|
US7067497B2
(en)
*
|
1992-09-29 |
2006-06-27 |
Isis Pharmaceuticals, Inc. |
Modulation of telomere length by oligonucleotides having a G-core sequence
|
|
US5523389A
(en)
*
|
1992-09-29 |
1996-06-04 |
Isis Pharmaceuticals, Inc. |
Inhibitors of human immunodeficiency virus
|
|
US6087491A
(en)
*
|
1993-01-08 |
2000-07-11 |
Hybridon, Inc. |
Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
|
|
EP0678096B1
(de)
*
|
1993-01-08 |
1997-03-19 |
HYBRIDON, Inc. |
Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
|
|
ATE138384T1
(de)
*
|
1993-01-25 |
1996-06-15 |
Hybridon Inc |
Olionukleotidalkylphosphonate und - phosphonothioate
|
|
DE4338704A1
(de)
*
|
1993-11-12 |
1995-05-18 |
Hoechst Ag |
Stabilisierte Oligonucleotide und deren Verwendung
|
|
CA2176256A1
(en)
*
|
1993-11-16 |
1995-05-26 |
Lyle John Arnold, Jr. |
Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages
|
|
WO1995013833A1
(en)
*
|
1993-11-16 |
1995-05-26 |
Genta Incorporated |
Synthetic oligomers having phosphonate internucleosidyl linkages of undefined chirality mixed with non-phosphonate internucleosidyl linkages
|
|
NZ276968A
(en)
*
|
1993-11-16 |
1998-04-27 |
Genta Inc |
Synthetic oligomers enriched for phosphonate internucleosidyl linkages of preselected chirality and their preparation
|
|
EP1167379A3
(de)
†
|
1994-07-15 |
2004-09-08 |
University Of Iowa Research Foundation |
Immunomodulatorische Oligonukleotide
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US20030026782A1
(en)
*
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
|
DE19502912A1
(de)
*
|
1995-01-31 |
1996-08-01 |
Hoechst Ag |
G-Cap Stabilisierte Oligonucleotide
|
|
US6166197A
(en)
*
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
|
WO1996027606A1
(en)
*
|
1995-03-06 |
1996-09-12 |
Isis Pharmaceuticals, Inc. |
Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom
|
|
WO1996029337A1
(en)
*
|
1995-03-23 |
1996-09-26 |
Hybridon, Inc. |
Thiono triester modified antisense oligodeoxynucleotide phosphorothioates
|
|
US6624293B1
(en)
|
1995-08-17 |
2003-09-23 |
Hybridon, Inc. |
Modified protein kinase A-specific oligonucleotides and methods of their use
|
|
US7074768B2
(en)
|
1995-08-17 |
2006-07-11 |
Idera Pharmaceuticals, Inc. |
Modified protein kinase A-specific oligonucleotides and methods of their use
|
|
US5652356A
(en)
*
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
WO1998007734A1
(en)
*
|
1996-08-21 |
1998-02-26 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
|
CA2294988C
(en)
|
1997-07-01 |
2015-11-24 |
Isis Pharmaceuticals Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
|
US7321828B2
(en)
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
|
WO1999060167A1
(en)
|
1998-05-21 |
1999-11-25 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
|
DE69939663D1
(de)
*
|
1998-11-05 |
2008-11-13 |
Univ Jefferson |
Behandlung von morbus parkinson mit oligonukleotiden
|
|
NZ512244A
(en)
|
1998-11-12 |
2003-12-19 |
Invitrogen Corp |
Polycationic transfection reagents for introducing anions into a cell
|
|
US20050136458A1
(en)
*
|
1998-12-31 |
2005-06-23 |
Oligos, Etc, Inc. |
Method for nucleic acid preparation
|
|
US6787136B1
(en)
*
|
1999-09-03 |
2004-09-07 |
The Brigham And Women's Hospital, Inc. |
Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
US6372722B1
(en)
|
2000-01-19 |
2002-04-16 |
Genteric, Inc. |
Method for nucleic acid transfection of cells
|
|
EP1337664A4
(de)
*
|
2000-10-27 |
2005-01-19 |
Invitrogen Corp |
Verfahren zur einführung von antisense-oligonukleotiden in eukaryontische zellen
|
|
US7128911B2
(en)
|
2001-01-19 |
2006-10-31 |
Cytos Biotechnology Ag |
