DK0738280T3 - Antagonist til vasoaktivt tarmpolypeptid (VTP) - Google Patents

Antagonist til vasoaktivt tarmpolypeptid (VTP)

Info

Publication number: DK0738280T3
Authority: DK; Denmark
Prior art keywords: vip; vasoactive intestinal; vtp; antagonist; relates
Prior art date: 1994-02-07

Application number

DK95909489T

Other languages

English (en)

Inventor

W Moody Terry

Illana Gozes

E Brenneman Douglas

Matityahu Fridkin

Original Assignee

Univ Ramot

Yeda Res & Dev

W Moody Terry

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-07

Filing date

1995-02-06

Publication date

2001-09-17

1995-02-06 Application filed by Univ Ramot, Yeda Res & Dev, W Moody Terry, Us Gov Health & Human Serv filed Critical Univ Ramot

2001-09-17 Application granted granted Critical

2001-09-17 Publication of DK0738280T3 publication Critical patent/DK0738280T3/da

Links

108010003205 Vasoactive Intestinal Peptide Proteins 0.000 title abstract 7
102400000015 Vasoactive intestinal peptide Human genes 0.000 title abstract 7
239000005557 antagonist Substances 0.000 title abstract 2
VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 5
230000000694 effects Effects 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
230000032823 cell division Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000005062 synaptic transmission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Vascular Medicine (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK95909489T 1994-02-07 1995-02-06 Antagonist til vasoaktivt tarmpolypeptid (VTP) DK0738280T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/194,591 US5565424A (en)	1994-02-07	1994-02-07	Superactive VIP antagonists
PCT/US1995/001496 WO1995021194A1 (en)	1994-02-07	1995-02-06	Superactive vip antagonists

Publications (1)

Publication Number	Publication Date
DK0738280T3 true DK0738280T3 (da)	2001-09-17

Family

ID=22718168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95909489T DK0738280T3 (da)	1994-02-07	1995-02-06	Antagonist til vasoaktivt tarmpolypeptid (VTP)

Country Status (11)

Country	Link
US (1)	US5565424A (da)
EP (1)	EP0738280B1 (da)
JP (1)	JP3588119B2 (da)
AT (1)	ATE199160T1 (da)
AU (1)	AU697829B2 (da)
CA (1)	CA2182795C (da)
DE (1)	DE69520092T2 (da)
DK (1)	DK0738280T3 (da)
ES (1)	ES2155886T3 (da)
IL (1)	IL112557A (da)
WO (1)	WO1995021194A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US6492330B1 (en) *	1996-08-16	2002-12-10	National Institute Of Immunology	Antiangiogenic drugs
US6156725A (en) *	1996-08-16	2000-12-05	National Institute Of Immunology	Drug for the treatment of cancer
EP0835662B1 (en) *	1996-10-08	2001-11-14	National Institute of Immunology	A drug for the treatment of cancer
US20020099003A1 (en) *	1997-10-28	2002-07-25	Wilson Leland F.	Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof
CA2346866A1 (en) *	1998-10-16	2000-04-27	The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services	Combination therapy with vip antagonist
EP1257575B1 (en)	2000-02-18	2007-02-28	Dabur Research Foundation	Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
US6489297B1 (en)	2000-02-18	2002-12-03	Dabur Research Foundation	Vasoactive intestinal peptide analogs
EP1409519A1 (en) *	2000-07-31	2004-04-21	Dabur Research Foundation	Lipid-peptide conjugates for treatment of cancer
US6828304B1 (en)	2000-07-31	2004-12-07	Dabur Research Foundation	Peptides for treatment of cancer
US20060075968A1 (en) *	2004-10-12	2006-04-13	Applied Materials, Inc.	Leak detector and process gas monitor
AU2012259470B2 (en)	2011-02-02	2017-01-12	Emory University	Antagonism of the VIP signaling pathway
US9458217B2 (en) *	2013-12-05	2016-10-04	Emory University	Methods of managing graft versus host disease
EP4261277A3 (en)	2016-04-08	2024-01-03	Emory University	Methods of treating cancer and infectious diseases using cell based therapies
WO2019094817A1 (en)	2017-11-10	2019-05-16	Emory University	Nanoparticles conjugated with vasoactive intestinal peptide antagonists
WO2019209952A2 (en)	2018-04-23	2019-10-31	Emory University	Vip antagonists and uses in treating cancer
WO2020102694A1 (en) *	2018-11-15	2020-05-22	Emory University	Compositions and uses of vasoactive intestinal peptide (vip) antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734400A (en) *	1984-10-09	1988-03-29	Hoffmann-La Roche Inc.	Synthetic vasoactive intestinal peptide analogs
US4605641A (en) *	1984-10-09	1986-08-12	Hoffmann-La Roche Inc.	Synthetic vasoactive intestinal peptide analogs
US5196315A (en) *	1990-05-01	1993-03-23	The Johns Hopkins University	Human neuronal cell line
DK0463450T3 (da) *	1990-06-26	1994-06-27	Sanwa Kagaku Kenkyusho Co	Vasoaktive intestinale polypeptid-analoger og udnyttelsen heraf
US5217953A (en) *	1990-11-30	1993-06-08	The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services	Vasoactive intestinal peptide antagonist
US5273963A (en) *	1991-03-29	1993-12-28	The George Washington University	Compositions and methods for treating small cell and nonsmall cell lung cancers
IL99924A (en) *	1991-10-31	1995-12-31	Yeda Res & Dev	Derivatives of structurally modified vip and pharmaceutical compositions containing them

