DE69414115D1 - Vitamin d analoge - Google Patents

Vitamin d analoge

Info

Publication number
DE69414115D1
DE69414115D1 DE69414115T DE69414115T DE69414115D1 DE 69414115 D1 DE69414115 D1 DE 69414115D1 DE 69414115 T DE69414115 T DE 69414115T DE 69414115 T DE69414115 T DE 69414115T DE 69414115 D1 DE69414115 D1 DE 69414115D1
Authority
DE
Germany
Prior art keywords
alpha
vitamin
azide
optionally substituted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414115T
Other languages
English (en)
Other versions
DE69414115T2 (de
Inventor
Robert Hesse
Malathi Ramgopal
Gaddam Reddy
Sundara Setty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Publication of DE69414115D1 publication Critical patent/DE69414115D1/de
Application granted granted Critical
Publication of DE69414115T2 publication Critical patent/DE69414115T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69414115T 1993-07-23 1994-07-22 Vitamin d analoge Expired - Fee Related DE69414115T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939315253A GB9315253D0 (en) 1993-07-23 1993-07-23 Chemical compounds
PCT/GB1994/001587 WO1995003273A1 (en) 1993-07-23 1994-07-22 Vitamin d analogues

Publications (2)

Publication Number Publication Date
DE69414115D1 true DE69414115D1 (de) 1998-11-26
DE69414115T2 DE69414115T2 (de) 1999-04-08

Family

ID=10739292

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414115T Expired - Fee Related DE69414115T2 (de) 1993-07-23 1994-07-22 Vitamin d analoge

Country Status (20)

Country Link
US (2) US5872140A (de)
EP (1) EP0710227B1 (de)
JP (1) JPH09500637A (de)
KR (1) KR100321415B1 (de)
CN (1) CN1043883C (de)
AT (1) ATE172451T1 (de)
AU (1) AU690565B2 (de)
CA (1) CA2167837A1 (de)
CZ (1) CZ20796A3 (de)
DE (1) DE69414115T2 (de)
DK (1) DK0710227T3 (de)
ES (1) ES2125466T3 (de)
FI (1) FI113535B (de)
GB (1) GB9315253D0 (de)
HU (1) HU221597B (de)
IL (1) IL110415A (de)
NO (1) NO314453B1 (de)
NZ (1) NZ268659A (de)
WO (1) WO1995003273A1 (de)
ZA (1) ZA945427B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE60019947T2 (de) 1999-09-29 2006-02-02 Colotech A/S Prävention von kolorektalem Krebs
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6555573B2 (en) * 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
US20030105031A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Methods for the treatment of skin disorders
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
JP4833553B2 (ja) * 2002-11-04 2011-12-07 オーシャン・ニュートリション・カナダ・リミテッド 複数の殻を有するマイクロカプセル及びそれらの調製方法
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
EP1846355B1 (de) * 2005-01-27 2009-12-16 Ocean Nutrition Canada Limited Fettsäure-benzenediol-derivate sowie herstellungs- und verwendungsverfahren dafür
US20080206316A1 (en) * 2005-01-27 2008-08-28 Colin Barrow Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
CA2643662A1 (en) * 2006-04-07 2007-10-25 Ocean Nutrition Canada Ltd. Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof
CA2654031C (en) * 2006-06-05 2016-05-24 Ocean Nutrition Canada Limited Microcapsules with improved shells
WO2008085997A2 (en) 2007-01-10 2008-07-17 Ocean Nutrition Canada, Ltd. Vegetarian microcapsules
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (de) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 und analoge davon zur behandlung von alopezie
WO2012158794A1 (en) 2011-05-17 2012-11-22 Wisconsin Alumni Research Foundation N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN104926739B (zh) * 2015-06-09 2017-06-27 南京理工大学 基于氮杂环修饰的维生素d2衍生物、合成及应用
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67153A (en) * 1981-11-02 1986-12-31 Res Inst Medicine Chem Intermediates in the production of vitamin d analogues and method for their production
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5446635A (en) * 1993-06-24 1995-08-29 Quarton, Inc. Laser assembly for marking a line on a workpiece for guiding a cutting tool

Also Published As

Publication number Publication date
CN1043883C (zh) 1999-06-30
IL110415A (en) 2000-01-31
CA2167837A1 (en) 1995-02-02
HU9600136D0 (en) 1996-03-28
DK0710227T3 (da) 1999-06-28
FI960303L (fi) 1996-03-22
EP0710227A1 (de) 1996-05-08
ATE172451T1 (de) 1998-11-15
EP0710227B1 (de) 1998-10-21
IL110415A0 (en) 1996-03-31
NO960251L (no) 1996-03-22
NO960251D0 (no) 1996-01-22
US6013814A (en) 2000-01-11
NO314453B1 (no) 2003-03-24
ZA945427B (en) 1995-08-24
FI113535B (fi) 2004-05-14
US5872140A (en) 1999-02-16
ES2125466T3 (es) 1999-03-01
HUT73846A (en) 1996-09-30
NZ268659A (en) 1996-09-25
GB9315253D0 (en) 1993-09-08
DE69414115T2 (de) 1999-04-08
CZ20796A3 (en) 1996-10-16
JPH09500637A (ja) 1997-01-21
AU7193994A (en) 1995-02-20
KR100321415B1 (ko) 2002-11-13
FI960303A0 (fi) 1996-01-22
WO1995003273A1 (en) 1995-02-02
CN1129441A (zh) 1996-08-21
HU221597B (hu) 2002-11-28
AU690565B2 (en) 1998-04-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee