ATE245418T1 - Verwendung von thiazolidindionen zur behandlung von atherosklerose und essstörungen - Google Patents

Verwendung von thiazolidindionen zur behandlung von atherosklerose und essstörungen

Info

Publication number: ATE245418T1
Authority: AT; Austria
Prior art keywords: substituted; group; unsubstituted; thiazolidindiones; pharmaceutically acceptable
Prior art date: 1993-04-23

Application number

AT94913693T

Other languages

English (en)

Inventor

Michael Anthony Cawthorne

Richard Mark Hindley

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-23

Filing date

1994-04-25

Publication date

2003-08-15

1994-04-25 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245418T1 publication Critical patent/ATE245418T1/de

Links

201000001320 Atherosclerosis Diseases 0.000 title abstract 2
208000030814 Eating disease Diseases 0.000 title 1
208000019454 Feeding and Eating disease Diseases 0.000 title 1
235000014632 disordered eating Nutrition 0.000 title 1
150000001467 thiazolidinediones Chemical class 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000037406 food intake Effects 0.000 abstract 1
235000012631 food intake Nutrition 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
230000003893 regulation of appetite Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94913693T 1993-04-23 1994-04-25 Verwendung von thiazolidindionen zur behandlung von atherosklerose und essstörungen ATE245418T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939308487A GB9308487D0 (en)	1993-04-23	1993-04-23	Novel compounds
PCT/GB1994/000879 WO1994025026A1 (en)	1993-04-23	1994-04-25	Use of thiazolidinediones for the treatment of atherosclerosis and eating disorders

Publications (1)

Publication Number	Publication Date
ATE245418T1 true ATE245418T1 (de)	2003-08-15

Family

ID=10734399

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94913693T ATE245418T1 (de)	1993-04-23	1994-04-25	Verwendung von thiazolidindionen zur behandlung von atherosklerose und essstörungen

Country Status (14)

Country	Link
EP (2)	EP1306086A3 (de)
JP (1)	JPH08509486A (de)
CN (1)	CN1121690A (de)
AT (1)	ATE245418T1 (de)
AU (1)	AU6574394A (de)
CA (1)	CA2161116A1 (de)
DE (1)	DE69432973T2 (de)
DK (1)	DK0695183T3 (de)
ES (1)	ES2202322T3 (de)
GB (1)	GB9308487D0 (de)
PT (1)	PT695183E (de)
SG (1)	SG47127A1 (de)
WO (1)	WO1994025026A1 (de)
ZA (1)	ZA942774B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5902726A (en) *	1994-12-23	1999-05-11	Glaxo Wellcome Inc.	Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
US5925656A (en) *	1995-04-10	1999-07-20	Dr. Reddy's Research Foundation	Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JPH09323930A (ja) *	1996-04-04	1997-12-16	Takeda Chem Ind Ltd	悪液質の予防・治療剤
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5801173A (en) *	1996-05-06	1998-09-01	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CA2258949C (en)	1996-07-01	2008-05-06	Reddy-Cheminor, Inc.	Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
JP2008094852A (ja) *	1996-07-15	2008-04-24	Daiichi Sankyo Co Ltd	医薬
JP2000514041A (ja) *	1996-07-26	2000-10-24	ドクター・レディーズ・リサーチ・ファウンデーション	抗糖尿病、低脂血、抗高血圧特性を有するチアゾリジンジオン化合物、それらの調製法、及びその薬学的組成物
US6313113B1 (en)	1997-04-15	2001-11-06	Reddy-Cheminor, Inc.	Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) *	1997-05-30	2000-01-04	Dr. Reddy's Research Foundation	Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
HU225919B1 (en) *	1999-12-18	2007-12-28	Richter Gedeon Nyrt	Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates
GB0023970D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
GB0023971D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
WO2009026172A2 (en)	2007-08-17	2009-02-26	The Regents Of The University Of California	New approach for designing diabetes drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0842925A1 (de) *	1987-09-04	1998-05-20	Beecham Group Plc	Substituierte Thiazolidindionderivate
GB8919417D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds
GB8919434D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds
TW222626B (de) *	1991-07-22	1994-04-21	Pfizer
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds

