DK0418099T3 - Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger - Google Patents

Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger

Info

Publication number: DK0418099T3
Authority: DK; Denmark
Prior art keywords: alkyl; methylenedioxy; camptothecin; ch2ch2ch2n; ch2ch2n
Prior art date: 1989-09-15

Application number

DK90310085T

Other languages

English (en)

Inventor

Govindarajan Researc Manikumar

Monroe E Wall

Allan W Nicholas

Mansukh C Wani

Original Assignee

Res Triangle Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-15

Filing date

1990-09-14

Publication date

2002-04-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27019995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0418099(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-09-15 Priority claimed from US07/407,749 external-priority patent/US5049668A/en

1990-09-13 Priority claimed from US07/581,916 external-priority patent/US5180722A/en

1990-09-14 Application filed by Res Triangle Inst filed Critical Res Triangle Inst

2002-04-02 Application granted granted Critical

2002-04-02 Publication of DK0418099T3 publication Critical patent/DK0418099T3/da

Links

RPFYDENHBPRCTN-UHFFFAOYSA-N 10,11-methylenedioxy-20(rs)-camptothecin Chemical compound C1=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=CC2=C1OCO2 RPFYDENHBPRCTN-UHFFFAOYSA-N 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 9
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical compound [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
150000001371 alpha-amino acids Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

DK90310085T 1989-09-15 1990-09-14 Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger DK0418099T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/407,749 US5049668A (en)	1989-09-15	1989-09-15	10,11-methylenedioxy-20(RS)-camptothecin analogs
US07/581,916 US5180722A (en)	1987-04-14	1990-09-13	10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs

Publications (1)

Publication Number	Publication Date
DK0418099T3 true DK0418099T3 (da)	2002-04-02

Family

ID=27019995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90310085T DK0418099T3 (da)	1989-09-15	1990-09-14	Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger

Country Status (8)

Country	Link
EP (1)	EP0418099B1 (da)
KR (1)	KR0180245B1 (da)
AT (1)	ATE211142T1 (da)
CA (1)	CA2066780C (da)
DE (1)	DE69033880T2 (da)
DK (1)	DK0418099T3 (da)
ES (1)	ES2165346T3 (da)
NZ (1)	NZ235329A (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5180722A (en) *	1987-04-14	1993-01-19	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5552154A (en)	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
WO1993009782A1 (en)	1991-11-15	1993-05-27	Smithkline Beecham Corporation	Combination chemotherapy
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
EP0556585A3 (en) *	1992-01-24	1993-09-01	Takeda Chemical Industries, Ltd.	Condensed camptothecin derivatives their production and use as antitumor agents
EP0678025B1 (en) *	1993-01-15	1998-04-15	The Stehlin Foundation For Cancer Research	Transdermal treatment of cancer with water-insoluble s-camptothecin of the closed lactone ring form
IS4152A (is) *	1993-04-29	1994-10-30	Glaxo Inc.	Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation
US5491237A (en) *	1994-05-03	1996-02-13	Glaxo Wellcome Inc.	Intermediates in pharmaceutical camptothecin preparation
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
ATE210673T1 (de) *	1996-09-30	2001-12-15	Bayer Ag	Glycokonjugate von modifizierten camptothecin- derivaten (20-o-verknüpfung)
DE19640207A1 (de) *	1996-09-30	1998-04-02	Bayer Ag	Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung)
SG88737A1 (en)	1996-10-30	2002-05-21	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en)	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
ID23424A (id) *	1997-05-14	2000-04-20	Bayer Ag	Glikokonjugat dari 20(s)-kamptotesin
US6214821B1 (en)	1998-03-05	2001-04-10	Washington State University Research Foundation	Methods and composition for the inhibition of cancer cells
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
ATE507240T1 (de)	2004-03-05	2011-05-15	Vegenics Pty Ltd	Materialien und verfahren für wachstumsfaktorbindende konstrukte
ES2575160T3 (es)	2010-03-15	2016-06-24	The Board Of Trustees Of The University Of Illinois	Inhibidores de las interacciones que unen la subunidad alfa de la beta integrina-proteína G
EP2655401B1 (en)	2010-12-20	2016-03-09	The Regents of the University of Michigan	Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
JP7264592B2 (ja)	2015-01-26	2023-04-25	ザユニバーシティーオブシカゴ	ＩＬ１３Ｒα２結合剤及び癌治療におけるその使用
EP3250611B1 (en)	2015-01-26	2021-04-21	The University of Chicago	Car t-cells recognizing cancer-specific il 13r-alpha2
MA49849A (fr)	2017-08-07	2020-06-17	Amgen Inc	Traitement du cancer du sein triple négatif ou du cancer colorectal comportant des métastases hépatiques par un anticorps anti-pd-l1 et un virus oncolytique
SG11202109986TA (en)	2019-03-20	2021-10-28	Univ California	Claudin-6 antibodies and drug conjugates
WO2020191344A1 (en)	2019-03-20	2020-09-24	The Regents Of The University Of California	Claudin-6 bispecific antibodies
CA3136496A1 (en)	2019-04-09	2020-10-15	The Board Of Trustees Of The University Of Illinois	Drug adsorbed highly porous activated carbon for enhanced drug delivery
JP2022530241A (ja)	2019-04-30	2022-06-28	インスチトゥートデメディシーナモリクラールジョアンロボアントゥネス	Ｃｄｋ阻害剤と組み合わせたｒａｎｋ経路阻害剤
WO2020242720A1 (en)	2019-05-02	2020-12-03	University Of Florida Research Foundation, Inc.	Compositions for treatment of diffuse intrinsic pontine glioma
EP3986441A1 (en)	2019-06-24	2022-04-27	Amgen Inc.	Inhibition of sirp-gamma for cancer treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
JPH0615547B2 (ja) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体

