ATE207488T1 - Heterozyklische verbindungen mit antidiabetischer wirkung, ihre herstellung und verwendung - Google Patents

Heterozyklische verbindungen mit antidiabetischer wirkung, ihre herstellung und verwendung

Info

Publication number
ATE207488T1
ATE207488T1 AT95302409T AT95302409T ATE207488T1 AT E207488 T1 ATE207488 T1 AT E207488T1 AT 95302409 T AT95302409 T AT 95302409T AT 95302409 T AT95302409 T AT 95302409T AT E207488 T1 ATE207488 T1 AT E207488T1
Authority
AT
Austria
Prior art keywords
group
formula
heterocyclic compounds
carboxylic acyl
atom
Prior art date
Application number
AT95302409T
Other languages
English (en)
Inventor
Takashi Fujita
Koichi Fujimoto
Takao Yoshioka
Hiroaki Yanagisawa
Toshihiko Fujiwara
Hiroyoshi Horikoshi
Minoru Oguchi
Kunio Wada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE207488T1 publication Critical patent/ATE207488T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
AT95302409T 1994-04-11 1995-04-11 Heterozyklische verbindungen mit antidiabetischer wirkung, ihre herstellung und verwendung ATE207488T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7208394 1994-04-11

Publications (1)

Publication Number Publication Date
ATE207488T1 true ATE207488T1 (de) 2001-11-15

Family

ID=13479165

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00102313T ATE222895T1 (de) 1994-04-11 1995-04-11 Zwischenprodukte zur hertellung von oxazolidindion- und thiazolidindionderivate
AT95302409T ATE207488T1 (de) 1994-04-11 1995-04-11 Heterozyklische verbindungen mit antidiabetischer wirkung, ihre herstellung und verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00102313T ATE222895T1 (de) 1994-04-11 1995-04-11 Zwischenprodukte zur hertellung von oxazolidindion- und thiazolidindionderivate

Country Status (21)

Country Link
US (6) US5624935A (de)
EP (2) EP0676398B1 (de)
KR (1) KR950032188A (de)
CN (1) CN1060173C (de)
AT (2) ATE222895T1 (de)
AU (1) AU683348B2 (de)
CA (1) CA2146701A1 (de)
CZ (1) CZ289317B6 (de)
DE (2) DE69523358T2 (de)
DK (2) DK0676398T3 (de)
ES (2) ES2165895T3 (de)
FI (1) FI951731A7 (de)
HU (1) HU219887B (de)
ID (1) ID20564A (de)
IL (1) IL113313A (de)
NO (2) NO305987B1 (de)
NZ (1) NZ270917A (de)
PT (2) PT1022274E (de)
RU (2) RU2151145C1 (de)
TW (2) TW407156B (de)
ZA (1) ZA952990B (de)

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US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
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Also Published As

Publication number Publication date
ZA952990B (en) 1995-12-21
DE69523358T2 (de) 2002-07-11
EP0676398A3 (de) 1998-07-01
DE69523358D1 (de) 2001-11-29
US5962470A (en) 1999-10-05
DE69528000D1 (de) 2002-10-02
HU219887B (hu) 2001-08-28
TW407156B (en) 2000-10-01
ES2165895T3 (es) 2002-04-01
RU95105423A (ru) 1997-03-20
NO951398L (no) 1995-10-12
CZ91095A3 (en) 1997-12-17
DE69528000T2 (de) 2003-05-28
DK0676398T3 (da) 2001-12-10
HU9501040D0 (en) 1995-06-28
EP0676398B1 (de) 2001-10-24
FI951731L (fi) 1995-10-12
CN1118781A (zh) 1996-03-20
AU1638395A (en) 1995-10-19
DK1022274T3 (da) 2002-10-28
ATE222895T1 (de) 2002-09-15
NZ270917A (en) 1996-12-20
PT1022274E (pt) 2002-11-29
FI951731A0 (fi) 1995-04-11
IL113313A0 (en) 1995-07-31
HUT73765A (en) 1996-09-30
NO305987B1 (no) 1999-08-30
ES2180477T3 (es) 2003-02-16
EP0676398A2 (de) 1995-10-11
RU2151145C1 (ru) 2000-06-20
EP1022274B1 (de) 2002-08-28
RU2114844C1 (ru) 1998-07-10
HK1011365A1 (en) 1999-07-09
ID20564A (id) 1999-01-14
NO983900L (no) 1995-10-12
PT676398E (pt) 2002-03-28
AU683348B2 (en) 1997-11-06
CZ289317B6 (cs) 2002-01-16
NO307299B1 (no) 2000-03-13
US5739345A (en) 1998-04-14
EP1022274A1 (de) 2000-07-26
HK1029338A1 (en) 2001-03-30
CA2146701A1 (en) 1995-10-12
KR950032188A (ko) 1995-12-20
IL113313A (en) 1999-09-22
US5834501A (en) 1998-11-10
US5977365A (en) 1999-11-02
NO983900D0 (no) 1998-08-25
NO951398D0 (no) 1995-04-10
TW503237B (en) 2002-09-21
CN1060173C (zh) 2001-01-03
US5624935A (en) 1997-04-29
US6117893A (en) 2000-09-12
FI951731A7 (fi) 1995-10-12

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