DK1571208T3 - Fremgangsmåde til ny faktor IX-rensning - Google Patents

Fremgangsmåde til ny faktor IX-rensning

Info

Publication number: DK1571208T3
Authority: DK; Denmark
Prior art keywords: purification; procedure; new factor; factor; hydroxyapatite
Prior art date: 1995-06-07

Application number

DK05012614.3T

Other languages

English (en)

Inventor

W Barry Foster

Robert J Costigan

Duane Bonam

Mary B Switzer

Rochelle Walsh

Original Assignee

Genetics Inst Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-05-21

Publication date

2011-01-24

1996-05-21 Application filed by Genetics Inst Llc filed Critical Genetics Inst Llc

2011-01-24 Application granted granted Critical

2011-01-24 Publication of DK1571208T3 publication Critical patent/DK1571208T3/da

Links

102100022641 Coagulation factor IX Human genes 0.000 title abstract 2
108010076282 Factor IX Proteins 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000000746 purification Methods 0.000 title abstract 2
229960004222 factor ix Drugs 0.000 title 1
238000005571 anion exchange chromatography Methods 0.000 abstract 1
229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
238000001597 immobilized metal affinity chromatography Methods 0.000 abstract 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK05012614.3T 1995-06-07 1996-05-21 Fremgangsmåde til ny faktor IX-rensning DK1571208T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/472,823 US5714583A (en)	1995-06-07	1995-06-07	Factor IX purification methods
EP96915892A EP0832200B1 (en)	1995-06-07	1996-05-21	Novel factor ix purification methods

Publications (1)

Publication Number	Publication Date
DK1571208T3 true DK1571208T3 (da)	2011-01-24

Family

ID=23877079

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK05012614.3T DK1571208T3 (da)	1995-06-07	1996-05-21	Fremgangsmåde til ny faktor IX-rensning
DK96915892T DK0832200T3 (da)	1995-06-07	1996-05-21	Nye metoder til rensning af faktor IX

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK96915892T DK0832200T3 (da)	1995-06-07	1996-05-21	Nye metoder til rensning af faktor IX

Country Status (11)

Country	Link
US (2)	US5714583A (da)
EP (2)	EP1571208B1 (da)
JP (1)	JP3676817B2 (da)
AT (2)	ATE393217T1 (da)
AU (1)	AU5754396A (da)
CA (1)	CA2220501C (da)
DE (2)	DE69637509T2 (da)
DK (2)	DK1571208T3 (da)
ES (2)	ES2306450T3 (da)
PT (2)	PT832200E (da)
WO (1)	WO1996040883A1 (da)

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US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
PT1223990E (pt)	1999-10-15	2004-12-31	Fidia Advanced Biopolymers Srl	Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
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TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
KR100451308B1 (ko) *	2001-12-28	2004-10-06	선바이오(주)	단백질 의약품 정제 방법에서의 바이러스 제거 방법
JP2006517415A (ja)	2003-01-09	2006-07-27	ジェネンテック・インコーポレーテッド	ポリペプチドの精製
MXPA05010846A (es) *	2003-04-09	2006-03-30	Nektar Therapeutics	Tratamiento de hemofilia mediante inhalacion de factores de coagulacion.
KR101146160B1 (ko) *	2004-06-30	2012-07-16	넥타르 테라퓨틱스	중합체인자 ｉｘ 부분의 접합체
EP1969127B8 (en)	2005-12-21	2017-12-13	Aptevo BioTherapeutics LLC	Method of producing biologically active vitamin k dependent proteins by recombinant methods
EP2004683B1 (en) *	2006-03-24	2016-05-11	Biogen Hemophilia Inc.	Pc5 as a factor ix propeptide processing enzyme
WO2008104372A1 (en) *	2007-02-28	2008-09-04	Baxter International Inc.	Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules
AU2008245524A1 (en) *	2007-04-26	2008-11-06	Cnj Holdings, Inc.	Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
RU2353386C1 (ru) *	2007-10-11	2009-04-27	Общество с ограниченной ответственностью "БиоГениус"	Способ получения концентрата ix фактора свертывания крови человека
CN101889025B (zh)	2007-10-30	2013-11-13	健泰科生物技术公司	通过阳离子交换层析进行的抗体纯化
US20110166332A1 (en) *	2008-09-12	2011-07-07	Ge Healthcare Bio-Sciences Ab	Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions
FR2946348B1 (fr)	2009-06-05	2011-08-05	Lab Francais Du Fractionnement	Procede de preparation d'une composition de complexe prothrombique a haut degre de purete
DK2451963T3 (da)	2009-07-10	2014-08-04	Csl Ltd	Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse
WO2011053738A1 (en)	2009-10-30	2011-05-05	Inspiration Biopharmaceuticals, Inc.	Method of producing recombinant vitamin k dependent proteins
WO2011064247A1 (en)	2009-11-24	2011-06-03	Novo Nordisk Health Care Ag	Method of purifying pegylated proteins
EP2553095B1 (en) *	2010-03-30	2016-10-12	Octapharma AG	A process for purifying vitamin K dependent proteins such as coagulation factor IX
DK2552948T3 (da)	2010-03-30	2016-10-17	Octapharma Ag	Fremgangsmåde til rensning af vækstfaktorprotein G-CSF
MX336728B (es) *	2010-04-29	2016-01-27	Baxter Int	Metodo de purificacion para proteinas de union de cation divalente en resina de intercambio anionico.
CA2821711C (en)	2010-12-15	2017-10-10	Baxter International Inc.	Eluate collection using conductivity gradient
BRPI1105317A2 (pt)	2011-01-24	2013-04-30	Fundacco Hemoct De Ribeirco Preto	produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
CN103814137A (zh) *	2011-09-06	2014-05-21	米迪缪尼有限公司	处理凝血因子的方法
AU2012322948B2 (en)	2011-10-14	2014-11-06	Takeda Pharmaceutical Company Limited	Protein purification by anion exchange chromatography
JP6117219B2 (ja)	2011-10-14	2017-04-19	バクスアルタゲーエムベーハー	陰イオン交換クロマトグラフィによるタンパク質の精製方法
WO2014140289A1 (en)	2013-03-15	2014-09-18	Baxter International Inc.	Purification method for vitamin k dependent proteins by anion exchange chromatography
US9663553B2 (en)	2014-01-29	2017-05-30	Hemarus Therapeutics Limited	Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
CN114134109B (zh) *	2021-12-10	2023-01-24	广州远想生物科技股份有限公司	Egf间充质干细胞外泌体的纯化方法

