DK0733104T3 - Oprensning af vitamin-K afhængig af proteiner ved membranchromatografi - Google Patents
Oprensning af vitamin-K afhængig af proteiner ved membranchromatografiInfo
- Publication number
- DK0733104T3 DK0733104T3 DK95903324T DK95903324T DK0733104T3 DK 0733104 T3 DK0733104 T3 DK 0733104T3 DK 95903324 T DK95903324 T DK 95903324T DK 95903324 T DK95903324 T DK 95903324T DK 0733104 T3 DK0733104 T3 DK 0733104T3
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin
- proteins
- purification
- depending
- membrane chromatography
- Prior art date
Links
- 229930003448 Vitamin K Natural products 0.000 title abstract 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 title abstract 2
- 235000019168 vitamin K Nutrition 0.000 title abstract 2
- 239000011712 vitamin K Substances 0.000 title abstract 2
- 150000003721 vitamin K derivatives Chemical class 0.000 title abstract 2
- 229940046010 vitamin k Drugs 0.000 title abstract 2
- 238000011140 membrane chromatography Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102000017975 Protein C Human genes 0.000 abstract 1
- 229940096437 Protein S Drugs 0.000 abstract 1
- 102000029301 Protein S Human genes 0.000 abstract 1
- 108010066124 Protein S Proteins 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 108010012557 prothrombin complex concentrates Proteins 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4342132A DE4342132C1 (de) | 1993-12-10 | 1993-12-10 | Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie |
| PCT/EP1994/004067 WO1995016030A1 (en) | 1993-12-10 | 1994-12-07 | Purification of vitamin-k dependent proteins by membrane chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0733104T3 true DK0733104T3 (da) | 2005-01-17 |
Family
ID=6504650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95903324T DK0733104T3 (da) | 1993-12-10 | 1994-12-07 | Oprensning af vitamin-K afhængig af proteiner ved membranchromatografi |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20020045240A1 (da) |
| EP (1) | EP0733104B1 (da) |
| JP (1) | JPH09506256A (da) |
| KR (1) | KR100320394B1 (da) |
| CN (1) | CN1175105C (da) |
| AT (1) | ATE276357T1 (da) |
| AU (1) | AU682560B2 (da) |
| CA (1) | CA2178208C (da) |
| CZ (1) | CZ291708B6 (da) |
| DE (2) | DE4342132C1 (da) |
| DK (1) | DK0733104T3 (da) |
| ES (1) | ES2224119T3 (da) |
| HU (1) | HU222084B1 (da) |
| IL (1) | IL111925A (da) |
| PL (1) | PL180179B1 (da) |
| PT (1) | PT733104E (da) |
| UA (1) | UA44261C2 (da) |
| WO (1) | WO1995016030A1 (da) |
| ZA (1) | ZA949820B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT409334B (de) * | 1997-09-19 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
| EP3087991A1 (en) | 2003-11-08 | 2016-11-02 | Prothera Biologics | Composition of inter-alpha inhibitor proteins from human plasma for therapeutic use |
| JP2005315666A (ja) * | 2004-04-28 | 2005-11-10 | Toshihiko Hanai | 糖結合充填剤およびその製造方法 |
| JP2008525381A (ja) * | 2004-12-23 | 2008-07-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 関心のあるビタミンｋ依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少 |
| KR100667860B1 (ko) | 2005-10-18 | 2007-01-11 | 주식회사 녹십자 | 고순도 사람 혈액응고 제9인자의 정제 방법 |
| JP5883849B2 (ja) * | 2010-04-29 | 2016-03-15 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法 |
| AU2011343813B2 (en) | 2010-12-15 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Eluate collection using conductivity gradient |
| CN103665098B (zh) * | 2012-09-20 | 2015-08-05 | 中国科学院大连化学物理研究所 | 双相柱膜蛋白质微反应器及其应用 |
| CN104447975A (zh) * | 2014-11-18 | 2015-03-25 | 深圳市人口和计划生育科学研究所 | 一种提取人肿瘤细胞膜蛋白的方法 |
| JP7432506B2 (ja) | 2017-10-30 | 2024-02-16 | 武田薬品工業株式会社 | 脂質エンベロープウイルスを不活化するための環境適合性の界面活性剤 |
| CN111378029B (zh) * | 2018-12-29 | 2023-05-05 | 四川远大蜀阳药业有限责任公司 | 一种人凝血因子ix的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0050061B2 (en) * | 1980-10-06 | 1990-06-20 | New York Blood Center, Inc. | Method of reducing undesirable activities of biological and pharmaceutical products |