Antigen arrays for treatment of bone disease
|
|
EP2221376B1
(de)
|
2001-06-21 |
2012-11-21 |
Isis Pharmaceuticals, Inc. |
Antisense-Modulation von Superoxid-Dismutase 1, Expression in Lösung
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
DE60234375D1
(de)
|
2001-09-14 |
2009-12-24 |
Cytos Biotechnology Ag |
VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
|
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
EP1456380B1
(de)
*
|
2001-11-02 |
2012-04-18 |
Giuliani International Limited |
Smad7-inhibitoren zur behandlung von krankheiten des zns
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
|
US20030220844A1
(en)
*
|
2002-05-24 |
2003-11-27 |
Marnellos Georgios E. |
Method and system for purchasing genetic data
|
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
BR0314236A
(pt)
|
2002-09-13 |
2005-08-09 |
Replicor Inc |
Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos
|
|
US7229976B2
(en)
|
2002-09-26 |
2007-06-12 |
Isis Pharmaceuticals, Inc. |
Modulation of forkhead box O1A expression
|
|
US20060183106A1
(en)
*
|
2002-10-18 |
2006-08-17 |
Adam Siddiqui-Jain |
Processes for identifying quadruplex-targeted antiviral molecules
|
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
|
CA2504720C
(en)
|
2002-11-05 |
2013-12-24 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
SI1569695T1
(sl)
|
2002-11-13 |
2013-08-30 |
Genzyme Corporation |
Protismiselna modulacija ekspresije apolipoproteina B
|
|
EP2336318B1
(de)
|
2002-11-13 |
2013-04-24 |
Genzyme Corporation |
Antisense-modulation von apolipoprotein-b-expression
|
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
|
EP2112229A3
(de)
|
2002-11-25 |
2009-12-02 |
Sequenom, Inc. |
Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
|
|
CA2502015A1
(en)
|
2002-12-11 |
2004-06-24 |
Coley Pharmaceutical Group, Inc. |
5' cpg nucleic acids and methods of use
|
|
CA2511824A1
(en)
|
2002-12-26 |
2004-07-22 |
Syngenta Participations Ag |
Cell proliferation-related polypeptides and uses therefor
|
|
NZ541637A
(en)
|
2003-02-11 |
2008-07-31 |
Antisense Therapeutics Pty Ltd |
Modulation of insulin like growth factor I receptor
|
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
|
AU2004224761A1
(en)
|
2003-03-26 |
2004-10-07 |
Cytos Biotechnology Ag |
HIV-peptide-carrier-conjugates
|
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
|
ITRM20030149A1
(it)
|
2003-04-02 |
2004-10-03 |
Giuliani Spa |
Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
|
JP4579911B2
(ja)
|
2003-06-03 |
2010-11-10 |
アイシス・ファーマシューティカルズ・インコーポレイテッド |
スルビビン発現の調節
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
WO2005074417A2
(en)
*
|
2003-09-03 |
2005-08-18 |
Salk Institute For Biological Studies |
Multiple antigen detection assays and reagents
|
|
EP2256201A3
(de)
|
2003-09-18 |
2012-07-04 |
Isis Pharmaceuticals, Inc. |
Modulation der eIF4E expression
|
|
AU2004275876B2
(en)
*
|
2003-09-25 |
2011-03-31 |
Coley Pharmaceutical Gmbh |
Nucleic acid-lipophilic conjugates
|
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
|
EP1711606A2
(de)
|
2004-01-20 |
2006-10-18 |
Isis Pharmaceuticals, Inc. |
Modulation der expression des glucocorticoidrezeptors
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
TWI235440B
(en)
*
|
2004-03-31 |
2005-07-01 |
Advanced Semiconductor Eng |
Method for making leadless semiconductor package
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
US7919472B2
(en)
|
2004-09-17 |
2011-04-05 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
|
AU2006241149A1
(en)
*
|
2005-04-26 |
2006-11-02 |
Coley Pharmaceutical Gmbh |
Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
|
|
US20090291437A1