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DE3101752A1 (de) *	1981-01-21	1982-08-26	Behringwerke Ag, 3550 Marburg	"verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
US4447416A (en) *	1982-04-28	1984-05-08	American National Red Cross	Plasma protein concentrates of reduced thrombogenicity and their use in clinical replacement therapy
US5055557A (en) *	1983-03-04	1991-10-08	Scripps Clinic & Research Foundation	Ultrapurification of factor IX and other vitamin K-dependent proteins
JPS61500226A (ja) *	1983-10-28	1986-02-06	ニュ−・イングランド・メディカル・センタ−・ホスピタルズ・インコ−ポレ−テッド	コンホメ−ション特異性抗体を用いる血液凝固タンパク質の精製および単離法
US4721572A (en) *	1985-07-12	1988-01-26	Miles Laboratories, Inc.	Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4786726A (en) *	1986-01-06	1988-11-22	Blood Systems, Inc.	Factor IX therapeutic blood product, means and methods of preparing same
US4725673A (en) *	1986-08-29	1988-02-16	Alpha Therapeutic Corporation	Plasma fraction purification using silica resin bound to a ligand
US4831118A (en) *	1987-08-07	1989-05-16	Scripps Clinic And Research Foundation	Flouroplastic immunoaffinity columns for purification of blood proteins
DE3877529T2 (de) *	1987-10-23	1996-11-07	Centre Regional De Transfusion	Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
WO1989005652A1 (en) *	1987-12-21	1989-06-29	American National Red Cross	Pure factor ix product
GB8729822D0 (en) *	1987-12-22	1988-02-03	Central Blood Lab Authority	Chemical process
CA1330302C (en) *	1988-01-18	1994-06-21	Miroslav Rybak	Concentrates of coagulation factors ii, vii, ix and x, method of their preparation and use
DE3826792C1 (da) *	1988-08-06	1989-07-06	Biotest Pharma Gmbh, 6072 Dreieich, De
US4981952A (en) *	1988-10-04	1991-01-01	Eli Lilly And Company	Method for the purification of vitamin K-dependent proteins
DE3914869C1 (da) *	1989-05-05	1990-08-09	Biotest Pharma Gmbh, 6072 Dreieich, De
AT402261B (de) *	1991-01-25	1997-03-25	Immuno Ag	Komplex enthaltend den gerinnungsfaktor ix
IT1262899B (it) *	1992-03-27	1996-07-22	Sclavo Spa	Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano
US5714583A (en) *	1995-06-07	1998-02-03	Genetics Institute, Inc.	Factor IX purification methods

