DK0693077T3 - Antivirusforbindelser - Google Patents

Antivirusforbindelser

Info

Publication number: DK0693077T3
Authority: DK; Denmark
Prior art keywords: pct; nucleoside analog; mono; sec; formula
Prior art date: 1993-04-05

Application number

DK94912709T

Other languages

English (en)

Inventor

Kjell Torgeir Stokke

Bernt Borretzen

Are Dalen

Finn Myhren

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-05

Filing date

1994-04-05

Publication date

1999-06-14

1994-04-05 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK0693077T3 publication Critical patent/DK0693077T3/da

Links

230000002155 anti-virotic effect Effects 0.000 title 1
239000002777 nucleoside Substances 0.000 abstract 3
150000003833 nucleoside derivatives Chemical class 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002771 monosaccharide derivatives Chemical class 0.000 abstract 1
235000021315 omega 9 monounsaturated fatty acids Nutrition 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Public Health (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK94912709T 1993-04-05 1994-04-05 Antivirusforbindelser DK0693077T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939307043A GB9307043D0 (en)	1993-04-05	1993-04-05	Chemical compounds
PCT/NO1994/000071 WO1994022887A1 (en)	1993-04-05	1994-04-05	New antiviral compounds

Publications (1)

Publication Number	Publication Date
DK0693077T3 true DK0693077T3 (da)	1999-06-14

Family

ID=10733340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94912709T DK0693077T3 (da)	1993-04-05	1994-04-05	Antivirusforbindelser

Country Status (20)

Country	Link
US (1)	US6153594A (da)
EP (1)	EP0693077B1 (da)
JP (1)	JP3049258B2 (da)
KR (1)	KR100309194B1 (da)
AT (1)	ATE171457T1 (da)
AU (1)	AU685104B2 (da)
CA (1)	CA2158853C (da)
CZ (1)	CZ287755B6 (da)
DE (1)	DE69413529T2 (da)
DK (1)	DK0693077T3 (da)
ES (1)	ES2124883T3 (da)
FI (1)	FI111370B (da)
GB (1)	GB9307043D0 (da)
HU (1)	HU228064B1 (da)
NZ (1)	NZ263888A (da)
PL (1)	PL177263B1 (da)
RU (1)	RU2139884C1 (da)
SK (1)	SK281231B6 (da)
UA (1)	UA41361C2 (da)
WO (1)	WO1994022887A1 (da)

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GB9515279D0 (en)	1995-07-25	1995-09-20	Norsk Hydro As	Improved therapeutic agents
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
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US7235583B1 (en)	1999-03-09	2007-06-26	Luitpold Pharmaceuticals, Inc.,	Fatty acid-anticancer conjugates and uses thereof
TWI245047B (en)	1999-08-20	2005-12-11	Sankyo Co	Novel A-500359 derivatives
US7638496B2 (en)	2000-02-15	2009-12-29	Valeant Pharmaceuticals North America	Nucleoside analogs with carboxamidine modified monocyclic base
WO2001081359A1 (en) *	2000-04-20	2001-11-01	Schering Corporation	Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
KR20080021797A (ko)	2000-05-26	2008-03-07	이데닉스(케이만)리미티드	플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
US20030229082A1 (en) *	2002-01-16	2003-12-11	The Regents Of The University Of California	Inhibition of RNA function
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
PL374781A1 (en)	2002-06-28	2005-10-31	Idenix (Cayman) Limited	2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
NZ537662A (en)	2002-06-28	2007-10-26	Idenix Cayman Ltd	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US20040077607A1 (en) *	2002-10-21	2004-04-22	Uckun Fatih M.	Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
WO2004039995A1 (en) *	2002-11-01	2004-05-13	Evogenix Pty Ltd	Mutagenesis methods using ribavirin and/or rna replicases
HUE033832T2 (en)	2002-11-15	2018-01-29	Idenix Pharmaceuticals Llc	2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
TWI332507B (en) *	2002-11-19	2010-11-01	Hoffmann La Roche	Antiviral nucleoside derivatives
RU2005121904A (ru)	2002-12-12	2006-01-20	Айденикс (Кайман) Лимитед (Ky)	Способ получения 2`-разветвленных нуклеозидов
BRPI0408561A (pt) *	2003-03-20	2006-03-21	Microbiol Quimica Farmaceutica	métodos para manufatura de 2'-desoxi-59-l-nucleosìeos
US20070160554A1 (en) *	2003-11-03	2007-07-12	Cognis Ip Management Gmbh	Acyl ribonucleosides and acyl deoxyribonucleosides, compositions of, and methods of making same
FR2874016B1 (fr)	2004-06-30	2006-11-24	Centre Nat Rech Scient Cnrse	Nanoparticules de derives de la gemcitabine
WO2008147454A1 (en) *	2006-11-16	2008-12-04	Case Western Reserve University	Selective inhibitors of translesion dna replication
US8114847B2 (en)	2005-03-16	2012-02-14	Case Western Reserve University	Selective inhibitors of translesion DNA replication
NO324263B1 (no) *	2005-12-08	2007-09-17	Clavis Pharma Asa	Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
EP1976382B1 (en)	2005-12-23	2013-04-24	IDENIX Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
US8497292B2 (en)	2005-12-28	2013-07-30	Translational Therapeutics, Inc.	Translational dysfunction based therapeutics
UA99308C2 (ru) *	2007-09-26	2012-08-10	Маунт Синай Скул Оф Медсин	Аналог азацитидина и его применение
US9988680B2 (en)	2011-09-01	2018-06-05	Case Western Reserve University	Non-natural nucleosides as theranostic agents
US9821173B2 (en)	2013-02-08	2017-11-21	Case Western Reserve University	Anti-cancer agents and methods of use