1994
- 1994-02-07 US US08/194,591 patent/US5565424A/en not_active Expired - Lifetime
1995
- 1995-02-06 IL IL11255795A patent/IL112557A/xx not_active IP Right Cessation
- 1995-02-06 DK DK95909489T patent/DK0738280T3/da active
- 1995-02-06 AT AT95909489T patent/ATE199160T1/de not_active IP Right Cessation
- 1995-02-06 WO PCT/US1995/001496 patent/WO1995021194A1/en not_active Ceased
- 1995-02-06 ES ES95909489T patent/ES2155886T3/es not_active Expired - Lifetime
- 1995-02-06 DE DE69520092T patent/DE69520092T2/de not_active Expired - Fee Related
- 1995-02-06 AU AU17438/95A patent/AU697829B2/en not_active Ceased
- 1995-02-06 EP EP95909489A patent/EP0738280B1/en not_active Expired - Lifetime
- 1995-02-06 CA CA002182795A patent/CA2182795C/en not_active Expired - Fee Related
- 1995-02-06 JP JP52080495A patent/JP3588119B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0738280B1 (en)	2001-02-14
IL112557A (en)	2000-02-17
WO1995021194A1 (en)	1995-08-10
CA2182795A1 (en)	1995-08-10
DE69520092T2 (de)	2001-08-02
US5565424A (en)	1996-10-15
JP3588119B2 (ja)	2004-11-10
AU1743895A (en)	1995-08-21
ES2155886T3 (es)	2001-06-01
CA2182795C (en)	2007-11-06
IL112557A0 (en)	1995-05-26
EP0738280A1 (en)	1996-10-23
JPH09511494A (ja)	1997-11-18
ATE199160T1 (de)	2001-02-15
AU697829B2 (en)	1998-10-15
DE69520092D1 (de)	2001-03-22

Publication	Publication Date	Title
DK0738280T3 (da)	2001-09-17	Antagonist til vasoaktivt tarmpolypeptid (VTP)
IL70944A (en)	1990-11-29	Octapeptide vasopressin antagonists,their preparation and pharmaceutical compositions comprising them
DE69939327D1 (de)	2008-09-25	Funktionelle antagonisten von hedgehog-aktivität
DE69942753D1 (de)	2010-10-21	Peptidantagonist von Zonulin und dessen Verwendung
ATE398630T1 (de)	2008-07-15	Zyklische conotoxin-peptide
YU50592A (sh)	1994-09-09	Antagonisti galanina
MXPA03001468A (es)	2004-05-04	Polipeptidos de claudia.
FI973691A7 (fi)	1997-09-15	Amlodipiinia tai sen suolaa tai felodipiinia ja ACE:n estäjää sisältäv iä koostumuksia
UA26845C2 (uk)	1999-12-29	Похідhі пептидів, що є аhтагоhістами речовиhи р та hейрокіhіhу а
AU6435700A (en)	2001-02-05	Cyclic peptidomimetic urokinase receptor antagonists
UA41300C2 (uk)	2001-09-17	Аналоги гормонів-антагоністів lhrh і спосіб їх отримання
EP1246619A4 (en)	2003-05-02	UROTENSIN II RECEPTOR ANTAGONISTS
DE69938130D1 (de)	2008-03-27	Neue peptide
DE69434151D1 (de)	2004-12-30	Therapeutische inhaltsstoffe
NO992298L (no)	1999-07-08	Konformasjonsbegrensede LH-RH analoger, anvendelse derav og farmas°ytiske sammensetninger inneholdende disse
DE69526738D1 (de)	2002-06-20	Endothelin-rezeptor-antagonisten
EP0154544A3 (en)	1988-10-05	Des-proline vasopressin antagonists
WO1999025732A3 (en)	1999-09-02	Design of coiled-coil dimer derived antagonists of 4-helix bundle cytokine specific receptors
PL1668027T3 (pl)	2010-10-29	Cykliczne peptydy działające jako antagoniści Urotensyny-II
MX9203582A (es)	1992-07-01	Peptidos y composiciones farmaceuticas con actividad agonista y antagonista de la hormona de glicoproteina.