1995
- 1995-06-07 US US08/472,823 patent/US5714583A/en not_active Expired - Lifetime
1996
- 1996-05-21 DE DE69637509T patent/DE69637509T2/de not_active Expired - Lifetime
- 1996-05-21 WO PCT/US1996/007305 patent/WO1996040883A1/en not_active Ceased
- 1996-05-21 DK DK05012614.3T patent/DK1571208T3/da active
- 1996-05-21 PT PT96915892T patent/PT832200E/pt unknown
- 1996-05-21 EP EP05012614A patent/EP1571208B1/en not_active Expired - Lifetime
- 1996-05-21 AT AT96915892T patent/ATE393217T1/de active
- 1996-05-21 ES ES96915892T patent/ES2306450T3/es not_active Expired - Lifetime
- 1996-05-21 ES ES05012614T patent/ES2353798T3/es not_active Expired - Lifetime
- 1996-05-21 EP EP96915892A patent/EP0832200B1/en not_active Expired - Lifetime
- 1996-05-21 AT AT05012614T patent/ATE488582T1/de active
- 1996-05-21 CA CA2220501A patent/CA2220501C/en not_active Expired - Lifetime
- 1996-05-21 JP JP50062497A patent/JP3676817B2/ja not_active Expired - Lifetime
- 1996-05-21 AU AU57543/96A patent/AU5754396A/en not_active Abandoned
- 1996-05-21 DK DK96915892T patent/DK0832200T3/da active
- 1996-05-21 DE DE69638291T patent/DE69638291D1/de not_active Expired - Lifetime
- 1996-05-21 PT PT05012614T patent/PT1571208E/pt unknown
1997
- 1997-10-17 US US08/953,143 patent/US6627737B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2306450T3 (es)	2008-11-01
EP0832200B1 (en)	2008-04-23
CA2220501A1 (en)	1996-12-19
DE69638291D1 (de)	2010-12-30
JP3676817B2 (ja)	2005-07-27
PT832200E (pt)	2008-07-17
DE69637509D1 (de)	2008-06-05
DK0832200T3 (da)	2008-07-21
ES2353798T3 (es)	2011-03-07
AU5754396A (en)	1996-12-30
ATE488582T1 (de)	2010-12-15
EP0832200A1 (en)	1998-04-01
DE69637509T2 (de)	2009-05-28
JPH11506603A (ja)	1999-06-15
EP1571208A1 (en)	2005-09-07
EP1571208B1 (en)	2010-11-17
US5714583A (en)	1998-02-03
CA2220501C (en)	2014-01-07
US6627737B1 (en)	2003-09-30
PT1571208E (pt)	2011-01-04
ATE393217T1 (de)	2008-05-15
WO1996040883A1 (en)	1996-12-19

Publication	Publication Date	Title
DK1571208T3 (da)	2011-01-24	Fremgangsmåde til ny faktor IX-rensning
PT1015585E (pt)	2006-10-31	Homologos de ligandos de tie
IL132249A0 (en)	2001-03-19	Type ii tgf-beta receptor/immunoglobulin constant region fusion proteins
DE69602638D1 (de)	1999-07-08	Naphthylverbindungen, Zwischenprodukte, Zusammensetzungen und Methoden
CA2220447A1 (en)	1996-12-05	Novel fusion protein recovery and purification methods
SE9404250D0 (sv)	1994-12-07	Affinity separation method
CA2132533A1 (en)	1993-09-30	Protein purification
ITTO940751A0 (it)	1994-09-28	Procedimento per la produzione di carburo di ferro.
DE69023413D1 (de)	1995-12-14	Reinigung des Faktor-VIII-Komplexes unter Anwendung von Heparinaffinitätschromatographie.
ATE167670T1 (de)	1998-07-15	N-alkylthiopolyaminderivate als radioprotektive mittel
NO961604L (no)	1996-06-21	Ketogruppe-introduserende enzym, DNA som koder for samme, samt fremgangsmåte for fremstilling av ketokarotenoid
ATE88718T1 (de)	1993-05-15	Verfahren zur reinigung des hepatitis-oberflaechen-antigens und das so erhaltene produkt.
DK0770077T3 (da)	2002-01-14	Fremgangsmåde til fremstilling af 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1h-benz[de]isoquinolin-1-on og mellemprodukter
EP0577253A3 (en)	1995-04-05	Enrichment of Quinuklidinolenantiomere.
DE58900532D1 (de)	1992-01-16	Verfahren zur herstellung von bifunktionellen anionenaustauschharzen, neue bifunktionelle anionenaustauschharze und ihre verwendung.
PL331321A1 (en)	1999-07-05	Treatment pf psychotic disorders
DK0815092T3 (da)	1999-12-06	Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
DK0683168T3 (da)	2001-12-03	Fremgangsmåde til fremstilling af 2-methylspiro(1,3-oxathiolan-5,3')quinuclidin
NO972221L (no)	1997-05-14	Fremgangsmåte for spyttanalyse
WO1997035015A3 (de)	1997-12-18	Tyrosin-phosphatase-verwandtes protein
DE59611293D1 (de)	2005-12-15	Protein mit dnase-aktivität
DE59601911D1 (de)	1999-06-24	Expansionsbindemittel
DE59405085D1 (de)	1998-02-26	Verfahren zur Herstellung von Tetrachlor-1,4-benzochinon
WO1998030687A3 (de)	1998-09-11	Srcr domäne-enthaltendes protein
WO1998044103A3 (de)	1999-03-18	Protein zur inhibierung von apoptose