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DE3100478A1 (de) *	1981-01-09	1982-08-12	Dr. Thilo & Co GmbH, 8021 Sauerlach	5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
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US5405837A (en) *	1993-05-18	1995-04-11	Indiana University Foundation	Method for the treatment of neoplastic disease utilizing tiazofurin and ribavirin
RU2071773C1 (ru) *	1993-07-19	1997-01-20	Товарищество с ограниченной ответственностью "Полисан"	Лекарственное средство для лечения синдромов приобретенного иммунодефицита, в том числе вич-обусловленных

1993
- 1993-04-05 GB GB939307043A patent/GB9307043D0/en active Pending
1994
- 1994-04-05 AU AU65141/94A patent/AU685104B2/en not_active Expired
- 1994-04-05 EP EP94912709A patent/EP0693077B1/en not_active Expired - Lifetime
- 1994-04-05 HU HU9502896A patent/HU228064B1/hu unknown
- 1994-04-05 PL PL94310970A patent/PL177263B1/pl unknown
- 1994-04-05 US US08/532,754 patent/US6153594A/en not_active Expired - Lifetime
- 1994-04-05 RU RU95119386A patent/RU2139884C1/ru active
- 1994-04-05 CA CA002158853A patent/CA2158853C/en not_active Expired - Lifetime
- 1994-04-05 CZ CZ19952593A patent/CZ287755B6/cs not_active IP Right Cessation
- 1994-04-05 DE DE69413529T patent/DE69413529T2/de not_active Expired - Lifetime
- 1994-04-05 SK SK1233-95A patent/SK281231B6/sk not_active IP Right Cessation
- 1994-04-05 UA UA95104367A patent/UA41361C2/uk unknown
- 1994-04-05 ES ES94912709T patent/ES2124883T3/es not_active Expired - Lifetime
- 1994-04-05 WO PCT/NO1994/000071 patent/WO1994022887A1/en not_active Ceased
- 1994-04-05 DK DK94912709T patent/DK0693077T3/da active
- 1994-04-05 NZ NZ263888A patent/NZ263888A/en not_active IP Right Cessation
- 1994-04-05 AT AT94912709T patent/ATE171457T1/de active
- 1994-04-05 KR KR1019950704292A patent/KR100309194B1/ko not_active Expired - Fee Related
- 1994-04-05 JP JP6521952A patent/JP3049258B2/ja not_active Expired - Lifetime
1995
- 1995-10-04 FI FI954727A patent/FI111370B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU228064B1 (en)	2012-09-28
FI111370B (fi)	2003-07-15
CZ259395A3 (en)	1996-06-12
SK281231B6 (sk)	2001-01-18
ATE171457T1 (de)	1998-10-15
EP0693077B1 (en)	1998-09-23
ES2124883T3 (es)	1999-02-16
WO1994022887A1 (en)	1994-10-13
UA41361C2 (uk)	2001-09-17
DE69413529T2 (de)	1999-04-29
CZ287755B6 (en)	2001-01-17
RU2139884C1 (ru)	1999-10-20
AU685104B2 (en)	1998-01-15
CA2158853C (en)	1999-07-27
HU9502896D0 (en)	1995-11-28
SK123395A3 (en)	1996-04-03
EP0693077A1 (en)	1996-01-24
CA2158853A1 (en)	1994-10-13
DE69413529D1 (de)	1998-10-29
FI954727A0 (fi)	1995-10-04
GB9307043D0 (en)	1993-05-26
JPH08508477A (ja)	1996-09-10
US6153594A (en)	2000-11-28
PL310970A1 (en)	1996-01-22
NZ263888A (en)	1998-05-27
HK1003437A1 (en)	1998-10-30
JP3049258B2 (ja)	2000-06-05
AU6514194A (en)	1994-10-24
PL177263B1 (pl)	1999-10-29
HUT73659A (en)	1996-09-30
FI954727L (fi)	1995-10-04
KR100309194B1 (ko)	2002-06-20

