DK0721459T3 - Hidtil ukendte oligosaccharidholdige 14-aminosteroidforbindelser og hidtil ukendt diastereoselektiv aminosteroidfremgangsmå - Google Patents

Hidtil ukendte oligosaccharidholdige 14-aminosteroidforbindelser og hidtil ukendt diastereoselektiv aminosteroidfremgangsmå

Info

Publication number: DK0721459T3
Authority: DK; Denmark
Prior art keywords: hydrogen; lower alkyl; acetoxy; carbon lower; benzoxy
Prior art date: 1993-09-24

Application number

DK94929315T

Other languages

Danish (da)

English (en)

Inventor

Paul Michael Dybas

Roland Norman Johnson

Randy Stuart Muth

David Edward Portlock

Song Liu

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-24

Filing date

1994-09-23

Publication date

2000-08-07

1994-09-23 Application filed by Procter & Gamble filed Critical Procter & Gamble

2000-08-07 Application granted granted Critical

2000-08-07 Publication of DK0721459T3 publication Critical patent/DK0721459T3/da

Links

150000002482 oligosaccharides Chemical class 0.000 title abstract 5
229920001542 oligosaccharide Polymers 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
NDDAQHROMJDMKS-XFYXLWKMSA-N [(2s,3s,5s,8r,9s,10s,13s,14s)-2-hydroxy-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]azanium;chloride Chemical compound Cl.C1[C@H](N)[C@@H](O)C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 NDDAQHROMJDMKS-XFYXLWKMSA-N 0.000 title 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 8
229910052799 carbon Inorganic materials 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 7
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000003277 amino group Chemical group 0.000 abstract 4
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 4
125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 4
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 4
150000003431 steroids Chemical class 0.000 abstract 4
125000001483 monosaccharide substituent group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
NPURPEXKKDAKIH-UHFFFAOYSA-N iodoimino(oxo)methane Chemical compound IN=C=O NPURPEXKKDAKIH-UHFFFAOYSA-N 0.000 abstract 2
-1 methylhydroxymethyl Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical group [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000005695 dehalogenation reaction Methods 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
External Artificial Organs (AREA)
Centrifugal Separators (AREA)

DK94929315T 1993-09-24 1994-09-23 Hidtil ukendte oligosaccharidholdige 14-aminosteroidforbindelser og hidtil ukendt diastereoselektiv aminosteroidfremgangsmå DK0721459T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12645993A	1993-09-24	1993-09-24
PCT/US1994/010778 WO1995008557A1 (fr)	1993-09-24	1994-09-23	Nouveaux composes 14-aminosteroides contenant un oligosaccharide, et nouveaux procedes de traitement chimique a l'aide des nouveaux aminosteroides diastereoselectifs

Publications (1)

Publication Number	Publication Date
DK0721459T3 true DK0721459T3 (da)	2000-08-07

Family

ID=22424936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94929315T DK0721459T3 (da)	1993-09-24	1994-09-23	Hidtil ukendte oligosaccharidholdige 14-aminosteroidforbindelser og hidtil ukendt diastereoselektiv aminosteroidfremgangsmå

Country Status (19)

Country	Link
US (2)	US5710259A (fr)
EP (2)	EP0721459B1 (fr)
JP (1)	JPH09502982A (fr)
KR (1)	KR960704914A (fr)
CN (1)	CN1135758A (fr)
AT (1)	ATE193538T1 (fr)
AU (1)	AU692187B2 (fr)
BR (1)	BR9407612A (fr)
CA (1)	CA2182530A1 (fr)
CZ (1)	CZ86696A3 (fr)
DE (1)	DE69424794D1 (fr)
DK (1)	DK0721459T3 (fr)
ES (1)	ES2146665T3 (fr)
GR (1)	GR3034028T3 (fr)
HU (1)	HUT74623A (fr)
NO (1)	NO961170L (fr)
PL (1)	PL313620A1 (fr)
RU (1)	RU2153503C2 (fr)
WO (1)	WO1995008557A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5922703A (en) *	1993-09-24	1999-07-13	The Procter & Gamble Company	Urethane-containing aminosteroid compounds
ES2343576T3 (es) *	2004-04-15	2010-08-04	Chr. Hansen A/S	Metodo para disminuir el contenido de organismos patogenos presentes en productos alimenticios.
CN107001528A (zh)	2014-07-09	2017-08-01	米德瑞（美国）有限公司	低聚糖组合物及其制备方法
HK1246600B (en)	2015-01-26	2020-04-09	Cadena Bio, Inc.	Oligosaccharide compositions for use animal feed and methods of producing thereof
HK1246604A1 (zh) *	2015-01-26	2018-09-14	Cadena Bio, Inc.	用作食品成分的寡糖组合物和其制造方法
CA2983236A1 (fr)	2015-04-23	2016-10-27	Kaleido Biosciences, Inc.	Agents therapeutiques de glycanes et procedes de traitement