| DE3045153A1 (de) * | 1980-11-29 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x |
| US4820805A (en) * | 1983-07-14 | 1989-04-11 | New York Blood Center, Inc. | Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives |
| US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| ATE130620T1 (de) * | 1986-01-06 | 1995-12-15 | Blood Systems Inc | Therapeutisches blutprodukt, mittel und verfahren zu dessen erzeugung. |
| EP0317376B2 (fr) * | 1987-10-23 | 1996-04-03 | Centre Regional De Transfusion Sanguine De Lille | Préparation de concentré de facteur IX humain de haute pureté et d'autres protéines plasmatiques |
| CA2001720C (en) * | 1988-10-31 | 2001-10-02 | Randal A. Goffe | Membrane affinity apparatus and purification methods related thereto |
| DE3914869C1 (da) * | 1989-05-05 | 1990-08-09 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
| EP0513332A4 (en) * | 1990-11-14 | 1993-03-17 | Cargill, Incorporated | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
| AT402261B (de) * | 1991-01-25 | 1997-03-25 | Immuno Ag | Komplex enthaltend den gerinnungsfaktor ix |
| AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
| DE4204694C3 (de) * | 1992-02-01 | 1995-10-12 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
-
1993
- 1993-12-10 DE DE4342132A patent/DE4342132C1/de not_active Expired - Lifetime
-
1994
- 1994-07-12 UA UA96062228A patent/UA44261C2/uk unknown
- 1994-12-07 PL PL94314801A patent/PL180179B1/pl not_active IP Right Cessation
- 1994-12-07 CN CNB94194445XA patent/CN1175105C/zh not_active Expired - Fee Related
- 1994-12-07 EP EP95903324A patent/EP0733104B1/en not_active Expired - Lifetime
- 1994-12-07 AT AT95903324T patent/ATE276357T1/de active
- 1994-12-07 KR KR1019960703050A patent/KR100320394B1/ko not_active Expired - Fee Related
- 1994-12-07 PT PT95903324T patent/PT733104E/pt unknown
- 1994-12-07 CZ CZ19961670A patent/CZ291708B6/cs not_active IP Right Cessation
- 1994-12-07 WO PCT/EP1994/004067 patent/WO1995016030A1/en not_active Ceased
- 1994-12-07 DK DK95903324T patent/DK0733104T3/da active
- 1994-12-07 JP JP7515975A patent/JPH09506256A/ja active Pending
- 1994-12-07 US US08/646,331 patent/US20020045240A1/en not_active Abandoned
- 1994-12-07 AU AU12425/95A patent/AU682560B2/en not_active Ceased
- 1994-12-07 ES ES95903324T patent/ES2224119T3/es not_active Expired - Lifetime
- 1994-12-07 IL IL11192594A patent/IL111925A/xx not_active IP Right Cessation
- 1994-12-07 DE DE69434001T patent/DE69434001T2/de not_active Expired - Lifetime
- 1994-12-07 CA CA002178208A patent/CA2178208C/en not_active Expired - Fee Related
- 1994-12-07 HU HU9601594A patent/HU222084B1/hu not_active IP Right Cessation
- 1994-12-09 ZA ZA949820A patent/ZA949820B/xx unknown
-
2002
- 2002-05-02 US US10/136,468 patent/US6893856B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2178208C (en) | 2009-06-02 |
| US6893856B2 (en) | 2005-05-17 |
| CN1137292A (zh) | 1996-12-04 |
| EP0733104A1 (en) | 1996-09-25 |
| WO1995016030A1 (en) | 1995-06-15 |
| DE4342132C1 (de) | 1994-11-03 |
| PT733104E (pt) | 2004-12-31 |
| CZ167096A3 (en) | 1996-09-11 |
| IL111925A (en) | 2000-06-01 |
| CZ291708B6 (cs) | 2003-05-14 |
| US20020045240A1 (en) | 2002-04-18 |
| ES2224119T3 (es) | 2005-03-01 |
| EP0733104B1 (en) | 2004-09-15 |
| CA2178208A1 (en) | 1995-06-15 |
| UA44261C2 (uk) | 2002-02-15 |
| DE69434001D1 (de) | 2004-10-21 |
| HUT76881A (en) | 1997-12-29 |
| IL111925A0 (en) | 1995-03-15 |
| ATE276357T1 (de) | 2004-10-15 |
| KR100320394B1 (ko) | 2002-07-31 |
| HU222084B1 (hu) | 2003-04-28 |
| CN1175105C (zh) | 2004-11-10 |
| AU682560B2 (en) | 1997-10-09 |
| JPH09506256A (ja) | 1997-06-24 |
| PL314801A1 (en) | 1996-09-30 |
| ZA949820B (en) | 1995-08-16 |
| DE69434001T2 (de) | 2005-09-22 |
| HU9601594D0 (en) | 1996-07-29 |
| PL180179B1 (pl) | 2000-12-29 |
| US20020182582A1 (en) | 2002-12-05 |
| AU1242595A (en) | 1995-06-27 |
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