ATE217634T1 - 2,2-difluor-3-carbamoylribosesulfonat- verbindungen und verfahren zur herstellung von beta-nukleosiden - Google Patents
2,2-difluor-3-carbamoylribosesulfonat- verbindungen und verfahren zur herstellung von beta-nukleosidenInfo
- Publication number
- ATE217634T1 ATE217634T1 AT96300158T AT96300158T ATE217634T1 AT E217634 T1 ATE217634 T1 AT E217634T1 AT 96300158 T AT96300158 T AT 96300158T AT 96300158 T AT96300158 T AT 96300158T AT E217634 T1 ATE217634 T1 AT E217634T1
- Authority
- AT
- Austria
- Prior art keywords
- ribose
- difluorine
- nucleosides
- carbamoyl
- sulfonate compounds
- Prior art date
Links
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 title abstract 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/373,998 US5521294A (en) | 1995-01-18 | 1995-01-18 | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE217634T1 true ATE217634T1 (de) | 2002-06-15 |
Family
ID=23474799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96300158T ATE217634T1 (de) | 1995-01-18 | 1996-01-09 | 2,2-difluor-3-carbamoylribosesulfonat- verbindungen und verfahren zur herstellung von beta-nukleosiden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5521294A (de) |
| EP (1) | EP0732338B1 (de) |
| JP (1) | JP3830999B2 (de) |
| AT (1) | ATE217634T1 (de) |
| CA (1) | CA2167361C (de) |
| DE (1) | DE69621180T2 (de) |
| DK (1) | DK0732338T3 (de) |
| ES (1) | ES2176402T3 (de) |
| PT (1) | PT732338E (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| US7435755B2 (en) * | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| EP1270008B1 (de) * | 2001-05-31 | 2006-07-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Kondensierte trizyklische Derivate des Guanosins zur Behandlung von Tumoren |
| DK1465615T3 (da) * | 2002-01-15 | 2012-11-12 | Dartmouth College | Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf |
| EP1567169A4 (de) * | 2002-11-04 | 2009-10-21 | Xenoport Inc | Gemcitabin-prodrugs, phramazeutische zusammensetzungen und verwendungen davon |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| CN101076536A (zh) * | 2004-07-30 | 2007-11-21 | 药华医药股份有限公司 | β－核苷的立体选择性合成 |
| WO2006092808A1 (en) * | 2005-03-04 | 2006-09-08 | Dabur Pharma Limited | Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides |
| TWI368621B (en) * | 2005-05-02 | 2012-07-21 | Leyoung Biotech Co Ltd | Stereoselective synthesis of β-nucleosides |
| WO2007070804A2 (en) * | 2005-12-13 | 2007-06-21 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| KR20080099263A (ko) * | 2006-02-07 | 2008-11-12 | 케마지스 리미티드 | 젬시타빈 및 관련된 중간체의 제조 방법 |
| US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US8299046B2 (en) * | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| CA2670099A1 (en) * | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
| CN100475832C (zh) | 2007-05-31 | 2009-04-08 | 南京卡文迪许生物工程技术有限公司 | 一种新颖的高立体选择性合成吉西他滨工艺及中间体 |
| US20090048205A1 (en) * | 2007-08-15 | 2009-02-19 | Colin Meyer | Combination therapy with synthetic triterpenoids and gemcitabine |
| JO2778B1 (en) | 2007-10-16 | 2014-03-15 | ايساي انك | Certain Compounds, Compositions and Methods |
| EP2217247A4 (de) * | 2007-11-06 | 2011-12-28 | Pharmaessentia Corp | Neue synthese von beta-nucleosiden |
| TWI492745B (zh) | 2008-01-11 | 2015-07-21 | Reata Pharmaceuticals Inc | 合成的三萜系化合物及其使用於治療疾病之方法 |
| MX2010011435A (es) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. |
| DK2276493T3 (da) | 2008-04-18 | 2019-01-02 | Reata Pharmaceuticals Inc | Antioxidative inflammationsmodulatorer: oleanolsyrederivater med amino- og andre modifikationer ved c-17 |
| EA022588B1 (ru) | 2008-04-18 | 2016-01-29 | Ритэ Фамэсутикл, Инк. | Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце |
