DK0725794T3 - Human monocyt-kemoattraktant protein-1 (MCP-1) derivater - Google Patents

Human monocyt-kemoattraktant protein-1 (MCP-1) derivater

Info

Publication number: DK0725794T3
Authority: DK; Denmark
Prior art keywords: mcp; derivatives; monocyte chemoattractant; substituted; activity
Prior art date: 1993-11-12

Application number

DK95902480T

Other languages

English (en)

Inventor

Barrett Rollins

Yu Jun Zhang

Original Assignee

Dana Farber Cancer Inst Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-12

Filing date

1994-11-07

Publication date

2001-12-10

1994-11-07 Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc

2001-12-10 Application granted granted Critical

2001-12-10 Publication of DK0725794T3 publication Critical patent/DK0725794T3/da

Links

101710155857 C-C motif chemokine 2 Proteins 0.000 title abstract 5
101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 title abstract 3
102000046768 human CCL2 Human genes 0.000 title abstract 3
102000000018 Chemokine CCL2 Human genes 0.000 title 1
102100021943 C-C motif chemokine 2 Human genes 0.000 abstract 4
102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 abstract 3
108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 abstract 3
230000031902 chemoattractant activity Effects 0.000 abstract 3
229940009098 aspartate Drugs 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
238000002399 angioplasty Methods 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical group N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 abstract 1
210000004351 coronary vessel Anatomy 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK95902480T 1993-11-12 1994-11-07 Human monocyt-kemoattraktant protein-1 (MCP-1) derivater DK0725794T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US15230193A	1993-11-12	1993-11-12
PCT/US1994/012874 WO1995013295A1 (en)	1993-11-12	1994-11-07	Human monocyte chemoattractant protein-1 (mcp-1) derivatives

Publications (1)

Publication Number	Publication Date
DK0725794T3 true DK0725794T3 (da)	2001-12-10

Family

ID=22542340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95902480T DK0725794T3 (da)	1993-11-12	1994-11-07	Human monocyt-kemoattraktant protein-1 (MCP-1) derivater

Country Status (10)

Country	Link
US (1)	US5459128A (da)
EP (1)	EP0725794B1 (da)
JP (3)	JP4040083B2 (da)
AT (1)	ATE204583T1 (da)
CA (1)	CA2176217A1 (da)
DE (1)	DE69428049T2 (da)
DK (1)	DK0725794T3 (da)
ES (1)	ES2162908T3 (da)
PT (1)	PT725794E (da)
WO (1)	WO1995013295A1 (da)