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3567712A (en) *	1966-10-31	1971-03-02	Lepetit Spa	10beta-amino-estranes and method for the preparation thereof
FR2464270A1 (fr) *	1979-08-31	1981-03-06	Nativelle Sa Ets	Nouveaux derives d'amino-14 steroides, et procede pour leur preparation
ES8404693A1 (es) *	1982-08-12	1984-05-01	Nativelle Sa Ets	Procedimiento de preparacion de nuevos amino-14 esteroides.
NZ205293A (en) *	1982-08-20	1986-12-05	Nativelle Sa Ets	14-aminosteroids and pharmaceutical compositions
ES8404694A1 (es) *	1982-08-20	1984-05-01	Nativelle Sa Ets	Procedimiento de preparacion de nuevos derivos de amino-14 esteroides
DD256134A1 (de) *	1985-06-06	1988-04-27	Akad Wissenschaften Ddr	Verfahren zur herstellung von derivaten von cardenoliden und cardenolidanalogen verbindungen
US5175281A (en) *	1985-09-12	1992-12-29	The Upjohn Company	Pharmaceutically active pyrimidinylpiperazinylsterioids
GB8600490D0 (en) *	1986-01-09	1986-02-12	Erba Farmitalia	Aminoglycoside norcholanic acid lactams
FR2621316B1 (fr) *	1987-10-02	1991-06-21	Nativelle Sa Ets	Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant
US5144017A (en) *	1988-07-13	1992-09-01	University Of Manitoba	Compounds that bind to digitalis receptor
FR2642973A1 (fr) *	1989-02-03	1990-08-17	Cote Ivoire Ministere Rech Sc	Composition medicamenteuse renfermant comme principe actif un derive glucidique dioxymethyle de la strophanthidine
EP0530224A1 (fr) *	1990-05-07	1993-03-10	The Board Of Regents Of The University Of Washington	Nouveaux glycosides steroides utiles pour la detection precoce de l'hypertension
JPH0429089A (ja) *	1990-05-25	1992-01-31	Toshiba Corp	燃料集合体
WO1993005790A1 (fr) *	1991-09-27	1993-04-01	Procter & Gamble Pharmaceuticals, Inc.	Emploi de 14-aminosteroides dans la fabrication d'un medicament destine a ralentir la vitesse de progression d'alterations structurelles myocardiques caracteristique de l'insuffisance cardiaque congestive
US5922703A (en) *	1993-09-24	1999-07-13	The Procter & Gamble Company	Urethane-containing aminosteroid compounds
CZ86796A3 (en) *	1993-09-24	1996-10-16	Procter & Gamble	Novel deoxy and on oxygen substituted sugar derivatives of aminosteroidal compounds

1994
- 1994-09-23 WO PCT/US1994/010778 patent/WO1995008557A1/fr not_active Ceased
- 1994-09-23 CA CA002182530A patent/CA2182530A1/fr not_active Abandoned
- 1994-09-23 DK DK94929315T patent/DK0721459T3/da active
- 1994-09-23 AU AU78414/94A patent/AU692187B2/en not_active Ceased
- 1994-09-23 HU HU9600734A patent/HUT74623A/hu unknown
- 1994-09-23 DE DE69424794T patent/DE69424794D1/de not_active Expired - Lifetime
- 1994-09-23 AT AT94929315T patent/ATE193538T1/de not_active IP Right Cessation
- 1994-09-23 EP EP94929315A patent/EP0721459B1/fr not_active Expired - Lifetime
- 1994-09-23 EP EP98103012A patent/EP0863149A1/fr not_active Withdrawn
- 1994-09-23 ES ES94929315T patent/ES2146665T3/es not_active Expired - Lifetime
- 1994-09-23 CZ CZ96866A patent/CZ86696A3/cs unknown
- 1994-09-23 KR KR1019960701529A patent/KR960704914A/ko not_active Withdrawn
- 1994-09-23 CN CN94194217A patent/CN1135758A/zh active Pending
- 1994-09-23 BR BR9407612A patent/BR9407612A/pt not_active Application Discontinuation
- 1994-09-23 JP JP7509952A patent/JPH09502982A/ja active Pending
- 1994-09-23 PL PL94313620A patent/PL313620A1/xx unknown
- 1994-09-23 RU RU96108236/04A patent/RU2153503C2/ru active
1995
- 1995-06-02 US US08/459,911 patent/US5710259A/en not_active Expired - Fee Related
1996
- 1996-03-22 NO NO961170A patent/NO961170L/no unknown
1997
- 1997-02-20 US US08/802,491 patent/US5849889A/en not_active Expired - Fee Related
2000
- 2000-07-26 GR GR20000401719T patent/GR3034028T3/el unknown

