ATE199160T1 - Hochaktive vip - antagonisten - Google Patents

Hochaktive vip - antagonisten

Info

Publication number: ATE199160T1
Authority: AT; Austria
Prior art keywords: vip; highly active; relates; vip antagonists; peptides
Prior art date: 1994-02-07

Application number

AT95909489T

Other languages

English (en)

Inventor

Terry W Moody

Illana Gozes

Douglas E Brenneman

Matityahu Fridkin

Original Assignee

Us Gov Health & Human Serv

Univ Ramot

Yeda Res & Dev

Terry W Moody

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-07

Filing date

1995-02-06

Publication date

2001-02-15

1995-02-06 Application filed by Us Gov Health & Human Serv, Univ Ramot, Yeda Res & Dev, Terry W Moody filed Critical Us Gov Health & Human Serv

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199160T1 publication Critical patent/ATE199160T1/de

Links

239000005557 antagonist Substances 0.000 title abstract 2
108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 5
102400000015 Vasoactive intestinal peptide Human genes 0.000 abstract 5
VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 5
230000000694 effects Effects 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
230000032823 cell division Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000005062 synaptic transmission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT95909489T 1994-02-07 1995-02-06 Hochaktive vip - antagonisten ATE199160T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/194,591 US5565424A (en)	1994-02-07	1994-02-07	Superactive VIP antagonists
PCT/US1995/001496 WO1995021194A1 (en)	1994-02-07	1995-02-06	Superactive vip antagonists

Publications (1)

Publication Number	Publication Date
ATE199160T1 true ATE199160T1 (de)	2001-02-15

Family

ID=22718168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95909489T ATE199160T1 (de)	1994-02-07	1995-02-06	Hochaktive vip - antagonisten

Country Status (11)

Country	Link
US (1)	US5565424A (de)
EP (1)	EP0738280B1 (de)
JP (1)	JP3588119B2 (de)
AT (1)	ATE199160T1 (de)
AU (1)	AU697829B2 (de)
CA (1)	CA2182795C (de)
DE (1)	DE69520092T2 (de)
DK (1)	DK0738280T3 (de)
ES (1)	ES2155886T3 (de)
IL (1)	IL112557A (de)
WO (1)	WO1995021194A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US6492330B1 (en) *	1996-08-16	2002-12-10	National Institute Of Immunology	Antiangiogenic drugs
US6156725A (en) *	1996-08-16	2000-12-05	National Institute Of Immunology	Drug for the treatment of cancer
EP0835662B1 (de) *	1996-10-08	2001-11-14	National Institute of Immunology	Arzneimittel zur Behandlung von Krebs
US20020099003A1 (en) *	1997-10-28	2002-07-25	Wilson Leland F.	Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof
JP2003530297A (ja) *	1998-10-16	2003-10-14	ザガバメントオブザユナイテッドステイツオブアメリカ，リプリゼンテッドバイザセクレタリーオブザデパートメントオブヘルスアンドヒューマンサービシーズ	Ｖｉｐアンタゴニストを用いる併用療法
DE60033697D1 (de)	2000-02-18	2007-04-12	Dabur Res Foundation Sahibabad	Radiomarkierte vip-analoge zur diagnose und therapie
AU2000265051A1 (en) *	2000-02-18	2001-08-27	Dabur Research Foundation	Vasoactive intestinal peptide analogs
US6828304B1 (en)	2000-07-31	2004-12-07	Dabur Research Foundation	Peptides for treatment of cancer
WO2002010193A1 (en) *	2000-07-31	2002-02-07	Dabur Research Foundation	Lipid-peptide conjugates for treatment of cancer
US20060075968A1 (en) *	2004-10-12	2006-04-13	Applied Materials, Inc.	Leak detector and process gas monitor
US9669092B2 (en)	2011-02-02	2017-06-06	Emory University	Antagonism of the VIP signaling pathway
US9458217B2 (en) *	2013-12-05	2016-10-04	Emory University	Methods of managing graft versus host disease
EP3439685B1 (de)	2016-04-08	2023-07-05	Emory University	Verfahren zur behandlung von krebs und infektionskrankheiten mit zellbasierten therapien
WO2019094817A1 (en)	2017-11-10	2019-05-16	Emory University	Nanoparticles conjugated with vasoactive intestinal peptide antagonists
WO2019209952A2 (en)	2018-04-23	2019-10-31	Emory University	Vip antagonists and uses in treating cancer
AU2019381809B2 (en) *	2018-11-15	2025-09-11	Emory University	Compositions and uses of vasoactive intestinal peptide (VIP) antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605641A (en) *	1984-10-09	1986-08-12	Hoffmann-La Roche Inc.	Synthetic vasoactive intestinal peptide analogs
US4734400A (en) *	1984-10-09	1988-03-29	Hoffmann-La Roche Inc.	Synthetic vasoactive intestinal peptide analogs
US5196315A (en) *	1990-05-01	1993-03-23	The Johns Hopkins University	Human neuronal cell line
DK0463450T3 (da) *	1990-06-26	1994-06-27	Sanwa Kagaku Kenkyusho Co	Vasoaktive intestinale polypeptid-analoger og udnyttelsen heraf
US5217953A (en) *	1990-11-30	1993-06-08	The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services	Vasoactive intestinal peptide antagonist
US5273963A (en) *	1991-03-29	1993-12-28	The George Washington University	Compositions and methods for treating small cell and nonsmall cell lung cancers
IL99924A (en) *	1991-10-31	1995-12-31	Yeda Res & Dev	Derivatives of structurally modified vip and pharmaceutical compositions containing them

