3 true DK0676398T3 (da)	2001-12-10

Family

ID=13479165

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK00102313T DK1022274T3 (da)	1994-04-11	1995-04-11	Mellemprodukter til fremstillingen af oxazolidindion og thiazolidindion derivater
DK95302409T DK0676398T3 (da)	1994-04-11	1995-04-11	Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK00102313T DK1022274T3 (da)	1994-04-11	1995-04-11	Mellemprodukter til fremstillingen af oxazolidindion og thiazolidindion derivater

Country Status (21)

Country	Link
US (6)	US5624935A (da)
EP (2)	EP0676398B1 (da)
KR (1)	KR950032188A (da)
CN (1)	CN1060173C (da)
AT (2)	ATE207488T1 (da)
AU (1)	AU683348B2 (da)
CA (1)	CA2146701A1 (da)
CZ (1)	CZ289317B6 (da)
DE (2)	DE69523358T2 (da)
DK (2)	DK1022274T3 (da)
ES (2)	ES2165895T3 (da)
FI (1)	FI951731A7 (da)
HU (1)	HU219887B (da)
ID (1)	ID20564A (da)
IL (1)	IL113313A (da)
NO (2)	NO305987B1 (da)
NZ (1)	NZ270917A (da)
PT (2)	PT1022274E (da)
RU (2)	RU2114844C1 (da)
TW (2)	TW503237B (da)
ZA (1)	ZA952990B (da)

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US5614544A (en) *	1993-09-14	1997-03-25	Takeda Chemical Industries, Ltd.	Oxazolidinedione derivatives and their use
CZ289317B6 (cs) *	1994-04-11	2002-01-16	Sankyo Company Limited	Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití

