DK0714400T3 - Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de - Google Patents

Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de

Info

Publication number: DK0714400T3
Authority: DK; Denmark
Prior art keywords: deoxy; benzoic acid; acid salt; thermodynamically stable; epimethylaminoavermectin
Prior art date: 1993-08-19

Application number

DK94926502T

Other languages

Danish (da)

English (en)

Inventor

Raymond Cvetovich

Richard Demchak

James A Mccauley

Richard J Varsalona

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-19

Filing date

1994-08-15

Publication date

2000-04-10

1994-08-15 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2000-04-10 Application granted granted Critical

2000-04-10 Publication of DK0714400T3 publication Critical patent/DK0714400T3/da

Links

150000001558 benzoic acid derivatives Chemical class 0.000 title abstract 2
239000013078 crystal Substances 0.000 title 1
ZFUKERYTFURFGA-UHFFFAOYSA-N Avermectin B1b Natural products O1C(C)C(O)C(OC)CC1OC1C(OC)CC(OC2C(=CCC3CC(CC4(O3)C=CC(C)C(C(C)C)O4)OC(=O)C3C=C(C)C(O)C4OCC(C34O)=CC=CC2C)C)OC1C ZFUKERYTFURFGA-UHFFFAOYSA-N 0.000 abstract 1
RRZXIRBKKLTSOM-UHFFFAOYSA-N avermectin B1a Natural products C1=CC(C)C(C(C)CC)OC11OC(CC=C(C)C(OC2OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C2)C(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 RRZXIRBKKLTSOM-UHFFFAOYSA-N 0.000 abstract 1
ZFUKERYTFURFGA-PVVXTEPVSA-N avermectin B1b Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C ZFUKERYTFURFGA-PVVXTEPVSA-N 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Environmental Sciences (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

DK94926502T 1993-08-19 1994-08-15 Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de DK0714400T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10918993A	1993-08-19	1993-08-19
PCT/US1994/009207 WO1995005390A1 (en)	1993-08-19	1994-08-15	THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4'-DEOXY-4'-EPI-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION

Publications (1)

Publication Number	Publication Date
DK0714400T3 true DK0714400T3 (da)	2000-04-10

Family

ID=22326282

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94926502T DK0714400T3 (da)	1993-08-19	1994-08-15	Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de

Country Status (25)

Country	Link
EP (1)	EP0714400B1 (pl)
JP (3)	JP3954093B2 (pl)
KR (1)	KR100370697B1 (pl)
CN (1)	CN1041523C (pl)
AT (1)	ATE187735T1 (pl)
AU (1)	AU684828B2 (pl)
BR (1)	BR9407300A (pl)
CA (1)	CA2168843C (pl)
CY (1)	CY2181B1 (pl)
CZ (1)	CZ287929B6 (pl)
DE (1)	DE69422182T2 (pl)
DK (1)	DK0714400T3 (pl)
ES (1)	ES2139753T3 (pl)
FI (2)	FI110783B (pl)
GR (1)	GR3032164T3 (pl)
HU (1)	HU217769B (pl)
LV (1)	LV12571B (pl)
NO (1)	NO305658B1 (pl)
NZ (1)	NZ273129A (pl)
PL (1)	PL176300B1 (pl)
PT (1)	PT714400E (pl)
RU (1)	RU2133753C1 (pl)
SK (1)	SK281684B6 (pl)
WO (1)	WO1995005390A1 (pl)
ZA (1)	ZA946203B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6486195B1 (en) *	1993-08-19	2002-11-26	Merck & Co., Inc.	Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
CR6574A (es)	2001-02-27	2004-10-28	Syngenta Participations Ag	Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
EG23124A (en) *	2001-02-27	2004-04-28	Syngenta Participations Ag	Avermectins substituted in the 4-position having pesticidal properties
GB0229804D0 (en) *	2002-12-20	2003-01-29	Syngenta Participations Ag	Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
DE102004057195A1 (de) *	2004-11-26	2006-06-01	Wilex Ag	Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon
WO2011105349A1 (ja) *	2010-02-23	2011-09-01	日本化薬株式会社	２－エチル－３，７－ジメチル－６－（４－（トリフルオロメトキシ）フェノキシ）キノリン－４－イルメチルカーボネートの安定型結晶およびその製造方法並びにその結晶を含有する農薬組成物
CN106995476B (zh) *	2017-05-16	2018-03-13	河北美荷药业有限公司	一种甲氨基阿维菌素b2苯甲酸盐的制备方法
CN108840893A (zh) *	2018-07-01	2018-11-20	李万强	一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN109912671B (zh) *	2019-04-12	2022-04-26	宁夏泰益欣生物科技有限公司	一种利用阿维菌素结晶母液提取阿维菌素B2a的方法

