DK0728207T3 - Telomeraseaktivitetsassays - Google Patents

Telomeraseaktivitetsassays

Info

Publication number
DK0728207T3
DK0728207T3 DK95903110T DK95903110T DK0728207T3 DK 0728207 T3 DK0728207 T3 DK 0728207T3 DK 95903110 T DK95903110 T DK 95903110T DK 95903110 T DK95903110 T DK 95903110T DK 0728207 T3 DK0728207 T3 DK 0728207T3
Authority
DK
Denmark
Prior art keywords
telomerase activity
activity assays
telomerase
sample
measured
Prior art date
Application number
DK95903110T
Other languages
English (en)
Inventor
Calvin Bruce Harley
Nam Woo Kim
Scott Lawrence Weinrich
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0728207(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/153,051 external-priority patent/US5645986A/en
Priority claimed from US08/151,477 external-priority patent/US5830644A/en
Priority claimed from US08/255,774 external-priority patent/US5989807A/en
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of DK0728207T3 publication Critical patent/DK0728207T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95903110T 1993-11-12 1994-11-10 Telomeraseaktivitetsassays DK0728207T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/153,051 US5645986A (en) 1992-05-13 1993-11-12 Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US08/151,477 US5830644A (en) 1992-05-13 1993-11-12 Method for screening for agents which increase telomerase activity in a cell
US08/255,774 US5989807A (en) 1992-05-13 1994-06-07 Detecting cancerous conditions by assaying for telomerase activity
US08/315,214 US5629154A (en) 1993-11-12 1994-09-28 Telomerase activity assays
PCT/US1994/012951 WO1995013381A1 (en) 1993-11-12 1994-11-10 Telomerase activity assays

Publications (1)

Publication Number Publication Date
DK0728207T3 true DK0728207T3 (da) 2000-10-02

Family

ID=27495974

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903110T DK0728207T3 (da) 1993-11-12 1994-11-10 Telomeraseaktivitetsassays

Country Status (12)