| WO2009129548A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
| TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| AU2009274037B2 (en) | 2008-07-22 | 2015-07-09 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| EP2417146B1 (de) * | 2009-04-06 | 2016-07-13 | Otsuka Pharmaceutical Co., Ltd. | Derives de la (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-one pour le traitment du cancer |
| US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
| JP5684787B2 (ja) * | 2009-04-06 | 2015-03-18 | 大塚製薬株式会社 | シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用 |
| ES2628580T3 (es) * | 2009-04-06 | 2017-08-03 | Otsuka Pharmaceutical Co., Ltd. | Combinación de decitabina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer el tratamiento de cáncer |
| US9913822B2 (en) | 2012-04-04 | 2018-03-13 | Halozyme, Inc. | Combination therapy with an anti-hyaluronan agent and therapeutic agent |
| US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
| NZ718607A (en) | 2013-10-29 | 2019-10-25 | Otsuka Pharma Co Ltd | Synthetic route to 2’-deoxy-2’,2’-difluorotetrahydrouridines |
| US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2949449A (en) * | 1959-01-14 | 1960-08-16 | Hoffmann La Roche | Synthesis of 3, 5-diaroyl-2-deoxy-d-ribofuranosyl ureas |
| US3575959A (en) * | 1969-05-13 | 1971-04-20 | Merck & Co Inc | 5'-substituted ribofuranosyl nucleosides |
| US3658786A (en) * | 1969-06-27 | 1972-04-25 | Syntex Corp | Branched chain ribofuranosyl nucleosides and intermediates |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US4760137A (en) * | 1984-08-06 | 1988-07-26 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| US4656260A (en) * | 1984-12-27 | 1987-04-07 | Kanto Ishi Pharmaceutical Co., Ltd. | Cyclic pyrazolo C-nucleoside compound and process for preparing the same |
| JPH0692392B2 (ja) * | 1986-04-04 | 1994-11-16 | 信彦 勝沼 | 新規プソイドウリジン誘導体 |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| DE3812681A1 (de) * | 1988-04-16 | 1989-11-02 | Bayer Ag | Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4954623A (en) * | 1989-03-20 | 1990-09-04 | Eli Lilly And Company | Recovery of difluoro sugar |
| US5216145A (en) * | 1991-05-10 | 1993-06-01 | American Cyanamid Company | Asymmetric synthesis of 3-substituted furanoside compounds |
| US5371210A (en) * | 1992-06-22 | 1994-12-06 | Eli Lilly And Company | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides |
| US5424416A (en) * | 1993-08-25 | 1995-06-13 | Eli Lilly And Company | Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides |
-
1995
- 1995-01-18 US US08/373,998 patent/US5521294A/en not_active Expired - Lifetime
-
1996
- 1996-01-09 DE DE69621180T patent/DE69621180T2/de not_active Expired - Lifetime
- 1996-01-09 EP EP96300158A patent/EP0732338B1/de not_active Expired - Lifetime
- 1996-01-09 DK DK96300158T patent/DK0732338T3/da active
- 1996-01-09 AT AT96300158T patent/ATE217634T1/de active
- 1996-01-09 PT PT96300158T patent/PT732338E/pt unknown
- 1996-01-09 ES ES96300158T patent/ES2176402T3/es not_active Expired - Lifetime
- 1996-01-16 CA CA002167361A patent/CA2167361C/en not_active Expired - Fee Related
- 1996-01-17 JP JP00563196A patent/JP3830999B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0732338B1 (de) | 2002-05-15 |
| JP3830999B2 (ja) | 2006-10-11 |
| DE69621180T2 (de) | 2002-10-31 |
| PT732338E (pt) | 2002-09-30 |
| DE69621180D1 (de) | 2002-06-20 |
| CA2167361A1 (en) | 1996-07-19 |
| US5521294A (en) | 1996-05-28 |
| CA2167361C (en) | 2007-09-18 |
| ES2176402T3 (es) | 2002-12-01 |
| EP0732338A1 (de) | 1996-09-18 |
| JPH08239374A (ja) | 1996-09-17 |
| DK0732338T3 (da) | 2002-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |