DK0467331T3 - O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler - Google Patents

O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler

Info

Publication number: DK0467331T3
Authority: DK; Denmark
Prior art keywords: azithromycin; methyl derivatives; co2ch2c6h5; derivatives; methyl
Prior art date: 1990-07-18

Application number

DK91111948.5T

Other languages

English (en)

Inventor

Gabrijela Kobrehel

Slobodan Djokic

Gorjana Lazarevski

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-18

Filing date

1991-07-17

Publication date

1996-02-05

1991-07-17 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

1996-02-05 Application granted granted Critical

1996-02-05 Publication of DK0467331T3 publication Critical patent/DK0467331T3/da

Links

229960004099 azithromycin Drugs 0.000 title abstract 2
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK91111948.5T 1990-07-18 1991-07-17 O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler DK0467331T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
YU140990		1990-07-18

Publications (1)

Publication Number	Publication Date
DK0467331T3 true DK0467331T3 (da)	1996-02-05

Family

ID=25554060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91111948.5T DK0467331T3 (da)	1990-07-18	1991-07-17	O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler

Country Status (20)

Country	Link
US (1)	US5250518A (da)
EP (1)	EP0467331B1 (da)
JP (1)	JP2657132B2 (da)
CN (1)	CN1029738C (da)
AT (1)	ATE129715T1 (da)
BG (1)	BG60593B1 (da)
CA (1)	CA2046956C (da)
CZ (1)	CZ280640B6 (da)
DE (1)	DE69114198T2 (da)
DK (1)	DK0467331T3 (da)
ES (1)	ES2081397T3 (da)
GR (1)	GR3018330T3 (da)
HR (1)	HRP920491B1 (da)
HU (4)	HU221803B1 (da)
PL (1)	PL166379B1 (da)
RO (1)	RO109338B1 (da)
RU (1)	RU2045533C1 (da)
SI (1)	SI9011409A (da)
SK (1)	SK279075B6 (da)
UA (1)	UA27105A1 (da)

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DK1036083T5 (da) *	1997-10-16	2005-04-04	Pliva Istrazivacki Inst D O O	Nye 9A-azalider
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RU2122549C1 (ru) *	1997-12-29	1998-11-27	Закрытое акционерное общество "Фосфосорб"	Способ хроматографического выделения и очистки белков, пептидов и их комплексов
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UA70972C2 (uk)	1998-11-20	2004-11-15	Пфайзер Продактс Інк.	13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) *	1998-12-30	2008-02-29	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	Novel oleandomycin derivatives
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
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US6465437B1 (en) *	1999-06-30	2002-10-15	Pfizer Inc.	Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
KR100336447B1 (ko) *	1999-11-24	2002-05-15	민경윤	클라리스로마이신의 개선된 제조방법
US6787342B2 (en) *	2000-02-16	2004-09-07	Merial Limited	Paste formulations
RU2230748C2 (ru) *	2000-03-15	2004-06-20	Ханми Фарм. Ко., Лтд.	Способ получения кларитромицина в виде кристаллов формы ii
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
RU2202619C2 (ru) *	2001-01-09	2003-04-20	Научно-исследовательский институт химии Нижегородского государственного университета им. Н.И. Лобачевского	Способ определения общей токсичности твердой, жидкой и газообразной сред
HRP20010301A2 (en) *	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US7271154B2 (en)	2002-02-15	2007-09-18	Merckle Gmbh	Antibiotic conjugates
AU2003219770B2 (en)	2002-02-15	2008-10-09	Merckle Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1483579A4 (en)	2002-02-15	2006-07-12	Merckle Gmbh	CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF
ITMI20022292A1 (it) *	2002-10-29	2004-04-30	Zambon Spa	9a-azalidi ad attivita' antiinfiammatoria.
AU2003264910A1 (en) *	2003-05-30	2005-01-21	Pliva - Istrazivacki Institut D.O.O.	Process for selective alkylation of macrolide and azalide derivatives
US7435805B2 (en)	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005021567A1 (en) *	2003-09-02	2005-03-10	Pliva - Istrazivacki Institut D.O.O.	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
PT1851236E (pt) *	2005-01-13	2010-10-25	Glaxosmithkline Zagreb	Macrólidos com actividade anti-inflamatória
US8362086B2 (en)	2005-08-19	2013-01-29	Merial Limited	Long acting injectable formulations
WO2010086350A1 (en)	2009-01-30	2010-08-05	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
CN102378763A (zh)	2009-01-30	2012-03-14	葛兰素集团有限公司	消炎的大环内酯
CN101830949B (zh) *	2009-03-13	2012-05-23	上海医药工业研究院	一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en)	2010-04-23	2011-10-27	Glaxo Group Limited	New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) *	2011-08-28	2013-03-06	山东方明药业集团股份有限公司	聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
AU2013239679A1 (en) *	2012-03-27	2014-10-30	Michael W. BURNET	Anti-inflammatory macrolides
GB201608236D0 (en)	2016-05-11	2016-06-22	Fidelta D O O	Seco macrolide compounds
CN110799516A (zh) *	2017-04-20	2020-02-14	来兴泰德基金会	作为抗癌剂的包含鏻离子的阿奇霉素衍生物
CA3060892A1 (en)	2017-04-20	2018-10-25	Rising Tide Foundation	Azithromycin derivatives containing a phosphonium ion as anticancer agents
EP3612177A4 (en)	2017-04-21	2021-01-13	Lunella Biotech, Inc.	TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
US11197872B2 (en)	2017-04-21	2021-12-14	Lunella Biotech, Inc.	Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
PH12019502594A1 (en)	2017-05-19	2020-10-26	Lunella Biotech Inc	Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
CA3063450A1 (en)	2017-05-19	2018-11-22	Lunella Biotech, Inc.	Companion diagnostics for mitochondrial inhibitors
KR102854338B1 (ko)	2017-06-26	2025-09-03	루넬라 바이오테크 인코포레이티드	미토케토신: 암 세포에서 케톤 대사를 표적화하는 미토콘드리아-기반의 치료제

