DK0676399T3 - Methotrexaderivater - Google Patents
MethotrexaderivaterInfo
- Publication number
- DK0676399T3 DK0676399T3 DK94903046T DK94903046T DK0676399T3 DK 0676399 T3 DK0676399 T3 DK 0676399T3 DK 94903046 T DK94903046 T DK 94903046T DK 94903046 T DK94903046 T DK 94903046T DK 0676399 T3 DK0676399 T3 DK 0676399T3
- Authority
- DK
- Denmark
- Prior art keywords
- methotrexate derivatives
- antirheumatic
- chem
- alkyl
- salt
- Prior art date
Links
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical class C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36202792 | 1992-12-25 | ||
| PCT/JP1993/001867 WO1994014810A1 (fr) | 1992-12-25 | 1993-12-24 | Derive de methotrexate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0676399T3 true DK0676399T3 (da) | 2000-03-20 |
Family
ID=18475662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94903046T DK0676399T3 (da) | 1992-12-25 | 1993-12-24 | Methotrexaderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5728692A (da) |
| EP (1) | EP0676399B1 (da) |
| KR (1) | KR100259742B1 (da) |
| CN (1) | CN1037771C (da) |
| AT (1) | ATE184605T1 (da) |
| AU (1) | AU5715894A (da) |
| CA (1) | CA2152485A1 (da) |
| DE (1) | DE69326479T2 (da) |
| DK (1) | DK0676399T3 (da) |
| ES (1) | ES2140524T3 (da) |
| GR (1) | GR3031864T3 (da) |
| SG (1) | SG52733A1 (da) |
| WO (1) | WO1994014810A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958928A (en) * | 1995-03-27 | 1999-09-28 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical agents containing methotrexate derivative |
| KR100343409B1 (ko) * | 1996-03-19 | 2002-08-22 | 쥬가이 세이야쿠 가부시키가이샤 | 포도막염치료제 |
| EP1090919A4 (en) * | 1998-06-26 | 2002-05-22 | Chugai Pharmaceutical Co Ltd | FINE POWDER OF L-ALPHA-AMINOADIPIC ACID DERIVATIVES, SOLID PREPARATIONS FOR ORAL USE AND A METHOD FOR TREATING Loose POWDER |
| JP3845307B2 (ja) * | 1999-08-17 | 2006-11-15 | 中外製薬株式会社 | 心筋梗塞治療薬 |
| US20060039985A1 (en) * | 2004-04-27 | 2006-02-23 | Bennett David B | Methotrexate compositions |
| US7741317B2 (en) * | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| CN102014919B (zh) | 2008-03-03 | 2015-02-25 | 托斯克公司 | 减少毒性的甲氨蝶呤佐剂及其使用方法 |
| EP2527322A1 (en) | 2011-05-24 | 2012-11-28 | Noscira, S.A. | Carbamyl alkylphenyl disulfide derivatives and their therapeutic uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2784670B2 (ja) * | 1989-08-09 | 1998-08-06 | 株式会社シーエスケイ | パチンコ景品交換システム |
| HU223948B1 (hu) * | 1990-08-14 | 2005-03-29 | Chugai Seiyaku Kabushiki Kaisha | Metotrexát-származékok, ilyeneket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
| JPH04368385A (ja) * | 1991-06-12 | 1992-12-21 | Chugai Pharmaceut Co Ltd | 新規メトトレキセート誘導体 |
| DE69330639T2 (de) * | 1992-01-27 | 2002-07-04 | Chugai Seiyaku K.K., Tokio/Tokyo | Methotrexat-derivate |
| JP3281099B2 (ja) * | 1992-02-13 | 2002-05-13 | 中外製薬株式会社 | 抗リウマチ剤 |
-
1993
- 1993-12-24 CN CN93121089A patent/CN1037771C/zh not_active Expired - Fee Related
- 1993-12-24 ES ES94903046T patent/ES2140524T3/es not_active Expired - Lifetime
- 1993-12-24 AT AT94903046T patent/ATE184605T1/de not_active IP Right Cessation
- 1993-12-24 KR KR1019950702631A patent/KR100259742B1/ko not_active Expired - Fee Related
- 1993-12-24 CA CA002152485A patent/CA2152485A1/en not_active Abandoned
- 1993-12-24 EP EP94903046A patent/EP0676399B1/en not_active Expired - Lifetime
- 1993-12-24 WO PCT/JP1993/001867 patent/WO1994014810A1/ja not_active Ceased
- 1993-12-24 DE DE69326479T patent/DE69326479T2/de not_active Expired - Fee Related
- 1993-12-24 AU AU57158/94A patent/AU5715894A/en not_active Abandoned
- 1993-12-24 DK DK94903046T patent/DK0676399T3/da active
- 1993-12-24 SG SG1996008496A patent/SG52733A1/en unknown
-
1995
- 1995-12-24 US US08/454,290 patent/US5728692A/en not_active Expired - Fee Related
-
1999
- 1999-11-17 GR GR990402959T patent/GR3031864T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2152485A1 (en) | 1994-07-07 |
| GR3031864T3 (en) | 2000-02-29 |
| KR100259742B1 (ko) | 2000-07-01 |
| ATE184605T1 (de) | 1999-10-15 |
| DE69326479D1 (de) | 1999-10-21 |
| AU5715894A (en) | 1994-07-19 |
| CN1037771C (zh) | 1998-03-18 |
| US5728692A (en) | 1998-03-17 |
| EP0676399B1 (en) | 1999-09-15 |
| ES2140524T3 (es) | 2000-03-01 |
| SG52733A1 (en) | 1998-09-28 |
| KR960700245A (ko) | 1996-01-19 |
| EP0676399A4 (en) | 1996-04-17 |
| WO1994014810A1 (fr) | 1994-07-07 |
| CN1093365A (zh) | 1994-10-12 |
| DE69326479T2 (de) | 2000-03-02 |
| EP0676399A1 (en) | 1995-10-11 |
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