ATE171457T1 - Antivirale verbindungen - Google Patents

Antivirale verbindungen

Info

Publication number
ATE171457T1
ATE171457T1 AT94912709T AT94912709T ATE171457T1 AT E171457 T1 ATE171457 T1 AT E171457T1 AT 94912709 T AT94912709 T AT 94912709T AT 94912709 T AT94912709 T AT 94912709T AT E171457 T1 ATE171457 T1 AT E171457T1
Authority
AT
Austria
Prior art keywords
pct
nucleoside analog
mono
sec
formula
Prior art date
Application number
AT94912709T
Other languages
English (en)
Inventor
Bernt Borretzen
Are Dalen
Finn Myhren
Kjell Torgeir Stokke
Original Assignee
Norsk Hydro As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro As filed Critical Norsk Hydro As
Application granted granted Critical
Publication of ATE171457T1 publication Critical patent/ATE171457T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
AT94912709T 1993-04-05 1994-04-05 Antivirale verbindungen ATE171457T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307043A GB9307043D0 (en) 1993-04-05 1993-04-05 Chemical compounds

Publications (1)

Publication Number Publication Date
ATE171457T1 true ATE171457T1 (de) 1998-10-15

Family

ID=10733340

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912709T ATE171457T1 (de) 1993-04-05 1994-04-05 Antivirale verbindungen

Country Status (20)

Country Link
US (1) US6153594A (de)
EP (1) EP0693077B1 (de)
JP (1) JP3049258B2 (de)
KR (1) KR100309194B1 (de)
AT (1) ATE171457T1 (de)
AU (1) AU685104B2 (de)
CA (1) CA2158853C (de)
CZ (1) CZ287755B6 (de)
DE (1) DE69413529T2 (de)
DK (1) DK0693077T3 (de)
ES (1) ES2124883T3 (de)
FI (1) FI111370B (de)
GB (1) GB9307043D0 (de)
HU (1) HU228064B1 (de)
NZ (1) NZ263888A (de)
PL (1) PL177263B1 (de)
RU (1) RU2139884C1 (de)
SK (1) SK281231B6 (de)
UA (1) UA41361C2 (de)
WO (1) WO1994022887A1 (de)

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CN100387237C (zh) * 1998-08-10 2008-05-14 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2'-脱氧-核苷
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
IL142423A0 (en) * 1998-10-16 2002-03-10 Schering Corp Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
US6277830B1 (en) 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
TWI245047B (en) 1999-08-20 2005-12-11 Sankyo Co Novel A-500359 derivatives
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
AU2001255495A1 (en) 2000-04-20 2001-11-07 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection
PY0111577A (es) 2000-05-23 2017-01-02 Idenix Cayman Ltd Métodos y composiciones para el tratamiento del virus de la hepatitis c
AP2006003708A0 (en) 2000-05-26 2006-08-31 Idenix Cayman Ltd Methods and compositions for treating flavivirusesand pestiviruses
AU2003222197A1 (en) * 2002-01-16 2003-09-02 The Regents Of The University Of California Inhibition of rna function
CN1678326A (zh) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
CA2503890A1 (en) * 2002-11-01 2004-05-13 Evogenix Pty Ltd Mutagenesis methods using ribavirin and/or rna replicases
RU2005118421A (ru) 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
PL377287A1 (pl) 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
WO2004084453A2 (en) * 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
WO2005049633A1 (en) * 2003-11-03 2005-06-02 Cognis Ip Management Gmbh Acyl ribonucleosides and acyl deoxyribonucleosides
FR2874016B1 (fr) * 2004-06-30 2006-11-24 Centre Nat Rech Scient Cnrse Nanoparticules de derives de la gemcitabine
US8114847B2 (en) 2005-03-16 2012-02-14 Case Western Reserve University Selective inhibitors of translesion DNA replication
WO2008147454A1 (en) * 2006-11-16 2008-12-04 Case Western Reserve University Selective inhibitors of translesion dna replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
US8497292B2 (en) 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
BRPI0817234A2 (pt) * 2007-09-26 2014-09-30 Sinai School Medicine Análogos de azacitidina e seus usos
WO2013033705A2 (en) 2011-09-01 2013-03-07 Case Western Reserve University Non-natural nucleosides as theranostic agents
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use

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Also Published As

Publication number Publication date
SK281231B6 (sk) 2001-01-18
FI111370B (fi) 2003-07-15
EP0693077B1 (de) 1998-09-23
DE69413529D1 (de) 1998-10-29
JP3049258B2 (ja) 2000-06-05
HU9502896D0 (en) 1995-11-28
HUT73659A (en) 1996-09-30
WO1994022887A1 (en) 1994-10-13
RU2139884C1 (ru) 1999-10-20
NZ263888A (en) 1998-05-27
CZ287755B6 (en) 2001-01-17
CA2158853A1 (en) 1994-10-13
GB9307043D0 (en) 1993-05-26
JPH08508477A (ja) 1996-09-10
PL177263B1 (pl) 1999-10-29
AU685104B2 (en) 1998-01-15
DE69413529T2 (de) 1999-04-29
SK123395A3 (en) 1996-04-03
CZ259395A3 (en) 1996-06-12
ES2124883T3 (es) 1999-02-16
FI954727L (fi) 1995-10-04
DK0693077T3 (da) 1999-06-14
KR100309194B1 (ko) 2002-06-20
UA41361C2 (uk) 2001-09-17
US6153594A (en) 2000-11-28
HU228064B1 (en) 2012-09-28
EP0693077A1 (de) 1996-01-24
CA2158853C (en) 1999-07-27
HK1003437A1 (en) 1998-10-30
FI954727A0 (fi) 1995-10-04
PL310970A1 (en) 1996-01-22
AU6514194A (en) 1994-10-24

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