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US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (en) *	1984-12-08	1986-10-29	Beecham Group Plc	Erythromycin derivatives
US4833236A (en) *	1986-05-02	1989-05-23	Taisho Pharmaceutical Co., Ltd.	Erythromycin derivatives
WO1989002271A1 (en) *	1987-09-10	1989-03-23	Pfizer	Azithromycin and derivatives as antiprotozoal agents

1990
- 1990-07-18 SI SI9011409A patent/SI9011409A/sl not_active IP Right Cessation
1991
- 1991-07-06 SK SK2195-91A patent/SK279075B6/sk unknown
- 1991-07-12 CA CA002046956A patent/CA2046956C/en not_active Expired - Fee Related
- 1991-07-16 RO RO148016A patent/RO109338B1/ro unknown
- 1991-07-16 CZ CS912195A patent/CZ280640B6/cs not_active IP Right Cessation
- 1991-07-17 EP EP91111948A patent/EP0467331B1/en not_active Expired - Lifetime
- 1991-07-17 RU SU915001127A patent/RU2045533C1/ru not_active IP Right Cessation
- 1991-07-17 AT AT91111948T patent/ATE129715T1/de not_active IP Right Cessation
- 1991-07-17 DE DE69114198T patent/DE69114198T2/de not_active Expired - Fee Related
- 1991-07-17 DK DK91111948.5T patent/DK0467331T3/da active
- 1991-07-17 ES ES91111948T patent/ES2081397T3/es not_active Expired - Lifetime
- 1991-07-17 UA UA5001127A patent/UA27105A1/uk unknown
- 1991-07-17 BG BG94837A patent/BG60593B1/bg unknown
- 1991-07-18 HU HU9802439A patent/HU221803B1/hu not_active IP Right Cessation
- 1991-07-18 US US07/731,781 patent/US5250518A/en not_active Expired - Lifetime
- 1991-07-18 JP JP3178514A patent/JP2657132B2/ja not_active Expired - Fee Related
- 1991-07-18 HU HU912408A patent/HUT59935A/hu unknown
- 1991-07-18 CN CN91104907A patent/CN1029738C/zh not_active Expired - Fee Related
- 1991-07-18 HU HU9202619A patent/HU215158B/hu unknown
- 1991-07-18 PL PL91291130A patent/PL166379B1/pl not_active IP Right Cessation
1992
- 1992-09-25 HR HRP-1409/90A patent/HRP920491B1/xx not_active IP Right Cessation
1995
- 1995-07-03 HU HU95P/P00748P patent/HU211659A9/hu unknown
- 1995-12-07 GR GR950403439T patent/GR3018330T3/el unknown

