DK0696275T3 - Vitamin D-amid-derivater - Google Patents

Vitamin D-amid-derivater

Info

Publication number: DK0696275T3
Authority: DK; Denmark
Prior art keywords: group; pct; alpha; vitamin; sec
Prior art date: 1993-05-07

Application number

DK94914472T

Other languages

Danish (da)

English (en)

Inventor

Robert Henry Hesse

Sundara Katugam Srinivas Setty

Malathi Ramgopal

Original Assignee

Res Inst Medicine Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-07

Filing date

1994-05-06

Publication date

1998-11-09

1994-05-06 Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem

1998-11-09 Application granted granted Critical

1998-11-09 Publication of DK0696275T3 publication Critical patent/DK0696275T3/da

Links

229930003316 Vitamin D Natural products 0.000 title abstract 2
-1 Vitamin D amide Chemical class 0.000 title abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
235000019166 vitamin D Nutrition 0.000 title abstract 2
239000011710 vitamin D Substances 0.000 title abstract 2
229940046008 vitamin d Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000000962 organic group Chemical group 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Oncology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK94914472T 1993-05-07 1994-05-06 Vitamin D-amid-derivater DK0696275T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939309422A GB9309422D0 (en)	1993-05-07	1993-05-07	Chemical compounds
PCT/GB1994/000975 WO1994026707A1 (en)	1993-05-07	1994-05-06	Vitamin d amide derivatives

Publications (1)

Publication Number	Publication Date
DK0696275T3 true DK0696275T3 (da)	1998-11-09

Family

ID=10735089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94914472T DK0696275T3 (da)	1993-05-07	1994-05-06	Vitamin D-amid-derivater

Country Status (20)

Country	Link
US (1)	US5756733A (de)
EP (1)	EP0696275B1 (de)
JP (1)	JP3703099B2 (de)
KR (1)	KR100321414B1 (de)
CN (1)	CN1093852C (de)
AT (1)	ATE169617T1 (de)
AU (1)	AU678246B2 (de)
CA (1)	CA2162272A1 (de)
CZ (1)	CZ291238B6 (de)
DE (1)	DE69412476T2 (de)
DK (1)	DK0696275T3 (de)
ES (1)	ES2122275T3 (de)
FI (1)	FI112361B (de)
GB (1)	GB9309422D0 (de)
HU (1)	HUT74165A (de)
IL (1)	IL109595A (de)
NO (1)	NO309187B1 (de)
NZ (1)	NZ265665A (de)
WO (1)	WO1994026707A1 (de)
ZA (1)	ZA943162B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9405715D0 (en) *	1994-03-23	1994-05-11	Res Inst Medicine Chem	Chemical compounds
JP3314938B2 (ja) *	1995-06-06	2002-08-19	ファイザー・インコーポレーテッド	グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
GB9623569D0 (en) *	1996-11-13	1997-01-08	Immunodiagnostic Systems Ltd	Vitamin D immumoassay systems
US6043385A (en) *	1997-12-16	2000-03-28	Hoffman-La Roche Inc.	Vitamin D derivatives
GB9804861D0 (en) *	1998-03-06	1998-04-29	Res Inst Medicine Chem	Chemical compounds
WO2000024712A1 (en) *	1998-10-23	2000-05-04	Teijin Limited	Vitamin d3 derivatives and remedies for inflammatory respiratory diseases containing the same
KR20080045300A (ko) *	1999-02-08	2008-05-22	알자 코포레이션	안정한 비수성 단일상 점성 비히클 및 그 비히클을이용하는 제형물
DE19935771A1 (de) *	1999-07-23	2001-02-01	Schering Ag	Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6703380B2 (en)	1999-09-29	2004-03-09	Colotech A/S	Prevention of cancer
DE60019947T2 (de)	1999-09-29	2006-02-02	Colotech A/S	Prävention von kolorektalem Krebs
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
ES2364623T3 (es) *	2000-06-15	2011-09-08	Chugai Seiyaku Kabushiki Kaisha	Derivados de vitamina d que poseen un átomo 22-oxa o 22-tia, una cadena lateral c17 sustituida con un grupo ácido, éster o amida y un enlace doble 16(17).
CA2411409C (en) *	2000-06-15	2011-05-17	Chugai Seiyaku Kabushiki Kaisha	Vitamin d derivatives
US6277877B1 (en)	2000-08-15	2001-08-21	Pfizer, Inc.	Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
RU2323926C2 (ru) *	2000-12-08	2008-05-10	Чугаи Сейяку Кабусики Кайся	Способ карбонилирования
ES2315494T3 (es) *	2002-04-26	2009-04-01	Schering Corporation	Antagonistas muscarinicos.
CA2653772C (en) *	2006-06-02	2014-04-08	Nippon Shinyaku Co., Ltd.	9,10-secopregnane derivative and pharmaceutical
WO2009117831A1 (en) *	2008-03-27	2009-10-01	The Royal Institution For The Advancement Of Learning/Mcgill University	Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (de)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 und analoge davon zur behandlung von alopezie
WO2012151058A1 (en)	2011-05-03	2012-11-08	Wisconsin Alumni Research Foundation	(20s)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin d3 analogs and their uses
WO2012158794A1 (en)	2011-05-17	2012-11-22	Wisconsin Alumni Research Foundation	N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
US9338493B2 (en)	2014-06-30	2016-05-10	Apple Inc.	Intelligent automated assistant for TV user interactions
US10548908B2 (en)	2016-09-15	2020-02-04	Nostopharma, LLC	Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8929059D0 (en) *	1989-12-22	1990-02-28	Leo Pharm Prod Ltd	Chemical compounds
ES2083771T3 (es) *	1991-11-07	1996-04-16	Res Inst Medicine Chem	Derivados amidicos de la vitamina d.