1994
- 1994-02-07 US US08/194,591 patent/US5565424A/en not_active Expired - Lifetime
1995
- 1995-02-06 IL IL11255795A patent/IL112557A/xx not_active IP Right Cessation
- 1995-02-06 WO PCT/US1995/001496 patent/WO1995021194A1/en not_active Ceased
- 1995-02-06 JP JP52080495A patent/JP3588119B2/ja not_active Expired - Fee Related
- 1995-02-06 ES ES95909489T patent/ES2155886T3/es not_active Expired - Lifetime
- 1995-02-06 AU AU17438/95A patent/AU697829B2/en not_active Ceased
- 1995-02-06 DE DE69520092T patent/DE69520092T2/de not_active Expired - Fee Related
- 1995-02-06 CA CA002182795A patent/CA2182795C/en not_active Expired - Fee Related
- 1995-02-06 EP EP95909489A patent/EP0738280B1/de not_active Expired - Lifetime
- 1995-02-06 AT AT95909489T patent/ATE199160T1/de not_active IP Right Cessation
- 1995-02-06 DK DK95909489T patent/DK0738280T3/da active

Also Published As

Publication number	Publication date
WO1995021194A1 (en)	1995-08-10
DK0738280T3 (da)	2001-09-17
JP3588119B2 (ja)	2004-11-10
CA2182795C (en)	2007-11-06
ES2155886T3 (es)	2001-06-01
DE69520092D1 (de)	2001-03-22
JPH09511494A (ja)	1997-11-18
AU1743895A (en)	1995-08-21
US5565424A (en)	1996-10-15
CA2182795A1 (en)	1995-08-10
IL112557A (en)	2000-02-17
IL112557A0 (en)	1995-05-26
EP0738280B1 (de)	2001-02-14
EP0738280A1 (de)	1996-10-23
AU697829B2 (en)	1998-10-15
DE69520092T2 (de)	2001-08-02

Legal Events

Date	Code	Title	Description
2001-06-15	UEP	Publication of translation of european patent specification
2010-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69520092D1 (de)	2001-03-22	Hochaktive VIP - Antagonisten
AU577778B2 (en)	1988-10-06	Octapeptide vasopressin antagonists
DK1091975T3 (da)	2006-04-18	Ny cyclosporin med forbedret aktivitetsprofil
DZ2509A1 (fr)	2003-01-25	Analogues peptidiques de la lh-rh leur utilisationet les compositions pharmaceutiques les contenant.
FI880509A7 (fi)	1988-08-06	LHRH:n nonapeptidi- ja dekapeptidianalogeja, jotka ovat käyttökelpoisia LHRH:n antagonisteina
DK0994710T4 (da)	2005-10-17	Farmaceutiske præparater til oral indgivelse omfattende en benzylhydrylpiperazin og en cyclodextrin
IL136285A0 (en)	2001-05-20	Pharmaceutical compositions containing an acid-labile active component
ATE286740T1 (de)	2005-01-15	Zyklische peptide mit breitspektrum antimikrobieller aktivität
DE69939327D1 (de)	2008-09-25	Funktionelle antagonisten von hedgehog-aktivität
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
DE69938935D1 (de)	2008-07-31	Zyklische conotoxin-peptide
FI954986L (fi)	1995-10-19	Uudet, suun kautta annettavat, syklosporiinia sisältävät farmaseuttiset valmisteet
WO2001005811A3 (de)	2001-07-19	Zyklische peptidomimetische urokinaserezeptorantagonisten
ITRM950273A0 (it)	1995-04-28	Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni farmaceutiche.
HRP20000400B1 (hr)	2009-06-30	Transmukozni pripravci levosimendana
SE9702794D0 (sv)	1997-07-24	New compounds
ZA9710254B (en)	1998-05-28	LH-RH peptide analogues, their uses and pharmaceutical composition containing them.
ATE283279T1 (de)	2004-12-15	Therapeutische inhaltsstoffe
BG102514A (en)	1999-04-30	New lh-rh-antagonists of improved effect
JO1362B1 (en)	1986-11-30	Antagonists that do not contain proline unit and have the effectiveness of vasopressin compounds
WO2002020437A3 (en)	2002-05-10	Basic compounds containing tertiary amides with activity on tachykinin receptors, and pharmaceutical compositions containing them
IE881484L (en)	1988-11-21	Cyclic peptide compounds, vasopressin antagonists
MY127600A (en)	2006-12-29	Solid oral dosage forms of valsartan
BG103873A (en)	2000-06-30	The use of protein-containing microparticles with adsorbed antibody for the preparation of pharmaceutical composition for intranasal administration