Publication	Publication Date	Title
DK0693077T3 (da)	1999-06-14	Antivirusforbindelser
SE9100342D0 (sv)	1991-02-04	Novel steroid esters
MX9205137A (es)	1993-04-01	O-heteroaril, o-alquilheteroaril, o-alquenilheteroaril y o-alquinilheteroarilmacrolidas que tienen actividad inmunosupresora.
DK0917540T3 (da)	2002-07-01	Termoplastisk forarbejdelige stivelses- eller stivelsesderivatpolymerblandinger
DK0670825T3 (da)	1997-10-13	Salpetersyreestere, der har farmakologisk aktivitet, og fremgangsmåde til deres fremstilling
TR200001982T2 (tr)	2001-02-21	Farmasötik vurulu salınımlı oral dozaj şekli.
EP0642525A1 (en)	1995-03-15	Chemical compounds.
ATE16488T1 (de)	1985-11-15	M-4- und isom-4-derivate, ihre herstellung und diese enthaltende zusammensetzungen.
MY106067A (en)	1995-03-31	Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors.
ATE214698T1 (de)	2002-04-15	Neue carbamazepin hapten analoge
ES2117976T3 (es)	1998-09-01	Preparacion de derivados n-acetil neuraminicos.
KR0140401B1 (en)	1998-06-01	Anti-bloom triglyceride compositions
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ES466037A1 (es)	1978-10-01	Un procedimiento para preparar derivados de oleandomicina.
DE69028320D1 (de)	1996-10-02	Illudin-analoge, verwendet als antitumormittel
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ATE92498T1 (de)	1993-08-15	Primycinkomponenten und verfahren zur trennung des antibiotischen komplexes.
ES8609482A1 (es)	1986-09-01	Un metodo para producir acido dihidrodesoxigriseolico y sa- les y esteres del mismo
DE3586344D1 (de)	1992-08-20	Esterderivate vom antibiotikum l 17046.
ES2074264T3 (es)	1995-09-01	Esteres de aminoacidos de la hidroquinona, su procedimiento de preparacion y composiciones farmaceuticas o cosmeticas que los contienen.
BR9707342A (pt)	1999-07-20	Dihidrobensofurano e compostos correlatod úteis como agentes antiinflamatórios
DE69120670D1 (de)	1996-08-08	Lipo-oligosaccharide als pflanzenspezifisches regulierendes mittel, verfahren zu ihrer herstellung und ihre verwendungen
ATE178334T1 (de)	1999-04-15	Di-lysogangliosidderivate
ES2144993T3 (es)	2000-07-01	Beta-dicetonas sustituidas y su uso en el tratamiento de enfermedades inflamatorias del intestino.
MX9301667A (es)	1993-11-01	Acidos 7-oxo-7h-pirido(1,2,3-de)(1,4)-benzoxacin-6-carboxilicos y sus esteres y medicamentos que los contienen.