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IL92937A0 (en) *	1989-01-31	1990-09-17	Us Health	Human derived monocyte attracting protein,pharmaceutical compositions comprising it and dna encoding it
US6869924B1 (en) *	1989-01-31	2005-03-22	The United States Of America As Represented By The Department Of Health And Human Services	Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof
ES2210255T3 (es)	1993-06-08	2004-07-01	Smithkline Beecham Corporation	Metodos para mejorar la actividad biologica de quimiocinas.
US5663450A (en) *	1993-08-17	1997-09-02	Cv Therapeutics	Macrophage lipid chemoattractant
US5739103A (en) *	1993-11-12	1998-04-14	Dana-Farber Cancer Institute	Chemokine N-terminal deletion mutations
US6132987A (en) *	1994-01-13	2000-10-17	The Regents Of The University Of California	Recombinant mammalian monocyte chemotactic protein-1 (MCP-1) receptors (MCP-1R, CCR-2)
US6100389A (en) *	1995-04-21	2000-08-08	Human Genome Sciences, Inc.	Polynucleotides encoding a human chemotactic protein
US5614649A (en)	1994-11-14	1997-03-25	Cephalon, Inc.	Multicatalytic protease inhibitors
US6491906B1 (en)	1995-06-01	2002-12-10	The Regents Of The University Of Michigan	CXC chemokines as regulators of angiogenesis
US5871723A (en) *	1995-06-06	1999-02-16	The Regent Of The University Of Michigan	CXC chemokines as regulators of angiogenesis
US7265083B2 (en)	1995-06-06	2007-09-04	The Regents Of The University Of Michigan	Treatment of idiopathic pulmonary fibrosis using IP-10
US6737513B1 (en)	1996-06-07	2004-05-18	Icos Corporation	Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same
US5688927A (en) *	1995-06-07	1997-11-18	Icos Corporation	Macrophage derived chemokine
US6498015B1 (en)	1995-06-07	2002-12-24	Icos Corporation	Methods of identifying agents that modulate the binding between MDC and an MDC receptor
US6320023B1 (en)	1995-06-07	2001-11-20	Icos Corporation	Macrophage derived chemokine
SK16497A3 (en) *	1995-06-07	1998-05-06	Icos Corp	Macrophage derived chemokine and chemokine analogs
US7018627B1 (en)	1995-06-07	2006-03-28	Icos Corporation	Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US6790947B1 (en)	1995-06-07	2004-09-14	Icos Corporation	Polynucleotides encoding macrophage derived chemokine
US6042821A (en) *	1995-11-21	2000-03-28	Smithkline Beecham Corporation	Method of treating sepsis with chemokines
US6274342B1 (en)	1996-09-18	2001-08-14	Center For Blood Research, Inc.	Nucleic acid molecules encoding monocyte chemotactic protein 5 (MCP-5) molecules and uses therefor
WO1998014573A1 (en) *	1996-09-30	1998-04-09	The General Hospital Corporation	Mcp-4 and mcp-5: novel chemokines
US6673915B1 (en)	1996-09-30	2004-01-06	General Hospital Corporation	Nucleic acid encoding monocyte chemotactic protein 4
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US6541208B1 (en)	1998-03-17	2003-04-01	University Of Maryland Biotechnology Institute	Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO2000042071A2 (en) *	1999-01-12	2000-07-20	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7309693B2 (en) *	2000-05-26	2007-12-18	Kensuke Egashira	Preventives and remedies for pulmonary hypertension
AU2001292301A1 (en) *	2000-10-11	2002-04-22	Daiichi Pharmaceutical Co., Ltd.	Novel drugs for liver diseases
US6902914B2 (en) *	2001-09-28	2005-06-07	Sigma-Aldrich, Co.	Recombinant DNA processes using a dNTP mixture containing modified nucleotides
US20040116341A1 (en) *	2001-10-23	2004-06-17	Holtzman Michael J.	Methods for ameliorating childhood infections
US7541139B2 (en) *	2002-06-28	2009-06-02	The United States Of America As Represented By The Department Of Health And Human Services	Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins
US8017113B2 (en) *	2003-03-12	2011-09-13	Rappaport Family Institute For Research In The Medical Sciences	Compositions and methods for diagnosing and treating an inflammation
WO2004080273A2 (en) *	2003-03-12	2004-09-23	Rappaport Family Institute For Research In The Medical Sciences	Compositions and methods for diagnosing and treating prostate cancer
AR046594A1 (es) *	2003-10-16	2005-12-14	Applied Research Systems	Usos terapeuticos de variantes de quemoquina
US8114964B2 (en) *	2005-05-19	2012-02-14	Centocor, Inc.	Anti-MCP-1 antibodies, compositions, methods and uses
WO2007021807A1 (en) *	2005-08-12	2007-02-22	Schering Corporation	Mcp1 fusions
US20100166733A1 (en) *	2006-06-21	2010-07-01	Zurit Levin	Mcp-1 splice variants and methods of using same
JP2011509156A (ja)	2008-01-08	2011-03-24	イェールユニバーシティ	血管移植片の開存性を促進するための組成物および方法
US8524217B2 (en)	2010-05-11	2013-09-03	Merck Sharp & Dohme Corp.	MCP1-Ig fusion variants
GB201016864D0 (en)	2010-10-06	2010-11-17	Univ Aston	Therapeutic methods
WO2017100782A1 (en)	2015-12-11	2017-06-15	Research Institute At Nationwide Children's Hospital	Systems and methods for optimized patent specific tissue engineering vascular grafts

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US5168051A (en) *	1985-03-22	1992-12-01	Genentech, Inc.	Nucleic acid encoding TGF-β its uses
IL92937A0 (en) *	1989-01-31	1990-09-17	Us Health	Human derived monocyte attracting protein,pharmaceutical compositions comprising it and dna encoding it
US5212073A (en) *	1989-05-12	1993-05-18	Genetics Institute, Inc.	Process for producing human JE cytokine
US5288711A (en) *	1992-04-28	1994-02-22	American Home Products Corporation	Method of treating hyperproliferative vascular disease

