DK0742796T3 - IL-3-variant-hæmatopoiesefusionsprotein - Google Patents

IL-3-variant-hæmatopoiesefusionsprotein

Info

Publication number
DK0742796T3
DK0742796T3 DK95908514T DK95908514T DK0742796T3 DK 0742796 T3 DK0742796 T3 DK 0742796T3 DK 95908514 T DK95908514 T DK 95908514T DK 95908514 T DK95908514 T DK 95908514T DK 0742796 T3 DK0742796 T3 DK 0742796T3
Authority
DK
Denmark
Prior art keywords
variant
hil
amino acid
relates
hæmatopoiesefusionsprotein
Prior art date
Application number
DK95908514T
Other languages
English (en)
Inventor
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Peter O Olins
Kumnan Paik
Christopher S Bauer
Barbara Kure Klein
Kearn John Patrick Mc
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0742796T3 publication Critical patent/DK0742796T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK95908514T 1994-02-04 1995-01-25 IL-3-variant-hæmatopoiesefusionsprotein DK0742796T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,299 US5738849A (en) 1992-11-24 1994-02-04 Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
PCT/US1995/000549 WO1995021197A1 (en) 1994-02-04 1995-01-25 Il-3 variant hematopoiesis fusion protein

Publications (1)

Publication Number Publication Date
DK0742796T3 true DK0742796T3 (da) 2003-08-11

Family

ID=22709107

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95908514T DK0742796T3 (da) 1994-02-04 1995-01-25 IL-3-variant-hæmatopoiesefusionsprotein

Country Status (12)

Country Link
US (4) US5738849A (da)
EP (2) EP0742796B1 (da)
JP (1) JPH09508524A (da)
AT (1) ATE237641T1 (da)
AU (1) AU700220B2 (da)
CA (1) CA2182483C (da)
DE (1) DE69530374T2 (da)
DK (1) DK0742796T3 (da)
ES (1) ES2197191T3 (da)
NZ (1) NZ279624A (da)
PT (1) PT742796E (da)
WO (1) WO1995021197A1 (da)

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US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
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US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
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US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
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US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
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ATE500838T1 (de) * 2000-09-08 2011-03-15 Amylin Pharmaceuticals Inc ßPSEUDOß-NATIVE CHEMISCHE LIGATION
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
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WO2002079415A2 (en) * 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
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Also Published As

Publication number Publication date
ATE237641T1 (de) 2003-05-15
US5858347A (en) 1999-01-12
WO1995021197A1 (en) 1995-08-10
AU700220B2 (en) 1998-12-24
US6132991A (en) 2000-10-17
HK1013655A1 (en) 1999-09-03
AU1680595A (en) 1995-08-21
US6074639A (en) 2000-06-13
ES2197191T3 (es) 2004-01-01
US5738849A (en) 1998-04-14
DE69530374D1 (de) 2003-05-22
JPH09508524A (ja) 1997-09-02
EP0742796A1 (en) 1996-11-20
EP0742796B1 (en) 2003-04-16
CA2182483C (en) 2002-04-02
CA2182483A1 (en) 1995-08-10
EP1323737A2 (en) 2003-07-02
EP1323737A3 (en) 2003-10-15
PT742796E (pt) 2003-08-29
DE69530374T2 (de) 2003-12-18
NZ279624A (en) 1998-05-27

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