(en)
*
|
2005-11-02 |
2009-11-26 |
O'brien Sean |
Methods for targeting quadruplex sequences
|
|
CA2636139A1
(en)
|
2005-12-14 |
2007-06-21 |
Cytos Biotechnology Ag |
Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
|
|
WO2007090071A2
(en)
|
2006-01-27 |
2007-08-09 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
JP2009536222A
(ja)
|
2006-05-05 |
2009-10-08 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
Pcsk9の発現を調節するための化合物および方法
|
|
WO2007137300A2
(en)
|
2006-05-23 |
2007-11-29 |
Bellicum Pharmaceuticals, Inc. |
Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
|
|
US8541559B2
(en)
|
2006-06-12 |
2013-09-24 |
Cytos Biotechnology Ag |
Process for producing aggregated oligonucleotides
|
|
PT2078080E
(pt)
|
2006-09-27 |
2015-09-18 |
Coley Pharm Gmbh |
Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
|
|
EP2114981B1
(de)
|
2007-01-29 |
2013-05-08 |
Isis Pharmaceuticals, Inc. |
Verbindungen und Methoden zur Modulation der Proteinexpression
|
|
WO2009045469A2
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
|
US8097422B2
(en)
|
2007-06-20 |
2012-01-17 |
Salk Institute For Biological Studies |
Kir channel modulators
|
|
KR101654007B1
(ko)
|
2007-08-15 |
2016-09-05 |
아이오니스 파마수티컬즈, 인코포레이티드 |
테트라하이드로피란 핵산 유사체
|
|
US8916531B2
(en)
|
2007-11-20 |
2014-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of CD40 expression
|
|
WO2009091934A1
(en)
|
2008-01-17 |
2009-07-23 |
Sequenom, Inc. |
Single molecule nucleic acid sequence analysis processes and compositions
|
|
EP2271772B1
(de)
*
|
2008-03-11 |
2014-07-16 |
Sequenom, Inc. |
Tests auf nukleinsäurebasis zur pränatalen geschlechtsbestimmung
|
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
|
EP2274423A2
(de)
|
2008-04-04 |
2011-01-19 |
Isis Pharmaceuticals, Inc. |
Bicyclische nukleoside umfassende oligomere verbindungen mit verringerter toxizität
|
|
US8476013B2
(en)
|
2008-09-16 |
2013-07-02 |
Sequenom, Inc. |
Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
US8962247B2
(en)
|
2008-09-16 |
2015-02-24 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
|
DK2361256T3
(da)
|
2008-09-24 |
2013-07-01 |
Isis Pharmaceuticals Inc |
Cyclohexenyl-nukleinsyreanaloger
|
|
EP2447274B1
(de)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomerverbindungen und Verfahren
|
|
US20120059045A1
(en)
|
2008-10-24 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
Methods of using oligomeric compounds comprising 2'-substituted nucleosides
|
|
WO2010087994A2
(en)
|
2009-01-30 |
2010-08-05 |
Whitehead Institute For Biomedical Research |
Methods for ligation and uses thereof
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
US20120021515A1
(en)
|
2009-02-06 |
2012-01-26 |
Swayze Eric E |
Oligomeric compounds and methods
|
|
WO2010118243A2
(en)
|
2009-04-08 |
2010-10-14 |
Genentech, Inc. |
Use of il-27 antagonists to treat lupus
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
ES2577017T3
(es)
|
2009-12-22 |
2016-07-12 |
Sequenom, Inc. |
Procedimientos y kits para identificar la aneuploidia
|
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011133931A1
(en)
|
2010-04-22 |
2011-10-27 |
Genentech, Inc. |
Use of il-27 antagonists for treating inflammatory bowel disease
|
|
EP2601204B1
(de)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
|
US9156873B2
(en)
|
2010-04-28 |
2015-10-13 |
Isis Pharmaceuticals, Inc. |
Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
PL2563920T3
(pl)
|
2010-04-29 |
2017-08-31 |
Ionis Pharmaceuticals, Inc. |
Modulacja ekspresji transtyretyny
|
|
US8877188B2
(en)
|
2010-05-04 |
2014-11-04 |
The Brigham And Women's Hospital, Inc. |
Detection and treatment of non-dermal fibrosis