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SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
JPS57212200A (en) *	1981-06-23	1982-12-27	Takeda Chem Ind Ltd	Preparation of echinoside a
US4423209A (en) *	1982-02-26	1983-12-27	Merck & Co., Inc.	Processes for the interconversion of avermectin compounds
US4587247A (en) *	1985-02-25	1986-05-06	Merck & Co., Inc.	Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
GB8518422D0 (en) *	1985-07-22	1985-08-29	Beecham Group Plc	Compounds
SU1678210A3 (ru) *	1986-06-13	1991-09-15	Санкио Компани Лимитед (Фирма)	Способ получени макролидных соединений
AR243528A1 (es) *	1986-12-11	1993-08-31	Sankyo Co	Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
US4874749A (en) *	1987-07-31	1989-10-17	Merck & Co., Inc.	4"-Deoxy-4-N-methylamino avermectin Bla/Blb
DE3727648A1 (de) *	1987-08-19	1989-03-02	Bayer Ag	Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung
IT1216059B (it) *	1988-03-11	1990-02-22	Crc Ricerca Chim	Procedimento per la separazione di diastereomeri macrociclici.
JPH0631302B2 (ja) *	1988-11-16	1994-04-27	日本化薬株式会社	エトポシド−２−ジメチルアミノ体塩酸二水和結晶及びその製造法
US4897383A (en) *	1989-02-13	1990-01-30	Merck & Co., Inc.	Avermectin derivatives
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
JPH0446192A (ja) *	1990-06-12	1992-02-17	Nippon Kayaku Co Ltd	オキセタノシンｇ無水物結晶及びその製造法
IL98599A (en) *	1990-06-28	1995-06-29	Merck & Co Inc	Stable salts of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b and insecticidal compositions containing them
JP2652272B2 (ja) *	1990-12-31	1997-09-10	住化ファインケム株式会社	１−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
EP0590150B1 (en) *	1991-05-15	1998-07-08	Yamanouchi Pharmaceutical Co. Ltd.	(-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro 4,5]decane l-tartrate
JP2848721B2 (ja) *	1991-08-09	1999-01-20	森永乳業株式会社	結晶ラクチュロース三水和物とその製造法

1994
- 1994-08-15 CA CA002168843A patent/CA2168843C/en not_active Expired - Lifetime
- 1994-08-15 AT AT94926502T patent/ATE187735T1/de active
- 1994-08-15 JP JP50713095A patent/JP3954093B2/ja not_active Expired - Lifetime
- 1994-08-15 EP EP94926502A patent/EP0714400B1/en not_active Expired - Lifetime
- 1994-08-15 KR KR1019960700754A patent/KR100370697B1/ko not_active Expired - Lifetime
- 1994-08-15 DE DE69422182T patent/DE69422182T2/de not_active Expired - Lifetime
- 1994-08-15 HU HU9600345A patent/HU217769B/hu unknown
- 1994-08-15 PT PT94926502T patent/PT714400E/pt unknown
- 1994-08-15 PL PL94313043A patent/PL176300B1/pl unknown
- 1994-08-15 AU AU76319/94A patent/AU684828B2/en not_active Expired
- 1994-08-15 WO PCT/US1994/009207 patent/WO1995005390A1/en not_active Ceased
- 1994-08-15 NZ NZ273129A patent/NZ273129A/en not_active IP Right Cessation
- 1994-08-15 CN CN94193136A patent/CN1041523C/zh not_active Expired - Lifetime
- 1994-08-15 ES ES94926502T patent/ES2139753T3/es not_active Expired - Lifetime
- 1994-08-15 BR BR9407300A patent/BR9407300A/pt not_active IP Right Cessation
- 1994-08-15 DK DK94926502T patent/DK0714400T3/da active
- 1994-08-15 SK SK209-96A patent/SK281684B6/sk not_active IP Right Cessation
- 1994-08-15 CZ CZ1996459A patent/CZ287929B6/cs not_active IP Right Cessation
- 1994-08-15 RU RU96107041A patent/RU2133753C1/ru active
- 1994-08-17 ZA ZA946203A patent/ZA946203B/xx unknown
1996
- 1996-02-16 FI FI960725A patent/FI110783B/fi not_active IP Right Cessation
- 1996-02-16 NO NO960618A patent/NO305658B1/no not_active IP Right Cessation
1999
- 1999-12-16 GR GR990403202T patent/GR3032164T3/el unknown
2000
- 2000-08-10 CY CY0000041A patent/CY2181B1/xx unknown
- 2000-09-07 LV LVP-00-120A patent/LV12571B/en unknown
2002
- 2002-06-11 FI FI20021120A patent/FI111165B/fi not_active IP Right Cessation
2007
- 2007-02-09 JP JP2007030096A patent/JP2007176946A/ja not_active Withdrawn
2011
- 2011-05-25 JP JP2011117141A patent/JP2011207899A/ja active Pending