Also Published As

Publication number	Publication date
EP0467331B1 (en)	1995-11-02
HUT62307A (en)	1993-04-28
PL166379B1 (en)	1995-05-31
HRP920491B1 (en)	1998-10-31
HU221803B1 (hu)	2003-01-28
CN1029738C (zh)	1995-09-13
HU9202619D0 (en)	1992-12-28
UA27105A1 (uk)	2000-02-28
CS219591A3 (en)	1992-03-18
CZ280640B6 (cs)	1996-03-13
CN1059728A (zh)	1992-03-25
HRP920491A2 (en)	1994-08-31
BG94837A (bg)	1993-12-24
CA2046956C (en)	1999-01-05
DE69114198D1 (de)	1995-12-07
CA2046956A1 (en)	1992-01-19
JPH05132497A (ja)	1993-05-28
HU9802439D0 (en)	1998-12-28
EP0467331A1 (en)	1992-01-22
RU2045533C1 (ru)	1995-10-10
HUT59935A (en)	1992-07-28
PL291130A1 (en)	1992-11-16
JP2657132B2 (ja)	1997-09-24
GR3018330T3 (en)	1996-03-31
SI9011409A (en)	1995-10-31
SK279075B6 (sk)	1998-06-03
HU215158B (hu)	1998-12-28
RO109338B1 (ro)	1995-01-30
BG60593B1 (bg)	1995-09-29
HU912408D0 (en)	1991-12-30
ES2081397T3 (es)	1996-03-01
HU211659A9 (en)	1995-12-28
DE69114198T2 (de)	1996-06-27
US5250518A (en)	1993-10-05
ATE129715T1 (de)	1995-11-15

Publication	Publication Date	Title
DK0467331T3 (da)	1996-02-05	O-methylderivater af azithromycin A, fremgangsmåde og mellemprodukter til fremstilling deraf og anve ndelse deraf ved fremstilling af lægemidler
DK0732338T3 (da)	2002-06-17	2,2-difluor-3-carbamoylribosesulfonatforbindelser og fremgangsmåde til fremstilling af beta-nucleosider
DK0879236T3 (da)	2010-01-18	Derivater af camptothecin til anvendelse ved behandling af cancer
ATE18902T1 (de)	1986-04-15	Aminosaeurederivate und ihre therapeutischen verwendungen.
MX9600943A (es)	1997-04-30	Compuestos de piridonsulfonilurea, procedimientos para su produccion y herbicidas que los contienen.
TW341573B (en)	1998-10-01	New erythromycin derivatives, their preparation process and their use as medicaments
DK0464465T3 (da)	1995-05-22	Substituerede aminoalkylbiphenylderivater, antimykotiske præparater indeholdende disse derivater og mellemprodukter til fremstilling deraf
DK0429627T3 (da)	1995-11-20	Derivater af quinolin-3-carboxanilider
DK0632805T3 (da)	1999-04-19	Melaminderivater til anvendelse i behandlingen af cancer
ES2152563T3 (es)	2001-02-01	Procedimiento para preparar derivados de dihidroxipirimidina.
EP1043312A4 (en)	2001-01-17	HETEROCYCLIC COMPOUNDS WITH INHIBITING ACTIVITIES
TR199802163T2 (xx)	1999-02-22	4'-Triflorometilbifenil-2-karboksilik asit
DK0781764T3 (da)	2000-07-10	Fremgangsmåde til fremstilling af alkoxyiminoacetamid-derivater
DK0975601T3 (da)	2003-06-16	Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
ES478786A1 (es)	1980-07-01	Procedimiento para la obtencion de pigmentos de azometina.
TW358114B (en)	1999-05-11	Diasazo dyestuffs for dyeing cellulosic materials
NO20040113L (no)	2004-03-09	Variolinderivater og deres anvendelse som antitumormidler
PT98389A (pt)	1992-05-29	Processo de preparacao de derivados de estreptogramina
FR2619810B1 (fr)	1990-01-05	Nouveaux monomeres ethyleniques polyfonctionnels
IT1231765B (it)	1991-12-21	Malte aeree a presa autogena.
DK0533131T3 (da)	1995-12-04	Fremgangsmåde til selektiv mono-ortho-hydroxy-alkylering af 4-substituerede pyridin-derivater
DK0678515T3 (da)	1998-11-02	Fremgangsmåde og mellemprodukter til fremstilling af 5-oxaspiro[2.4]heptan-on
DK112392A (da)	1992-09-14	Bis(aminomethyl)bicyklooe2,2,1aaheptan-derivater og anvendelsen deraf til inhibering af udfaeldning af metalioner fra deres vandige oploesninger
AR007463A1 (es)	1999-10-27	Colorantes monoazoicos sustituidos por grupos haloalquilcarbamato y sulfonilfluoruro