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2580228B1
(de)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituierte 2 '-amino- und 2 '-thio-bicyclische nukleoside und daraus hergestellte oligomere verbindungen
|
|
CA2817256A1
(en)
|
2010-11-12 |
2012-05-18 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
AU2012249531B2
(en)
|
2011-04-29 |
2017-06-29 |
Sequenom, Inc. |
Quantification of a minority nucleic acid species
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
WO2013033230A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
AU2012308320C1
(en)
|
2011-09-14 |
2018-08-23 |
Translate Bio Ma, Inc. |
Multimeric oligonucleotide compounds
|
|
EP2820129A1
(de)
|
2012-03-02 |
2015-01-07 |
Sequenom, Inc. |
Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
|
|
EP2639238A1
(de)
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclische Nukleoside und daraus hergestellte oligomere Verbindungen
|
|
EP2850092B1
(de)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclische nukleinsäureanaloga
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
SG11201407483YA
(en)
|
2012-05-16 |
2014-12-30 |
Rana Therapeutics Inc |
Compositions and methods for modulating smn gene family expression
|
|
AU2013262699A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating ATP2A2 expression
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
EA201492122A1
(ru)
|
2012-05-16 |
2015-10-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии utrn
|
|
BR112014028631A2
(pt)
|
2012-05-16 |
2017-10-17 |
Rana Therapeutics Inc |
composições e métodos para modulação da expressão da família de genes da hemoglobina
|
|
EA201492116A1
(ru)
|
2012-05-16 |
2015-05-29 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии mecp2
|
|
US9920361B2
(en)
|
2012-05-21 |
2018-03-20 |
Sequenom, Inc. |
Methods and compositions for analyzing nucleic acid
|
|
KR20150016336A
(ko)
|
2012-05-21 |
2015-02-11 |
더 스크립스 리서치 인스티튜트 |
리보솜 폴리뉴클레오티드 및 관련 발현 시스템
|
|
US10504613B2
(en)
|
2012-12-20 |
2019-12-10 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
US20140093873A1
(en)
|
2012-07-13 |
2014-04-03 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
US20150247141A1
(en)
|
2012-09-14 |
2015-09-03 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US11060145B2
(en)
|
2013-03-13 |
2021-07-13 |
Sequenom, Inc. |
Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus
|
|
DK2992098T3
(da)
|
2013-05-01 |
2019-06-17 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
|
|
WO2015051283A1
(en)
|
2013-10-04 |
2015-04-09 |
Rana Therapeutics, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
|
JP2016537965A
(ja)
|
2013-10-11 |
2016-12-08 |
ジェネンテック, インコーポレイテッド |
Nsp4阻害剤及び使用方法
|
|
DK3077510T3
(da)
|
2013-12-02 |
2020-06-08 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser og anvendelser deraf
|
|
EP3736344A1
(de)
|
2014-03-13 |
2020-11-11 |
Sequenom, Inc. |
Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
|
|
EP3119789B1
(de)
|
2014-03-17 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Bicyclische carbocyclische nukleoside und daraus hergestellte oligomere verbindungen
|
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
WO2015168172A1
(en)
|
2014-04-28 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
EA036496B1
(ru)
|
2014-05-01 |
2020-11-17 |
Ионис Фармасьютикалз, Инк. |
Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b
|
|
US9382540B2
(en)
|
2014-05-01 |
2016-07-05 |
Isis Pharmaceuticals, Inc |
Compositions and methods for modulating angiopoietin-like 3 expression
|
|
KR102524543B1
(ko)
|
2014-06-10 |
2023-04-20 |
에라스무스 유니버시티 메디컬 센터 로테르담 |