1993
- 1993-05-07 GB GB939309422A patent/GB9309422D0/en active Pending
1994
- 1994-05-06 NZ NZ265665A patent/NZ265665A/en unknown
- 1994-05-06 CA CA002162272A patent/CA2162272A1/en not_active Abandoned
- 1994-05-06 AU AU66832/94A patent/AU678246B2/en not_active Ceased
- 1994-05-06 CN CN94192435A patent/CN1093852C/zh not_active Expired - Fee Related
- 1994-05-06 EP EP94914472A patent/EP0696275B1/de not_active Expired - Lifetime
- 1994-05-06 HU HU9503190A patent/HUT74165A/hu unknown
- 1994-05-06 KR KR1019950704980A patent/KR100321414B1/ko not_active Expired - Fee Related
- 1994-05-06 ZA ZA943162A patent/ZA943162B/xx unknown
- 1994-05-06 CZ CZ19952903A patent/CZ291238B6/cs not_active IP Right Cessation
- 1994-05-06 WO PCT/GB1994/000975 patent/WO1994026707A1/en not_active Ceased
- 1994-05-06 ES ES94914472T patent/ES2122275T3/es not_active Expired - Lifetime
- 1994-05-06 JP JP52511994A patent/JP3703099B2/ja not_active Expired - Fee Related
- 1994-05-06 DK DK94914472T patent/DK0696275T3/da active
- 1994-05-06 US US08/532,799 patent/US5756733A/en not_active Expired - Fee Related
- 1994-05-06 AT AT94914472T patent/ATE169617T1/de not_active IP Right Cessation
- 1994-05-06 DE DE69412476T patent/DE69412476T2/de not_active Expired - Fee Related
- 1994-05-08 IL IL10959594A patent/IL109595A/xx not_active IP Right Cessation
1995
- 1995-11-06 NO NO954426A patent/NO309187B1/no unknown
- 1995-11-06 FI FI955316A patent/FI112361B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI955316A0 (fi)	1995-11-06
EP0696275B1 (de)	1998-08-12
DE69412476T2 (de)	1999-03-11
CZ291238B6 (cs)	2003-01-15
WO1994026707A1 (en)	1994-11-24
NO954426D0 (no)	1995-11-06
CN1093852C (zh)	2002-11-06
DE69412476D1 (de)	1998-09-17
US5756733A (en)	1998-05-26
JPH08509971A (ja)	1996-10-22
CA2162272A1 (en)	1994-11-24
NO954426L (no)	1996-01-08
CZ290395A3 (en)	1996-06-12
CN1125436A (zh)	1996-06-26
NO309187B1 (no)	2000-12-27
AU6683294A (en)	1994-12-12
GB9309422D0 (en)	1993-06-23
AU678246B2 (en)	1997-05-22
JP3703099B2 (ja)	2005-10-05
NZ265665A (en)	1997-05-26
IL109595A0 (en)	1994-08-26
KR100321414B1 (ko)	2002-12-05
FI955316A7 (fi)	1995-12-22
EP0696275A1 (de)	1996-02-14
HU9503190D0 (en)	1996-01-29
ZA943162B (en)	1995-04-13
IL109595A (en)	1999-04-11
FI112361B (fi)	2003-11-28
HUT74165A (en)	1996-11-28
ATE169617T1 (de)	1998-08-15
ES2122275T3 (es)	1998-12-16

Publication	Publication Date	Title
ATE169617T1 (de)	1998-08-15	Vitamin-d-amid-derivate
PL326159A1 (en)	1998-08-31	Heterocyclic fungicides
DE69414115D1 (de)	1998-11-26	Vitamin d analoge
FI942114A0 (fi)	1994-05-06	D-vitamiiniamidijohdannaiset
DE69425980D1 (de)	2000-10-26	Vitamin d amin- und amidderivate
NO963949D0 (no)	1996-09-20	Amidderivater av vitamin D
DE69122812D1 (de)	1996-11-28	Glutathionderivat