1993
- 1993-04-23 GB GB939308487A patent/GB9308487D0/en active Pending
1994
- 1994-04-21 ZA ZA942774A patent/ZA942774B/xx unknown
- 1994-04-25 WO PCT/GB1994/000879 patent/WO1994025026A1/en not_active Ceased
- 1994-04-25 EP EP03075243A patent/EP1306086A3/de not_active Withdrawn
- 1994-04-25 PT PT94913693T patent/PT695183E/pt unknown
- 1994-04-25 SG SG1996009433A patent/SG47127A1/en unknown
- 1994-04-25 EP EP94913693A patent/EP0695183B1/de not_active Expired - Lifetime
- 1994-04-25 AT AT94913693T patent/ATE245418T1/de not_active IP Right Cessation
- 1994-04-25 JP JP6524013A patent/JPH08509486A/ja not_active Ceased
- 1994-04-25 ES ES94913693T patent/ES2202322T3/es not_active Expired - Lifetime
- 1994-04-25 DE DE69432973T patent/DE69432973T2/de not_active Expired - Fee Related
- 1994-04-25 CA CA002161116A patent/CA2161116A1/en not_active Abandoned
- 1994-04-25 AU AU65743/94A patent/AU6574394A/en not_active Abandoned
- 1994-04-25 DK DK94913693T patent/DK0695183T3/da active
- 1994-04-25 CN CN94191887A patent/CN1121690A/zh active Pending

Also Published As

Publication number	Publication date
SG47127A1 (en)	1998-03-20
CN1121690A (zh)	1996-05-01
PT695183E (pt)	2003-12-31
EP0695183A1 (de)	1996-02-07
WO1994025026A1 (en)	1994-11-10
GB9308487D0 (en)	1993-06-09
JPH08509486A (ja)	1996-10-08
AU6574394A (en)	1994-11-21
DK0695183T3 (da)	2003-11-10
DE69432973T2 (de)	2004-05-06
ES2202322T3 (es)	2004-04-01
EP0695183B1 (de)	2003-07-23
DE69432973D1 (de)	2003-08-28
EP1306086A2 (de)	2003-05-02
ZA942774B (en)	1995-04-12
EP1306086A3 (de)	2003-08-27
CA2161116A1 (en)	1994-11-10

Legal Events

Date

Code

Title

Description

2004-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0695183

Country of ref document: EP

2006-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE245418T1 (de)	2003-08-15	Verwendung von thiazolidindionen zur behandlung von atherosklerose und essstörungen
DE10199003I2 (de)	2003-09-18
ATE127797T1 (de)	1995-09-15	Aminocoumaranderivate, ihre herstellung und verwendung.
GB8919417D0 (en)	1989-10-11	Novel compounds
ATE102193T1 (de)	1994-03-15	Thiazolidinedionederivate.
ATE157355T1 (de)	1997-09-15	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
NO305318B1 (no)	1999-05-10	Heterocykliske forbindelser og anvendelser derav
ATE202702T1 (de)	2001-07-15	Verwendung von oestrogenagonisten und - antagonisten zur herstellung eines medikaments zur behandlung von atherosklerose, unabhängig von lipidsenkung
ATE246196T1 (de)	2003-08-15	Sulphostinanaloga und verfahren zur herstellung von sulphostin und analoga davon
ATE154020T1 (de)	1997-06-15	Kondensierte heterocyclische ketonderivate, ihre herstellung und ihre verwendung
DE69104314D1 (de)	1994-11-03	Verwendung von 1-[3-(Dimethylamino)propyl]-1-phenylphthalenen zur Behandlung zerebrovaskulärer Störungen.
ATE52499T1 (de)	1990-05-15	5-alkylsulfonylsalicylanilide und mikrobizide zusammensetzungen fuer die regulierung des wachstums von mikroorganismen.
ATE149494T1 (de)	1997-03-15	Benzopyranderivate und verfahren zu deren herstellung
FR2549064B1 (fr)	1985-10-25	Nouveaux derives de synergistines utiles pour la preparation de nouveaux medicaments antimicrobiens et leur preparation
ITMI920082A1 (it)	1993-07-17	Derivati solforati di acidi biliari
IT1261958B (it)	1996-06-11	2-(sostituite immino)-tiazolidine e procedimento per la loro preparazione e loro impiego quali antianginose e/o analgesiche