1995
- 1995-04-10 CZ CZ1995910A patent/CZ289317B6/cs not_active IP Right Cessation
- 1995-04-10 RU RU95105423/04A patent/RU2114844C1/ru not_active IP Right Cessation
- 1995-04-10 CA CA002146701A patent/CA2146701A1/en not_active Abandoned
- 1995-04-10 IL IL11331395A patent/IL113313A/xx not_active IP Right Cessation
- 1995-04-10 NO NO951398A patent/NO305987B1/no not_active IP Right Cessation
- 1995-04-10 RU RU95118736/04A patent/RU2151145C1/ru not_active IP Right Cessation
- 1995-04-11 FI FI951731A patent/FI951731A7/fi unknown
- 1995-04-11 ES ES95302409T patent/ES2165895T3/es not_active Expired - Lifetime
- 1995-04-11 PT PT00102313T patent/PT1022274E/pt unknown
- 1995-04-11 AU AU16383/95A patent/AU683348B2/en not_active Ceased
- 1995-04-11 DK DK00102313T patent/DK1022274T3/da active
- 1995-04-11 ZA ZA952990A patent/ZA952990B/xx unknown
- 1995-04-11 ES ES00102313T patent/ES2180477T3/es not_active Expired - Lifetime
- 1995-04-11 TW TW087114283A patent/TW503237B/zh not_active IP Right Cessation
- 1995-04-11 ID IDP981611A patent/ID20564A/id unknown
- 1995-04-11 DK DK95302409T patent/DK0676398T3/da active
- 1995-04-11 EP EP95302409A patent/EP0676398B1/en not_active Expired - Lifetime
- 1995-04-11 NZ NZ270917A patent/NZ270917A/en unknown
- 1995-04-11 TW TW084103469A patent/TW407156B/zh not_active IP Right Cessation
- 1995-04-11 AT AT95302409T patent/ATE207488T1/de not_active IP Right Cessation
- 1995-04-11 DE DE69523358T patent/DE69523358T2/de not_active Expired - Fee Related
- 1995-04-11 KR KR1019950008429A patent/KR950032188A/ko not_active Abandoned
- 1995-04-11 PT PT95302409T patent/PT676398E/pt unknown
- 1995-04-11 EP EP00102313A patent/EP1022274B1/en not_active Expired - Lifetime
- 1995-04-11 AT AT00102313T patent/ATE222895T1/de not_active IP Right Cessation
- 1995-04-11 CN CN95105765A patent/CN1060173C/zh not_active Expired - Fee Related
- 1995-04-11 US US08/419,919 patent/US5624935A/en not_active Expired - Fee Related
- 1995-04-11 DE DE69528000T patent/DE69528000T2/de not_active Expired - Fee Related
- 1995-04-11 HU HU9501040A patent/HU219887B/hu not_active IP Right Cessation
1996
- 1996-09-13 US US08/713,543 patent/US5834501A/en not_active Expired - Fee Related
- 1996-11-08 US US08/745,377 patent/US5739345A/en not_active Expired - Fee Related
1997
- 1997-12-30 US US09/001,093 patent/US5962470A/en not_active Expired - Fee Related
1998
- 1998-07-07 US US09/110,693 patent/US5977365A/en not_active Expired - Fee Related
- 1998-08-25 NO NO983900A patent/NO307299B1/no not_active IP Right Cessation
1999
- 1999-03-03 US US09/261,645 patent/US6117893A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR950032188A (ko)	1995-12-20
US5624935A (en)	1997-04-29
NO983900D0 (no)	1998-08-25
ATE207488T1 (de)	2001-11-15
AU683348B2 (en)	1997-11-06
CA2146701A1 (en)	1995-10-12
US5739345A (en)	1998-04-14
AU1638395A (en)	1995-10-19
EP0676398B1 (en)	2001-10-24
NO307299B1 (no)	2000-03-13
PT676398E (pt)	2002-03-28
NO983900L (no)	1995-10-12
HK1029338A1 (en)	2001-03-30
ES2180477T3 (es)	2003-02-16
IL113313A (en)	1999-09-22
EP0676398A3 (en)	1998-07-01
DE69523358T2 (de)	2002-07-11
NO951398D0 (no)	1995-04-10
TW503237B (en)	2002-09-21
FI951731L (fi)	1995-10-12
DE69528000T2 (de)	2003-05-28
NO951398L (no)	1995-10-12
CZ289317B6 (cs)	2002-01-16
US5977365A (en)	1999-11-02
RU2151145C1 (ru)	2000-06-20
NO305987B1 (no)	1999-08-30
CN1118781A (zh)	1996-03-20
NZ270917A (en)	1996-12-20
HK1011365A1 (en)	1999-07-09
RU95105423A (ru)	1997-03-20
FI951731A0 (fi)	1995-04-11
IL113313A0 (en)	1995-07-31
RU2114844C1 (ru)	1998-07-10
DE69528000D1 (de)	2002-10-02
HU219887B (hu)	2001-08-28
HU9501040D0 (en)	1995-06-28
HUT73765A (en)	1996-09-30
EP1022274A1 (en)	2000-07-26
ID20564A (id)	1999-01-14
TW407156B (en)	2000-10-01
EP0676398A2 (en)	1995-10-11
EP1022274B1 (en)	2002-08-28
ES2165895T3 (es)	2002-04-01
ATE222895T1 (de)	2002-09-15
DK1022274T3 (da)	2002-10-28
CN1060173C (zh)	2001-01-03
US6117893A (en)	2000-09-12
CZ91095A3 (en)	1997-12-17
DE69523358D1 (de)	2001-11-29
US5834501A (en)	1998-11-10
FI951731A7 (fi)	1995-10-12
US5962470A (en)	1999-10-05
PT1022274E (pt)	2002-11-29
ZA952990B (en)	1995-12-21

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DK0676398T3 (da)	2001-12-10	Heterocykliske forbindelser, som har antidiabetisk aktivitet, deres fremstilling og deres anvendelse
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DE69717970D1 (de)	2003-01-30	Chinolin carbonsaure-derivate und ihre salze
DK0508687T3 (da)	1996-02-05	ATP-analoger
ATE150964T1 (de)	1997-04-15	Restenosehemmer nach perkutaner koronarer arterioplastie
DK0508740T3 (da)	1997-10-20	Thiazolidindionderivater, deres fremstilling og anvendelse.
IL146968A0 (en)	2002-08-14	Benzamide derivatives, insecticides fro agricultural and horticultural use and usage thereof
DK0547231T3 (da)	1996-09-16	Phospholipase-A2-inhibitor
NO921282D0 (no)	1992-04-02	Benzotiazolderivater og deres anvendelse
DE69607890D1 (de)	2000-05-31	Aromatische Hydroxamsäure-Verbindungen, ihre Herstellung und Verwendung
HU9602534D0 (en)	1996-11-28	Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
DK0579169T3 (da)	1999-05-31	Alkylendiaminderivater
SE9402596L (sv)	1995-01-31	Karboximetylidencykloheptimidazolderivat, förfarande för deras framställning och terapeutiska medel innehållande dessa föreningar
ATE143591T1 (de)	1996-10-15	Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus