DK0695183T3 - Anvendelse af thiazolidindioner til behandling af atherosklerose og spiseforstyrrelser - Google Patents

Anvendelse af thiazolidindioner til behandling af atherosklerose og spiseforstyrrelser

Info

Publication number: DK0695183T3
Authority: DK; Denmark
Prior art keywords: substituted; group; atherosclerosis; treatment; unsubstituted
Prior art date: 1993-04-23

Application number

DK94913693T

Other languages

English (en)

Inventor

Michael Anthony Cawthorne

Richard Mark Hindley

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-23

Filing date

1994-04-25

Publication date

2003-11-10

1994-04-25 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2003-11-10 Application granted granted Critical

2003-11-10 Publication of DK0695183T3 publication Critical patent/DK0695183T3/da

Links

201000001320 Atherosclerosis Diseases 0.000 title abstract 2
238000011282 treatment Methods 0.000 title abstract 2
208000030814 Eating disease Diseases 0.000 title 1
208000019454 Feeding and Eating disease Diseases 0.000 title 1
229940123464 Thiazolidinedione Drugs 0.000 title 1
235000014632 disordered eating Nutrition 0.000 title 1
150000001467 thiazolidinediones Chemical class 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000037406 food intake Effects 0.000 abstract 1
235000012631 food intake Nutrition 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
230000003893 regulation of appetite Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK94913693T 1993-04-23 1994-04-25 Anvendelse af thiazolidindioner til behandling af atherosklerose og spiseforstyrrelser DK0695183T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939308487A GB9308487D0 (en)	1993-04-23	1993-04-23	Novel compounds
PCT/GB1994/000879 WO1994025026A1 (en)	1993-04-23	1994-04-25	Use of thiazolidinediones for the treatment of atherosclerosis and eating disorders

Publications (1)

Publication Number	Publication Date
DK0695183T3 true DK0695183T3 (da)	2003-11-10

Family

ID=10734399

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94913693T DK0695183T3 (da)	1993-04-23	1994-04-25	Anvendelse af thiazolidindioner til behandling af atherosklerose og spiseforstyrrelser

Country Status (14)

Country	Link
EP (2)	EP1306086A3 (da)
JP (1)	JPH08509486A (da)
CN (1)	CN1121690A (da)
AT (1)	ATE245418T1 (da)
AU (1)	AU6574394A (da)
CA (1)	CA2161116A1 (da)
DE (1)	DE69432973T2 (da)
DK (1)	DK0695183T3 (da)
ES (1)	ES2202322T3 (da)
GB (1)	GB9308487D0 (da)
PT (1)	PT695183E (da)
SG (1)	SG47127A1 (da)
WO (1)	WO1994025026A1 (da)
ZA (1)	ZA942774B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5902726A (en) *	1994-12-23	1999-05-11	Glaxo Wellcome Inc.	Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
US5925656A (en) *	1995-04-10	1999-07-20	Dr. Reddy's Research Foundation	Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JPH09323930A (ja)	1996-04-04	1997-12-16	Takeda Chem Ind Ltd	悪液質の予防・治療剤
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) *	1996-05-06	1998-09-01	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973850B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US6114526A (en)	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CZ298812B6 (cs)	1996-07-01	2008-02-13	Dr. Reddy's Laboratories Limited	Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
JP2008094852A (ja) *	1996-07-15	2008-04-24	Daiichi Sankyo Co Ltd	医薬
CN1221417A (zh) *	1996-07-26	1999-06-30	雷迪博士研究基金会	具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物
US6011036A (en) *	1997-04-15	2000-01-04	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
US6011031A (en) *	1997-05-30	2000-01-04	Dr. Reddy's Research Foundation	Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
HU225919B1 (en) *	1999-12-18	2007-12-28	Richter Gedeon Nyrt	Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates
GB0023971D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
GB0023970D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
US8350007B2 (en)	2007-08-17	2013-01-08	The Regents Of The University Of California	Crystal structure of human mitoNEET protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG59988A1 (en) *	1987-09-04	1999-02-22	Beecham Group Plc	Substituted thiazolidinedione derivatives
GB8919417D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds
GB8919434D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds
TW222626B (da) *	1991-07-22	1994-04-21	Pfizer
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds

1993
- 1993-04-23 GB GB939308487A patent/GB9308487D0/en active Pending
1994
- 1994-04-21 ZA ZA942774A patent/ZA942774B/xx unknown
- 1994-04-25 WO PCT/GB1994/000879 patent/WO1994025026A1/en not_active Ceased
- 1994-04-25 SG SG1996009433A patent/SG47127A1/en unknown
- 1994-04-25 DE DE69432973T patent/DE69432973T2/de not_active Expired - Fee Related
- 1994-04-25 EP EP03075243A patent/EP1306086A3/en not_active Withdrawn
- 1994-04-25 DK DK94913693T patent/DK0695183T3/da active
- 1994-04-25 EP EP94913693A patent/EP0695183B1/en not_active Expired - Lifetime
- 1994-04-25 ES ES94913693T patent/ES2202322T3/es not_active Expired - Lifetime
- 1994-04-25 CN CN94191887A patent/CN1121690A/zh active Pending
- 1994-04-25 PT PT94913693T patent/PT695183E/pt unknown
- 1994-04-25 JP JP6524013A patent/JPH08509486A/ja not_active Ceased
- 1994-04-25 AU AU65743/94A patent/AU6574394A/en not_active Abandoned
- 1994-04-25 AT AT94913693T patent/ATE245418T1/de not_active IP Right Cessation
- 1994-04-25 CA CA002161116A patent/CA2161116A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1306086A3 (en)	2003-08-27
EP0695183A1 (en)	1996-02-07
EP0695183B1 (en)	2003-07-23
CA2161116A1 (en)	1994-11-10
ZA942774B (en)	1995-04-12
JPH08509486A (ja)	1996-10-08
CN1121690A (zh)	1996-05-01
SG47127A1 (en)	1998-03-20
AU6574394A (en)	1994-11-21
EP1306086A2 (en)	2003-05-02
PT695183E (pt)	2003-12-31
GB9308487D0 (en)	1993-06-09
DE69432973T2 (de)	2004-05-06
ES2202322T3 (es)	2004-04-01
ATE245418T1 (de)	2003-08-15
WO1994025026A1 (en)	1994-11-10
DE69432973D1 (de)	2003-08-28

Publication	Publication Date	Title
DK0695183T3 (da)	2003-11-10	Anvendelse af thiazolidindioner til behandling af atherosklerose og spiseforstyrrelser
DE3856378D1 (de)	1999-12-23	Substituierte Thiazolidindionderivate
ATE118487T1 (de)	1995-03-15	Thiazolidinedionederivate.
NO305318B1 (no)	1999-05-10	Heterocykliske forbindelser og anvendelser derav
ATE102193T1 (de)	1994-03-15	Thiazolidinedionederivate.
FI813033L (fi)	1982-04-04	Substituerade acylderivat av 1,2,3,4-tetrahydroisokinolin-3-karboxylsyror
DE69221794D1 (de)	1997-10-02	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
NO930783D0 (no)	1993-03-03	Kondenserte heterocykliske ketonderivater deres fremstilling og anveendelse
FI935798A0 (fi)	1993-12-22	Alkylsubstituerade heterocykliska foereningar
DK23089A (da)	1989-07-22	Thioformamidderivater og deres anvendelse
FR2549064B1 (fr)	1985-10-25	Nouveaux derives de synergistines utiles pour la preparation de nouveaux medicaments antimicrobiens et leur preparation