Country Link
US (1) US5629154A (da)
EP (1) EP0728207B1 (da)
JP (2) JP2875394B2 (da)
AT (1) ATE193554T1 (da)
AU (1) AU682082B2 (da)
CA (1) CA2173872C (da)
DE (1) DE69424797T2 (da)
DK (1) DK0728207T3 (da)
ES (1) ES2147602T3 (da)
GR (1) GR3034249T3 (da)
PT (1) PT728207E (da)
WO (1) WO1995013381A1 (da)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693474A (en) * 1992-05-13 1997-12-02 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5863726A (en) * 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US5804380A (en) * 1993-11-12 1998-09-08 Geron Corporation Telomerase activity assays
US5876979A (en) * 1994-07-07 1999-03-02 Cold Spring Harbor Laboratory RNA component of mouse, rat, Chinese hamster and bovine telomerase
US6013468A (en) * 1994-07-07 2000-01-11 Cold Spring Harbor Laboratory RNA component of telomerase
US5698686A (en) 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5741677A (en) * 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
JPH11507839A (ja) * 1995-06-07 1999-07-13 ジェロン コーポレイション テロメラーゼ活性検定
US5840490A (en) * 1995-06-07 1998-11-24 Mcmaster University Telomerase activity associated with hematological and colorectal malignancies
US6004939A (en) 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
US6054442A (en) * 1995-07-06 2000-04-25 Board Of Regents, University Of Texas System Methods and compositions for modulation and inhibition of telomerase in vitro
US5856096A (en) * 1995-09-20 1999-01-05 Ctrc Research Foundation Rapid and sensitive assays for detecting and distinguishing between processive and non-processive telomerase activities
DE19644302A1 (de) * 1995-11-28 1997-06-05 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Telomerase-Aktivität
JPH09262100A (ja) * 1996-03-27 1997-10-07 Mount Sinai School Medicine City Univ New York テロメラーゼ活性の存在を測定することによる尿試料中のヒト膀胱癌細胞の検出方法
JPH1052300A (ja) * 1996-06-03 1998-02-24 Kyowa Hakko Kogyo Co Ltd 細胞内テロメラーゼ活性の測定法
JP3336230B2 (ja) 1996-06-28 2002-10-21 中外製薬株式会社 テロメラーゼ活性の検出方法
AU3276497A (en) 1996-06-28 1998-01-21 Chugai Seiyaku Kabushiki Kaisha Method for detecting telomerase activity
JPH1028600A (ja) * 1996-07-17 1998-02-03 Kyowa Hakko Kogyo Co Ltd テロメラーゼ活性の測定法
EA199900355A1 (ru) 1996-10-01 2000-08-28 Джерон Корпорейшн Теломераза обратная тринскриптаза
CA2270132A1 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
EP0951568A1 (en) 1996-12-20 1999-10-27 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
DE19705071A1 (de) * 1997-02-11 1998-08-13 Guido Dr Krupp Verfahren zur "Echtzeit-Analyse" von Telomeraseaktivität
AU2307599A (en) 1997-12-31 1999-07-19 University Of Texas System, The Improved telomerase extraction method
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
AU3456099A (en) 1998-03-31 1999-10-18 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
US6017709A (en) * 1998-04-29 2000-01-25 University Of Houston DNA replication templates stabilized by guanine quartets
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US6664046B1 (en) 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
EP1170378A1 (en) * 2000-06-26 2002-01-09 Boehringer Ingelheim International GmbH Method for monitoring the effect of cancer therapies
US20020045219A1 (en) * 2000-08-02 2002-04-18 Whitehead Institute For Biomedical Research Production of human monoclonal antibodies
US6428962B1 (en) 2001-02-12 2002-08-06 Dna Analysis, Inc. Nucleic acid collection barrier method and apparatus
EP1321768A1 (en) * 2001-12-18 2003-06-25 Roche Diagnostics GmbH Diagnosis of endometriosis from menstrual blood
EP1472340A4 (en) * 2002-02-05 2006-11-08 Rappaport Family Inst For Res STEM CELLS DETERMINED FOR A LINE SELECTED FOR THE PROMOTER ACTIVITY OF TELOMERASE
AU2003220187A1 (en) * 2002-03-11 2003-09-29 Regents Of The University Of Minnesota Immortal porcine cells
RU2005118073A (ru) * 2002-11-12 2006-06-10 Эллайд Байотек, Инк. (Us) Способы и композиции для детекции теломеразной активности
AP2280A (en) * 2003-06-23 2011-10-31 Geron Corp Compositions and methods for increasing telomeraseactivity.
US9248088B2 (en) 2003-06-25 2016-02-02 Telomerase Activation Sciences, Inc. Compositions and methods for skin conditioning
US20070122501A1 (en) * 2003-06-27 2007-05-31 Hong Kong University Of Science And Technology Formulations containing astragalus extracts and uses thereof
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
CN101313219B (zh) * 2005-04-01 2016-10-05 麦德维特科学控股有限公司 一种诊断和治疗方法及其所使用的试剂
EP1876893B1 (en) 2005-04-15 2012-04-11 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
EP4600359A2 (en) * 2006-10-30 2025-08-13 Geron Corporation Combined telomerase inhibitor and gemcitabine for the treatment of cancer
PT2152663E (pt) 2007-06-04 2014-06-03 Univ Ben Gurion Compostos de triarilo e composições que compreendem os mesmos
CA2703060A1 (en) * 2007-10-22 2009-04-30 The Wistar Institute Method for identifying a compound that modulates telomerase activity
EP2437606B1 (en) * 2009-05-18 2016-07-27 Telomerase Activation Sciences, Inc. Compositions and methods for increasing telomerase activity
WO2010141385A1 (en) * 2009-06-01 2010-12-09 Geron Corporation Assay for telomerase activity using microfluidic device
US9249452B2 (en) * 2010-02-26 2016-02-02 Zhu Zhen Pirot Method of detecting and assaying telomerase activity of telomerase bound by anti-telomerase antibodies
NZ701866A (en) 2010-04-16 2016-07-29 Zeus Scientific Inc Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
CA2857490C (en) 2011-12-22 2020-03-31 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
EP3052512A4 (en) 2013-09-30 2017-02-22 Geron Corporation Phosphorodiamidate backbone linkage for oligonucleotides
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
AU2018218003B2 (en) 2017-02-12 2024-02-08 Neuromagen Pharma Ltd. Telomerase activating compounds for use in fertility and related applications
IT201800002511A1 (it) 2018-02-08 2019-08-08 Univ Degli Studi Cagliari Metodo per la misurazione dell’attività della telomerasi