1990
- 1990-09-14 DK DK90310085T patent/DK0418099T3/da active
- 1990-09-14 NZ NZ235329A patent/NZ235329A/en unknown
- 1990-09-14 EP EP90310085A patent/EP0418099B1/en not_active Expired - Lifetime
- 1990-09-14 AT AT90310085T patent/ATE211142T1/de not_active IP Right Cessation
- 1990-09-14 DE DE69033880T patent/DE69033880T2/de not_active Expired - Fee Related
- 1990-09-14 ES ES90310085T patent/ES2165346T3/es not_active Expired - Lifetime
- 1990-09-17 KR KR1019920700585A patent/KR0180245B1/ko not_active Expired - Fee Related
- 1990-09-17 CA CA002066780A patent/CA2066780C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR0180245B1 (ko)	1999-03-20
CA2066780A1 (en)	1991-03-16
CA2066780C (en)	2002-04-02
KR920702362A (ko)	1992-09-03
DE69033880D1 (de)	2002-01-31
EP0418099A3 (en)	1992-01-15
ES2165346T3 (es)	2002-03-16
EP0418099B1 (en)	2001-12-19
DE69033880T2 (de)	2002-06-06
ATE211142T1 (de)	2002-01-15
EP0418099A2 (en)	1991-03-20
NZ235329A (en)	1992-01-29

Publication	Publication Date	Title
EP0418099A3 (en)	1992-01-15	10, 11-methylenedioxy-20 (rs) camptothecin and 10, 11-methylenedioxy-20 (s) - camptothecin analog
IT1196500B (it)	1988-11-16	Derivati dell'acido malonico e metodi per la loro sintesi
FI893632A0 (fi)	1989-07-31	Foereningar.
NZ214843A (en)	1989-02-24	Thyromimetic analogues and intermediates: pharmaceutical compositions
IL99628A0 (en)	1992-08-18	Backbone cyclic peptides,processes for their preparation and pharmaceutical compositions containing them
WO1991004260A3 (en)	1991-05-02	10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
KR910007704A (ko)	1991-05-30	피브리노겐 수용체 길항제
HU9400595D0 (en)	1994-05-30	Isatinoxime derivatives and pharmaceutical compositions containing them
ES2012720A6 (es)	1990-04-01	Procedimiento para la obtencion de sales de adicion de acido de taurina o glicina amidada.
FR2556594B1 (fr)	1988-09-09	Solutions d'acides amines
ITRM910189A1 (it)	1992-09-22	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
FR2643076B1 (fr)	1991-06-21	Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline
EP0295316A3 (en)	1990-03-14	Antitumor amino acid and peptide derivatives of 1,4-bisû (aminoalkyl and hydroxyaminoalkyl)- amino¨-5,8 dihydroxyanthraquinones
DE3786706D1 (de)	1993-09-02	Pharmakologisch aktive peptide.
DE69015072D1 (de)	1995-01-26	Naphthalen- und Tetrahydronaphthalen-gem-diphosphonat-Derivate.
IL84195A0 (en)	1988-03-31	The synthesis of peptide amino-alkylamides and peptide hydrazides by the solid-phase method and novel compounds thus produced
DK0451626T3 (da)	1998-04-20	Anvendelse af benzodiazepinforbindelser til fremstilling af et farmaceutisk præparat mod med excitatoriske aminosyrer forbundne forstyrrelser i centralnervesystemet
ATE46347T1 (de)	1989-09-15	Immunostimulierende peptide.
PT95324A (pt)	1991-05-22	Processo de preparacao de 20(s) ou 20(rs)-camptotecinas, dos seus sais e intermediarios e de composicoes farmaceuticas que os contem
DE69120357D1 (de)	1996-07-25	Carbocyklische Nukleosidanaloge als Immunsuppressoren
DE68901361D1 (de)	1992-06-04	Anorexigenische und hypotensive peptide.
SE8305362D0 (sv)	1983-09-30	Novel substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
HUP9902307A2 (hu)	1999-12-28	Új, áthidalt gyűrűs aminosavak, előállításuk és intermedierjeik