DK0732338T3 - 2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider - Google Patents
2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosiderInfo
- Publication number
- DK0732338T3 DK0732338T3 DK96300158T DK96300158T DK0732338T3 DK 0732338 T3 DK0732338 T3 DK 0732338T3 DK 96300158 T DK96300158 T DK 96300158T DK 96300158 T DK96300158 T DK 96300158T DK 0732338 T3 DK0732338 T3 DK 0732338T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbamoylribose
- nucleosides
- difluoro
- beta
- preparation
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/373,998 US5521294A (en) | 1995-01-18 | 1995-01-18 | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0732338T3 true DK0732338T3 (da) | 2002-06-17 |
Family
ID=23474799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96300158T DK0732338T3 (da) | 1995-01-18 | 1996-01-09 | 2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5521294A (da) |
| EP (1) | EP0732338B1 (da) |
| JP (1) | JP3830999B2 (da) |
| AT (1) | ATE217634T1 (da) |
| CA (1) | CA2167361C (da) |
| DE (1) | DE69621180T2 (da) |
| DK (1) | DK0732338T3 (da) |
| ES (1) | ES2176402T3 (da) |
| PT (1) | PT732338E (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7435755B2 (en) * | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| EP1270008B1 (en) * | 2001-05-31 | 2006-07-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Fused tricyclic analogues of guanosine for treating tumors |
| US7176237B2 (en) * | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| US7265096B2 (en) * | 2002-11-04 | 2007-09-04 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| WO2006015346A1 (en) * | 2004-07-30 | 2006-02-09 | Pharmaessentia Corp. | STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES |
| KR20070112774A (ko) * | 2005-03-04 | 2007-11-27 | 다브르 파마 리미티드 | 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법 |
| WO2006119347A1 (en) * | 2005-05-02 | 2006-11-09 | Pharmaessentia Corp. | STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES |
| KR20080094890A (ko) * | 2005-12-13 | 2008-10-27 | 케마지스 리미티드 | 젬시타빈 및 관련 중간체의 제조 방법 |
| WO2007092705A2 (en) * | 2006-02-07 | 2007-08-16 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US8299046B2 (en) * | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| WO2008064133A1 (en) * | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
| CN100475832C (zh) | 2007-05-31 | 2009-04-08 | 南京卡文迪许生物工程技术有限公司 | 一种新颖的高立体选择性合成吉西他滨工艺及中间体 |
| US20090048205A1 (en) * | 2007-08-15 | 2009-02-19 | Colin Meyer | Combination therapy with synthetic triterpenoids and gemcitabine |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| WO2009061894A1 (en) * | 2007-11-06 | 2009-05-14 | Pharmaessentia Corporation | Novel synthesis of beta-nucleosides |
| HUE043175T2 (hu) | 2008-01-11 | 2019-08-28 | Reata Pharmaceuticals Inc | Szintetikus triterpenoidok és alkalmazásuk betegség kezelésében |
| US8071632B2 (en) * | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| CN104250280A (zh) * | 2008-04-18 | 2014-12-31 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物 |
| ES2703274T3 (es) | 2008-04-18 | 2019-03-07 | Reata Pharmaceuticals Inc | Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17 |
| KR101713140B1 (ko) | 2008-04-18 | 2017-03-08 | 리타 파마슈티컬스 잉크. | Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체 |
| MX339476B (es) | 2008-04-18 | 2016-05-27 | Reata Pharmaceuticals Inc | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. |
| EP2309860B1 (en) | 2008-07-22 | 2014-01-08 | Trustees of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| ES2628609T3 (es) * | 2009-04-06 | 2017-08-03 | Otsuka Pharmaceutical Co., Ltd. | Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer |
| US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
| WO2010118010A1 (en) * | 2009-04-06 | 2010-10-14 | Eisai Inc. | Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer |
| EP2417146B1 (en) * | 2009-04-06 | 2016-07-13 | Otsuka Pharmaceutical Co., Ltd. | (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-one derivatives for treating cancer |
| NZ700073A (en) | 2012-04-04 | 2016-08-26 | Halozyme Inc | Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| RU2681939C2 (ru) | 2013-10-29 | 2019-03-14 | Оцука Фармасьютикал Ко., Лтд. | Путь синтезирования 2'-дезокси-2'2'-дифтортетрагидроуридинов |
| US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
| WO2026090323A1 (en) | 2024-10-23 | 2026-04-30 | Incyte Corporation | Combination therapy using a kras g12d inhibitor, and a nucleoside analog, and/or a microtubule inhibitor and its use in the treatment of cancer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949449A (en) * | 1959-01-14 | 1960-08-16 | Hoffmann La Roche | Synthesis of 3, 5-diaroyl-2-deoxy-d-ribofuranosyl ureas |