Also Published As

Publication number	Publication date
ES2146665T3 (es)	2000-08-16
HUT74623A (en)	1997-01-28
WO1995008557A1 (fr)	1995-03-30
GR3034028T3 (en)	2000-11-30
AU7841494A (en)	1995-04-10
NO961170D0 (no)	1996-03-22
EP0863149A1 (fr)	1998-09-09
US5849889A (en)	1998-12-15
PL313620A1 (en)	1996-07-08
CN1135758A (zh)	1996-11-13
NO961170L (no)	1996-05-24
CZ86696A3 (en)	1996-10-16
US5710259A (en)	1998-01-20
BR9407612A (pt)	1997-01-14
HU9600734D0 (en)	1996-05-28
CA2182530A1 (fr)	1995-03-30
EP0721459B1 (fr)	2000-05-31
ATE193538T1 (de)	2000-06-15
JPH09502982A (ja)	1997-03-25
AU692187B2 (en)	1998-06-04
EP0721459A1 (fr)	1996-07-17
RU2153503C2 (ru)	2000-07-27
DE69424794D1 (de)	2000-07-06
KR960704914A (ko)	1996-10-09

Publication	Publication Date	Title
CA2290709A1 (fr)	1997-03-27	Composes 2,6-diaminopyridine en tant qu'intermediaires pour produire des derives de l'acide carboxylique dihydropyridone anti-bacteriens
AU8682191A (en)	1992-04-30	Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use
AU679859B2 (en)	1997-07-10	Novel compound, process for producing the same, and antitumor agent
EP0870765A4 (fr)	1998-10-14
HUP0000079A2 (hu)	2001-10-28	Indán- és dihidroindolszármazékok
CA1104126A (fr)	1981-06-30	Methode de production des derives de l'acide penicillanique
ATE161848T1 (de)	1998-01-15	Glycyrrheticsäurederivate
GB1519636A (en)	1978-08-02	Derivatives of histidyl-prolinamide
DK0721459T3 (da)	2000-08-07	Hidtil ukendte oligosaccharidholdige 14-aminosteroidforbindelser og hidtil ukendt diastereoselektiv aminosteroidfremgangsmå
ATE98253T1 (de)	1993-12-15	Synthese von 6-methylenandrosta-1,4-dien-3,17dion-derivate.
KR860007201A (ko)	1986-10-08	항생 작용을 갖는 악타가르딘의 염기성 모노카르복시아미드 유도체의 제조방법
KR950703557A (ko)	1995-09-20	약제로서 사용되는 헤테로아릴 화합물(Heteroaryl Compounds Used as Pharmaceuticals)
MX9800904A (es)	1998-11-30	Proceso para producir derivados de eritromicina.
HUT50337A (en)	1990-01-29	Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
IL132799A0 (en)	2001-03-19	17Beta-allyloxy(thio)alkyl-androstane derivatives for the modulation of meiosis
AU3285000A (en)	2000-09-28	22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
KR880009986A (ko)	1988-10-06	에르골리닐 헤테로사이클
IE790872L (en)	1978-10-27	Piperazine methanimine derivatives
CA2377233A1 (fr)	2001-01-04	Intermediaires pour la synthese de composes de benzimidazole et procede de preparation
JPS61152676A (ja)	1986-07-11	ジベンズ〔ｂ，ｅ〕オキセピン誘導体の製造法
KR880000429A (ko)	1988-03-25	T-부틸 에르골린 유도체
ES2000330A6 (es)	1988-02-16	Procedkimiento para la preparacion de derivados de n-metilados de la ergolina
KR900701752A (ko)	1990-12-06	인돌 아세트산 유도체, 그의 제조법 및 이를 유효성분으로 하는 의약
US3666755A (en)	1972-05-30	2-imidazolylbicyclo{8 2.2.2{9 octanes
MX9407369A (es)	2002-08-20	Compuestos 14-aminoesteroides novedosos desoxi y oxigeno sustituidos que contienen azucar.