DK0712860T3 - Fremgangsmåde til oprensning og isolation af 2'-deoxy-2',2'-diflournukleosider - Google Patents

Fremgangsmåde til oprensning og isolation af 2'-deoxy-2',2'-diflournukleosider

Info

Publication number
DK0712860T3
DK0712860T3 DK95308034T DK95308034T DK0712860T3 DK 0712860 T3 DK0712860 T3 DK 0712860T3 DK 95308034 T DK95308034 T DK 95308034T DK 95308034 T DK95308034 T DK 95308034T DK 0712860 T3 DK0712860 T3 DK 0712860T3
Authority
DK
Denmark
Prior art keywords
deoxy
isolation
purification
nucleosides
difluoro
Prior art date
Application number
DK95308034T
Other languages
Danish (da)
English (en)
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0712860(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0712860T3 publication Critical patent/DK0712860T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DK95308034T 1994-11-17 1995-11-09 Fremgangsmåde til oprensning og isolation af 2'-deoxy-2',2'-diflournukleosider DK0712860T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (1)

Publication Number Publication Date
DK0712860T3 true DK0712860T3 (da) 2002-03-04

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95308034T DK0712860T3 (da) 1994-11-17 1995-11-09 Fremgangsmåde til oprensning og isolation af 2'-deoxy-2',2'-diflournukleosider

Country Status (34)

Country Link
US (1) US5606048A (cs)
EP (1) EP0712860B1 (cs)
JP (1) JPH10509170A (cs)
KR (1) KR100424990B1 (cs)
CN (1) CN1044119C (cs)
AR (1) AR001045A1 (cs)
AT (1) ATE210142T1 (cs)
AU (1) AU702588B2 (cs)
BG (1) BG62737B1 (cs)
BR (1) BR9509904A (cs)
CA (1) CA2205350C (cs)
CO (1) CO4600741A1 (cs)
CZ (1) CZ292013B6 (cs)
DE (1) DE69524365T2 (cs)
DK (1) DK0712860T3 (cs)
ES (1) ES2164745T3 (cs)
HU (1) HU219019B (cs)
IL (1) IL115854A (cs)
MX (1) MX9703548A (cs)
MY (1) MY115183A (cs)
NO (1) NO308305B1 (cs)
NZ (1) NZ296712A (cs)
PE (1) PE50196A1 (cs)
PL (1) PL182052B1 (cs)
PT (1) PT712860E (cs)
RO (1) RO118296B1 (cs)
RU (1) RU2161622C2 (cs)
SI (1) SI0712860T1 (cs)
SK (1) SK283160B6 (cs)
TW (1) TW377356B (cs)
UA (1) UA53614C2 (cs)
WO (1) WO1996016072A1 (cs)
YU (1) YU49446B (cs)
ZA (1) ZA959321B (cs)

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EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
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JP2009513623A (ja) 2005-10-28 2009-04-02 アーチ ファーマラブズ リミテッド 塩酸ジェムシタビンの改良された製造方法
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WO2007117760A2 (en) * 2006-02-06 2007-10-18 Dr. Reddy's Laboratories Ltd. Preparation of gemcitabine
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US7714012B2 (en) * 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
JP5349342B2 (ja) * 2007-03-23 2013-11-20 ドンウ シンテック カンパニー リミテッド ２’−デオキシ−２’，２’−ジフルオロシチジンの製造方法
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
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JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
PL2252283T3 (pl) 2008-01-11 2019-09-30 Reata Pharmaceuticals, Inc. Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
CA2721665C (en) * 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
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ES2449396T3 (es) * 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
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Also Published As

Publication number Publication date
DE69524365D1 (de) 2002-01-17
ES2164745T3 (es) 2002-03-01
NO972214L (no) 1997-05-14
CN1165519A (zh) 1997-11-19
RU2161622C2 (ru) 2001-01-10
WO1996016072A1 (en) 1996-05-30
AU4139396A (en) 1996-06-17
CZ148197A3 (en) 1997-08-13
UA53614C2 (uk) 2003-02-17
YU49446B (sh) 2006-03-03
SI0712860T1 (en) 2002-04-30
HU219019B (hu) 2001-01-29
CA2205350A1 (en) 1996-05-30
MX9703548A (es) 1997-08-30
JPH10509170A (ja) 1998-09-08
PE50196A1 (es) 1996-11-30
BG62737B1 (bg) 2000-06-30
NO972214D0 (no) 1997-05-14
EP0712860A3 (en) 1996-09-25
PL182052B1 (pl) 2001-10-31
CO4600741A1 (es) 1998-05-08
SK48597A3 (en) 1997-11-05
SK283160B6 (sk) 2003-03-04
BG101485A (en) 1998-03-31
ATE210142T1 (de) 2001-12-15
PL320634A1 (en) 1997-10-13
AU702588B2 (en) 1999-02-25
DE69524365T2 (de) 2002-08-14
CN1044119C (zh) 1999-07-14
AR001045A1 (es) 1997-09-24
CZ292013B6 (cs) 2003-07-16
IL115854A (en) 2000-07-16
US5606048A (en) 1997-02-25
TW377356B (en) 1999-12-21
BR9509904A (pt) 1997-10-14
KR100424990B1 (ko) 2004-05-20
RO118296B1 (ro) 2003-04-30
IL115854A0 (en) 1996-01-31
CA2205350C (en) 2007-09-04
EP0712860B1 (en) 2001-12-05
ZA959321B (en) 1997-05-05
EP0712860A2 (en) 1996-05-22
YU70995A (sh) 1998-09-18
NO308305B1 (no) 2000-08-28
PT712860E (pt) 2002-05-31
HUT77926A (hu) 1998-11-30
MY115183A (en) 2003-04-30
NZ296712A (en) 1999-01-28
KR970707143A (ko) 1997-12-01

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