| US3575959A (en) * | 1969-05-13 | 1971-04-20 | Merck & Co Inc | 5'-substituted ribofuranosyl nucleosides |
| US3658786A (en) * | 1969-06-27 | 1972-04-25 | Syntex Corp | Branched chain ribofuranosyl nucleosides and intermediates |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US4760137A (en) * | 1984-08-06 | 1988-07-26 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| US4656260A (en) * | 1984-12-27 | 1987-04-07 | Kanto Ishi Pharmaceutical Co., Ltd. | Cyclic pyrazolo C-nucleoside compound and process for preparing the same |
| JPH0692392B2 (ja) * | 1986-04-04 | 1994-11-16 | 信彦 勝沼 | 新規プソイドウリジン誘導体 |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| DE3812681A1 (de) * | 1988-04-16 | 1989-11-02 | Bayer Ag | Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4954623A (en) * | 1989-03-20 | 1990-09-04 | Eli Lilly And Company | Recovery of difluoro sugar |
| US5216145A (en) * | 1991-05-10 | 1993-06-01 | American Cyanamid Company | Asymmetric synthesis of 3-substituted furanoside compounds |
| US5371210A (en) * | 1992-06-22 | 1994-12-06 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US5424416A (en) * | 1993-08-25 | 1995-06-13 | Eli Lilly And Company | Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides |
-
1995
- 1995-01-18 US US08/373,998 patent/US5521294A/en not_active Expired - Lifetime
-
1996
- 1996-01-09 DK DK96300158T patent/DK0732338T3/da active
- 1996-01-09 AT AT96300158T patent/ATE217634T1/de active
- 1996-01-09 DE DE69621180T patent/DE69621180T2/de not_active Expired - Lifetime
- 1996-01-09 EP EP96300158A patent/EP0732338B1/en not_active Expired - Lifetime
- 1996-01-09 PT PT96300158T patent/PT732338E/pt unknown
- 1996-01-09 ES ES96300158T patent/ES2176402T3/es not_active Expired - Lifetime
- 1996-01-16 CA CA002167361A patent/CA2167361C/en not_active Expired - Fee Related
- 1996-01-17 JP JP00563196A patent/JP3830999B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE217634T1 (de) | 2002-06-15 |
| JP3830999B2 (ja) | 2006-10-11 |
| PT732338E (pt) | 2002-09-30 |
| US5521294A (en) | 1996-05-28 |
| DE69621180T2 (de) | 2002-10-31 |
| CA2167361C (en) | 2007-09-18 |
| CA2167361A1 (en) | 1996-07-19 |
| JPH08239374A (ja) | 1996-09-17 |
| DE69621180D1 (de) | 2002-06-20 |
| EP0732338B1 (en) | 2002-05-15 |
| EP0732338A1 (en) | 1996-09-18 |
| ES2176402T3 (es) | 2002-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2176402T3 (es) | Compuestos sulfatos de 2,2-difluoro-3-carbomoil-ribosa y procedimientopara la preparacion de beta-nucleosidos. | |
| DK0789578T3 (da) | Inhibitorer af multikatalytisk protease | |
| PT618190E (pt) | 9-¬glicil substituido)amido|-6-(substituido)-5-hidroxi-6-desoxitetraciclinas | |
| TR199800011T1 (xx) | Benzo$g] kuinolin t�revleri | |
| GR3020451T3 (en) | Retroviral protease inhibitors | |
| NO950533L (no) | Hydroksyetylaminosulfonamider som er nyttige som retrovirale proteasehemmere | |
| ES2110421T3 (es) | O-bencil-oximeteres y los agentes protectores de las plantas que contienen estos compuestos. | |
| DK0572166T3 (da) | Hidtil ukendte 7beta-substitueret-4-aza-5beta-androstan-3-oner som 5beta-reduktaseinhibitorer | |
| DK0467331T3 (da) | O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler | |
| BG101833A (bg) | Гуаниново производно | |
| NO932873D0 (no) | 9-((substituerte glycyl)amido)-6-dementyl-6-deoksotetrasykliner | |
| DK0918776T3 (da) | Totalsyntese af antitumor acylfulvener | |
| KR960702830A (ko) | 방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents) | |
| TW223630B (en) | Retroviral protease inhibitors | |
| NO981393D0 (no) | Guanidinoproteasehemmere | |
| CA2018403A1 (en) | N-phenylpyrazole derivatives | |
| IT1293777B1 (it) | Processo per la preparazione di tetraazamacrocicli | |
| DK0736009T3 (da) | N-oxider af 4-arylpiperaziner og 4-arylpiperidiner som antipsykotiske medikamenter | |
| DK0552758T3 (da) | N-5-Beskyttede 2,5-diamino-4,6-dichlorpyrimidiner og fremgangsmåde til deres fremstilling | |
| BR9807785A (pt) | Processo para a preparação do composto, e, composto | |
| DK0975601T3 (da) | Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor | |
| DK0779895T3 (da) | Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider | |
| DK0640092T3 (da) | Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer | |
| TR199900016T2 (xx) | Benzo $g] kuinolin t�revleri. | |
| MX9603450A (es) | Procedimiento para la obtencion de aminotriazolinas substituidas. |