폼페병의 치료에 유용한 안티센스 올리고뉴클레오티드
|
|
EP3169310A1
(de)
|
2014-07-15 |
2017-05-24 |
Life Technologies Corporation |
Zusammensetzungen mit lipidaggregaten und verfahren zur effizienten bereitstellung von molekülen an zellen
|
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
|
WO2016070060A1
(en)
|
2014-10-30 |
2016-05-06 |
The General Hospital Corporation |
Methods for modulating atrx-dependent gene repression
|
|
US11097005B2
(en)
|
2014-12-15 |
2021-08-24 |
The Brigham And Women's Hospital, Inc. |
Use of cadherin-11 antagonists to treat metabolic disorders and/or increase insulin sensitivity
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10758558B2
(en)
|
2015-02-13 |
2020-09-01 |
Translate Bio Ma, Inc. |
Hybrid oligonucleotides and uses thereof
|
|
WO2016149455A2
(en)
|
2015-03-17 |
2016-09-22 |
The General Hospital Corporation |
The rna interactome of polycomb repressive complex 1 (prc1)
|
|
AU2016276981B2
(en)
|
2015-06-12 |
2022-10-06 |
Alector Llc |
Anti-CD33 antibodies and methods of use thereof
|
|
HK1252675A1
(zh)
|
2015-06-12 |
2019-05-31 |
Alector Llc |
抗cd33抗体及其使用方法
|
|
KR20180054639A
(ko)
|
2015-08-28 |
2018-05-24 |
알렉터 엘엘씨 |
항-siglec-7 항체 및 이의 사용 방법
|
|
US12048753B2
(en)
|
2015-10-01 |
2024-07-30 |
Whitehead Institute For Biomedical Research |
Labeling of antibodies
|
|
CA3003458A1
(en)
|
2015-10-29 |
2017-05-04 |
Alector Llc |
Anti-siglec-9 antibodies and methods of use thereof
|
|
KR20250078597A
(ko)
|
2015-11-06 |
2025-06-02 |
아이오니스 파마수티컬즈, 인코포레이티드 |
아포리포프로테인 (a) 발현 조정
|
|
WO2017099579A1
(en)
|
2015-12-07 |
2017-06-15 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for pompe disease
|
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
|
US11400161B2
(en)
|
2016-10-06 |
2022-08-02 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
|
US11147249B2
(en)
|
2016-12-08 |
2021-10-19 |
Alector Llc |
Siglec transgenic mice and methods of use thereof
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
EP3625258A1
(de)
|
2017-05-16 |
2020-03-25 |
Alector LLC |
Anti-siglec-5-antikörper und verfahren zur verwendung davon
|
|
BR112019023789A2
(pt)
|
2017-08-03 |
2020-07-28 |
Alector Llc |
anticorpos anti-cd33 e métodos de uso dos mesmos
|
|
US11470827B2
(en)
|
2017-12-12 |
2022-10-18 |
Alector Llc |
Transgenic mice expressing human TREM proteins and methods of use thereof
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
JP7576835B2
(ja)
|
2018-03-22 |
2024-11-01 |
ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム |
自己免疫疾患および癌を治療するための可溶性インターロイキン7受容体(sIL7R)調節療法
|
|
CN119841953A
(zh)
|
2018-06-08 |
2025-04-18 |
艾利妥 |
抗siglec-7抗体及其使用方法
|
|
US12258398B2
(en)
|
2018-07-27 |
2025-03-25 |
Alector Llc |
Anti-Siglec-5 antibodies and methods of use thereof
|
|
CR20210155A
(es)
|
2018-08-31 |
2021-05-10 |
Alector Llc |
Anticuerpos anti-cd33 y métodos para usarlos
|
|
KR20220062517A
(ko)
|
2019-08-15 |
2022-05-17 |
아이오니스 파마수티컬즈, 인코포레이티드 |
결합 변형된 올리고머 화합물 및 이의 용도
|
|
SG10201914033YA
(en)
|
2019-12-31 |
2021-07-29 |
Wilmar International Ltd |
Polypeptides with Lipase Activity and Uses Thereof
|
|
CA3185019A1
(en)
|
2020-05-29 |
2021-12-02 |
Front Range Biosciences, Inc. |
Methods and compositions for pathogen detection in plants
|
|
US20230002779A1
(en)
|
2020-06-29 |
2023-01-05 |
Front Range Biosciences, Inc. |
Characterization of plant cultivars based on terpene synthase gene profiles
|
|
CR20250257A
(es)
|
2022-12-02 |
2025-08-28 |
Shanghai Argo Biopharmaceutical Co Ltd |
Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos
|
|
KR20250174651A
(ko)
|
2023-04-06 |
2025-12-12 |
상하이 아르고 바이오파마슈티칼 씨오., 엘티디. |
5'-포스포네이트 변형 뉴클레오시드 유사체 및 이로부터 제조된 올리고뉴클레오티드
|