Also Published As

Publication number	Publication date
SK20996A3 (en)	1996-06-05
CA2168843A1 (en)	1995-02-23
LV12571A (en)	2000-11-20
JP3954093B2 (ja)	2007-08-08
HU9600345D0 (en)	1996-04-29
LV12571B (en)	2001-04-20
CA2168843C (en)	2004-10-19
NO960618L (no)	1996-02-16
JPH09502169A (ja)	1997-03-04
RU2133753C1 (ru)	1999-07-27
NO960618D0 (no)	1996-02-16
FI960725A0 (fi)	1996-02-16
AU684828B2 (en)	1998-01-08
EP0714400B1 (en)	1999-12-15
PT714400E (pt)	2000-05-31
ES2139753T3 (es)	2000-02-16
HU217769B (hu)	2000-04-28
CZ45996A3 (en)	1996-05-15
ATE187735T1 (de)	2000-01-15
NZ273129A (en)	1996-08-27
CN1129453A (zh)	1996-08-21
SK281684B6 (sk)	2001-06-11
BR9407300A (pt)	1996-10-08
DE69422182T2 (de)	2000-06-21
CN1041523C (zh)	1999-01-06
AU7631994A (en)	1995-03-14
JP2007176946A (ja)	2007-07-12
KR100370697B1 (ko)	2003-06-11
CZ287929B6 (cs)	2001-03-14
DE69422182D1 (de)	2000-01-20
NO305658B1 (no)	1999-07-05
PL176300B1 (pl)	1999-05-31
FI111165B (fi)	2003-06-13
FI20021120L (fi)	2002-06-11
WO1995005390A1 (en)	1995-02-23
GR3032164T3 (en)	2000-04-27
EP0714400A1 (en)	1996-06-05
KR960703936A (ko)	1996-08-31
FI110783B (fi)	2003-03-31
JP2011207899A (ja)	2011-10-20
FI960725L (fi)	1996-02-16
ZA946203B (en)	1995-03-31
PL313043A1 (en)	1996-05-27
CY2181B1 (en)	2002-08-23
HUT73552A (en)	1996-08-28

Publication	Publication Date	Title
IE802658L (en)	1981-06-18	Crystalline sweetener
DK0453899T3 (da)	1994-03-07	Anvendelse af alkylcarboxylsyre-dimethylamider som krystallisationsinhibitorer
PT84183A (pt)	1987-02-01	Process for the preparation of agrochemical compositions for reducing moisture loss from plants due to transpiration containing substituted nitrogen hexagonal or pentagonal heterocyclic compounds
DK0714400T3 (da)	2000-04-10	Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de
AU635415B2 (en)	1993-03-18	Use of n-alkyl-lactams as crystallization inhibitors
DK0737169T3 (da)	1999-09-27	Sammensætning til behandling af vand og rensning af jord
DK383788A (da)	1988-10-26	Hydroxyalkyl-azolyl-derivater, deres fremstilling og anvendelse som fungicider og plandtevaekstregulatorer
DE3470738D1 (en)	1988-06-01	Substituted 4,5-dimethoxypyridazones, process for their preparation, herbicides containing them and their use in combating the growth of undesirable plants
DK465484D0 (da)	1984-09-28	Cyclohexenon-derivater til anvendelse som herbicider og fremgangsmaade til fremstilling af saadanne derivater
DK54689A (da)	1989-09-26	Ferroelektrisk flydende-krystal-praeparat
ES2119919T3 (es)	1998-10-16	Derivados de dihidrobenzofurano, su preparacion y su utilizacion.
FR2424873A1 (fr)	1979-11-30	Hypochlorite de calcium dihydrate et sa preparation
AU6989487A (en)	1987-09-17	Phenylimidazolecarboxylic acid amides, their preparation and their use as growth regulators
ES2105927A1 (es)	1997-10-16	Procedimiento para el control de insectos.
HUT61655A (en)	1993-03-01	Selective herbicide compositions containing salicylic acid derivatives as active components and process for producing the active components
DE68919688D1 (de)	1995-01-12	Verfahren zur kristallisation von subtilisin.
BR8804998A (pt)	1989-05-02	Composicao e processo para proteger plantas de cultura e para o controle seletivo de ervas daninhas,derivados,processo para sua preparacao
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JPS5683410A (en)	1981-07-08	Plant growth regulator
JPS57131709A (en)	1982-08-14	Agricultural and horticultural fungicide
DK146992D0 (da)	1992-12-08	Sammensatte krystaller af sukker og salt samt fremgangsmaade til fremstilling af samme
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