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3942482A (en) * 1974-10-09 1976-03-09 Foster Wheeler Energy Corporation Bayonet tube steam generator
US4424279A (en) * 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
CH663475A5 (de) * 1983-09-02 1987-12-15 Zellweger Uster Ag Verfahren und vorrichtung zum programmieren von messgeraeten und reglern.
JPS60135753A (ja) * 1983-12-23 1985-07-19 Koa Sangyo Kk 非接触水分検知装置
JPS60161554A (ja) * 1984-02-01 1985-08-23 Furuno Electric Co Ltd 塩分濃度計
US5310652A (en) * 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5334499A (en) * 1989-04-17 1994-08-02 Eastman Kodak Company Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction
US5231015A (en) * 1989-10-18 1993-07-27 Eastman Kodak Company Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme
US5413924A (en) * 1992-02-13 1995-05-09 Kosak; Kenneth M. Preparation of wax beads containing a reagent for release by heating
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
IL107150A0 (en) * 1992-09-29 1993-12-28 Isis Pharmaceuticals Inc Oligonucleotides having a conserved g4 core sequence

Also Published As

Publication number Publication date
JP2875394B2 (ja) 1999-03-31
AU682082B2 (en) 1997-09-18
GR3034249T3 (en) 2000-12-29
US5629154A (en) 1997-05-13
DE69424797T2 (de) 2000-12-28
CA2173872C (en) 2001-08-28
PT728207E (pt) 2000-11-30
ATE193554T1 (de) 2000-06-15
EP0728207A1 (en) 1996-08-28
ES2147602T3 (es) 2000-09-16
AU1209095A (en) 1995-05-29
JPH09502102A (ja) 1997-03-04
HK1011384A1 (en) 1999-07-09
JPH11243998A (ja) 1999-09-14
CA2173872A1 (en) 1995-05-18
EP0728207B1 (en) 2000-05-31
WO1995013381A1 (en) 1995-05-18
DE69424797D1 (de) 2000-07-06

Similar Documents

Publication Publication Date Title
ATE193554T1 (de) Telomerase-aktivitätsversuche
AU6644198A (en) Process for introducing a functionality
BRPI9816332B8 (pt) tira de teste de biossensor eletroquímico aperfeiçoada
EP0467078A3 (en) An analyte-subtitute reagent for use in specific binding assay methods, devices and kits
AU6031094A (en) Sensitive nucleic acid sandwich hybridization assays and kits
DE69411926D1 (de) Digital-analog-wandlung mit nicht-uniformen abtastraten
CA2142868A1 (en) Chemical and microbiological test kit
DE69840331D1 (de) Polyvalente und polyspezifische reagentienmit hoher avidität
AU4372199A (en) Electrochemical based assay processes, instrument and labels
AU4965799A (en) Bioreactor and cell culturing processes using the bioreactor
FR2659982B1 (fr) Utilisation de substrats chromogenes dans la determination de candida.
ITMI930837A1 (it) Coatings a base di perfluoropolieteri contenenti gruppi acrilici
DE69616689D1 (de) Stanzbearbeitungsverfahren und mit diesem Bearbeitungsverfahren benutztes rollenförmiges Werkzeug
ATE170092T1 (de) Künstliche rezeptoren, antikörper und enzyme
AU4346597A (en) Cycle labeling and sequencing with thermostable polymerases
WO2002102908A3 (en) Marking substrates
BR9003462A (pt) Dispersao tixotropica,composicao de revestimento e substrato revestido
AU6647490A (en) Enzyme assay and assay kit to measure cellular activation
GB9417793D0 (en) Bioluminescence and assay reagents
AU7862387A (en) Immunoassay reagents, kits and methods
FI954765L (fi) Deallylointireagenssi ja deallylointimenetelmä, jossa mainittua reagenssiä käytetään
AU2948789A (en) Enzyme labelled biochemical assay for two analytes
TW247884B (en) Ornamental aluminum panel and method for making the same
EP0811693A3 (en) A method of determining intracellular telomerase activity
BR9407433A (pt) Reagente e teste de célula