1994
- 1994-10-27 US US08/330,218 patent/US5459128A/en not_active Expired - Lifetime
- 1994-11-07 PT PT95902480T patent/PT725794E/pt unknown
- 1994-11-07 JP JP51395595A patent/JP4040083B2/ja not_active Expired - Fee Related
- 1994-11-07 EP EP95902480A patent/EP0725794B1/en not_active Expired - Lifetime
- 1994-11-07 DE DE69428049T patent/DE69428049T2/de not_active Expired - Fee Related
- 1994-11-07 WO PCT/US1994/012874 patent/WO1995013295A1/en not_active Ceased
- 1994-11-07 AT AT95902480T patent/ATE204583T1/de not_active IP Right Cessation
- 1994-11-07 DK DK95902480T patent/DK0725794T3/da active
- 1994-11-07 CA CA002176217A patent/CA2176217A1/en not_active Abandoned
- 1994-11-07 ES ES95902480T patent/ES2162908T3/es not_active Expired - Lifetime
2006
- 2006-05-16 JP JP2006136983A patent/JP2006225402A/ja not_active Withdrawn
2007
- 2007-09-06 JP JP2007231416A patent/JP2008007520A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EP0725794B1 (en)	2001-08-22
DE69428049D1 (de)	2001-09-27
JP2006225402A (ja)	2006-08-31
EP0725794A1 (en)	1996-08-14
DE69428049T2 (de)	2002-04-18
CA2176217A1 (en)	1995-05-18
JP2008007520A (ja)	2008-01-17
ATE204583T1 (de)	2001-09-15
JPH09505053A (ja)	1997-05-20
ES2162908T3 (es)	2002-01-16
JP4040083B2 (ja)	2008-01-30
WO1995013295A1 (en)	1995-05-18
US5459128A (en)	1995-10-17
PT725794E (pt)	2002-02-28

Publication	Publication Date	Title
DK0725794T3 (da)	2001-12-10	Human monocyt-kemoattraktant protein-1 (MCP-1) derivater
ATE389724T1 (de)	2008-04-15	Menschliche dnase i hyperaktive varianten
NZ248377A (en)	2000-01-28	Use of interleukin-1 beta protease and interleukin-1 beta protease inhibitors
DE69738948D1 (de)	2008-10-09	Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten
RU95110938A (ru)	1997-01-10	Производные 1-(2-оксоацетил)пиперидин-2-карбоновых кислот, фармацевтическая композиция, способ лечения, способ получения
NO952744D0 (no)	1995-07-11	Cytokinbegrensende midler
HUP0000492A1 (hu)	2000-05-28	N-(Aril/heteroaril-acetil)-aminosav-észterek, azokat tartalmazó gyógyászati készítmények, valamint módszerek béta-amiloid fehérje képződése és felszabadulása gátlására e vegyületek felhasználásával
GEP20012413B (en)	2001-04-25	Novel Substituted Cyclic Amino Acids as Pharmaceutical Agents
ATE245977T1 (de)	2003-08-15	Therapeutische substituierte guanidine
NO940809D0 (no)	1994-03-08	Farmasöytisk preparat inneholdende en uricosurisk og en eksitatorisk aminosyre-antagonist
MY106067A (en)	1995-03-31	Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors.
LV10108A (lv)	1994-05-10	Sunu proliferacijas inhibitori farmaceitiska kompozicija savienojumu iegusanas metode sunu proliferacijas inhibesanas panemieni
PT652900E (pt)	2002-05-31	Inibidores da trombina
DE69818823D1 (de)	2003-11-13	Dipohosphonsäuresalze für die behandlung von osteoporose
NO921906D0 (no)	1992-05-14	Nye 2-amino-5-cyano-1,4-dihydropyridiner, deres fremstilling og anvendelse i legemidler
MX9709361A (es)	1998-02-28	Monomero de 4.4-ciclohexan-1-ols disubstituido y compuestos relacionados.
ES2191825T3 (es)	2003-09-16	Sales metalicas de acidos biliares con accion fisiologica y su uso en terapia.
DK0811068T3 (da)	2003-03-10	Humane DNase I varianter
KR950704358A (ko)	1995-11-20	카텝신 l 특이적 저해 폴리펩티드
ES2160102T3 (es)	2001-11-01	Tratamiento del eritema provocado por uv.
ATE139702T1 (de)	1996-07-15	Die freisetzung des histamin hemmenden faktors sowie diesen enthaltende präparate
FR2564831B3 (fr)	1986-09-05	Nouveaux derives des acides aroyl- ou hydroaroyl n-alcoyl pyrrolyl-2 carboxyliques et nouvelles compositions pharmaceutiques a action immuno-suppressive
BG100367A (en)	1996-07-31	The use of esters of n-alkylated, 1,4-dihydropyrimidinedicarboxylic acids as medicamentous forms
ATE306260T1 (de)	2005-10-15	Monomere der 4,4-(disubstituierten)cyclohexan-1- ole und verwandte verbindungen
BG101847A (bg)	1998-07-31	Варианти на човешка дезоксирибонуклеаза i